Enhanced skin permeation of naltrexone by pulsed electromagnetic fields in human skin in vitro

Journal of Pharmaceutical Sciences

Volumn 99, Issue 6, 2010, Pages 2724-2731

  Krishnan, Gayathri ^a   Edwards, Jeffrey ^b   Chen, Yan ^a   Benson, Heather A E ^a  

^a CURTIN UNIVERSITY   (Australia)

^b OBJ Ltd   (Australia)

Author keywords

Dermatology; Inductive energy; Noninvasive; Pulsed electro magnetic field; Skin penetration enhancement

Indexed keywords

GOLD NANOPARTICLE; NALTREXONE;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; ELECTROMAGNETIC FIELD; ENERGY; EPIDERMIS; HUMAN; IN VITRO STUDY; MULTIPHOTON MICROSCOPY; SKIN; STRATUM CORNEUM;

EID: 77951592421     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22024     Document Type: Article

References (43)

1. Kirchmayer U, Davoli M, Verster AD, Amato L, Ferri A, Perucci CA. 2002. A systematic review on the efficacy of naltrexone maintenance treatment in opioid dependence. Addiction 97:1241-1249.
2. Swift R. 2007. Emerging approaches to managing alcohol dependence. Am J Health Syst Pharm 64:S12-S22. (Pubitemid 46339256)
3. Srisurapanont M, Jarusuraisin N. 2005. Opioid antagonists for alcohol dependence. Cochrane Database Syst Rev 1:CD001867.
4. Meyer MC, Straughn AB, Lo MW, Schary WL, Whitney CC. 1984. Bioequivalence, dose-proportionality, and pharmacokinetics of naltrexone after oral administration. J Clin Psychiatr 45:15-19. (Pubitemid 14030105)
5. Gonzalez JP, Brogden RN. 1988. Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence. Drugs 35:192-213.
6. Stinchcomb AL, Swaan PW, Ekabo O, Harris KK, Browe J, Hammell DC, Cooperman TA, Pearsall M. 2002. Straight-chain naltrexone ester prodrugs: Diffusion and concurrent esterase biotransformation in human skin. J Pharm Sci 91:2571-2578. (Pubitemid 35379414)
7. Giannola LI, De Caro V, Giandalia G, Siragusa MG, Tripodo C, Florena AM, Campisi G. 2007. Release of naltrexone on buccal mucosa: Permeation studies, histological aspects and matrix system design. Eur J Pharm Biopharm 67:425-433. (Pubitemid 47211903)
8. Hussain MA, Aungst BJ, Koval CA, Shefter E. 1988. Improved buccal delivery of opioid analgesics and antagonists with bitterless prodrugs. Pharm Res 5:615-618.
9. Johnson BA. 2006. A synopsis of the pharmacological rationale, properties and therapeutic effects of depot preparations of naltrexone for treating alcohol dependence. Exp Opin Pharmacother 7:1065-1073.
10. Galloway GP, Koch M, Cello R, Smith DE. 2005. Pharmacokinetics, safety, and tolerability of a depot formulation of naltrexone in alcoholics: An open-label trial. BMC Psychiatry 5:18. (Pubitemid 41460708)
11. Paudel KS, Nalluri BN, Hammell DC, Valiveti S, Kiptoo P, Hamad MO, Crooks PA, Stinchcomb AL. 2005. Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo. J Pharm Sci 94:1965-1975. (Pubitemid 41554146)
12. Nalluri BN, Milligan C, Chen J, Crooks PA, Stinchcomb AL. 2005. In vitro release studies on matrix type transdermal drug delivery systems of naltrexone and its acetyl prodrug. Drug Dev Ind Pharm 31:871-877.
13. Hammell DC, Stolarczyk EI, Klausner M, Hamad MO, Crooks PA, Stinchcomb AL. 2005. Bioconversion of naltrexone and its 3-O-alkyl-ester prodrugs in a human skin equivalent. J Pharm Sci 94:828-836. (Pubitemid 40577315)
14. Hammell DC, Hamad M, Vaddi HK, Crooks PA, Stinchcomb AL. 2004. A duplex "Gemini" prodrug of naltrexone for transdermal delivery. J Control Release 97:283-290. (Pubitemid 38759485)
15. Wermeling DP, Banks SL, Hudson DA, Gill HS, Gupta J, Prausnitz MR, Stinchcomb AL. 2008. Microneedles permit transdermal delivery of a skin-impermeant medication to humans. Proc Natl Acad Sci USA 105:2058-2063. (Pubitemid 351439464)
16. Banks SL, Pinninti RR, Gill HS, Crooks PA, Prausnitz MR, Stinchcomb AL. 2008. Flux across of microneedle-treated skin is increased by increasing charge of naltrexone and naltrexol in vitro. Pharm Res 25:1677-1685.
17. Kiptoo PK, Paudel KS, Hammell DC, Hamad MO, Crooks PA, Stinchcomb AL. 2008. In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs. Eur J Pharm Sci 33:371-379.
18. Cacetta R, Eijkenboom M, Edwards J, Namjoshi S, Benson HAE. 2007. Increased transdermal delivery of local anaesthetics by the novel penetration enhancement technology Dermaportation; in vitro and in vivo assessment. Amsterdam: Pharmaceutical Sciences World Congress.
