Genetic analysis of Mint/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family

Journal of Neuroscience

Volumn 26, Issue 50, 2006, Pages 13089-13101

  Ho, Angela ^a   Morishita, Wade ^c   Atasoy, Deniz ^a   Liu, Xinran ^a   Tabuchi, Katsuhiko ^a   Hammer, Robert E ^a,b   Malenka, Robert C ^c   Südhof, Thomas C ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adaptor proteins; Knock out; Mint; Neurotransmitter release; Survival; X11

Indexed keywords

ADAPTOR PROTEIN; MUNC18 PROTEIN; PROTEIN FE65; PROTEIN MINT;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENETIC ANALYSIS; HIPPOCAMPUS; KNOCKOUT MOUSE; LOCOMOTION; MOUSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RETROVIRUS INFECTION; WEIGHT REDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CELLS, CULTURED; HIPPOCAMPUS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; NEURONS; NEUROTRANSMITTER AGENTS; NUCLEAR PROTEINS; PRESYNAPTIC TERMINALS; PROTEIN ISOFORMS; PROTEINS; SYNAPTIC TRANSMISSION;

EID: 33845646925     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2855-06.2006     Document Type: Article

References (37)

1. Biederer T, Südhof TC (2000) Mints as adaptors: direct binding to neurexins and recruitment of munc18. J Biol Chem 275:39803-39806.
2. Biederer T, Cao X, Südhof TC, Liu X (2002) Regulation of APP-dependent transcription complexes by Mint/X11s: Differential functions of mint isoforms. J Neurosci 22:7340-7351.
3. Borg JP, Ooi J, Levy E, Margolis B (1996) The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol Cell Biol 16:6229-6241.
4. Borg JP, Straight SW, Kaech SM, de Taddeo-Borg M, Kroon DE, Karnak D, Turner RS, Kim SK, Margolis B (1998) Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem 273:31633-31636.
5. Borg JP, Lopez-Figueroa MO, de Taddeo-Borg M, Kroon DE, Turner RS, Watson SJ, Margolis B (1999) Molecular analysis of the X11-mLin-2/CASK complex in brain. J Neurosci 19:1307-1316.
6. Butz S, Okamoto M, Südhof TC (1998) A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell 94:773-782.
7. Duclos F, Koenig M (1995) Comparison of primary structure of a neuron-specific protein, X11, between human and mouse. Mamm Genome 6:57-58.
8. Duclos F, Boschert U, Sirugo G, Mandel JL, Hen R, Koenig M (1993) Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system. Proc Natl Acad Sci USA 90:109-113.
9. Fowler SC, Birkestrand BR, Chen R, Moss SJ, Vorontsova E, Wang G, Zarcone TJ (2001) A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies, and tremor. J Neurosci Methods 107:107-124.
10. Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (2000) Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction. J Biol Chem 275:25616-25624.
11. Guenette SY, Chang Y, Hyman BT, Tanzi RE, Rebeck GW (2002) Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J Neurochem 82:755-762.
12. Guenette S, Chang Y, Hiesberger T, Richardson JA, Eckman CB, Eckman EA, Hammer RE, Herz J (2006) Essential roles for the FE65 amyloid precursor protein interacting proteins in brain development. EMBO J 25:420-431.
13. Hata Y, Slaughter CA, Südhof TC (1993) Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature 366:347-351.
14. Hata Y, Butz S, Südhof TC (1996) CASK: a novel dlg/PSD95 homolog with an N-terminal CaM kinase domain identified by interaction with neurexins. J Neurosci 16:2488-2494.
15. Herz J, Strickland DK (2001) LRP: a multifunctional scavenger and signaling receptor. J Clin Invest 108:779-784.
16. Herz J, Kowal RC, Ho YK, Brown MS, Goldstein JL (1990) Low-density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver. J Biol Chem 265:21355-21362.
17. Ho A, Morishita W, Hammer RE, Malenka RC, Südhof TC (2003) A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc Natl Acad Sci USA 100:1409-1414.
18. 2+ regulators in neurotransmitter release. Neuron 24:1003-1016.
19. Kaech SM, Whitfield CW, Kim SK (1998) The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell 94:761-771.
20. Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH (2000) Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. J Clin Invest 106:1159-1166.
21. Kavalali ET, Klingauf J, Tsien RW (1999) Activity-dependent regulation of synaptic clustering in a hippocampal culture system. Proc Natl Acad Sci USA 96:12893-12900.
22. Lau KF, McLoughlin DM, Standen C, Miller CC (2000) X11 alpha and X11 beta interact with presenilin-1 via their PDZ domains. Mol Cell Neurosci 16:557-565.
23. Maximov A, Südhof TC, Bezprozvanny I (1999) Association of neuronal calcium channels with modular adaptor protein. J Biol Chem 274:24453-24456.
24. McLoughlin DM, Miller CC (1996) The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosine-binding domain proteins in the yeast two-hybrid system. FEBS Lett 397:197-200.
25. Mori A, Okuyama K, Horie M, Taniguchi Y, Wadatsu T, Nishino N, Shimada Y, Miyazawa N, Takeda S, Niimi M, Kyushiki H, Kondo M, Mitsumoto Y (2002) Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice. Neurosci Res 43:251-257.
26. Okamoto M, Südhof TC (1997) Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. J Biol Chem 272:31459-31464.
27. Okamoto M, Südhof TC (1998) Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or 2. Eur J Cell Biol 77:161-165.
28. Olsen O, Moore KA, Fukata M, Kazuta T, Trinidad JC, Kauer FW, Streuli M, Misawa H, Burlingame AL, Nicoll RA, Bredt DS (2005) Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. J Cell Biol 170:1127-1134.
29. Pietrzik CU, Il-Sang Y, Jaeger S, Busse T, Weggen S, Koo EH (2004) FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci 24:4259-4265.
30. Rongo C, Whitfield CW, Rodal A, Kim SK, Kaplan JM (1998) LIN-10 is a shared component of the polarized protein localization pathways in neurons and epithelia. Cell 94:751-759.
31. Rosahl TW, Spillane D, Missler M, Herz J, Selig DK, Wolff JR, Hammer RE, Malenka RC, Südhof TC (1995) Essential functions of synapsins I and II in synaptic vesicle regulation. Nature 375:488-493.
32. Rosenmund C, Stevens CF (1996) Definition of the readily releasable pool of vesicles at hippocampal synapses. Neuron 16:1197-1207.
33. Sastre M, Turner RS, Levy E (1998) X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion 273:22351-22357.
34. Setou M, Nakagawa T, Seog DH, Hirokawa N (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288:1796-1802.
35. Südhof TC (2004) The synaptic vesicle cycle. Annu Rev Neurosci 27:509-547.
36. Trommsdorff M, Borg JP, Margolis B, Herz J (1998) Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein. J Biol Chem 273:33445-33560.
37. Whitfield CW, Benard C, Barnes T, Hekimi S, Kim SK (1999) Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol Biol Cell 10:2087-2100.