Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins

Journal of Biological Chemistry

Volumn 287, Issue 24, 2012, Pages 20356-20368

  Zheng, Jin ^a,b   Watanabe, Hirotaka ^a   Wines Samuelson, Mary ^a   Zhao, Huailong ^a   Gridley, Thomas ^c   Kopan, Raphael ^d   Shen, Jie ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Maine Medical Center Research Institute   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGE-RELATED; CEREBRAL CORTEX; CRE RECOMBINASE; EXCITATORY NEURONS; GENOMIC DELETIONS; INTRACELLULAR DOMAIN; KNOCK OUTS; NEURODEGENERATION; NEURONAL LOSS; NEURONAL SURVIVAL; NICASTRIN; NOTCH SIGNALING; PRESENILINS; PYRAMIDAL NEURON; SECRETASE COMPLEX; SECRETASES; TRANSGENIC MICE;

GENES; NEURAL NETWORKS;

MAMMALS;

BRAIN PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CRE RECOMBINASE; GAMMA SECRETASE; MESSENGER RNA; NICASTRIN; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PRESENILIN;

ALLELE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CELL CULTURE; CELL SURVIVAL; CONTROLLED STUDY; DNA MODIFICATION; EXON; FEMALE; FOREBRAIN; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; GENOME; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; NOTCH1 GENE; NOTCH2 GENE; PERINATAL PERIOD; PRIORITY JOURNAL; TRANSGENIC MOUSE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; GENE DELETION; HEK293 CELLS; HUMANS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PYRAMIDAL CELLS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RNA, MESSENGER;

MUS; MUS MUSCULUS;

EID: 84862026249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.349738     Document Type: Article

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