메뉴 건너뛰기




Volumn 7, Issue 2, 2012, Pages 129-144

Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence

Author keywords

NR2B neuroprotection; Polyamine; Relapse

Indexed keywords

4 (CHLOROBENZYLIDENAMINO)GUANIDINE HYDROCHLORIDE; ACAMPROSATE; AGMATINE; ALCOHOL; DIZOCILPINE; GLUTAMIC ACID; IFENPRODIL; JR 220; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALTREXONE; POLYAMINE; TOPIRAMATE; TRAXOPRODIL; UNCLASSIFIED DRUG;

EID: 84861732546     PISSN: 15748898     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488912800673128     Document Type: Review
Times cited : (20)

References (257)
  • 1
    • 77958195816 scopus 로고    scopus 로고
    • Multiple Authors, Summarized in Alcohol Alert. National Institute on Alcohol Abuse and Alcoholism. October
    • Multiple Authors. National Epidemiologic Survey on Alcohol and Related Conditions. Summarized in Alcohol Alert. National Institute on Alcohol Abuse and Alcoholism. October 2006.
    • (2006) National Epidemiologic Survey on Alcohol and Related Conditions
  • 2
    • 33644801321 scopus 로고    scopus 로고
    • Rates and predictors of relapse after natural and treated remission from alcohol use disorders
    • Moos RH, Moos BS. Rates and predictors of relapse after natural and treated remission from alcohol use disorders. Addiction 2006; 101: 212-22.
    • (2006) Addiction , vol.101 , pp. 212-222
    • Moos, R.H.1    Moos, B.S.2
  • 3
    • 0029057338 scopus 로고
    • Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism
    • Nevo I, Hamon M. Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism. Neurochem Int 1995; 26: 305-36.
    • (1995) Neurochem Int , vol.26 , pp. 305-336
    • Nevo, I.1    Hamon, M.2
  • 4
    • 77955570062 scopus 로고    scopus 로고
    • Glutamate receptors, neurotoxicity and neurodegeneration
    • Lau A, Tymianski M. Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 2010; 460: 525-42.
    • (2010) Pflugers Arch , vol.460 , pp. 525-542
    • Lau, A.1    Tymianski, M.2
  • 5
    • 2142757234 scopus 로고    scopus 로고
    • The ups and downs of addiction: Role of metabotropic glutamate receptors
    • Kenny PJ, Markou A. The ups and downs of addiction: role of metabotropic glutamate receptors. Trends Pharmacol Sci 2004; 25: 265-72.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 265-272
    • Kenny, P.J.1    Markou, A.2
  • 6
    • 0024535962 scopus 로고
    • Ethanol inhibits NMDAactivated ion current in hippocampal neurons
    • Lovinger DM, White G, Weight FF. Ethanol inhibits NMDAactivated ion current in hippocampal neurons. Sci 1989; 243: 1721-4.
    • (1989) Sci , vol.243 , pp. 1721-1724
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 7
    • 0033064654 scopus 로고    scopus 로고
    • Ethanol inhibition of synaptically evoked kainate responses in rat hippocampal CA3 pyramidal neurons
    • Weiner JL, Dunwiddie TV, Valenzuela CF. Ethanol inhibition of synaptically evoked kainate responses in rat hippocampal CA3 pyramidal neurons. Mol Pharmacol 1999; 56: 85-90.
    • (1999) Mol Pharmacol , vol.56 , pp. 85-90
    • Weiner, J.L.1    Dunwiddie, T.V.2    Valenzuela, C.F.3
  • 8
    • 0031695511 scopus 로고    scopus 로고
    • Glutamatergic neurotransmission in alcoholism
    • Tsai G. Glutamatergic neurotransmission in alcoholism. J Biomed Sci 1998; 5: 309-20.
    • (1998) J Biomed Sci , vol.5 , pp. 309-320
    • Tsai, G.1
  • 9
    • 1542652346 scopus 로고    scopus 로고
    • NMDA receptors in alcoholism
    • Hoffman PL. NMDA receptors in alcoholism. Int Rev Neurobiol 2003; 56: 35-82.
    • (2003) Int Rev Neurobiol , vol.56 , pp. 35-82
    • Hoffman, P.L.1
  • 10
    • 0026756917 scopus 로고
    • Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes
    • Dildy-Mayfield JE, Harris RA. Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 1992; 262: 487-94.
    • (1992) J Pharmacol Exp Ther , vol.262 , pp. 487-494
    • Dildy-Mayfield, J.E.1    Harris, R.A.2
  • 11
    • 0027417127 scopus 로고
    • Excitotoxicity and alcohol-related brain damage
    • Lovinger DM. Excitotoxicity and alcohol-related brain damage. Alcohol Clin Exp Res 1993; 17: 19-27.
    • (1993) Alcohol Clin Exp Res , vol.17 , pp. 19-27
    • Lovinger, D.M.1
  • 12
    • 0028930262 scopus 로고
    • Ethanol inhibits kainate responses of glutamate receptors expressed in Xenopus oocytes: Role of calcium and protein kinase C
    • Dildy-Mayfield JE, Harris RA. Ethanol inhibits kainate responses of glutamate receptors expressed in Xenopus oocytes: role of calcium and protein kinase C. J Neurosci 1995; 15: 3162-71.
    • (1995) J Neurosci , vol.15 , pp. 3162-3171
    • Dildy-Mayfield, J.E.1    Harris, R.A.2
  • 13
    • 0033658695 scopus 로고    scopus 로고
    • Mechanism of inhibition by ethanol of NMDA and AMPA receptor channel functions in cultured rat cortical neurons
    • Wirkner K, Eberts C, Poelchen W, Allgaier C, Illes P. Mechanism of inhibition by ethanol of NMDA and AMPA receptor channel functions in cultured rat cortical neurons. Naunyn Schmiedebergs Arch Pharmacol 2000; 362: 568-76.
    • (2000) Naunyn Schmiedebergs Arch Pharmacol , vol.362 , pp. 568-576
    • Wirkner, K.1    Eberts, C.2    Poelchen, W.3    Allgaier, C.4    Illes, P.5
  • 15
    • 0024580689 scopus 로고
    • Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons
    • Tang CM, Dichter M, Morad M. Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons. Sci 1989; 243: 1474-7.
    • (1989) Sci , vol.243 , pp. 1474-1477
    • Tang, C.M.1    Dichter, M.2    Morad, M.3
  • 16
    • 0024713443 scopus 로고
    • Glutamate receptor desensitization and its role in synaptic transmission
    • Trussell LO, Fischbach GD. Glutamate receptor desensitization and its role in synaptic transmission. Neuron 1989; 3: 209-18.
    • (1989) Neuron , vol.3 , pp. 209-218
    • Trussell, L.O.1    Fischbach, G.D.2
  • 17
    • 0026496388 scopus 로고
    • Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex
    • Hestrin S. Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex. Neuron 1992; 9: 991-9.
    • (1992) Neuron , vol.9 , pp. 991-999
    • Hestrin, S.1
  • 18
    • 0028238967 scopus 로고
    • Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells
    • Barbour B, Keller BU, Llano I, Marty A. Prolonged presence of glutamate during excitatory synaptic transmission to cerebellar Purkinje cells. Neuron 1994; 12: 1331-43.
    • (1994) Neuron , vol.12 , pp. 1331-1343
    • Barbour, B.1    Keller, B.U.2    Llano, I.3    Marty, A.4
  • 19
    • 67649205915 scopus 로고    scopus 로고
    • Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations
    • Moykkynen TP, Coleman SK, Keinanen K, Lovinger DM, Korpi ER. Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations. Alcohol 2009; 43: 277-84.
    • (2009) Alcohol , vol.43 , pp. 277-284
    • Moykkynen, T.P.1    Coleman, S.K.2    Keinanen, K.3    Lovinger, D.M.4    Korpi, E.R.5
  • 20
    • 0030732735 scopus 로고    scopus 로고
    • Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: Whole-cell patch-clamp analysis
    • Peoples RW, White G, Lovinger DM, Weight FF. Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: whole-cell patch-clamp analysis. Br J Pharmacol 1997; 122: 1035-42.
