Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway

Toxicology Letters

Volumn 209, Issue 3, 2012, Pages 211-220

  Lu, Zhijian ^a   Lu, Na ^a   Li, Chenglin ^a   Li, Fanni ^a   Zhao, Kai ^a   Lin, Biqi ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

AP 1; MAPK; Metastasis

Indexed keywords

ANTIMETASTATIC AGENT; DACARBAZINE; GELATINASE A; GELATINASE B; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OROXYLIN A; PROTEIN C FOS; PROTEIN KINASE C DELTA; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; CANCER INVASION; CELL ADHESION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SCREENING; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LUNG METASTASIS; MELANOMA; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLAVONOIDS; HUMANS; MAP KINASE SIGNALING SYSTEM; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; PLANT ROOTS; REAL-TIME POLYMERASE CHAIN REACTION; SCUTELLARIA BAICALENSIS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSCRIPTION, GENETIC; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MURINAE; SCUTELLARIA RADIX;

EID: 84862801153     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.12.022     Document Type: Article

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