The E249K mutator mutant of DNA polymerase β extends mispaired termini

Journal of Biological Chemistry

Volumn 274, Issue 50, 1999, Pages 35866-35572

  Kosa, Jessica L ^a   Sweasy, Joann B ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA;

ARTICLE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; BASE SEQUENCE; DNA; DNA POLYMERASE BETA; DNA PRIMERS; GLUTAMIC ACID; KINETICS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS; NUCLEIC ACID CONFORMATION; PHENOTYPE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SIMPLEXVIRUS; THYMIDINE KINASE; ZIDOVUDINE;

EID: 0033544858     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.50.35866     Document Type: Article

References (35)

1. Singhal, R. K., Prasad, R., and Wilson, S. H. (1995) J. Biol. Chem. 270, 949-957
2. Chagovetz, A. M., Sweasy, J. B., and Preston, B. D. (1997) J. Biol. Chem. 272, 27501-27504
3. Clairmont, C. A., and Sweasy, J. B. (1996) J. Bacteriol. 178, 656-661
4. Sobol, R. W., Horton, J. K., Kuhn, R., Gu, H., Singhal, R. K., Prasad, R., Rajewsky, K., and Wilson, S. H. (1996) Nature 379, 183-186
5. Plug, A. W., Clairmont, C. A., Sapi, E., Ashley, T., and Sweasy, J. B. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 1327-1331
6. Gu, H., Marth, J., Orban, P., Mossmann, H., and Rajewsky, K. (1994) Science 265, 103-106
7. Bennett, R. A. O., Wilson, D. M., III, Wong, D., and Demple, B. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 7166-7169
8. Srivastava, D. K., Vande Berg, B. J., Prasad, R., Molina, J. T., Beard, W. A., Tomkinson, A. E., and Wilson, S. H. (1998) J. Biol. Chem. 273, 21203-21209
9. Matsumoto, Y., and Kim, K. (1995) Science 269, 699-702
10. Dianov, G., and Lindahl, T. (1994) Curr. Biol. 4, 1069-1076
11. Jenkins, T. M., Saxena, J. K., Kumar, A., Wilson, S. H., and Ackerman, E. J. (1992) Science 258, 475-478
12. Sweasy, J. B., and Loeb, L. A. (1992) J. Biol. Chem. 267, 1407-1410
13. Sweasy, J. B., Chen, M., and Loeb, L. A. (1995) J. Bacteriol. 177, 2923-2925
14. Matsukage, A., Nishikawa, K., Ooi, T., Seta, Y., and Yamaguchi, M. (1987) J. Biol. Chem. 262, 8960-8962
15. Anderson, R. S., Lawrence, C. B., Wilson, S. H., and Beattie, K. L. (1987) Gene (Amst.) 60, 163-173
16. Kosa, J. L., and Sweasy, J. B. (1999) J. Biol. Chem. 274, 3851-3858
17. Li, S.-X., Vaccaro, J. A., and Sweasy, J. B. (1999) Biochemistry 38, 4800-4808
18. Eckert, K. A., Hile, S. E., and Vargo, P. L. (1997) Nucleic Acids Res. 25, 1450-1457
19. Suzuki, M., Avicola, A. K., Hood, L., and Loeb, L. A. (1997) J. Biol. Chem. 272, 11228-11235
20. Johnson, K. A. (1995) Methods Enzymol 249, 38-61
21. Singhal, R. K., and Wilson, S. H. (1993) J. Biol. Chem. 268, 15906-15911
22. Ahn, J., Werneburg, B. G., and Tsai, D. M. (1997) Biochemistry 36,1100-1107
23. Carson, M. (1991) J. Appl. Crystallogr. 24, 958-961
24. Echols, H., and Goodman, M. F. (1991) Annu. Rev. Biochem. 60, 477-511
25. Opresko, P. L., Sweasy, J. B., and Eckert, K. A. (1998) Biochemistry 37, 2111-2119
26. Perrino, F. W., Preston, B. D., Sandell, L. L., and Loeb, L. A. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 8343-8347
27. Perrino, F. W., and Loeb, L. A. (1989) J. Biol. Chem. 264, 2898-2905
28. Mendelman, L. V., Petruska, J., and Goodman, M. F. (1990) J. Biol. Chem. 265, 2338-2346
29. Kuchta, R. D., Benkovi, P., and Benkovic, S. J. (1988) Biochemistry 27, 6716-6725
30. Sawaya, M. R., Prasad, R., Wilson, S. H., Kraut, J., and Pelletier, H. (1997) Biochemistry 36, 11205-11215
31. Pelletier, H., Sawaya, M. R., Wolfe, W., Wilson, S. H., and Kraut, J. (1996) Biochemistry 35, 12742-12761
32. Beard, W., and Wilson, S. (1998) Chem. Biol. 5, R7-R13
33. Stein, C. A., Levantis, P., and Oxford, J. S. (1994) J. Med. Virol. 44, 115-121
34. Kohlstaedt, L. A., Wang, J., Friedman, J. M., Rice, P. A., and Steitz, T. A. (1992) Science 256, 1783-1790
35. Tantillo, C., Ding, J., Jacobo-Molina, A., Nanni, R. G., Boyer, P. L., Hughes, S. H., Pauwels, R., Andries, K., Janssen, P. A., and Arnold, E. (1994) J. Mol. Biol. 243, 369-387