    • (1997) Br J Pharmacol , vol.122 , pp. 1035-1042
    • Peoples, R.W.1    White, G.2    Lovinger, D.M.3    Weight, F.F.4
  • 22
    • 0035139197 scopus 로고    scopus 로고
    • Role of glutamatergic and GABAergic systems in alcoholism
    • Davis KM, Wu JY. Role of glutamatergic and GABAergic systems in alcoholism. J Biomed Sci 2001; 8: 7-19.
    • (2001) J Biomed Sci , vol.8 , pp. 7-19
    • Davis, K.M.1    Wu, J.Y.2
  • 24
    • 33646576836 scopus 로고    scopus 로고
    • Survival signaling pathways activated by NMDA receptors
    • Hetman M, Kharebava G. Survival signaling pathways activated by NMDA receptors. Curr Top Med Chem. 2006; 6: 787-99.
    • (2006) Curr Top Med Chem , vol.6 , pp. 787-799
    • Hetman, M.1    Kharebava, G.2
  • 25
    • 58549090329 scopus 로고    scopus 로고
    • The molecular and cellular biology of enhanced cognition
    • Lee YS, Silva AJ. The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci 2009; 10: 126-40.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 126-140
    • Lee, Y.S.1    Silva, A.J.2
  • 26
    • 0024829451 scopus 로고
    • Excitatory amino acid receptors in the vertebrate central nervous system
    • Collingridge GL, Lester RA. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 1989; 41: 143-210.
    • (1989) Pharmacol Rev , vol.41 , pp. 143-210
    • Collingridge, G.L.1    Lester, R.A.2
  • 27
    • 0025338354 scopus 로고
    • Excitatory amino acid receptors and synaptic plasticity
    • Collingridge GL, Singer W. Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol Sci 1990; 11: 290-6.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 290-296
    • Collingridge, G.L.1    Singer, W.2
  • 28
    • 0028179069 scopus 로고
    • N-methyl-D-aspartic acid receptor structure and function
    • McBain CJ, Mayer ML. N-methyl-D-aspartic acid receptor structure and function. Physiol Rev 1994; 74: 723-60.
    • (1994) Physiol Rev , vol.74 , pp. 723-760
    • McBain, C.J.1    Mayer, M.L.2
  • 29
    • 0037442813 scopus 로고    scopus 로고
    • Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits
    • Schorge S, Colquhoun D. Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits. J Neurosci 2003; 23: 1151-8.
    • (2003) J Neurosci , vol.23 , pp. 1151-1158
    • Schorge, S.1    Colquhoun, D.2
  • 30
    • 0026456890 scopus 로고
    • Molecular diversity of the glutamate receptors
    • Pt A
    • Nakanishi S. Molecular diversity of the glutamate receptors. Clin Neuropharmacol 1992; 15 Suppl 1 Pt A: 4A-5A.
    • (1992) Clin Neuropharmacol , vol.15 , Issue.SUPPL. 1
    • Nakanishi, S.1
  • 31
    • 0027440215 scopus 로고
    • Preferential co-assembly of recombinant NMDA receptors composed of three different subunits
    • Wafford KA, Bain CJ, Le Bourdelles B, Whiting PJ, Kemp JA. Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. Neuroreport 1993; 4: 1347-9.
    • (1993) Neuroreport , vol.4 , pp. 1347-1349
    • Wafford, K.A.1    Bain, C.J.2    Le Bourdelles, B.3    Whiting, P.J.4    Kemp, J.A.5
  • 32
    • 0031733467 scopus 로고    scopus 로고
    • Molecular determinants of NMDA receptor pharmacological diversity
    • Monaghan DT, Andaloro VJ, Skifter DA. Molecular determinants of NMDA receptor pharmacological diversity. Prog Brain Res 1998; 116: 171-90.
    • (1998) Prog Brain Res , vol.116 , pp. 171-190
    • Monaghan, D.T.1    Andaloro, V.J.2    Skifter, D.A.3
  • 33
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • Cull-Candy S, Brickley S, Farrant M. NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol 2001; 11: 327-35.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 34
    • 8544232133 scopus 로고    scopus 로고
    • Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand
    • Chung HJ, Huang YH, Lau LF, Huganir RL. Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci 2004; 24: 10248-59.
    • (2004) J Neurosci , vol.24 , pp. 10248-10259
    • Chung, H.J.1    Huang, Y.H.2    Lau, L.F.3    Huganir, R.L.4
  • 35
    • 0024348985 scopus 로고
    • N-methyl-Daspartate receptors and ethanol: Inhibition of calcium flux and cyclic GMP production
    • Hoffman PL, Rabe CS, Moses F, Tabakoff B. N-methyl-Daspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neurochem 1989; 52: 1937-40.
    • (1989) J Neurochem , vol.52 , pp. 1937-1940
    • Hoffman, P.L.1    Rabe, C.S.2    Moses, F.3    Tabakoff, B.4
  • 36
    • 0030569408 scopus 로고    scopus 로고
    • Single-channel and wholecell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons
    • Wright JM, Peoples RW, Weight FF. Single-channel and wholecell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons. Brain Res 1996; 738: 249-56.
    • (1996) Brain Res , vol.738 , pp. 249-256
    • Wright, J.M.1    Peoples, R.W.2    Weight, F.F.3
  • 37
    • 70450190132 scopus 로고    scopus 로고
    • Effects of ethanol on persistent activity and up-States in excitatory and inhibitory neurons in prefrontal cortex
    • Woodward JJ, Pava MJ. Effects of ethanol on persistent activity and up-States in excitatory and inhibitory neurons in prefrontal cortex. Alcohol Clin Exp Res 2009; 33: 2134-40.
    • (2009) Alcohol Clin Exp Res , vol.33 , pp. 2134-2140
    • Woodward, J.J.1    Pava, M.J.2
  • 38
    • 0032252740 scopus 로고    scopus 로고
    • Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol
    • Calton JL, Wilson WA, Moore SD. Magnesium-dependent inhibition of N-methyl-D-aspartate receptor-mediated synaptic transmission by ethanol. J Pharmacol Exp Ther 1998; 287: 1015-9.
    • (1998) J Pharmacol Exp Ther , vol.287 , pp. 1015-1019
    • Calton, J.L.1    Wilson, W.A.2    Moore, S.D.3
  • 40
    • 0028149213 scopus 로고
    • Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms
    • Nie Z, Madamba SG, Siggins GR. Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J Pharmacol Exp Ther 1994; 271: 1566-73.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1566-1573
    • Nie, Z.1    Madamba, S.G.2    Siggins, G.R.3
  • 41
    • 34249865364 scopus 로고    scopus 로고
    • Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum
    • Yin HH, Park BS, Adermark L, Lovinger DM. Ethanol reverses the direction of long-term synaptic plasticity in the dorsomedial striatum. Eur J Neurosci 2007; 25: 3226-32.
    • (2007) Eur J Neurosci , vol.25 , pp. 3226-3232
    • Yin, H.H.1    Park, B.S.2    Adermark, L.3    Lovinger, D.M.4
  • 42
    • 34047108635 scopus 로고    scopus 로고
    • Ethanol induces long-term facilitation of NR2BNMDA receptor activity in the dorsal striatum: Implications for alcohol drinking behavior
    • Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, et al. Ethanol induces long-term facilitation of NR2BNMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci 2007; 27: 3593-602.
    • (2007) J Neurosci , vol.27 , pp. 3593-3602
    • Wang, J.1    Carnicella, S.2    Phamluong, K.3    Jeanblanc, J.4    Ronesi, J.A.5    Chaudhri, N.6
  • 43
    • 0031808863 scopus 로고    scopus 로고
    • Ethanol sensitivity and subunit composition of NMDA receptors in cultured striatal neurons
    • Popp RL, Lickteig R, Browning MD, Lovinger DM. Ethanol sensitivity and subunit composition of NMDA receptors in cultured striatal neurons. Neuropharmacology 1998; 37: 45-56.
