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Volumn 32, Issue 8, 2011, Pages 427-445

Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones

Author keywords

Drug herb interaction; Pharmacokinetics; Pharmacological effect; Radix Scutellariae

Indexed keywords

5,2' DIHYDROXY 6,7,8,3' TETRAMETHOXYFLAVONE; 5,7,2',5' TETRAHYDROXYFLAVONE; BAICALEIN; BAICALIN; CHRYSIN 8 C BETA DEXTRO GLUCOPYRANOSIDE; ERIODICTYOL; FLAVONE DERIVATIVE; OROXYLIN A; OROXYLIN A 7 GLUCURONIDE; RIVULARIN; SKULLCAPFLAVONE I; UNCLASSIFIED DRUG; VISCIDULIN III 2' O BETA DEXTRO GLUCOSIDE; WOGONIN; WOGONOSIDE;

EID: 80054884803     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.771     Document Type: Review
Times cited : (230)

References (135)
  • 1
    • 0035984276 scopus 로고    scopus 로고
    • Natural and hemisynthetic neoclerodane diterpenoids from Scutellaria and their antifeedant activity
    • DOI 10.1039/b111150g
    • Bruno M, Piozzi F, Rosselli S. Natural and hemisynthetic neoclerodane diterpenoids from scutellaria and their antifeedant activity. Nat Prod Rep 2002; 19: 357-378. (Pubitemid 34653056)
    • (2002) Natural Product Reports , vol.19 , Issue.3 , pp. 357-378
    • Bruno, M.1    Piozzi, F.2    Rosselli, S.3
  • 2
    • 84857192977 scopus 로고    scopus 로고
    • websiteUSDoA
    • websiteUSDoA. http://www.ars-grin.gov/cgi-bin/npgs/html/taxon.pl.33424.
  • 3
    • 80054924336 scopus 로고    scopus 로고
    • The analysis of the germplasm resources and cultivation of Scutellaria baicalensis Georgi
    • Cui L, Gu HX, Lu JX, Lin HB, Lin JQ. The analysis of the germplasm resources and cultivation of Scutellaria baicalensis Georgi. Acta Chin Med Pharmacol 2010; 38: 69-72.
    • (2010) Acta Chin Med Pharmacol , vol.38 , pp. 69-72
    • Cui, L.1    Gu, H.X.2    Lu, J.X.3    Lin, H.B.4    Lin, J.Q.5
  • 4
    • 75249102511 scopus 로고    scopus 로고
    • Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies
    • Saif MW, Lansigan F, Ruta S, et al. Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies. Phytomedicine 2010; 17: 161-169.
    • (2010) Phytomedicine , vol.17 , pp. 161-169
    • Saif, M.W.1    Lansigan, F.2    Ruta, S.3
  • 5
    • 71949107671 scopus 로고    scopus 로고
    • Phase I/II study of PHY 906/Capecitabine in advanced hepatocellular carcinoma
    • Yen Y, So S, Rose M, et al. Phase I/II study of PHY 906/Capecitabine in advanced hepatocellular carcinoma. Anticancer Res 2009; 29: 4083-4092.
    • (2009) Anticancer Res , vol.29 , pp. 4083-4092
    • Yen, Y.1    So, S.2    Rose, M.3
  • 7
    • 18144407267 scopus 로고    scopus 로고
    • Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography
    • DOI 10.1016/j.chroma.2005.03.088
    • Li HB, Chen F. Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed countercurrent chromatography. J Chromatogr A 2005; 1074: 107-110. (Pubitemid 40615049)
    • (2005) Journal of Chromatography A , vol.1074 , Issue.1-2 , pp. 107-110
    • Li, H.-B.1    Chen, F.2
  • 8
    • 68849119520 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages
    • Yoon SB, Lee YJ, Park SK, et al. Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages. J Ethnopharmacol 2009; 125: 286-290.
    • (2009) J Ethnopharmacol , vol.125 , pp. 286-290
    • Yoon, S.B.1    Lee, Y.J.2    Park, S.K.3
  • 9
    • 33646483929 scopus 로고    scopus 로고
    • Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray
    • Chen CS, Chen NJ, Lin LW, Hsieh CC, Chen GW, Hsieh MT. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. J Ethnopharmacol 2006; 105: 346-351.
    • (2006) J Ethnopharmacol , vol.105 , pp. 346-351
    • Chen, C.S.1    Chen, N.J.2    Lin, L.W.3    Hsieh, C.C.4    Chen, G.W.5    Hsieh, M.T.6
  • 11
    • 27944446104 scopus 로고    scopus 로고
    • 2a cells
    • DOI 10.1016/j.molbrainres.2005.09.006, PII S0169328X05003621
    • Kang K, Oh YK, Choue R, Kang SJ. Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N(2)a cells. Brain Res Mol Brain Res 2005; 142: 139-145. (Pubitemid 41681281)
    • (2005) Molecular Brain Research , vol.142 , Issue.2 , pp. 139-145
    • Kang, K.1    Oh, Y.K.2    Choue, R.3    Kang, S.J.4
  • 12
    • 0037126950 scopus 로고    scopus 로고
    • Antioxidant activity of anti-inflammatory plant extracts
    • DOI 10.1016/S0024-3205(01)01482-5, PII S0024320501014825
    • Schinella GR, Tournier HA, Prieto JM, Mordujovich de Buschiazzo P, Rios JL. Antioxidant activity of anti-inflammatory plant extracts. Life Sci 2002; 70: 1023-1033. (Pubitemid 34085094)
    • (2002) Life Sciences , vol.70 , Issue.9 , pp. 1023-1033
    • Schinella, G.R.1    Tournier, H.A.2    Prieto, J.M.3    Mordujovich, D.B.P.4    Rios, J.L.5
  • 14
    • 35649004932 scopus 로고    scopus 로고
    • Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats
    • Chung HL, Yue GG, To KF, Su YL, Huang Y, Ko WH. Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats. World J Gastroenterol 2007; 13: 5605-5611. (Pubitemid 350031481)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.42 , pp. 5605-5611
    • Chung, H.-L.1    Yue, G.G.-L.2    To, K.-F.3    Su, Y.-L.4    Huang, Y.5    Ko, W.-H.6
  • 15
    • 2442713689 scopus 로고    scopus 로고
    • Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95
    • DOI 10.1078/0944711041495173
    • Tang W, Sun X, Fang JS, Zhang M, Sucher NJ. Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95. Phytomedicine 2004; 11: 277-284. (Pubitemid 38657456)
    • (2004) Phytomedicine , vol.11 , Issue.4 , pp. 277-284
    • Tang, W.1    Sun, X.2    Fang, J.-S.3    Zhang, M.4    Sucher, N.J.5
  • 17
    • 73749087913 scopus 로고    scopus 로고
    • Potential ex vivo immunomodulatory effects of San-Huang-Xie-Xin-Tang and its component herbs on mice and humans
    • Li CY, Hou YC, Lee Chao PD, Shia CS, Hsu IC, Fang SH. Potential ex vivo immunomodulatory effects of San-Huang-Xie-Xin-Tang and its component herbs on mice and humans. J Ethnopharmacol 2010; 127: 292-298.
