Unfavorable electrostatic and steric interactions in DNA polymerase β E295K mutant interfere with the enzymes pathway

Journal of the American Chemical Society

Volumn 134, Issue 24, 2012, Pages 9999-10010

  Li, Yunlang ^a   Gridley, Chelsea L ^b   Jaeger, Joachim ^b,c   Sweasy, Joann B ^d   Schlick, Tamar ^a  

^a NEW YORK UNIVERSITY   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

^c WADSWORTH CENTER   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BASE EXCISION REPAIRS; BINARY CRYSTALS; CLOSED FORM; CONFORMATIONAL CHANGE; CONFORMATIONAL PATHWAYS; DNA POLYMERASE; ENZYMATIC PATHWAYS; EXPERIMENTAL DATA; GASTRIC CARCINOMA; HIGH-ENERGY BARRIERS; HUMAN TUMORS; KEY RESIDUES; RATE-LIMITING STEPS; REACTION BARRIERS; STERIC INTERACTIONS; TRANSITION PATH SAMPLING; TRANSITION STATE; WILD TYPES; WILD-TYPE ENZYMES;

CHEMICAL REACTIONS; DNA; ELECTROSTATICS; ENERGY BARRIERS; ENZYMES; FACTOR ANALYSIS;

CONFORMATIONS;

DNA DIRECTED DNA POLYMERASE BETA; ENZYME;

ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL REACTION; CHEMISTRY; CONFORMATIONAL TRANSITION; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; EXCISION REPAIR; GENE MUTATION; STATIC ELECTRICITY; STEREOSPECIFICITY; STOMACH CARCINOMA;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE BETA; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; RATS; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84862540846     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja300361r     Document Type: Article

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