    • (1998) Neuropharmacology , vol.37 , pp. 45-56
    • Popp, R.L.1    Lickteig, R.2    Browning, M.D.3    Lovinger, D.M.4
  • 45
    • 0025407309 scopus 로고
    • NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat
    • Lovinger DM, White G, Weight FF. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. J Neurosci 1990; 10: 1372-9.
    • (1990) J Neurosci , vol.10 , pp. 1372-1379
    • Lovinger, D.M.1    White, G.2    Weight, F.F.3
  • 46
    • 0025947757 scopus 로고
    • Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner
    • Morrisett RA, Martin D, Oetting TA, Lewis DV, Wilson WA, Swartzwelder HS. Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner. Neuropharmacol 1991; 30: 1173-8.
    • (1991) Neuropharmacol , vol.30 , pp. 1173-1178
    • Morrisett, R.A.1    Martin, D.2    Oetting, T.A.3    Lewis, D.V.4    Wilson, W.A.5    Swartzwelder, H.S.6
  • 47
    • 9444233326 scopus 로고    scopus 로고
    • BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol
    • Kolb JE, Trettel J, Levine ES. BDNF enhancement of postsynaptic NMDA receptors is blocked by ethanol. Synapse 2005; 55: 52-7.
    • (2005) Synapse , vol.55 , pp. 52-57
    • Kolb, J.E.1    Trettel, J.2    Levine, E.S.3
  • 48
    • 0027717219 scopus 로고
    • Ethanol inhibits glutamateinduced currents in heteromeric NMDA receptor subtypes
    • Kuner T, Schoepfer R, Korpi ER. Ethanol inhibits glutamateinduced currents in heteromeric NMDA receptor subtypes. Neuroreport 1993; 5: 297-300.
    • (1993) Neuroreport , vol.5 , pp. 297-300
    • Kuner, T.1    Schoepfer, R.2    Korpi, E.R.3
  • 49
    • 0028930865 scopus 로고
    • Ethanol sensitivity of heteromeric NMDA receptors: Effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants
    • Mirshahi T, Woodward J. Ethanol sensitivity of heteromeric NMDA receptors: effects of subunit assembly, glycine and NMDAR1 Mg(2+)-insensitive mutants. Neuropharmacol 1995; 34: 347-55.
    • (1995) Neuropharmacol , vol.34 , pp. 347-355
    • Mirshahi, T.1    Woodward, J.2
  • 50
    • 0028081936 scopus 로고
    • Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits
    • Masood K, Wu C, Brauneis U, Weight FF. Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol 1994; 45: 324-9.
    • (1994) Mol Pharmacol , vol.45 , pp. 324-329
    • Masood, K.1    Wu, C.2    Brauneis, U.3    Weight, F.F.4
  • 51
    • 0036883545 scopus 로고    scopus 로고
    • Ethanol sensitivity of NMDA receptors
    • Allgaier C. Ethanol sensitivity of NMDA receptors. Neurochem Int 2002; 41: 377-82.
    • (2002) Neurochem Int , vol.41 , pp. 377-382
    • Allgaier, C.1
  • 53
    • 0029896353 scopus 로고    scopus 로고
    • Alcohol addiction: An enigma among us
    • Tabakoff B, Hoffman PL. Alcohol addiction: an enigma among us. Neuron 1996; 16: 909-12.
    • (1996) Neuron , vol.16 , pp. 909-912
    • Tabakoff, B.1    Hoffman, P.L.2
  • 54
    • 0033654978 scopus 로고    scopus 로고
    • Regulation of NMDA receptors by ethanol
    • Kumari M, Ticku MK. Regulation of NMDA receptors by ethanol. Prog Drug Res 2000; 54: 152-89.
    • (2000) Prog Drug Res , vol.54 , pp. 152-189
    • Kumari, M.1    Ticku, M.K.2
  • 56
    • 0025731207 scopus 로고
    • Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal
    • Gulya K, Grant KA, Valverius P, Hoffman PL, Tabakoff B. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res 1991; 547: 129-34.
    • (1991) Brain Res , vol.547 , pp. 129-134
    • Gulya, K.1    Grant, K.A.2    Valverius, P.3    Hoffman, P.L.4    Tabakoff, B.5
  • 57
    • 0027405992 scopus 로고
    • Radioligand binding to the Nmethyl-D-aspartate receptor/ionophore complex: Alterations by ethanol in vitro and by chronic in vivo ethanol ingestion
    • Snell LD, Tabakoff B, Hoffman PL. Radioligand binding to the Nmethyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res 1993; 602: 91-8.
    • (1993) Brain Res , vol.602 , pp. 91-98
    • Snell, L.D.1    Tabakoff, B.2    Hoffman, P.L.3
  • 58
    • 0028921947 scopus 로고
    • Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain
    • Follesa P, Ticku MK. Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain. Mol Brain Res 1995; 29: 99-106.
    • (1995) Mol Brain Res , vol.29 , pp. 99-106
    • Follesa, P.1    Ticku, M.K.2
  • 59
    • 0032528124 scopus 로고    scopus 로고
    • Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment
    • Kalluri HS, Mehta AK, Ticku MK. Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment. Mol Brain Res 1998; 58: 221-4.
    • (1998) Mol Brain Res , vol.58 , pp. 221-224
    • Kalluri, H.S.1    Mehta, A.K.2    Ticku, M.K.3
  • 60
    • 0033585888 scopus 로고    scopus 로고
    • Chronic ethanol exposure and withdrawal influence NMDA receptor subunit and splice variant mRNA expression in the rat cerebral cortex
    • Hardy PA, Chen W, Wilce PA. Chronic ethanol exposure and withdrawal influence NMDA receptor subunit and splice variant mRNA expression in the rat cerebral cortex. Brain Res 1999; 819: 33-9.
    • (1999) Brain Res , vol.819 , pp. 33-39
    • Hardy, P.A.1    Chen, W.2    Wilce, P.A.3
  • 61
    • 77956182850 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure
    • Pian JP, Criado JR, Milner R, Ehlers CL. N-methyl-D-aspartate receptor subunit expression in adult and adolescent brain following chronic ethanol exposure. Neurosci 2010; 170: 645-54.
    • (2010) Neurosci , vol.170 , pp. 645-654
    • Pian, J.P.1    Criado, J.R.2    Milner, R.3    Ehlers, C.L.4
  • 62
    • 23644447022 scopus 로고    scopus 로고
    • Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons
    • Maler JM, Esselmann H, Wiltfang J, Kunz N, Lewczuk P, Reulbach U, et al. Memantine inhibits ethanol-induced NMDA receptor up-regulation in rat hippocampal neurons. Brain Res 2005; 1052: 156-62.
    • (2005) Brain Res , vol.1052 , pp. 156-162
    • Maler, J.M.1    Esselmann, H.2    Wiltfang, J.3    Kunz, N.4    Lewczuk, P.5    Reulbach, U.6
  • 63
    • 0029901605 scopus 로고    scopus 로고
    • Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture
    • Follesa P, Ticku MK. Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J Biol Chem 1996; 271: 13297-9.
    • (1996) J Biol Chem , vol.271 , pp. 13297-13299
    • Follesa, P.1    Ticku, M.K.2
  • 64
    • 0031010080 scopus 로고    scopus 로고
    • Chronic ethanol increases N-methyl-D-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons
    • Chandler LJ, Sutton G, Norwood D, Sumners C, Crews FT. Chronic ethanol increases N-methyl-D-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons. Mol Pharmacol 1997; 51: 733-40.
    • (1997) Mol Pharmacol , vol.51 , pp. 733-740
    • Chandler, L.J.1    Sutton, G.2    Norwood, D.3    Sumners, C.4    Crews, F.T.5
  • 65
    • 0034604819 scopus 로고    scopus 로고
    • Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence
    • Narita M, Soma M, Mizoguchi H, Tseng LF, Suzuki T. Implications of the NR2B subunit-containing NMDA receptor localized in mouse limbic forebrain in ethanol dependence. Eur J Pharmacol 2000; 401: 191-5.