    • (2010) J Ethnopharmacol , vol.127 , pp. 292-298
    • Li, C.Y.1    Hou, Y.C.2    Lee Chao, P.D.3    Shia, C.S.4    Hsu, I.C.5    Fang, S.H.6
  • 18
    • 33845642523 scopus 로고    scopus 로고
    • Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell
    • DOI 10.1016/j.canlet.2006.01.011, PII S0304383506000553
    • Himeji M, Ohtsuki T, Fukazawa H, et al. Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell. Cancer Lett 2007; 245: 269-274. (Pubitemid 44959358)
    • (2007) Cancer Letters , vol.245 , Issue.1-2 , pp. 269-274
    • Himeji, M.1    Ohtsuki, T.2    Fukazawa, H.3    Tanaka, M.4    Yazaki, S.-i.5    Ui, S.6    Nishio, K.7    Yamamoto, H.8    Tasaka, K.9    Mimura, A.10
  • 19
    • 0034025809 scopus 로고    scopus 로고
    • Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines
    • DOI 10.1016/S0090-4295(00)00467-2, PII S0090429500004672
    • Ikemoto S, Sugimura K, Yoshida N, et al. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 2000; 55: 951-955. (Pubitemid 30330816)
    • (2000) Urology , vol.55 , Issue.6 , pp. 951-955
    • Ikemoto, S.1    Sugimura, K.2    Yoshida, N.3    Yasumoto, R.4    Wada, S.5    Yamamoto, K.6    Kishimoto, T.7
  • 20
    • 11244255019 scopus 로고    scopus 로고
    • Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry
    • DOI 10.1021/jf049172w
    • Ong ES, Len SM, Lee AC. Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry. J Agric Food Chem 2005; 53: 8-16. (Pubitemid 40066462)
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , Issue.1 , pp. 8-16
    • Ong, E.S.1    Len, S.M.2    Lee, A.C.H.3
  • 21
    • 0033797211 scopus 로고    scopus 로고
    • Anticonvulsant effect of water extract of Scutellariae radix in mice
    • Wang HH, Liao JF, Chen CF. Anticonvulsant effect of water extract of Scutellariae radix in mice. J Ethnopharmacol 2000; 73: 185-190.
    • (2000) J Ethnopharmacol , vol.73 , pp. 185-190
    • Wang, H.H.1    Liao, J.F.2    Chen, C.F.3
  • 23
    • 34548599695 scopus 로고    scopus 로고
    • The extract of compound Radix Scutellariae on mRNA replication and IFN expression of influenza virus in mice
    • Chu M, Chu ZY, Wang DD. The extract of compound Radix Scutellariae on mRNA replication and IFN expression of influenza virus in mice. Zhong Yao Cai 2007; 30: 63-65.
    • (2007) Zhong Yao Cai , vol.30 , pp. 63-65
    • Chu, M.1    Chu, Z.Y.2    Wang, D.D.3
  • 24
    • 77649187990 scopus 로고    scopus 로고
    • The genus Scutellaria an ethnopharmacological and phytochemical review
    • Shang X, He X, He X, et al. The genus Scutellaria an ethnopharmacological and phytochemical review. J Ethnopharmacol 2010; 128: 279-313.
    • (2010) J Ethnopharmacol , vol.128 , pp. 279-313
    • Shang, X.1    He, X.2    He, X.3
  • 26
    • 0029134964 scopus 로고
    • Determination of flavonoids and alkaloids in the scute-coptis herb couple by capillary electrophoresis
    • Li KL, Sheu SJ. Determination of flavonoids and alkaloids in the scute-coptis herb couple by capillary electrophoresis. Anal Chim Acta 1995; 313: 113-120.
    • (1995) Anal Chim Acta , vol.313 , pp. 113-120
    • Li, K.L.1    Sheu, S.J.2
  • 28
    • 0011254679 scopus 로고    scopus 로고
    • A new flavone C-glycoside from Scutellaria aicalensis
    • Zhang YY, Guo YZ, Ageta H. A new flavone C-glycoside from Scutellaria aicalensis. J Chin Pharm Sci 1997; 6: 182-186.
    • (1997) J Chin Pharm Sci , vol.6 , pp. 182-186
    • Zhang, Y.Y.1    Guo, Y.Z.2    Ageta, H.3
  • 29
    • 0032740534 scopus 로고    scopus 로고
    • Flavone production in transformed root cultures of Scutellaria baicalensis Georgi
    • Nishikawa K, Furukawa H, Fujioka T, et al. Flavone production in transformed root cultures of Scutellaria baicalensis Georgi. Phytochemistry 1999; 52: 885-890.
    • (1999) Phytochemistry , vol.52 , pp. 885-890
    • Nishikawa, K.1    Furukawa, H.2    Fujioka, T.3
  • 30
    • 14144254022 scopus 로고    scopus 로고
    • Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography
    • DOI 10.1016/j.chroma.2005.01.054, PII S002196730500124X
    • Wu S, Sun A, Liu R. Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by highspeed counter-current chromatography. J Chromatogr A 2005; 1066: 243-247. (Pubitemid 40283571)
    • (2005) Journal of Chromatography A , vol.1066 , Issue.1-2 , pp. 243-247
    • Wu, S.1    Sun, A.2    Liu, R.3
  • 31
    • 8844271824 scopus 로고    scopus 로고
    • The application of solid-phase extraction and reversed phase high-performance liquid chromatography for simultaneous isolation and determination of plant flavonoids and phenolic acids
    • Zgórka G, Hajnos A. The application of solid-phase extraction and reversed phase high-performance liquid chromatography for simultaneous isolation and determination of plant flavonoids and phenolic acids. Chromatographia Supplement 2003; 57: 77-80.
    • (2003) Chromatographia Supplement , vol.57 , pp. 77-80
    • Zgórka, G.1    Hajnos, A.2
  • 32
    • 34548476287 scopus 로고    scopus 로고
    • Effects of processing and extracting methods on active components in Radix Scutellariae by HPLC analysis
    • Wang HZ, Yu CH, Gao J, Zhao GR. Effects of processing and extracting methods on active components in Radix Scutellariae by HPLC analysis. Zhongguo Zhong Yao Za Zhi 2007; 32: 1637-1640.
    • (2007) Zhongguo Zhong Yao Za Zhi , vol.32 , pp. 1637-1640
    • Wang, H.Z.1    Yu, C.H.2    Gao, J.3    Zhao, G.R.4
  • 33
    • 57049188643 scopus 로고    scopus 로고
    • Determination of the flavonoids contents in Scutellaria baicalensis Georgi from different areas by HPLC
    • Song SH, Zhang Y, Wang ZZ. Determination of the flavonoids contents in Scutellaria baicalensis Georgi from different areas by HPLC. Zhongguo Zhong Yao Za Zhi 2006; 31: 598-600.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , pp. 598-600
    • Song, S.H.1    Zhang, Y.2    Wang, Z.Z.3
  • 34
    • 76949106023 scopus 로고    scopus 로고
    • On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi
    • You J, Gao S, Jin H, Li W, Zhang H, Yu A. On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi. J Chromatogr A 2010; 1217: 1875-1881.