19. Bassett CA. 1989. Fundamental and practical aspects of therapeutic uses of pulsed electromagnetic fields (PEMFs). Crit Rev Biomed Eng 17:451-529.
20. Bassett CA. 1993. Beneficial effects of electromagnetic fields. J Cell Biochem 51:387-393.
21. Polk C, Postow E. 1996. Handbook of biological effects of electromagnetic fields, 9th edition. Boca Raton: CRC Press.
22. Matic M, Lazetic B, Poljacki M, Djuran V, Matic A, Gajinov Z. 2009. Influence of different types of electromagnetic fields on skin reparatory processes in experimental animals. Lasers Med Sci 24:321-327.
23. Scardino MS, Swaim SF, Sartin EA, Steiss JE, Spano JS, Hoffman CE, Coolman SL, Peppin BL. 1998. Evaluation of treatment with a pulsed electromagnetic field on wound healing, clinicopathologic variables, and central nervous system activity of dogs. Am J Vet Res 59:1177-1181.
24. Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, Simon BJ, Gurtner GC. 2008. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. Plast Reconstr Surg 121:130-141.
25. Milgram J, Shahar R, Levin-Harrus T, Kass P. 2004. The effect of short, high intensity magnetic field pulses on the healing of skin wounds in rats. Bioelectromagnetics 25:271-277. (Pubitemid 38596473)
26. Ahmadian S, Zarchi SR, Bolouri B. 2006. Effects of extremely-low- frequency pulsed electromagnetic fields on collagen synthesis in rat skin. Biotechnol Appl Biochem 43:71-75. (Pubitemid 43235452)
27. Colson DJ, Browett JP, Fiddian NJ, Watson B. 1988. Treatment of delayed- and non-union of fractures using pulsed electromagnetic fields. J Biomed Eng 10:301-304.
28. Pang L, Baciu C, Traitcheva N, Berg H. 2001. Photodynamic effect on cancer cells influenced by electromagnetic fields. J Photochem Photobiol B 64:21-26. (Pubitemid 33064725)
29. Namjoshi S, Cacetta R, Edwards J, Benson HAE. 2007. Liquid chromatography assay for 5-aminolevulinic acid: Application to in vitro assessment of skin penetration via Dermaportation. J Chromatogr 852:49-55. (Pubitemid 46830092)
30. Namjoshi S, Chen Y, Edwards J, Benson HA. 2008. Enhanced transdermal delivery of a dipeptide by dermaportation. Biopolymers 90:655-662.
31. Murthy SN, Hiremath SR. 2001. Physical and chemical permeation enhancers in transdermal delivery of terbutaline sulphate. AAPS PharmSciTech 2:E-TN1.
32. Murthy SN, Hiremath SR. 1999. Effect of magnetic field on the permeation of salbutamol sulphate. Indian Drugs 36:663-664.
33. Murthy SN. 1999. Magnetophoresis: An approach to enhance transdermal drug diffusion. Die Pharmazie 54:377-379.
34. Blokhra RL, Joshi J. 1999. Flow through Porous Media XVI: Electrokinetic transport coefficients of aqueous solutions of mercuric chloride and glycine through a sintered disc impregnated with a cellulose acetate membrane under a magnetic field. J Colloid Interface Sci 220:458-464. (Pubitemid 30045795)
35. Kligman A, Christophers E. 1963. Preparation of isolated sheets of human stratum corneum. Arch Dermatol 88:70-73.
36. Fasano WJ, Manning LA, Green JW. 2002. Rapid integrity assessment of rat and human epidermal membranes for in vitro dermal regulatory testing: Correlation of electrical resistance with tritiated water permeability. Toxicol In Vitro 16:731-740.
37. Megrab NA, Williams AC, Barry BA. 1995. Oestradiol permeation through human skin and silastic membrane: Effects of propylene glycol and supersaturation. J Control Release 36:277-294.
38. Vaughan TE, Weaver JC. 1996. Energetic constraints on the creation of cell membrane pores by magnetic particles. Biophys J 71:616-622.
39. Weaver JC, Vaughan TE, Martin GT. 1999. Biological effects due to weak electric and magnetic fields: The temperature variation threshold. Biophys J 76:3026-3030.
40. Zewert TE, Pliquett UF, Vanbever R, Langer R, Weaver JC. 1999. Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem Bioenerg 49:11-20.
41. Ortega VV, Martinez AF, Gascon JY, Sanchez NA, Banos MA, Rubiales FC. 2006. Transdermal transport of India ink by electromagnetic electroporation in Guinea pigs: An ultrastructural study. Ultrastruct Pathol 30:65-74.
42. Silva CL, Nunes SC, Eusebio ME, Sousa JJ, Pais AA. 2006. Study of human stratum corneum and extracted lipids by thermomicroscopy and DSC. Chem Phys Lipids 140:36-47.
43. Delgado-Charro MB, Guy RH. 1994. Characterization of convective solvent flow during iontophoresis. Pharm Res 11:929-935.