    • (2000) Eur J Pharmacol , vol.401 , pp. 191-195
    • Narita, M.1    Soma, M.2    Mizoguchi, H.3    Tseng, L.F.4    Suzuki, T.5
  • 66
    • 67349196360 scopus 로고    scopus 로고
    • N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal
    • Biermann T, Reulbach U, Lenz B, Frieling H, Muschler M, Hillemacher T, et al. N-methyl-D-aspartate 2b receptor subtype (NR2B) promoter methylation in patients during alcohol withdrawal. J Neural Transm 2009; 116: 615-22.
    • (2009) J Neural Transm , vol.116 , pp. 615-622
    • Biermann, T.1    Reulbach, U.2    Lenz, B.3    Frieling, H.4    Muschler, M.5    Hillemacher, T.6
  • 67
    • 0030222090 scopus 로고    scopus 로고
    • Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion
    • Snell LD, Nunley KR, Lickteig RL, Browning MD, Tabakoff B, Hoffman PL. Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion. Mol Brain Res 1996; 40: 71-8.
    • (1996) Mol Brain Res , vol.40 , pp. 71-78
    • Snell, L.D.1    Nunley, K.R.2    Lickteig, R.L.3    Browning, M.D.4    Tabakoff, B.5    Hoffman, P.L.6
  • 68
    • 0033058120 scopus 로고    scopus 로고
    • Chronic ethanol upregulates NMDA and AMPA, but not kainate receptor subunit proteins in rat primary cortical cultures
    • Chandler LJ, Norwood D, Sutton G. Chronic ethanol upregulates NMDA and AMPA, but not kainate receptor subunit proteins in rat primary cortical cultures. Alcohol Clin Exp Res 1999; 23: 363-70.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 363-370
    • Chandler, L.J.1    Norwood, D.2    Sutton, G.3
  • 69
    • 0043234820 scopus 로고    scopus 로고
    • Novel uncompetitive Nmethyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure
    • Holter SM, Danysz W, Spanagel R. Novel uncompetitive Nmethyl-D-aspartate (NMDA)-receptor antagonist MRZ 2/579 suppresses ethanol intake in long-term ethanol-experienced rats and generalizes to ethanol cue in drug discrimination procedure. J Pharmacol Exp Ther 2000; 292: 545-52.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 545-552
    • Holter, S.M.1    Danysz, W.2    Spanagel, R.3
  • 70
    • 0030972046 scopus 로고    scopus 로고
    • Effects of gamma-aminobutyric acid agonists and N-methyl-D-aspartate antagonists on a multiple schedule of ethanol and saccharin self-administration in rats
    • Shelton KL, Balster RL. Effects of gamma-aminobutyric acid agonists and N-methyl-D-aspartate antagonists on a multiple schedule of ethanol and saccharin self-administration in rats. J Pharmacol Exp Ther 1997; 280: 1250-60.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 1250-1260
    • Shelton, K.L.1    Balster, R.L.2
  • 71
    • 0031713499 scopus 로고    scopus 로고
    • Ethanol-reinforced behaviour in the rat: Effects of uncompetitive NMDA receptor antagonist, memantine
    • Piasecki J, Koros E, Dyr W, Kostowski W, Danysz W, Bienkowski P. Ethanol-reinforced behaviour in the rat: effects of uncompetitive NMDA receptor antagonist, memantine. Eur J Pharmacol 1998; 354: 135-43.
    • (1998) Eur J Pharmacol , vol.354 , pp. 135-143
    • Piasecki, J.1    Koros, E.2    Dyr, W.3    Kostowski, W.4    Danysz, W.5    Bienkowski, P.6
  • 72
    • 0032787789 scopus 로고    scopus 로고
    • Effects of Nmethyl-D-aspartate receptor antagonists on reinforced and nonreinforced responding for ethanol in rats
    • Bienkowski P, Koros E, Kostowski W, Danysz W. Effects of Nmethyl-D-aspartate receptor antagonists on reinforced and nonreinforced responding for ethanol in rats. Alcohol 1999; 18: 131-7.
    • (1999) Alcohol , vol.18 , pp. 131-137
    • Bienkowski, P.1    Koros, E.2    Kostowski, W.3    Danysz, W.4
  • 73
    • 16844386330 scopus 로고    scopus 로고
    • The role of the NMDA receptor in alcohol relapse: A pharmacological mapping study using the alcohol deprivation effect
    • Vengeliene V, Bachteler D, Danysz W, Spanagel R. The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacol 2005; 48: 822-9.
    • (2005) Neuropharmacol , vol.48 , pp. 822-829
    • Vengeliene, V.1    Bachteler, D.2    Danysz, W.3    Spanagel, R.4
  • 74
    • 3242795113 scopus 로고    scopus 로고
    • The role of NMDA receptor binding sites in ethanol place conditioning
    • Boyce-Rustay JM, Cunningham CL. The role of NMDA receptor binding sites in ethanol place conditioning. Behav Neurosci 2004; 118: 822-34.
    • (2004) Behav Neurosci , vol.118 , pp. 822-834
    • Boyce-Rustay, J.M.1    Cunningham, C.L.2
  • 75
    • 0345711461 scopus 로고    scopus 로고
    • Blockade of the acquisition of ethanolinduced conditioned place preference by N-methyl-D-aspartate receptor antagonists
    • Biala G, Kotlinska J. Blockade of the acquisition of ethanolinduced conditioned place preference by N-methyl-D-aspartate receptor antagonists. Alcohol Alcohol 1999; 34: 175-82.
    • (1999) Alcohol Alcohol , vol.34 , pp. 175-182
    • Biala, G.1    Kotlinska, J.2
  • 76
    • 0033058925 scopus 로고    scopus 로고
    • Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice
    • Broadbent J, Weitemier AZ. Dizocilpine (MK-801) prevents the development of sensitization to ethanol in DBA/2J mice. Alcohol Alcohol 1999; 34: 283-8.
    • (1999) Alcohol Alcohol , vol.34 , pp. 283-288
    • Broadbent, J.1    Weitemier, A.Z.2
  • 77
    • 0013069245 scopus 로고    scopus 로고
    • Bivalent effects of MK-801 on ethanolinduced sensitization do not parallel its effects on ethanol-induced tolerance
    • Meyer PJ, Phillips TJ. Bivalent effects of MK-801 on ethanolinduced sensitization do not parallel its effects on ethanol-induced tolerance. Behav Neurosci 2003; 117: 641-9.
    • (2003) Behav Neurosci , vol.117 , pp. 641-649
    • Meyer, P.J.1    Phillips, T.J.2
  • 78
    • 0036797201 scopus 로고    scopus 로고
    • Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    • Mayer S, Harris BR, Gibson DA, Blanchard JA, Prendergast MA, Holley RC, et al. Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcohol Clin Exp Res 2002; 26: 1468-78.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1468-1478
    • Mayer, S.1    Harris, B.R.2    Gibson, D.A.3    Blanchard, J.A.4    Prendergast, M.A.5    Holley, R.C.6
  • 80
    • 1542380960 scopus 로고    scopus 로고
    • Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors
    • Prendergast MA, Harris BR, Mullholland PJ, Blanchard JA, 2nd, Gibson DA, Holley RC, et al. Hippocampal CA1 region neurodegeneration produced by ethanol withdrawal requires activation of intrinsic polysynaptic hippocampal pathways and function of N-methyl-D-aspartate receptors. Neurosci 2004; 124: 869-77.
    • (2004) Neurosci , vol.124 , pp. 869-877
    • Prendergast, M.A.1    Harris, B.R.2    Mullholland, P.J.3    Blanchard II, J.A.4    Gibson, D.A.5    Holley, R.C.6
  • 81
    • 0035026478 scopus 로고    scopus 로고
    • MK-801 can exacerbate or attenuate behavioral alterations associated with neonatal alcohol exposure in the rat, depending on the timing of administration
    • Thomas J, Fleming And S, Riley E. MK-801 can exacerbate or attenuate behavioral alterations associated with neonatal alcohol exposure in the rat, depending on the timing of administration. Alcohol Clin Exp Res 2001; 25: 764-73.