    • (2010) J Chromatogr A , vol.1217 , pp. 1875-1881
    • You, J.1    Gao, S.2    Jin, H.3    Li, W.4    Zhang, H.5    Yu, A.6
  • 35
    • 33745507122 scopus 로고    scopus 로고
    • Determination of contents of the effective ingredients in root of Scutellaria baicalensis by HPLC-ECD
    • Zhou XN, Yang B. Determination of contents of the effective ingredients in root of Scutellaria baicalensis by HPLC-ECD. Zhongguo Zhong Yao Za Zhi 2006; 31: 47-50.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , pp. 47-50
    • Zhou, X.N.1    Yang, B.2
  • 36
    • 0141501197 scopus 로고    scopus 로고
    • Determination of flavone for Scutellaria baicalensis from different areas by HPLC
    • Yang LX, Liu D, Feng XF, et al. Determination of flavone for Scutellaria baicalensis from different areas by HPLC. Zhongguo Zhong Yao Za Zhi 2002; 27: 166-170.
    • (2002) Zhongguo Zhong Yao Za Zhi , vol.27 , pp. 166-170
    • Yang, L.X.1    Liu, D.2    Feng, X.F.3
  • 37
    • 33750938279 scopus 로고    scopus 로고
    • Determination of Baicalin and wogonoside in seven species of Radix scutellariae by RP-HPLC
    • Liu ML, Yang LX, Wan YH, Zuo F. Determination of Baicalin and wogonoside in seven species of Radix scutellariae by RP-HPLC. Chin J Pharm Anal 2002; 22: 99-102.
    • (2002) Chin J Pharm Anal , vol.22 , pp. 99-102
    • Liu, M.L.1    Yang, L.X.2    Wan, Y.H.3    Zuo, F.4
  • 38
    • 67650214705 scopus 로고    scopus 로고
    • Contents of major bioactive flavones in proprietary traditional Chinesemedicine products and reference herb of radix Scutellariae
    • Li C, Zhou L, Lin G, Zuo Z. Contents of major bioactive flavones in proprietary traditional Chinesemedicine products and reference herb of radix Scutellariae. J Pharm Biomed Anal 2009; 50: 298-306.
    • (2009) J Pharm Biomed Anal , vol.50 , pp. 298-306
    • Li, C.1    Zhou, L.2    Lin, G.3    Zuo, Z.4
  • 39
    • 64549128148 scopus 로고    scopus 로고
    • Upregulation of interferon-gamma and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 Tcells
    • Kang H, Choi TW, Ahn KS, et al. Upregulation of interferon-gamma and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 Tcells. J Ethnopharmacol 2009; 123: 6-14.
    • (2009) J Ethnopharmacol , vol.123 , pp. 6-14
    • Kang, H.1    Choi, T.W.2    Ahn, K.S.3
  • 40
    • 34147213589 scopus 로고    scopus 로고
    • Sho-Saiko-Ko (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line
    • Chang JS, Wang KC, Liu HW, Chen MC, Chiang LC, Lin CC. Sho-Saiko-Ko (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line. Am J Chin Med 2007; 35: 341-351.
    • (2007) Am J Chin Med , vol.35 , pp. 341-351
    • Chang, J.S.1    Wang, K.C.2    Liu, H.W.3    Chen, M.C.4    Chiang, L.C.5    Lin, C.C.6
  • 41
    • 0033022302 scopus 로고    scopus 로고
    • Inhibitory effects of baicalein and wogonin on lipopolysaccharide- induced nitric oxide production in macrophages
    • Wakabayashi I. Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages. Pharmacol Toxicol 1999; 84: 288-291. (Pubitemid 29282218)
    • (1999) Pharmacology and Toxicology , vol.84 , Issue.6 , pp. 288-291
    • Wakabayashi, I.1
  • 43
    • 0033829034 scopus 로고    scopus 로고
    • The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines
    • Li BQ, Fu T, Gong WH, et al. The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines. Immunopharmacology 2000; 49: 295-306.
    • (2000) Immunopharmacology , vol.49 , pp. 295-306
    • Li, B.Q.1    Fu, T.2    Gong, W.H.3
  • 44
    • 33646542712 scopus 로고    scopus 로고
    • Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity
    • Woo KJ, Lim JH, Suh SI, et al. Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity. Immunobiology 2006; 211: 359-368.
    • (2006) Immunobiology , vol.211 , pp. 359-368
    • Woo, K.J.1    Lim, J.H.2    Suh, S.I.3
  • 46
    • 0032750323 scopus 로고    scopus 로고
    • Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi
    • DOI 10.1016/S0304-4165(99)00152-X, PII S030441659900152X
    • Gao Z, Huang K, Yang X, Xu H. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1999; 1472: 643-650. (Pubitemid 29516652)
    • (1999) Biochimica et Biophysica Acta - General Subjects , vol.1472 , Issue.3 , pp. 643-650
    • Gao, Z.1    Huang, K.2    Yang, X.3    Xu, H.4
  • 47
    • 0036765656 scopus 로고    scopus 로고
    • Anticancer, antiradical and antioxidative actions of novel Antoksyd S and its major components, baicalin and baicalein
    • Ciesielska E, Gwardys A, Metodiewa D. Anticancer, antiradical and antioxidative actions of novel Antoksyd S and its major components, baicalin and baicalein. Anticancer Res 2002; 22: 2885-2891.
