메뉴 건너뛰기




Volumn 136, Issue 5, 2010, Pages 667-675

Oroxylin A inhibits angiogenesis through blocking vascular endothelial growth factor-induced KDR/Flk-1 phosphorylation

Author keywords

Angiogenesis; KDR Flk 1; Oroxylin A; VEGF

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OROXYLIN A; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ANGIOGENESIS INHIBITOR; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE KINASE; ONCOPROTEIN; VASCULOTROPIN A;

EID: 77950482760     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00432-009-0705-2     Document Type: Article
Times cited : (42)

References (36)
  • 1
    • 14244252824 scopus 로고    scopus 로고
    • A murine model of ex vivo angiogenesis using aortic disks grown in Wbrin clot
    • Berger AC, Wang XQ, Zalatoris A et al (2004) A murine model of ex vivo angiogenesis using aortic disks grown in Wbrin clot. Microvasc Res 68:179-187
    • (2004) Microvasc Res , vol.68 , pp. 179-187
    • Berger, A.C.1    Wang, X.Q.2    Zalatoris, A.3
  • 2
    • 1642472018 scopus 로고    scopus 로고
    • Antiangiogenic therapy and tumor progression
    • Blagosklonny MV (2004) Antiangiogenic therapy and tumor progression. Cancer Cell 5:13-17
    • (2004) Cancer Cell , vol.5 , pp. 13-17
    • Blagosklonny, M.V.1
  • 3
    • 36049026182 scopus 로고    scopus 로고
    • Role of anti-angiogenesis agents in treating NSCLC: Focus on bevacizumab and VEGFR tyrosine kinase inhibitors
    • Cabebe E, Wakelee H (2007) Role of anti-angiogenesis agents in treating NSCLC: focus on bevacizumab and VEGFR tyrosine kinase inhibitors. Curr Treat Options Oncol 8:15-27
    • (2007) Curr Treat Options Oncol , vol.8 , pp. 15-27
    • Cabebe, E.1    Wakelee, H.2
  • 4
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653-660
    • (2003) Nat Med , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 5
    • 4544364825 scopus 로고    scopus 로고
    • Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-Xuorouracil efficacy on human colon tumor xenografts
    • Carnesecchi S, Bras-Goncalves R, Bradaia A et al (2004) Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-Xuorouracil efficacy on human colon tumor xenografts. Cancer Lett 215:53-59
    • (2004) Cancer Lett , vol.215 , pp. 53-59
    • Carnesecchi, S.1    Bras-Goncalves, R.2    Bradaia, A.3
  • 6
    • 0036479214 scopus 로고    scopus 로고
    • Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR
    • Colavitti R, Pani G, Bedogni B et al (2002) Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. J Biol Chem 277:3101-3108
    • (2002) J Biol Chem , vol.277 , pp. 3101-3108
    • Colavitti, R.1    Pani, G.2    Bedogni, B.3
  • 7
    • 13844262927 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor and angiogenesis for the treatment of colorectal cancer
    • Collins TS, Hurwitz HI (2005) Targeting vascular endothelial growth factor and angiogenesis for the treatment of colorectal cancer. Semin Oncol 32:61-68
    • (2005) Semin Oncol , vol.32 , pp. 61-68
    • Collins, T.S.1    Hurwitz, H.I.2
  • 8
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: Biology and therapeutic implications
    • Ellis LM, Takahashi Y, Liu W, Shaheen RM (2000) Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. Oncologist 5(suppl 1):11-15
    • (2000) Oncologist , vol.5 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3    Shaheen, R.M.4
  • 9
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J (2002) Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29:15-18
    • (2002) Semin Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 10
    • 32944463899 scopus 로고    scopus 로고
    • Angiogenesis
    • Folkman J (2006) Angiogenesis. Annu Rev Med 57:1-18
    • (2006) Annu Rev Med , vol.57 , pp. 1-18
    • Folkman, J.1
  • 11
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • DOI 10.1038/nrd2115, PII NRD2115
    • Folkman J (2007) Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6:273-286 (Pubitemid 46505878)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 12
    • 35948991121 scopus 로고    scopus 로고
    • In vitro assays of angiogenesis for assessment of angiogenic and anti-angiogenic agents
    • Goodwin AM (2007) In vitro assays of angiogenesis for assessment of angiogenic and anti-angiogenic agents. Microvasc Res 74:172-183
    • (2007) Microvasc Res , vol.74 , pp. 172-183
    • Goodwin, A.M.1
  • 13