    • (2001) Alcohol Clin Exp Res , vol.25 , pp. 764-773
    • Thomas, J.1    Fleming And, S.2    Riley, E.3
  • 82
    • 0001817507 scopus 로고
    • Ethanol-like discriminative stimulus effects of non-competitive nmethyl-d-aspartate antagonists
    • Grant KA, Knisely JS, Tabakoff B, Barrett JE, Balster RL. Ethanol-like discriminative stimulus effects of non-competitive nmethyl-d-aspartate antagonists. Behav Pharmacol. 1991 2: 87-95.
    • (1991) Behav Pharmacol , vol.2 , pp. 87-95
    • Grant, K.A.1    Knisely, J.S.2    Tabakoff, B.3    Barrett, J.E.4    Balster, R.L.5
  • 84
    • 0033426878 scopus 로고    scopus 로고
    • Abuse liability assessment of neuroprotectants
    • Klein M, Calderon S, Hayes B. Abuse liability assessment of neuroprotectants. Ann N Y Acad Sci 1999; 890: 515-25.
    • (1999) Ann N Y Acad Sci , vol.890 , pp. 515-525
    • Klein, M.1    Calderon, S.2    Hayes, B.3
  • 85
    • 0032947526 scopus 로고    scopus 로고
    • Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain
    • Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vockler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Sci 1999; 283: 70-4.
    • (1999) Sci , vol.283 , pp. 70-74
    • Ikonomidou, C.1    Bosch, F.2    Miksa, M.3    Bittigau, P.4    Vockler, J.5    Dikranian, K.6
  • 86
    • 77955513190 scopus 로고    scopus 로고
    • Comparative analyses of the neurodegeneration induced by the non-competitive NMDA-receptor-antagonist drug MK801 in mice and rats
    • Bender C, de Olmos S, Bueno A, de Olmos J, Lorenzo A. Comparative analyses of the neurodegeneration induced by the non-competitive NMDA-receptor-antagonist drug MK801 in mice and rats. Neurotoxicol Teratol 2010; 32: 542-50.
    • (2010) Neurotoxicol Teratol , vol.32 , pp. 542-550
    • Bender, C.1    de Olmos, S.2    Bueno, A.3    de Olmos, J.4    Lorenzo, A.5
  • 87
    • 57249116909 scopus 로고    scopus 로고
    • Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine
    • Stepanyan TD, Farook JM, Kowalski A, Kaplan E, Barron S, Littleton JM. Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine. Alcohol Clin Exp Res 2008; 32: 2128-35.
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 2128-2135
    • Stepanyan, T.D.1    Farook, J.M.2    Kowalski, A.3    Kaplan, E.4    Barron, S.5    Littleton, J.M.6
  • 88
    • 33744500234 scopus 로고    scopus 로고
    • Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity
    • Volbracht C, van Beek J, Zhu C, Blomgren K, Leist M. Neuroprotective properties of memantine in different in vitro and in vivo models of excitotoxicity. Eur J Neurosci 2006; 23: 2611-22.
    • (2006) Eur J Neurosci , vol.23 , pp. 2611-2622
    • Volbracht, C.1    van Beek, J.2    Zhu, C.3    Blomgren, K.4    Leist, M.5
  • 89
    • 0032190650 scopus 로고    scopus 로고
    • An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones
    • Kew JN, Kemp JA. An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J Physiol 1998; 512: 17-28.
    • (1998) J Physiol , vol.512 , pp. 17-28
    • Kew, J.N.1    Kemp, J.A.2
  • 90
    • 0032990133 scopus 로고    scopus 로고
    • Zinc and ifenprodil allosterically inhibit two separate polyamine-sensitive sites at N-methyl-D-aspartate receptor complex
    • Berger ML, Rebernik P. Zinc and ifenprodil allosterically inhibit two separate polyamine-sensitive sites at N-methyl-D-aspartate receptor complex. J Pharmacol Exp Ther 1999; 289: 1584-91.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 1584-1591
    • Berger, M.L.1    Rebernik, P.2
  • 91
    • 0032521090 scopus 로고    scopus 로고
    • Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons
    • Kew JN, Richards JG, Mutel V, Kemp JA. Developmental changes in NMDA receptor glycine affinity and ifenprodil sensitivity reveal three distinct populations of NMDA receptors in individual rat cortical neurons. J Neurosci 1998; 18: 1935-43.
    • (1998) J Neurosci , vol.18 , pp. 1935-1943
    • Kew, J.N.1    Richards, J.G.2    Mutel, V.3    Kemp, J.A.4
  • 92
    • 18144406855 scopus 로고    scopus 로고
    • NMDA/NR2B selective antagonists in the treatment of ischemic brain injury
    • Wang CX, Shuaib A. NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. Curr Drug Targets CNS Neurol Disord 2005; 4: 143-51.
    • (2005) Curr Drug Targets CNS Neurol Disord , vol.4 , pp. 143-151
    • Wang, C.X.1    Shuaib, A.2
  • 93
    • 0032966426 scopus 로고    scopus 로고
    • Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpinetreated rat
    • Nash JE, Hill MP, Brotchie JM. Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpinetreated rat. Exp Neurol 1999; 155: 42-8.
    • (1999) Exp Neurol , vol.155 , pp. 42-48
    • Nash, J.E.1    Hill, M.P.2    Brotchie, J.M.3
  • 94
    • 0033834442 scopus 로고    scopus 로고
    • Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease
    • Nash JE, Fox SH, Henry B, Hill MP, Peggs D, McGuire S, et al. Antiparkinsonian actions of ifenprodil in the MPTP-lesioned marmoset model of Parkinson's disease. Exp Neurol 2000; 165: 136-42.
    • (2000) Exp Neurol , vol.165 , pp. 136-142
    • Nash, J.E.1    Fox, S.H.2    Henry, B.3    Hill, M.P.4    Peggs, D.5    McGuire, S.6
  • 95
    • 23844495851 scopus 로고    scopus 로고
    • NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses
    • Chizh BA, Headley PM. NMDA antagonists and neuropathic pain--multiple drug targets and multiple uses. Curr Pharm Des 2005; 11: 2977-94.
    • (2005) Curr Pharm Des , vol.11 , pp. 2977-2994
    • Chizh, B.A.1    Headley, P.M.2
  • 96
    • 0027496763 scopus 로고
    • Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons
    • Tamura Y, Sato Y, Yokota T, Akaike A, Sasa M, Takaori S. Ifenprodil prevents glutamate cytotoxicity via polyamine modulatory sites of N-methyl-D-aspartate receptors in cultured cortical neurons. J Pharmacol Exp Ther 1993; 265: 1017-25.
    • (1993) J Pharmacol Exp Ther , vol.265 , pp. 1017-1025
    • Tamura, Y.1    Sato, Y.2    Yokota, T.3    Akaike, A.4    Sasa, M.5    Takaori, S.6
  • 97
    • 0029901314 scopus 로고    scopus 로고
    • The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia
    • Bath CP, Farrell LN, Gilmore J, Ward MA, Hicks CA, O'Neill MJ, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol 1996; 299: 103-12.
    • (1996) Eur J Pharmacol , vol.299 , pp. 103-112
    • Bath, C.P.1    Farrell, L.N.2    Gilmore, J.3    Ward, M.A.4    Hicks, C.A.5    O'Neill, M.J.6
  • 98
    • 12244255365 scopus 로고    scopus 로고
    • Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors
    • Pawlak R, Melchor JP, Matys T, Skrzypiec AE, Strickland S. Ethanol-withdrawal seizures are controlled by tissue plasminogen activator via modulation of NR2B-containing NMDA receptors. Proc Natl Acad Sci USA 2005; 102: 443-8.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 443-448
    • Pawlak, R.1    Melchor, J.P.2    Matys, T.3    Skrzypiec, A.E.4    Strickland, S.5
  • 99
    • 0027313217 scopus 로고
    • Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window
    • Toulmond S, Serrano A, Benavides J, Scatton B. Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window. Brain Res 1993; 620: 32-41.