    • (2002) Anticancer Res , vol.22 , pp. 2885-2891
    • Ciesielska, E.1    Gwardys, A.2    Metodiewa, D.3
  • 48
    • 0029781370 scopus 로고    scopus 로고
    • Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices
    • So FV, Guthrie N, Chambers AF, Moussa M, Carroll KK. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutr Cancer 1996; 26: 167-181. (Pubitemid 26300196)
    • (1996) Nutrition and Cancer , vol.26 , Issue.2 , pp. 167-181
    • So, F.V.1    Guthrie, N.2    Chambers, A.F.3    Moussa, M.4    Carroll, K.K.5
  • 49
    • 17444390875 scopus 로고    scopus 로고
    • Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells
    • Lee HZ, Leung HW, Lai MY, Wu CH. Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells. Anticancer Res 2005; 25: 959-964. (Pubitemid 40546869)
    • (2005) Anticancer Research , vol.25 , Issue.2 A , pp. 959-964
    • Lee, H.Z.1    Leung, H.W.C.2    Lai, M.Y.3    Wu, C.H.4
  • 50
    • 2442497431 scopus 로고    scopus 로고
    • Antitumor Effects of Lipoxygenase Inhibitors on Murine Bladder Cancer Cell Line (MBT-2)
    • Ikemoto S, Sugimura K, Kuratukuri K, Nakatani T. Antitumor effects of lipoxygenase inhibitors on murine bladder cancer cell line (MBT-2). Anticancer Res 2004; 24: 733-736. (Pubitemid 38625014)
    • (2004) Anticancer Research , vol.24 , Issue.2 B , pp. 733-736
    • Ikemoto, S.1    Sugimura, K.2    Kuratukuri, K.3    Nakatani, T.4
  • 51
    • 18844437520 scopus 로고    scopus 로고
    • Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma
    • DOI 10.1158/1078-0432.CCR-04-1974
    • Bonham M, Posakony J, Coleman I, Montgomery B, Simon J, Nelson PS. Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma. Clin Cancer Res 2005; 11: 3905-3914. (Pubitemid 40685612)
    • (2005) Clinical Cancer Research , vol.11 , Issue.10 , pp. 3905-3914
    • Bonham, M.1    Posakony, J.2    Coleman, I.3    Montgomery, B.4    Simon, J.5    Nelson, P.S.6
  • 54
    • 27744472231 scopus 로고    scopus 로고
    • Human cytomegalovirus-inhibitory flavonoids: Studies on antiviral activity and mechanism of action
    • DOI 10.1016/j.antiviral.2005.08.002, PII S0166354205001701
    • Evers DL, Chao CF, Wang X, Zhang Z, Huong SM, Huang ES. Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. Antiviral Res 2005; 68: 124-134. (Pubitemid 41612456)
    • (2005) Antiviral Research , vol.68 , Issue.3 , pp. 124-134
    • Evers, D.L.1    Chao, C.-F.2    Wang, X.3    Zhang, Z.4    Huong, S.-M.5    Huang, E.-S.6
  • 55
    • 27644565158 scopus 로고    scopus 로고
    • Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an in vitro replicative system
    • DOI 10.1016/j.antiviral.2005.07.005, PII S0166354205001476
    • Romero MR, Efferth T, Serrano MA, et al. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an in vitro replicative system. Antiviral Res 2005; 68: 75-83. (Pubitemid 41565521)
    • (2005) Antiviral Research , vol.68 , Issue.2 , pp. 75-83
    • Romero, M.R.1    Efferth, T.2    Serrano, M.A.3    Castano, B.4    MacIas, R.I.R.5    Briz, O.6    Marin, J.J.G.7
  • 56
    • 36749068009 scopus 로고    scopus 로고
    • Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes
    • DOI 10.1016/j.neuroscience.2007.09.033, PII S0306452207011724
    • Lapchak PA, Maher P, Schubert D, Zivin JA. Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. Neuroscience 2007; 150: 585-591. (Pubitemid 350214501)
    • (2007) Neuroscience , vol.150 , Issue.3 , pp. 585-591
    • Lapchak, P.A.1    Maher, P.2    Schubert, D.3    Zivin, J.A.4
  • 57
    • 33846612024 scopus 로고    scopus 로고
    • Baicalin attenuates oxygen-glucose deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons
    • DOI 10.1016/j.phrs.2006.11.007, PII S1043661806002106
    • Ge QF, Hu X, Ma ZQ, et al. Baicalin attenuates oxygen-glucose deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons. Pharmacol Res 2007; 55: 148-157. (Pubitemid 46186042)
    • (2007) Pharmacological Research , vol.55 , Issue.2 , pp. 148-157
    • Ge, Q.-F.1    Hu, X.2    Ma, Z.-Q.3    Liu, J.-R.4    Zhang, W.-P.5    Chen, Z.6    Wei, E.-Q.7
  • 58
    • 33846938772 scopus 로고    scopus 로고
    • The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke
    • Chang CP, Huang WT, Cheng BC, Hsu CC, Lin MT. The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke. Neuropharmacology 2007; 52: 1024-1033.
    • (2007) Neuropharmacology , vol.52 , pp. 1024-1033
    • Chang, C.P.1    Huang, W.T.2    Cheng, B.C.3    Hsu, C.C.4    Lin, M.T.5
  • 59
    • 0035873932 scopus 로고    scopus 로고
    • Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells
    • Chi YS, Cheon BS, Kim HP. Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Biochem Pharmacol 2001; 61: 1195-1203.
    • (2001) Biochem Pharmacol , vol.61 , pp. 1195-1203
    • Chi, Y.S.1    Cheon, B.S.2    Kim, H.P.3
  • 60
    • 0035839226 scopus 로고    scopus 로고
    • Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix
    • DOI 10.1016/S0014-2999(01)01187-6, PII S0014299901011876
    • Park BK, Heo MY, Park H, Kim HP. Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix. Eur J Pharmacol 2001; 425: 153-157. (Pubitemid 32739162)
    • (2001) European Journal of Pharmacology , vol.425 , Issue.2 , pp. 153-157
    • Park, B.K.1    Heo, M.Y.2    Park, H.3    Kim, H.P.4
  • 61
    • 0037141773 scopus 로고    scopus 로고
    • In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production
    • Shen SC, Lee WR, Lin HY, et al. In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. Eur J Pharmacol 2002; 446: 187-194.
    • (2002) Eur J Pharmacol , vol.446 , pp. 187-194
    • Shen, S.C.1    Lee, W.R.2    Lin, H.Y.3
  • 62
    • 0032814249 scopus 로고    scopus 로고
    • Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships
    • DOI 10.1016/S0006-2952(99)00160-4, PII S0006295299001604
    • Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP. Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 1999; 58: 759-765. (Pubitemid 29329524)
    • (1999) Biochemical Pharmacology , vol.58 , Issue.5 , pp. 759-765
    • Kim, H.K.1    Cheon, B.S.2    Kim, Y.H.3    Kim, S.Y.4    Kim, H.P.5
  • 63
    • 0037081782 scopus 로고    scopus 로고
    • Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease
    • Lee WR, Shen SC, Lin HY, Hou WC, Yang LL, Chen YC. Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease. Biochem Pharmacol 2002; 63: 225-236.
