The D246V mutant of DNA polymerase β misincorporates nucleotides. Evidence for a role for the flexible loop in DNA positioning within the active site

Journal of Biological Chemistry

Volumn 279, Issue 1, 2004, Pages 577-584

  Dalal, Shibani ^a   Kosa, Jessica L ^b   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DNA; ENZYMES; GENES; STRUCTURE (COMPOSITION);

BASE EXCISION REPAIR;

BIOCHEMISTRY;

ASPARTIC ACID; DNA DIRECTED DNA POLYMERASE BETA; OLIGONUCLEOTIDE;

ARTICLE; D246V GENE; DNA TEMPLATE; ENZYME KINETICS; GENE MUTATION; MUTATOR GENE; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BASE PAIRING; BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA; DNA POLYMERASE BETA; DNA REPAIR; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEIC ACID CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; ZIDOVUDINE;

EID: 0347052870     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M309607200     Document Type: Article

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