    • (1993) Brain Res , vol.620 , pp. 32-41
    • Toulmond, S.1    Serrano, A.2    Benavides, J.3    Scatton, B.4
  • 100
    • 4544258218 scopus 로고    scopus 로고
    • Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits
    • Thomas JD, Garcia GG, Dominguez HD, Riley EP. Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. Psychopharmacology (Berl) 2004; 175: 189-95.
    • (2004) Psychopharmacology (Berl) , vol.175 , pp. 189-195
    • Thomas, J.D.1    Garcia, G.G.2    Dominguez, H.D.3    Riley, E.P.4
  • 101
    • 0032567695 scopus 로고    scopus 로고
    • Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage
    • Reyes M, Reyes A, Opitz T, Kapin MA, Stanton PK. Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. Brain Res 1998; 782: 212-8.
    • (1998) Brain Res , vol.782 , pp. 212-218
    • Reyes, M.1    Reyes, A.2    Opitz, T.3    Kapin, M.A.4    Stanton, P.K.5
  • 102
    • 0026088184 scopus 로고
    • Separation of alpha 1 adrenergic and Nmethyl-D-aspartate antagonist activity in a series of ifenprodil compounds
    • Chenard BL, Shalaby IA, Koe BK, Ronau RT, Butler TW, Prochniak MA, et al. Separation of alpha 1 adrenergic and Nmethyl-D-aspartate antagonist activity in a series of ifenprodil compounds. J Med Chem 1991; 34: 3085-90.
    • (1991) J Med Chem , vol.34 , pp. 3085-3090
    • Chenard, B.L.1    Shalaby, I.A.2    Koe, B.K.3    Ronau, R.T.4    Butler, T.W.5    Prochniak, M.A.6
  • 103
    • 0028979586 scopus 로고
    • Ifenprodil inhibition of the 5-hydroxytryptamine3 receptor
    • McCool BA, Lovinger DM. Ifenprodil inhibition of the 5-hydroxytryptamine3 receptor. Neuropharmacology 1995; 34: 621-9.
    • (1995) Neuropharmacology , vol.34 , pp. 621-629
    • McCool, B.A.1    Lovinger, D.M.2
  • 104
    • 0028360281 scopus 로고
    • The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons
    • Biton B, Granger P, Carreau A, Depoortere H, Scatton B, Avenet P. The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons. Eur J Pharmacol 1994; 257: 297-301.
    • (1994) Eur J Pharmacol , vol.257 , pp. 297-301
    • Biton, B.1    Granger, P.2    Carreau, A.3    Depoortere, H.4    Scatton, B.5    Avenet, P.6
  • 105
    • 0030923522 scopus 로고    scopus 로고
    • Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors
    • Brimecombe JC, Boeckman FA, Aizenman E. Functional consequences of NR2 subunit composition in single recombinant N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A 1997; 94: 11019-24.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 11019-11024
    • Brimecombe, J.C.1    Boeckman, F.A.2    Aizenman, E.3
  • 106
    • 0032428348 scopus 로고    scopus 로고
    • An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors
    • Brimecombe JC, Gallagher MJ, Lynch DR, Aizenman E. An NR2B point mutation affecting haloperidol and CP101,606 sensitivity of single recombinant N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 1998; 286: 627-34.
    • (1998) J Pharmacol Exp Ther , vol.286 , pp. 627-634
    • Brimecombe, J.C.1    Gallagher, M.J.2    Lynch, D.R.3    Aizenman, E.4
  • 107
    • 0036122295 scopus 로고    scopus 로고
    • Studies on the subtype selectivity of CP-101,606: Evidence for two classes of NR2Bselective NMDA receptor antagonists
    • Chazot PL, Lawrence S, Thompson CL. Studies on the subtype selectivity of CP-101,606: evidence for two classes of NR2Bselective NMDA receptor antagonists. Neuropharmacology 2002; 42: 319-24.
    • (2002) Neuropharmacology , vol.42 , pp. 319-324
    • Chazot, P.L.1    Lawrence, S.2    Thompson, C.L.3
  • 108
    • 0032987252 scopus 로고    scopus 로고
    • Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: Correlation with restricted localisation of NR2B subunit in dorsal horn
    • Boyce S, Wyatt A, Webb JK, O'Donnell R, Mason G, Rigby M, et al. Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn. Neuropharmacology 1999; 38: 611-23.
    • (1999) Neuropharmacology , vol.38 , pp. 611-623
    • Boyce, S.1    Wyatt, A.2    Webb, J.K.3    O'Donnell, R.4    Mason, G.5    Rigby, M.6
  • 109
    • 0033978673 scopus 로고    scopus 로고
    • Prevention of cocaine-induced convulsions and lethality in mice: Effectiveness of targeting different sites on the NMDA receptor complex
    • Brackett RL, Pouw B, Blyden JF, Nour M, Matsumoto RR. Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex. Neuropharmacology 2000; 39: 407-18.
    • (2000) Neuropharmacology , vol.39 , pp. 407-418
    • Brackett, R.L.1    Pouw, B.2    Blyden, J.F.3    Nour, M.4    Matsumoto, R.R.5
  • 110
    • 3042833166 scopus 로고    scopus 로고
    • The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease
    • Nash JE, Ravenscroft P, McGuire S, Crossman AR, Menniti FS, Brotchie JM. The NR2B-selective NMDA receptor antagonist CP-101,606 exacerbates L-DOPA-induced dyskinesia and provides mild potentiation of anti-parkinsonian effects of L-DOPA in the MPTP-lesioned marmoset model of Parkinson's disease. Exp Neurol 2004; 188: 471-9.
    • (2004) Exp Neurol , vol.188 , pp. 471-479
    • Nash, J.E.1    Ravenscroft, P.2    McGuire, S.3    Crossman, A.R.4    Menniti, F.S.5    Brotchie, J.M.6
  • 111
    • 0034067617 scopus 로고    scopus 로고
    • Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors
    • Steece-Collier K, Chambers LK, Jaw-Tsai SS, Menniti FS, Greenamyre JT. Antiparkinsonian actions of CP-101,606, an antagonist of NR2B subunit-containing N-methyl-d-aspartate receptors. Exp Neurol 2000; 163: 239-43.
    • (2000) Exp Neurol , vol.163 , pp. 239-243
    • Steece-Collier, K.1    Chambers, L.K.2    Jaw-Tsai, S.S.3    Menniti, F.S.4    Greenamyre, J.T.5
  • 112
    • 0032507754 scopus 로고    scopus 로고
    • Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat
    • Okiyama K, Smith DH, White WF, McIntosh TK. Effects of the NMDA antagonist CP-98,113 on regional cerebral edema and cardiovascular, cognitive, and neurobehavioral function following experimental brain injury in the rat. Brain Res 1998; 792: 291-8.
    • (1998) Brain Res , vol.792 , pp. 291-298
    • Okiyama, K.1    Smith, D.H.2    White, W.F.3    McIntosh, T.K.4
  • 113
    • 0030832277 scopus 로고    scopus 로고
    • The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat
    • Tsuchida E, Rice M, Bullock R. The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat. J Neurotrauma 1997; 14: 409-17.
    • (1997) J Neurotrauma , vol.14 , pp. 409-417
    • Tsuchida, E.1    Rice, M.2    Bullock, R.3
  • 114
    • 0942290536 scopus 로고    scopus 로고
    • The NMDA NR2B subunit-selective receptor antagonist, CP-101,606, enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain damage after cortical compressioninduced brain ischemia
    • Kundrotiene J, Cebers G, Wagner A, Liljequist S. The NMDA NR2B subunit-selective receptor antagonist, CP-101,606, enhances the functional recovery the NMDA NR2B subunit-selective receptor and reduces brain damage after cortical compressioninduced brain ischemia. J Neurotrauma 2004; 21: 83-93.
    • (2004) J Neurotrauma , vol.21 , pp. 83-93
    • Kundrotiene, J.1    Cebers, G.2    Wagner, A.3    Liljequist, S.4
  • 116
    • 3042727938 scopus 로고    scopus 로고
    • The NR2B subtype of NMDA receptor: A potential target for the treatment of alcohol dependence
    • Nagy J. The NR2B subtype of NMDA receptor: a potential target for the treatment of alcohol dependence. Curr Drug Targets CNS Neurol Disord 2004; 3: 169-79.