    • (2002) Biochem Pharmacol , vol.63 , pp. 225-236
    • Lee, W.R.1    Shen, S.C.2    Lin, H.Y.3    Hou, W.C.4    Yang, L.L.5    Chen, Y.C.6
  • 64
    • 1642497587 scopus 로고    scopus 로고
    • Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells
    • DOI 10.1016/j.ejphar.2003.11.064
    • Cho J, Lee HK. Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells. Eur J Pharmacol 2004; 485: 105-110. (Pubitemid 38134403)
    • (2004) European Journal of Pharmacology , vol.485 , Issue.1-3 , pp. 105-110
    • Cho, J.1    Lee, H.-K.2
  • 65
    • 2942604860 scopus 로고    scopus 로고
    • Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation
    • DOI 10.1016/j.ejphar.2004.04.017, PII S0014299904004029
    • Son D, Lee P, Lee J, Kim H, Kim SY. Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. Eur J Pharmacol 2004; 493: 99-102. (Pubitemid 38746937)
    • (2004) European Journal of Pharmacology , vol.493 , Issue.1-3 , pp. 99-102
    • Son, D.1    Lee, P.2    Lee, J.3    Kim, H.4    Kim, S.Y.5
  • 68
    • 33847642568 scopus 로고    scopus 로고
    • Anti-hepatitis B virus activity of wogonin in vitro and in vivo
    • DOI 10.1016/j.antiviral.2007.01.002, PII S0166354207000046
    • Guo Q, Zhao L, You Q, et al. Anti-hepatitis B virus activity of wogonin in vitro and in vivo. Antiviral Res 2007; 74: 16-24. (Pubitemid 46366014)
    • (2007) Antiviral Research , vol.74 , Issue.1 , pp. 16-24
    • Guo, Q.1    Zhao, L.2    You, Q.3    Yang, Y.4    Gu, H.5    Song, G.6    Lu, N.7    Xin, J.8
  • 69
    • 0034213030 scopus 로고    scopus 로고
    • Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation
    • DOI 10.1016/S0006-2952(00)00255-0, PII S0006295200002550
    • Chen Y, Yang L, Lee TJ. Oroxylin A inhibition of lipopolysaccharide- induced iNOS and COX-2 gene expression via suppression of nuclear factor-kappaB activation. Biochem Pharmacol 2000; 59: 1445-1457. (Pubitemid 30177363)
    • (2000) Biochemical Pharmacology , vol.59 , Issue.11 , pp. 1445-1457
    • Chen, Y.-C.1    Yang, L.-L.2    Lee, T.J.-F.3
  • 70
    • 0038005574 scopus 로고    scopus 로고
    • 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties
    • DOI 10.1016/S0006-2952(03)00233-8
    • Huen MS, Leung JW, Ng W, et al. 5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties. Biochem Pharmacol 2003; 66: 125-132. (Pubitemid 36724906)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.1 , pp. 125-132
    • Huen, M.S.Y.1    Leung, J.W.C.2    Ng, W.3    Lui, W.S.4    Chan, M.N.S.5    Wong, J.T.-F.6    Xue, H.7
  • 75
    • 69549116609 scopus 로고    scopus 로고
    • MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cells
    • Liu W, Mu R, Nie FF, et al. MAC related mitochondrial pathway in oroxylin A induces apoptosis in human hepatocellular carcinoma HepG2 cells. Cancer Lett 2009; 284: 198-207.
    • (2009) Cancer Lett , vol.284 , pp. 198-207
    • Liu, W.1    Mu, R.2    Nie, F.F.3
  • 76
    • 58649105305 scopus 로고    scopus 로고
    • Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo
    • Li HN, Nie FF, Liu W, et al. Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology 2009; 257: 80-85.
    • (2009) Toxicology , vol.257 , pp. 80-85
    • Li, H.N.1    Nie, F.F.2    Liu, W.3
  • 78
    • 77955712205 scopus 로고    scopus 로고
    • Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers
    • Marques MR, Stuker C, Kichik N, et al. Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers. Fitoterapia 2010; 81: 552-556.
    • (2010) Fitoterapia , vol.81 , pp. 552-556
    • Marques, M.R.1    Stuker, C.2    Kichik, N.3
  • 79
    • 33846318189 scopus 로고    scopus 로고
    • Studies on the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines
    • Liu TM, Jiang XH. Studies on the absorption kinetics of baicalin and baicalein in rats' stomachs and intestines. Zhongguo Zhong Yao Za Zhi 2006; 31: 999-1001.
    • (2006) Zhongguo Zhong Yao Za Zhi , vol.31 , pp. 999-1001
    • Liu, T.M.1    Jiang, X.H.2
  • 81
    • 51349086819 scopus 로고    scopus 로고
    • Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihutang across human intestinal Caco-2 cell monolayers
    • Dai JY, Yang JL, Li C. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihutang across human intestinal Caco-2 cell monolayers. Acta Pharmacol Sin 2008; 29: 1086-1093.
    • (2008) Acta Pharmacol Sin , vol.29 , pp. 1086-1093
    • Dai, J.Y.1    Yang, J.L.2    Li, C.3
  • 82
    • 23744497186 scopus 로고    scopus 로고
    • Role of intestinal first-pass metabolism of baicalein in its absorption process
    • DOI 10.1007/s11095-005-5303-7
    • Zhang L, Lin G, Chang Q, Zuo Z. Role of intestinal first-pass metabolism of baicalein in its absorption process. Pharm Res 2005; 22: 1050-1058. (Pubitemid 41127062)
    • (2005) Pharmaceutical Research , vol.22 , Issue.7 , pp. 1050-1058
    • Zhang, L.1    Lin, G.2    Chang, Q.3    Zuo, Z.4
  • 83
    • 21644436299 scopus 로고    scopus 로고
    • Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: Involvement of multidrug resistance-associated protein 2
    • DOI 10.1023/B:PHAM.0000048205.02478.b5
    • Akao T, Sakashita Y, Hanada M, Goto H, Shimada Y, Terasawa K. Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2. Pharm Res 2004; 21: 2120-2126. (Pubitemid 40941234)
    • (2004) Pharmaceutical Research , vol.21 , Issue.11 , pp. 2120-2126
    • Akao, T.1    Sakashita, Y.2    Hanada, M.3    Goto, H.4    Shimada, Y.5    Terasawa, K.6
  • 84
    • 33845424456 scopus 로고    scopus 로고
    • Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein
    • DOI 10.1007/s11095-006-9126-y
    • Zhang L, Lin G, Zuo Z. Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein. Pharm Res 2007; 24: 81-89. (Pubitemid 44902573)
    • (2007) Pharmaceutical Research , vol.24 , Issue.1 , pp. 81-89
    • Zhang, L.1    Lin, G.2    Zuo, Z.3
  • 85
    • 77955473210 scopus 로고    scopus 로고
    • Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes
    • Zhou Q, Zheng Z, Xia B, et al. Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharm Res 2010; 27: 1568-1583.
    • (2010) Pharm Res , vol.27 , pp. 1568-1583
    • Zhou, Q.1    Zheng, Z.2    Xia, B.3
  • 86
    • 44349185775 scopus 로고    scopus 로고
    • A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the caco-2 cell monolayer: Demonstration of substrate inhibition
    • DOI 10.1124/jpet.108.137463
    • Sun H, Zhang L, Chow EC, Lin G, Zuo Z, Pang KS. A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition. J Pharmacol Exp Ther 2008; 326: 117-126. (Pubitemid 351872137)
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.326 , Issue.1 , pp. 117-126
    • Sun, H.1    Zhang, L.2    Chow, E.C.Y.3    Lin, G.4    Zuo, Z.5    Pang, K.S.6
  • 87
    • 1642528478 scopus 로고    scopus 로고
    • Absorption and metabolism of flavonoids
    • DOI 10.1016/j.freeradbiomed.2004.01.002, PII S0891584904000346
    • Walle T. Absorption and metabolism of flavonoids. Free Radic Biol Med 2004; 36: 829-837. (Pubitemid 38401062)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.7 , pp. 829-837
    • Walle, T.1
  • 88
    • 0038382966 scopus 로고    scopus 로고
    • Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans
    • Lai MY, Hsiu SL, Chen CC, Hou YC, Chao PD. Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans. Biol Pharm Bull 2003; 26: 79-83.
