The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin

European Biophysics Journal

Volumn 41, Issue 3, 2012, Pages 297-306

  Shao, Yong Xian ^a   Zhao, Peng ^a   Li, Zhe ^a   Liu, Ming ^a   Liu, Peiqing ^a   Huang, Min ^a   Luo, Hai Bin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Binding free energy; CYP 1A2; Inhibition; Mechanism; Oroxylin; Wogonin

Indexed keywords

ALPHA NAPHTHOFLAVONE; ALPHA-NAPHTHOFLAVONE; BENZOFLAVONE DERIVATIVE; CYTOCHROME P450 1A2; ENZYME INHIBITOR; FLAVANONE DERIVATIVE; FLAVONOID; HERBACEOUS AGENT; WOGONIN;

ARTICLE; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; METABOLISM; MOLECULAR DYNAMICS; PHYSICAL CHEMISTRY; PROTEIN BINDING; REPRODUCIBILITY; THERMODYNAMICS;

BENZOFLAVONES; BINDING SITES; CYTOCHROME P-450 CYP1A2; DRUG DESIGN; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; FLAVANONES; FLAVONOIDS; HUMANS; MOLECULAR DYNAMICS SIMULATION; PHYSICOCHEMICAL PROCESSES; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; THERMODYNAMICS;

EID: 84857362231     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-011-0785-1     Document Type: Article

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