    • (2004) Curr Drug Targets CNS Neurol Disord , vol.3 , pp. 169-179
    • Nagy, J.1
  • 117
    • 0022899164 scopus 로고
    • Role of ornithine decarboxylase and the polyamines in nervous system development: A review
    • Slotkin T, Bartolome J. Role of ornithine decarboxylase and the polyamines in nervous system development: a review. Brain Res Bull 1986; 17: 307-20.
    • (1986) Brain Res Bull , vol.17 , pp. 307-320
    • Slotkin, T.1    Bartolome, J.2
  • 118
    • 0034704301 scopus 로고    scopus 로고
    • Neonatal polyamine depletion by alpha-difluoromethylornithine: Effects on adenylyl cyclase cell signaling are separable from effects on brain region growth
    • Slotkin TA, Ferguson SA, Cada AM, McCook EC, Seidler FJ. Neonatal polyamine depletion by alpha-difluoromethylornithine: effects on adenylyl cyclase cell signaling are separable from effects on brain region growth. Brain Res 2000; 887: 16-22.
    • (2000) Brain Res , vol.887 , pp. 16-22
    • Slotkin, T.A.1    Ferguson, S.A.2    Cada, A.M.3    McCook, E.C.4    Seidler, F.J.5
  • 119
    • 0031659624 scopus 로고    scopus 로고
    • Chronic ethanol treatment leads to increased ornithine decarboxylase activity: Implications for a role of polyamines in ethanol dependence and withdrawal
    • Davidson M, Wilce P. Chronic ethanol treatment leads to increased ornithine decarboxylase activity: implications for a role of polyamines in ethanol dependence and withdrawal. Alcohol Clin Exp Res 1998; 22: 1205-11.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 1205-1211
    • Davidson, M.1    Wilce, P.2
  • 120
    • 0038712981 scopus 로고    scopus 로고
    • Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor
    • Gibson DA, Harris BR, Prendergast MA, Hart SR, Blanchard JA, 2nd, Holley RC, et al. Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor. Alcohol Clin Exp Res 2003; 27: 1099-106.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 1099-1106
    • Gibson, D.A.1    Harris, B.R.2    Prendergast, M.A.3    Hart, S.R.4    Blanchard II, J.A.5    Holley, R.C.6
  • 121
    • 0017324987 scopus 로고
    • Effect of maternal ethanol ingestion on neonatal rat brain and heart ornithine decarboxylase
    • Thadani PV, Lau C, Slotkin TA, Schanberg SM. Effect of maternal ethanol ingestion on neonatal rat brain and heart ornithine decarboxylase. Biochem Pharmacol 1977; 26: 523-7.
    • (1977) Biochem Pharmacol , vol.26 , pp. 523-527
    • Thadani, P.V.1    Lau, C.2    Slotkin, T.A.3    Schanberg, S.M.4
  • 122
    • 0028912349 scopus 로고
    • Ethanol's effect on tissue polyamines and ornithine decarboxylase activity: A concise review
    • Shibley IA, Jr., Gavigan MD, Pennington SN. Ethanol's effect on tissue polyamines and ornithine decarboxylase activity: a concise review. Alcohol Clin Exp Res 1995; 19: 209-15.
    • (1995) Alcohol Clin Exp Res , vol.19 , pp. 209-215
    • Shibley Jr., I.A.1    Gavigan, M.D.2    Pennington, S.N.3
  • 123
    • 0027478922 scopus 로고
    • Increased sensitivity of the hippocampus in ethanol-dependent rats to toxic effect of N-methyl-D-aspartic acid in vivo
    • Davidson MD, Wilce P, Shanley BC. Increased sensitivity of the hippocampus in ethanol-dependent rats to toxic effect of N-methyl-D-aspartic acid in vivo. Brain Res 1993; 606: 5-9.
    • (1993) Brain Res , vol.606 , pp. 5-9
    • Davidson, M.D.1    Wilce, P.2    Shanley, B.C.3
  • 124
    • 71549154666 scopus 로고    scopus 로고
    • Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors
    • Butler TR, Self RL, Smith KJ, Sharrett-Field LJ, Berry JN, Littleton JM, et al. Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience 2010; 165: 525-34.
    • (2010) Neuroscience , vol.165 , pp. 525-534
    • Butler, T.R.1    Self, R.L.2    Smith, K.J.3    Sharrett-Field, L.J.4    Berry, J.N.5    Littleton, J.M.6
  • 125
    • 0037329682 scopus 로고    scopus 로고
    • Alcoholism: Allostasis and beyond
    • Koob GF. Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 2003; 27: 232-43.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 232-243
    • Koob, G.F.1
  • 126
    • 0002456867 scopus 로고    scopus 로고
    • Neurochemical mechanisms underlying alcohol withdrawal
    • Littleton J. Neurochemical mechanisms underlying alcohol withdrawal. Alcohol Health Res World 1998; 22: 13-24.
    • (1998) Alcohol Health Res World , vol.22 , pp. 13-24
    • Littleton, J.1
  • 127
    • 0038587675 scopus 로고    scopus 로고
    • Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence
    • Littleton J, Zieglgansberger W. Pharmacological mechanisms of naltrexone and acamprosate in the prevention of relapse in alcohol dependence. Am J Addict 2003; 12 Suppl 1: S3-11.
    • (2003) Am J Addict , vol.12 , Issue.SUPPL. 1
    • Littleton, J.1    Zieglgansberger, W.2
  • 128
    • 33747632742 scopus 로고    scopus 로고
    • Effects of acamprosate on sleep during alcohol withdrawal: A double-blind placebo-controlled polysomnographic study in alcohol-dependent subjects
    • Staner L, Boeijinga P, Danel T, Gendre I, Muzet M, Landron F, et al. Effects of acamprosate on sleep during alcohol withdrawal: A double-blind placebo-controlled polysomnographic study in alcohol-dependent subjects. Alcohol Clin Exp Res 2006; 30: 1492-9.
    • (2006) Alcohol Clin Exp Res , vol.30 , pp. 1492-1499
    • Staner, L.1    Boeijinga, P.2    Danel, T.3    Gendre, I.4    Muzet, M.5    Landron, F.6
  • 129
    • 33846239323 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacology of alcohol dependence
    • Tambour S, Quertemont E. Preclinical and clinical pharmacology of alcohol dependence. Fundam Clin Pharmacol 2007; 21: 9-28.
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 9-28
    • Tambour, S.1    Quertemont, E.2
  • 130
    • 0030451485 scopus 로고    scopus 로고
    • What is a relapse? Fifty ways to leave the wagon
    • Miller WR. What is a relapse? Fifty ways to leave the wagon. Addiction 1996; 91 Suppl: S15-27.
    • (1996) Addiction , vol.91 , Issue.SUPPL.
    • Miller, W.R.1
  • 131
    • 0030461672 scopus 로고    scopus 로고
    • Conceptualizations of relapse: A summary of psychological and psychobiological models
    • Connors GJ, Maisto SA, Donovan DM. Conceptualizations of relapse: a summary of psychological and psychobiological models. Addiction 1996; 91 Suppl: S5-13.
    • (1996) Addiction , vol.91 , Issue.SUPPL.
    • Connors, G.J.1    Maisto, S.A.2    Donovan, D.M.3
  • 132
    • 0019048651 scopus 로고
    • The opponent-process theory of acquired motivation: The costs of pleasure and the benefits of pain
    • Solomon RL. The opponent-process theory of acquired motivation: the costs of pleasure and the benefits of pain. Am Psychol 1980; 35: 691-712.
    • (1980) Am Psychol , vol.35 , pp. 691-712
    • Solomon, R.L.1
  • 134
    • 0038022706 scopus 로고    scopus 로고
    • Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence
    • Valdez GR, Zorrilla EP, Roberts AJ, Koob GF. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol 2003; 29: 55-60.