    • (2003) Biol Pharm Bull , vol.26 , pp. 79-83
    • Lai, M.Y.1    Hsiu, S.L.2    Chen, C.C.3    Hou, Y.C.4    Chao, P.D.5
  • 89
    • 27644442245 scopus 로고    scopus 로고
    • Absorption and enterohepatic circulation of baicalin in rats
    • DOI 10.1016/j.lfs.2005.04.072, PII S0024320505007356
    • Xing J, Chen X, Zhong D. Absorption and enterohepatic circulation of baicalin in rats. Life Sci 2005; 78: 140-146. (Pubitemid 41560966)
    • (2005) Life Sciences , vol.78 , Issue.2 , pp. 140-146
    • Xing, J.1    Chen, X.2    Zhong, D.3
  • 90
    • 0034534704 scopus 로고    scopus 로고
    • Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form
    • DOI 10.1211/0022357001777621
    • Akao T, Kawabata K, Yanagisawa E, et al. Baicalin, the predominant flavone glucuronide of scutellariae radix, is absorbed from the rat gastrointestinal tract as the aglycone and restored to its original form. J Pharm Pharmacol 2000; 52: 1563-1568. (Pubitemid 32058657)
    • (2000) Journal of Pharmacy and Pharmacology , vol.52 , Issue.12 , pp. 1563-1568
    • Akao, T.1    Kawabata, K.2    Yanagisawa, E.3    Ishihara, K.4    Mizuhara, Y.5    Wakui, Y.6    Sakashita, Y.7    Kobashi, K.8
  • 92
    • 0037377562 scopus 로고    scopus 로고
    • Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: The role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter
    • DOI 10.1016/S0006-2952(03)00039-X
    • Day AJ, Gee JM, DuPont MS, Johnson IT, Williamson G. Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter. Biochem Pharmacol 2003; 65: 1199-1206. (Pubitemid 36349759)
    • (2003) Biochemical Pharmacology , vol.65 , Issue.7 , pp. 1199-1206
    • Day, A.J.1    Gee, J.M.2    DuPont, M.S.3    Johnson, I.T.4    Williamson, G.5
  • 93
    • 33751280008 scopus 로고    scopus 로고
    • Study on the metabolism of the precipitation of Xiexin decoction in rats I
    • Li JR, Zuo F, Zhang L, Nakamura N, Hattori M. Study on the metabolism of the precipitation of Xiexin decoction in rats I. Zhongguo Zhong Yao Za Zhi 2005; 30: 1673-1676. (Pubitemid 44795737)
    • (2005) Zhongguo Zhongyao Zazhi , vol.30 , Issue.21 , pp. 1673-1676
    • Li, J.-R.1    Zuo, F.2    Zhang, L.3    Norio, N.4    Masao, H.5
  • 94
    • 27944438159 scopus 로고    scopus 로고
    • Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract
    • DOI 10.1016/j.jep.2005.07.013, PII S0378874105004757
    • Zhang L, Xing D, Wang W, Wang R, Du L. Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract. J Ethnopharmacol 2006; 103: 120-125. (Pubitemid 41681149)
    • (2006) Journal of Ethnopharmacology , vol.103 , Issue.1 , pp. 120-125
    • Zhang, L.1    Xing, D.2    Wang, W.3    Wang, R.4    Du, L.5
  • 95
    • 0034620261 scopus 로고    scopus 로고
    • Herb-drug interactions
    • Fugh-Berman A. Herb-drug interactions. Lancet 2000; 355: 134-138. (Pubitemid 30068565)
    • (2000) Lancet , vol.355 , Issue.9198 , pp. 134-138
    • Fugh-Berman, A.1
  • 96
    • 1542344492 scopus 로고    scopus 로고
    • Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis
    • Lai MY, Hsiu SL, Hou YC, Tsai SY, Chao PD. Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis. Planta Med 2004; 70: 132-137.
    • (2004) Planta Med , vol.70 , pp. 132-137
    • Lai, M.Y.1    Hsiu, S.L.2    Hou, Y.C.3    Tsai, S.Y.4    Chao, P.D.5
  • 97
    • 34548808066 scopus 로고    scopus 로고
    • Metabolism of dietary polyphenols and possible interactions with drugs
    • DOI 10.2174/138920007780866870
    • Lambert JD, Sang S, Lu AY, Yang CS. Metabolism of dietary polyphenols and possible interactions with drugs. Curr Drug Metab 2007; 8: 499-507. (Pubitemid 47603414)
    • (2007) Current Drug Metabolism , vol.8 , Issue.5 , pp. 499-507
    • Lambert, J.D.1    Sang, S.2    Lu, A.Y.H.3    Yang, C.S.4
  • 98
    • 12744256734 scopus 로고    scopus 로고
    • Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2
    • van Zanden JJ, Wortelboer HM, Bijlsma S, et al. Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. Biochem Pharmacol 2005; 69: 699-708.
    • (2005) Biochem Pharmacol , vol.69 , pp. 699-708
    • Van Zanden, J.J.1    Wortelboer, H.M.2    Bijlsma, S.3
  • 99
    • 33847790184 scopus 로고    scopus 로고
    • Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats
    • DOI 10.1016/j.jep.2006.09.036, PII S0378874106005137
    • Lu T, Song J, Huang F, et al. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. J Ethnopharmacol 2007; 110: 412-418. (Pubitemid 46389634)
    • (2007) Journal of Ethnopharmacology , vol.110 , Issue.3 , pp. 412-418
    • Lu, T.1    Song, J.2    Huang, F.3    Deng, Y.4    Xie, L.5    Wang, G.6    Liu, X.7
  • 101
    • 33947164202 scopus 로고    scopus 로고
    • Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats
    • Kim YH, Jeong DW, Kim YC, Sohn DH, Park ES, Lee HS. Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats. Arch Pharm Res 2007; 30: 260-265.
    • (2007) Arch Pharm Res , vol.30 , pp. 260-265
    • Kim, Y.H.1    Jeong, D.W.2    Kim, Y.C.3    Sohn, D.H.4    Park, E.S.5    Lee, H.S.6
  • 103
    • 0032903199 scopus 로고    scopus 로고
    • Supercritical fluid extraction of flavonoids from Scutellariae Radix
    • Lin MC, Tsai MJ, Wen KC. Supercritical fluid extraction of flavonoids from Scutellariae Radix. J Chromatogr A 1999; 830: 387-395.
    • (1999) J Chromatogr A , vol.830 , pp. 387-395
    • Lin, M.C.1    Tsai, M.J.2    Wen, K.C.3
  • 104
    • 0038464586 scopus 로고    scopus 로고
    • Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties
    • DOI 10.1002/ptr.1216
    • Bochorakova H, Paulova H, Slanina J, Musil P, Taborska E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res 2003; 17: 640-644. (Pubitemid 36781740)
    • (2003) Phytotherapy Research , vol.17 , Issue.6 , pp. 640-644
    • Bochorakova, H.1    Paulova, H.2    Slanina, J.3    Musil, P.4    Taborska, E.5
  • 105
    • 11144301919 scopus 로고    scopus 로고
    • Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant Huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection
    • DOI 10.1016/j.chroma.2004.11.030, PII S0021967304020424
    • Horvath CR, Martos PA, Saxena PK. Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection. J Chromatogr A 2005; 1062: 199-207. (Pubitemid 40037399)
    • (2005) Journal of Chromatography A , vol.1062 , Issue.2 , pp. 199-207
    • Horvath, C.R.1    Martos, P.A.2    Saxena, P.K.3
  • 106
    • 80054939995 scopus 로고    scopus 로고
    • Determination of three flavones in Scutellaria baicalensis Georgi by RP-HPLC
    • Liu Y, Deng SW, Yuan WP, Ma SC. Determination of three flavones in Scutellaria baicalensis Georgi by RP-HPLC. Chin Tradit Herbal Drugs 2005; 36: 1247-1248.