    • 33750532964 scopus 로고    scopus 로고
    • Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity
    • Hu Y, Yang Y, You QD et al (2006) Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Biochem Biophys Res Commun 351:521-527
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 521-527
    • Hu, Y.1    Yang, Y.2    You, Q.D.3
  • 15
    • 0015822275 scopus 로고
    • Culture of human endothelial cells derived from umbilical veins. IdentiWcation by morphologic and immunologic criteria
    • JaVe EA, Nachman RL, Becker CG et al (1973) Culture of human endothelial cells derived from umbilical veins. IdentiWcation by morphologic and immunologic criteria. J Clin Invest 52:2745-2756
    • (1973) J Clin Invest , vol.52 , pp. 2745-2756
    • Jave, E.A.1    Nachman, R.L.2    Becker, C.G.3
  • 17
    • 0036225894 scopus 로고    scopus 로고
    • Clinical signiWcance of vascular endothelial growth factor expression in gastric cancer
    • Kakeji Y, Koga T, Sumiyoshi Y (2002) Clinical signiWcance of vascular endothelial growth factor expression in gastric cancer. J Exp Clin Cancer Res 21:125-129
    • (2002) J Exp Clin Cancer Res , vol.21 , pp. 125-129
    • Kakeji, Y.1    Koga, T.2    Sumiyoshi, Y.3
  • 18
    • 0034690028 scopus 로고    scopus 로고
    • Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF eVects in human vascular endothelial cells
    • Kanno S, Oda N, Abe M et al (2000) Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF eVects in human vascular endothelial cells. Oncogene 19:2138-2146
    • (2000) Oncogene , vol.19 , pp. 2138-2146
    • Kanno, S.1    Oda, N.2    Abe, M.3
  • 19
    • 40249116837 scopus 로고    scopus 로고
    • Regulation of VEGFmediated angiogenesis by the Akt/PKB substrate Girdin
    • Kitamura T, Asai N, Enomoto A et al (2008) Regulation of VEGFmediated angiogenesis by the Akt/PKB substrate Girdin. Nat Cell Biol 10:329-337
    • (2008) Nat Cell Biol , vol.10 , pp. 329-337
    • Kitamura, T.1    Asai, N.2    Enomoto, A.3
  • 20
    • 18144407267 scopus 로고    scopus 로고
    • Isolation and puriWcation of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography
    • Li HB, Chen F (2005) Isolation and puriWcation of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography. J Chromatogr A 1074:107-110
    • (2005) J Chromatogr A , vol.1074 , pp. 107-110
    • Li, H.B.1    Chen, F.2
  • 21
    • 58649105305 scopus 로고    scopus 로고
    • Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo
    • Li HN, Nie FF, Liu W et al (2009) Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology 257:80-85
    • (2009) Toxicology , vol.257 , pp. 80-85
    • Li, H.N.1    Nie, F.F.2    Liu, W.3
  • 22
    • 34547106834 scopus 로고    scopus 로고
    • Endostar, a novel recombinant human endostatin, exerts antiangiogenic Effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells
    • Ling Y, Yang Y, Lu N et al (2007) Endostar, a novel recombinant human endostatin, exerts antiangiogenic Effect via blocking VEGF-induced tyrosine phosphorylation of KDR/Flk-1 of endothelial cells. Biochem Biophys Res Commun 361:79-84
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 79-84
    • Ling, Y.1    Yang, Y.2    Lu, N.3
  • 23
    • 0037791833 scopus 로고    scopus 로고
    • Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems?
    • Meyer RD, Rahimi (2003) Comparative structure-function analysis of VEGFR-1 and VEGFR-2: What have we learned from chimeric systems? Ann N Y Acad Sci 995:200-207
    • (2003) Ann N y Acad Sci , vol.995 , pp. 200-207
    • Meyer, R.D.1    Rahimi2
  • 24
    • 1642556787 scopus 로고    scopus 로고
    • Capsaicin inhibits in vitro and in vivo angiogenesis
    • Min JK, Han KY, Kim EC et al (2004) Capsaicin inhibits in vitro and in vivo angiogenesis. Cancer Res 64:644-651
    • (2004) Cancer Res , vol.64 , pp. 644-651
    • Min, J.K.1    Han, K.Y.2    Kim, E.C.3
  • 25
    • 0026757433 scopus 로고
    • Large-vessel endothelium switches to a microvascular phenotype during angiogenesis in collagen gel culture of rat aorta
    • Nicosia RF, Bonanno E, Villaschi S (1992) Large-vessel endothelium switches to a microvascular phenotype during angiogenesis in collagen gel culture of rat aorta. Atherosclerosis 95:191-199
    • (1992) Atherosclerosis , vol.95 , pp. 191-199
    • Nicosia, R.F.1    Bonanno, E.2    Villaschi, S.3
  • 26
    • 0034222468 scopus 로고    scopus 로고
