Conformational transitions in DNA polymerase I revealed by single-molecule FRET

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 2, 2010, Pages 715-720

  Santoso, Yusdi ^a   Joyce, Catherine M ^b   Potapova, Olga ^b   Le Reste, Ludovic ^a   Hohlbein, Johannes ^a   Torella, Joseph P ^a   Grindley, Nigel D F ^b   Kapanidis, Achillefs N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b YALE UNIVERSITY   (United States)

Author keywords

Alternating laser excitation; Conformational dynamics; Fidelity checkpoints; Fingers closing; Klenow fragment

Indexed keywords

DEOXYRIBONUCLEOTIDE; DNA DIRECTED DNA POLYMERASE BETA;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE RESONANCE ENERGY TRANSFER; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TIME;

BACTERIAL PROTEINS; COMPUTER SIMULATION; DNA POLYMERASE I; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; GEOBACILLUS STEAROTHERMOPHILUS; KINETICS; MICROSCOPY, CONFOCAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; SEQUENCE DELETION;

EID: 76249127905     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0910909107     Document Type: Article

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