N-Nitrosodiethylamine genotoxicity in primary rat hepatocytes: Effects of cytochrome P450 induction by phenobarbital

Toxicology Letters

Volumn 206, Issue 2, 2011, Pages 139-143

  Aiub, Claudia A F ^a   Gadermaier, Gabriele ^b   Oliveira, Izaura ^a   Felzenszwalb, Israel ^a   Ferreira, Fátima ^b   Pinto, Luis Felipe Ribeiro ^a   Eckl, Peter ^b  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Cytochrome P450 isoforms; Genotoxicity; Hepatocytes; N Nitrosodiethylamine; Phenobarbital

Indexed keywords

CYTOCHROME P450 2A1; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 2E1; DIETHYLNITROSAMINE; MESSENGER RNA; PHENOBARBITAL; RNA 18S;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CHROMOSOME ABERRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; GENOTOXICITY; LIVER CELL; LIVER TOXICITY; MICRONUCLEUS; MITOSIS INDEX; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENS; CELL DEATH; CELLS, CULTURED; CHROMOSOME ABERRATIONS; COCARCINOGENESIS; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLNITROSAMINE; ENZYME INDUCTION; FEMALE; HEPATOCYTES; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MITOTIC INDEX; MUTAGENS; PHENOBARBITAL; RATS; RNA, MESSENGER; STEROID HYDROXYLASES; UP-REGULATION;

RATTUS;

EID: 80052087578     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.07.002     Document Type: Article

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