    • Evaluation of angiogenesis in canine mammary tumors by quantitative platelet endothelial cell adhesion molecule immunohistochemistry
    • Restucci B, De Vico G, Maiolino P (2000) Evaluation of angiogenesis in canine mammary tumors by quantitative platelet endothelial cell adhesion molecule immunohistochemistry. Vet Pathol 37:297-301
    • (2000) Vet Pathol , vol.37 , pp. 297-301
    • Restucci, B.1    De Vico, G.2    Maiolino, P.3
  • 27
    • 36948998969 scopus 로고    scopus 로고
    • Antiangiogenic therapy in malignant glioma: Promise and challenge
    • DOI 10.2174/138161207782794130
    • Sathornsumetee S, Rich JN (2007) Antiangiogenic therapy in malignant glioma: promise and challenge. Curr Pharm Des 13:3545-3558 (Pubitemid 350238925)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.35 , pp. 3545-3558
    • Sathornsumetee, S.1    Rich, J.N.2
  • 28
    • 33750842076 scopus 로고    scopus 로고
    • DiVerential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
    • Shibuya M (2006a) DiVerential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis. J Biochem Mol Biol 39:469-478
    • (2006) J Biochem Mol Biol , vol.39 , pp. 469-478
    • Shibuya, M.1
  • 29
    • 33746858881 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF)-receptor2: Its biological functions, major signaling pathway, and speciWc ligand VEGF-E
    • Shibuya M (2006b) Vascular endothelial growth factor (VEGF)-receptor2: its biological functions, major signaling pathway, and speciWc ligand VEGF-E. Endothelium 13:63-69
    • (2006) Endothelium , vol.13 , pp. 63-69
    • Shibuya, M.1
  • 30
    • 1442277696 scopus 로고    scopus 로고
    • Cytotoxic activities of Xavonoids from two Scutellaria plants in Chinese medicine
    • Sonoda M, Nishiyama T, Matsukawa Y et al (2004) Cytotoxic activities of Xavonoids from two Scutellaria plants in Chinese medicine. J Ethnopharmacol 91:65-68
    • (2004) J Ethnopharmacol , vol.91 , pp. 65-68
    • Sonoda, M.1    Nishiyama, T.2    Matsukawa, Y.3
  • 31
    • 58249104244 scopus 로고    scopus 로고
    • Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase- 2/9 in MDA-MB-435 human breast cancer cells
    • Sun Y, Lu N, Ling Y et al (2009) Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase- 2/9 in MDA-MB-435 human breast cancer cells. Eur J Pharmacol 603:22-28
    • (2009) Eur J Pharmacol , vol.603 , pp. 22-28
    • Sun, Y.1    Lu, N.2    Ling, Y.3
  • 32
    • 0034807692 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803
    • Tian X, Song S, Wu J (2001) Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun 286:505-512
    • (2001) Biochem Biophys Res Commun , vol.286 , pp. 505-512
    • Tian, X.1    Song, S.2    Wu, J.3
  • 33
    • 0030512898 scopus 로고    scopus 로고
    • QuantiWcation of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation
    • Vermeulen PB, Gasparini G, Fox SB et al (1996) QuantiWcation of angiogenesis in solid human tumours: an international consensus on the methodology and criteria of evaluation. Eur J Cancer 32A:2474-2484
    • (1996) Eur J Cancer , vol.32 A , pp. 2474-2484
    • Vermeulen, P.B.1    Gasparini, G.2    Fox, S.B.3
  • 34
    • 0029127219 scopus 로고
    • Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors
    • Weidner N (1995) Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat 36:169-180
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 169-180
    • Weidner, N.1
  • 35
    • 20344405555 scopus 로고    scopus 로고
    • Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells
    • Wu ZQ, Guo QL, You QD et al (2004) Gambogic acid inhibits proliferation of human lung carcinoma SPC-A1 cells in vivo and in vitro and represses telomerase activity and telomerase reverse transcriptase mRNA expression in the cells. Biol Pharm Bull 27:1769-1774
    • (2004) Biol Pharm Bull , vol.27 , pp. 1769-1774
    • Wu, Z.Q.1    Guo, Q.L.2    You, Q.D.3
  • 36
    • 54949098511 scopus 로고    scopus 로고
    • Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells
    • Yang Y, Hu Y, Gu HY et al (2008) Oroxylin A induces G2/M phase cell-cycle arrest via inhibiting Cdk7-mediated expression of Cdc2/p34 in human gastric carcinoma BGC-823 cells. J Pharm Pharmacol 60:1459-1463
    • (2008) J Pharm Pharmacol , vol.60 , pp. 1459-1463
    • Yang, Y.1    Hu, Y.2    Gu, H.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.