Effect of oxidatively damaged DNA on the active site preorganization during nucleotide incorporation in a high fidelity polymerase from Bacillus stearothermophilus

Proteins: Structure, Function and Genetics

Volumn 71, Issue 3, 2008, Pages 1360-1372

  Venkatramani, Ravindra ^a,b   Radhakrishnan, Ravi ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

8 oxoguanine; Active site preorganization; DNA base pair synthesis; Free energy; High fidelity polymerase; Molecular dynamics; Oxidative damage

Indexed keywords

8 HYDROXYGUANINE; ADENOSINE TRIPHOSPHATE; CYTIDINE TRIPHOSPHATE; DEOXYCYTIDINE KINASE; DNA; DNA POLYMERASE; GUANINE; NUCLEOTIDE;

ARTICLE; BASE PAIRING; CALCULATION; CATALYSIS; CORRELATION ANALYSIS; DNA DAMAGE; DNA REPLICATION; DNA STRAND BREAKAGE; DNA STRUCTURE; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEOBACILLUS STEAROTHERMOPHILUS; MOLECULAR DYNAMICS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DNA INTERACTION; SIMULATION;

BACILLUS STEAROTHERMOPHILUS; BACTERIAL PROTEINS; BINDING SITES; DNA DAMAGE; DNA, BACTERIAL; DNA-DIRECTED DNA POLYMERASE; GUANINE; NUCLEOTIDES; OXIDATIVE STRESS;

GEOBACILLUS STEAROTHERMOPHILUS;

EID: 42449128363     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21824     Document Type: Article

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