    • (2005) Chin Tradit Herbal Drugs , vol.36 , pp. 1247-1248
    • Liu, Y.1    Deng, S.W.2    Yuan, W.P.3    Ma, S.C.4
  • 107
    • 67650258682 scopus 로고    scopus 로고
    • Content determination of five active components in four sources of Scutellaria baicalensis by RP-HPLC
    • Zhang J, Xiao LH, Li FM. Content determination of five active components in four sources of Scutellaria baicalensis by RP-HPLC. J Chin Med Materials 2005; 28: 389-391.
    • (2005) J Chin Med Materials , vol.28 , pp. 389-391
    • Zhang, J.1    Xiao, L.H.2    Li, F.M.3
  • 108
    • 33748520218 scopus 로고    scopus 로고
    • Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive
    • DOI 10.1016/j.chroma.2006.08.016, PII S0021967306015378
    • Zhang H, Tian K, Tang J, et al. Analysis of baicalein, baicalin and wogonin in Scutellariae radix and its preparation by microemulsion electrokinetic chromatography with 1-butyl-3-methylimizolium tetrafluoborate ionic liquid as additive. J Chromatogr A 2006; 1129: 304-307. (Pubitemid 44373944)
    • (2006) Journal of Chromatography A , vol.1129 , Issue.2 , pp. 304-307
    • Zhang, H.1    Tian, K.2    Tang, J.3    Qi, S.4    Chen, H.5    Chen, X.6    Hu, Z.7
  • 110
    • 33845602745 scopus 로고    scopus 로고
    • Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis
    • DOI 10.1016/j.jpba.2006.08.011, PII S0731708506005723
    • Yu K, Gong Y, Lin Z, Cheng Y. Quantitative analysis and chromatographic fingerprinting for the quality evaluation of Scutellaria baicalensis Georgi using capillary electrophoresis. J Pharm Biomed Anal 2007; 43: 540-548. (Pubitemid 44960586)
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.43 , Issue.2 , pp. 540-548
    • Yu, K.1    Gong, Y.2    Lin, Z.3    Cheng, Y.4
  • 111
    • 77950371283 scopus 로고    scopus 로고
    • Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers
    • Li Y, Wu T, Zhu J, et al. Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers. J Pharm Biomed Anal 2010; 52: 597-602.
    • (2010) J Pharm Biomed Anal , vol.52 , pp. 597-602
    • Li, Y.1    Wu, T.2    Zhu, J.3
  • 112
    • 33845225728 scopus 로고    scopus 로고
    • Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography
    • DOI 10.1016/j.jpba.2006.06.013, PII S0731708506004195
    • Qu H, Ma Y, Yu K, Cheng Y. Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography. J Pharm Biomed Anal 2007; 43: 66-72. (Pubitemid 44856190)
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.43 , Issue.1 , pp. 66-72
    • Qu, H.1    Ma, Y.2    Yu, K.3    Cheng, Y.4
  • 113
    • 80054887324 scopus 로고    scopus 로고
    • HPLC determination of baicalin in compound Puqin tablets
    • Li BL, Chen ZL, Jiang SP. HPLC determination of baicalin in compound Puqin tablets. Clin J Pharm Anal 2010; 30: 703-705.
    • (2010) Clin J Pharm Anal , vol.30 , pp. 703-705
    • Li, B.L.1    Chen, Z.L.2    Jiang, S.P.3
  • 114
    • 64949158527 scopus 로고    scopus 로고
    • Evaluating the quality of niuhuangjiedu tablets by the systematic quantified fingerprint method
    • Sun GX, Hu YS, Bi KS. Evaluating the quality of niuhuangjiedu tablets by the systematic quantified fingerprint method. Yao Xue Xue Bao 2009; 44: 401-405.
    • (2009) Yao Xue Xue Bao , vol.44 , pp. 401-405
    • Sun, G.X.1    Hu, Y.S.2    Bi, K.S.3
  • 115
    • 34547791891 scopus 로고    scopus 로고
    • Simultaneous determination of geniposide, baicalin and berberine hydrochloride in Angong Niuhuang pill by RPHPLC
    • Han FM, Li Y, Li LJ, Chen Y. Simultaneous determination of geniposide, baicalin and berberine hydrochloride in Angong Niuhuang pill by RPHPLC. Zhongguo Zhong Yao Za Zhi 2007; 32: 1406-1408.
    • (2007) Zhongguo Zhong Yao Za Zhi , vol.32 , pp. 1406-1408
    • Han, F.M.1    Li, Y.2    Li, L.J.3    Chen, Y.4
  • 116
    • 70350576604 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry
    • Liang X, Zhang L, Zhang X, et al. Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry. J Pharm Biomed Anal 2010; 51: 565-571.
    • (2010) J Pharm Biomed Anal , vol.51 , pp. 565-571
    • Liang, X.1    Zhang, L.2    Zhang, X.3
  • 117
    • 68649115569 scopus 로고    scopus 로고
    • Analysis of fuzhisan and quantitation of baicalin and ginsenoside Rb(1) by HPLC-DAD-ELSD
    • Zhao J, Wang D, Duan S, Wang J, Bai J, Li W. Analysis of fuzhisan and quantitation of baicalin and ginsenoside Rb(1) by HPLC-DAD-ELSD. Arch Pharm Res 2009; 32: 989-996.
    • (2009) Arch Pharm Res , vol.32 , pp. 989-996
    • Zhao, J.1    Wang, D.2    Duan, S.3    Wang, J.4    Bai, J.5    Li, W.6
  • 118
    • 0034326671 scopus 로고    scopus 로고
    • Determination of baicalein, baicalin and quercetin in Scutellariae Radix and its preparations by capillary electrophoresis with electrochemical detection
    • Chen G, Zhang H, Ye J. Determination of baicalein, baicalin and quercetin in Scutellariae Radix and its preparations by capillary electrophoresis with electrochemical detection. Talanta 2000; 53: 471-479.
    • (2000) Talanta , vol.53 , pp. 471-479
    • Chen, G.1    Zhang, H.2    Ye, J.3
  • 119
    • 33646428094 scopus 로고    scopus 로고
    • Development of the chromatographic fingerprint of herbal preparations Shuang-Huang-Lian oral liquid
    • Cao Y, Wang L, Yu X, Ye J. Development of the chromatographic fingerprint of herbal preparations Shuang-Huang-Lian oral liquid. J Pharm Biomed Anal 2006; 41: 845-856.
