Activation of the unfolded protein response contributed to the selective cytotoxicity of oroxylin A in human hepatocellular carcinoma HepG2 cells

Toxicology Letters

Volumn 212, Issue 2, 2012, Pages 113-125

  Xu, Min ^a   Lu, Na ^a   Sun, Zhongying ^a   Zhang, Haiwei ^a   Dai, Qinsheng ^a   Wei, Libin ^a   Li, Zhiyu ^a   You, Qidong ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

AKT; CHOP; Cytotoxicity; Hepatocellular carcinoma; Oroxylin A; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HYDROGEN PEROXIDE; INITIATION FACTOR 2ALPHA; OROXYLIN A; PANCREATIC ER KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CHEMICAL STRUCTURE; CYTOTOXICITY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; NECROSIS; PRIORITY JOURNAL; PROTEIN FOLDING; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE PROTEINS; CELL SURVIVAL; FLAVONOIDS; HEP G2 CELLS; HUMANS; HYDROGEN PEROXIDE; NECROSIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REPRESSOR PROTEINS; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE;

EID: 84861812085     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.05.008     Document Type: Article

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