    • (2006) J Pharm Biomed Anal , vol.41 , pp. 845-856
    • Cao, Y.1    Wang, L.2    Yu, X.3    Ye, J.4
  • 120
    • 0029966431 scopus 로고    scopus 로고
    • Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sannjoong-kuey-jian-tang by high-performance liquid chromatography
    • Lin SJ, Tseng HH, Wen KC, Suen TT. Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sannjoong-kuey-jian-tang by high-performance liquid chromatography. J Chromatogr A 1996; 730: 17-23.
    • (1996) J Chromatogr A , vol.730 , pp. 17-23
    • Lin, S.J.1    Tseng, H.H.2    Wen, K.C.3    Suen, T.T.4
  • 121
    • 77953498531 scopus 로고    scopus 로고
    • Simultaneous determination of five active constituents in Xiaochaihu Tang by HPLC
    • Liu Q, Zhao J, Yan L, Yi J, Song J. [Simultaneous determination of five active constituents in Xiaochaihu Tang by HPLC]. Zhongguo Zhong Yao Za Zhi 2010; 35: 708-710.
    • (2010) Zhongguo Zhong Yao Za Zhi , vol.35 , pp. 708-710
    • Liu, Q.1    Zhao, J.2    Yan, L.3    Yi, J.4    Song, J.5
  • 122
    • 0344642935 scopus 로고    scopus 로고
    • Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats
    • Lai MY, Hsiu SL, Tsai SY, Hou YC, Chao PD. Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats. J Pharm Pharmacol 2003; 55: 205-209.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 205-209
    • Lai, M.Y.1    Hsiu, S.L.2    Tsai, S.Y.3    Hou, Y.C.4    Chao, P.D.5
  • 123
    • 33748433372 scopus 로고    scopus 로고
    • Pharmacokinetic comparisons of Shuang-Huang-Lian with the different combinations of its constitutional herbs
    • DOI 10.1016/j.jep.2006.03.030, PII S0378874106001760
    • Di B, Feng N, Liu W. Pharmacokinetic comparisons of Shuang-Huang-Lian with the different combinations of its constitutional herbs. J Ethnopharmacol 2006; 107: 401-405. (Pubitemid 44344431)
    • (2006) Journal of Ethnopharmacology , vol.107 , Issue.3 , pp. 401-405
    • Di, B.1    Feng, N.2    Liu, W.3
  • 124
    • 34548435160 scopus 로고    scopus 로고
    • Pharmacokinetics of flavonoids from xiexin decoction in rats
    • Yan JC, Liu ZM, Wang TM, Shi R, Ma YM. Pharmacokinetics of flavonoids from xiexin decoction in rats. Yao Xue Xue Bao 2007; 42: 722-729.
    • (2007) Yao Xue Xue Bao , vol.42 , pp. 722-729
    • Yan, J.C.1    Liu, Z.M.2    Wang, T.M.3    Shi, R.4    Ma, Y.M.5
  • 126
    • 7444221110 scopus 로고    scopus 로고
    • High-performance liquid chromatographic method for simultaneous determination of baicalein and baicalein 7-glucuronide in rat plasma
    • DOI 10.1016/j.jpba.2004.07.024, PII S0731708504003267
    • Zhang L, Lin G, Zuo Z. High-performance liquid chromatographicmethod for simultaneous determination of baicalein and baicalein 7-glucuronide in rat plasma. J Pharm Biomed Anal 2004; 36: 637-641. (Pubitemid 39441337)
    • (2004) Journal of Pharmaceutical and Biomedical Analysis , vol.36 , Issue.3 , pp. 637-641
    • Zhang, L.1    Lin, G.2    Zuo, Z.3
  • 127
    • 0037025836 scopus 로고    scopus 로고
    • Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry
    • DOI 10.1016/S1570-0232(02)00288-X, PII S157002320200288X
    • Chen X, Wang H, Du Y, Zhong D. Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2002; 775: 169-178. (Pubitemid 34756413)
    • (2002) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.775 , Issue.2 , pp. 169-178
    • Chen, X.1    Wang, H.2    Du, Y.3    Zhong, D.4
  • 128
    • 67449135860 scopus 로고    scopus 로고
    • Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs
    • Peng J, Qi Q, You Q, et al. Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs. J Ethnopharmacol 2009; 124: 257-262.
    • (2009) J Ethnopharmacol , vol.124 , pp. 257-262
    • Peng, J.1    Qi, Q.2    You, Q.3
  • 130
    • 16644375017 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetics of hawthorn phenolics in extract versus individual pure compound
    • Chang Q, Zuo Z, Ho WK, Chow MS. Comparison of the pharmacokinetics of hawthorn phenolics in extract versus individual pure compound. J Clin Pharmacol 2005; 45: 106-112.
    • (2005) J Clin Pharmacol , vol.45 , pp. 106-112
    • Chang, Q.1    Zuo, Z.2    Ho, W.K.3    Chow, M.S.4
  • 132
    • 69949094176 scopus 로고    scopus 로고
    • Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats
    • Wu H, Zhu Z, Zhang G, et al. Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats. J Ethnopharmacol 2009; 125: 444-449.
    • (2009) J Ethnopharmacol , vol.125 , pp. 444-449
    • Wu, H.1    Zhu, Z.2    Zhang, G.3
  • 133
    • 35748982105 scopus 로고    scopus 로고
    • A in rat
    • DOI 10.1016/j.ejps.2007.07.007, PII S0928098707002989
    • Song M, Hang TJ, Zhang Z, Chen HY. Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat. Eur J Pharm Sci 2007; 32: 247-253. (Pubitemid 350051887)
    • (2007) European Journal of Pharmaceutical Sciences , vol.32 , Issue.4-5 , pp. 247-253
    • Song, M.1    Hang, T.-J.2    Zhang, Z.3    Chen, H.-Y.4
  • 134
    • 48849099097 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between tanshinones and polyphenolic extracts of Salvia miltiorrhiza Bunge after intravenous administration in rats
    • Guo ZJ, Zhang Y, Tang X, Li H, Sun QS. Pharmacokinetic interaction between tanshinones and polyphenolic extracts of Salvia miltiorrhiza Bunge after intravenous administration in rats. Biol Pharm Bull 2008; 31: 1469-1474.
    • (2008) Biol Pharm Bull , vol.31 , pp. 1469-1474
    • Guo, Z.J.1    Zhang, Y.2    Tang, X.3    Li, H.4    Sun, Q.S.5
  • 135
    • 37349022457 scopus 로고    scopus 로고
    • Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats
    • DOI 10.1016/j.jep.2007.10.016, PII S037887410700548X
    • Xu M, Wang G, Xie H, Huang Q, Wang W, Jia Y. Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats. J Ethnopharmacol 2008; 115: 483-488. (Pubitemid 350299087)
    • (2007) Journal of Ethnopharmacology , vol.115 , Issue.3 , pp. 483-488
    • Xu, M.1    Wang, G.2    Xie, H.3    Huang, Q.4    Wang, W.5    Jia, Y.6


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