    • (2003) Alcohol , vol.29 , pp. 55-60
    • Valdez, G.R.1    Zorrilla, E.P.2    Roberts, A.J.3    Koob, G.F.4
  • 135
    • 0030726784 scopus 로고    scopus 로고
    • Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core
    • Kelley AE, Smith-Roe SL, Holahan MR. Response-reinforcement learning is dependent on N-methyl-D-aspartate receptor activation in the nucleus accumbens core. Proc Natl Acad Sci USA 1997; 94: 12174-9.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12174-12179
    • Kelley, A.E.1    Smith-Roe, S.L.2    Holahan, M.R.3
  • 136
    • 0030802884 scopus 로고    scopus 로고
    • Second-order fear conditioning prevented by blocking NMDA receptors in amygdala
    • Gewirtz JC, Davis M. Second-order fear conditioning prevented by blocking NMDA receptors in amygdala. Nature 1997; 388: 471-4.
    • (1997) Nature , vol.388 , pp. 471-474
    • Gewirtz, J.C.1    Davis, M.2
  • 137
    • 0030203911 scopus 로고    scopus 로고
    • Synaptic transmission and plasticity in the amygdala. An emerging physiology of fear conditioning circuits
    • Maren S. Synaptic transmission and plasticity in the amygdala. An emerging physiology of fear conditioning circuits. Mol Neurobiol 1996; 13: 1-22.
    • (1996) Mol Neurobiol , vol.13 , pp. 1-22
    • Maren, S.1
  • 138
    • 0030449233 scopus 로고    scopus 로고
    • Predictive validity of Marlatt's relapse taxonomy versus a more general relapse code
    • Stout RL, Longabaugh R, Rubin A. Predictive validity of Marlatt's relapse taxonomy versus a more general relapse code. Addiction 1996; 91 Suppl: S99-110.
    • (1996) Addiction , vol.91 , Issue.SUPPL.
    • Stout, R.L.1    Longabaugh, R.2    Rubin, A.3
  • 139
    • 0029057803 scopus 로고
    • Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol
    • Paille FM, Guelfi JD, Perkins AC, Royer RJ, Steru L, Parot P. Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol. Alcohol Alcohol 1995; 30: 239-47.
    • (1995) Alcohol Alcohol , vol.30 , pp. 239-247
    • Paille, F.M.1    Guelfi, J.D.2    Perkins, A.C.3    Royer, R.J.4    Steru, L.5    Parot, P.6
  • 140
    • 0029737567 scopus 로고    scopus 로고
    • Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence
    • Sass H, Soyka M, Mann K, Zieglgansberger W. Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence. Arch Gen Psychiatry 1996; 53: 673-80.
    • (1996) Arch Gen Psychiatry , vol.53 , pp. 673-680
    • Sass, H.1    Soyka, M.2    Mann, K.3    Zieglgansberger, W.4
  • 141
    • 0030041684 scopus 로고    scopus 로고
    • Naltrexone in the treatment of alcoholism: A clinical review
    • O'Brien CP, Volpicelli LA, Volpicelli JR. Naltrexone in the treatment of alcoholism: a clinical review. Alcohol 1996; 13: 35-9.
    • (1996) Alcohol , vol.13 , pp. 35-39
    • O'Brien, C.P.1    Volpicelli, L.A.2    Volpicelli, J.R.3
  • 143
    • 0031081578 scopus 로고    scopus 로고
    • Anti-craving compounds for ethanol: New pharmacological tools to study addictive processes
    • Spanagel R, Zieglgansberger W. Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 1997; 18: 54-9.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 54-59
    • Spanagel, R.1    Zieglgansberger, W.2
  • 144
    • 18744422986 scopus 로고    scopus 로고
    • The anticraving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal
    • Putzke J, Spanagel R, Tolle TR, Zieglgansberger W. The anticraving drug acamprosate reduces c-fos expression in rats undergoing ethanol withdrawal. Eur J Pharmacol 1996; 317: 39-48.
    • (1996) Eur J Pharmacol , vol.317 , pp. 39-48
    • Putzke, J.1    Spanagel, R.2    Tolle, T.R.3    Zieglgansberger, W.4
  • 145
    • 0342281459 scopus 로고    scopus 로고
    • Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat
    • Spanagel R, Holter SM, Allingham K, Landgraf R, Zieglgansberger W. Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 1996; 305: 39-44.
    • (1996) Eur J Pharmacol , vol.305 , pp. 39-44
    • Spanagel, R.1    Holter, S.M.2    Allingham, K.3    Landgraf, R.4    Zieglgansberger, W.5
  • 146
    • 0032007883 scopus 로고    scopus 로고
    • Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats
    • Heyser CJ, Schulteis G, Durbin P, Koob GF. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology 1998; 18: 125-33.
    • (1998) Neuropsychopharmacology , vol.18 , pp. 125-133
    • Heyser, C.J.1    Schulteis, G.2    Durbin, P.3    Koob, G.F.4
  • 147
    • 0032953635 scopus 로고    scopus 로고
    • Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour
    • Cole JC, Littleton JM, Little HJ. Effects of repeated ethanol administration in the plus maze; a simple model for conditioned abstinence behaviour. Psychopharmacology (Berl) 1999; 142: 270-9.
    • (1999) Psychopharmacology (Berl) , vol.142 , pp. 270-279
    • Cole, J.C.1    Littleton, J.M.2    Little, H.J.3
  • 148
    • 16844382736 scopus 로고    scopus 로고
    • The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat
    • Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R. The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology 2005; 30: 1104-10.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 1104-1110
    • Bachteler, D.1    Economidou, D.2    Danysz, W.3    Ciccocioppo, R.4    Spanagel, R.5
  • 149
    • 36148934049 scopus 로고    scopus 로고
    • Acamprosate in the treatment of alcohol dependence: Clinical and economic considerations
    • Mason BJ, Crean R. Acamprosate in the treatment of alcohol dependence: clinical and economic considerations. Expert Rev Neurother 2007; 7: 1465-77.
    • (2007) Expert Rev Neurother , vol.7 , pp. 1465-1477
    • Mason, B.J.1    Crean, R.2
  • 151
    • 0030598634 scopus 로고    scopus 로고
    • Alcohol drinking is reduced by a mu1-but not by a delta-opioid receptor antagonist in alcohol-preferring rats
    • Honkanen A, Vilamo L, Wegelius K, Sarviharju M, Hyytia P, Korpi ER. Alcohol drinking is reduced by a mu1-but not by a delta-opioid receptor antagonist in alcohol-preferring rats. Eur J Pharmacol 1996; 304: 7-13.
    • (1996) Eur J Pharmacol , vol.304 , pp. 7-13
    • Honkanen, A.1    Vilamo, L.2    Wegelius, K.3    Sarviharju, M.4    Hyytia, P.5    Korpi, E.R.6
  • 152
    • 0031868767 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain
    • Naassila M, Hammoumi S, Legrand E, Durbin P, Daoust M. Mechanism of action of acamprosate. Part I. Characterization of spermidine-sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 1998; 22: 802-9.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 802-809
    • Naassila, M.1    Hammoumi, S.2    Legrand, E.3    Durbin, P.4    Daoust, M.5
  • 153
    • 0031813519 scopus 로고    scopus 로고
    • Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex
    • Al Qatari M, Bouchenafa O, Littleton J. Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 1998; 22: 810-4.
    • (1998) Alcohol Clin Exp Res , vol.22 , pp. 810-814
    • Al Qatari, M.1    Bouchenafa, O.2    Littleton, J.3
  • 154
    • 38849099417 scopus 로고    scopus 로고
    • Acamprosate in alcohol dependence: Implications of a unique mechanism of action
    • Littleton JM. Acamprosate in alcohol dependence: Implications of a unique mechanism of action. Journal of Addiction Medicine 2007; 1: 115-25 10
    • (2007) Journal of Addiction Medicine , vol.1 , pp. 115-125
    • Littleton, J.M.1
  • 155
    • 12244265522 scopus 로고    scopus 로고
    • Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors
    • Harris BR, Prendergast MA, Gibson DA, Rogers DT, Blanchard JA, Holley RC, et al. Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors. Alcohol Clin Exp Res 2002; 26: 1779-93.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1779-1793
    • Harris, B.R.1    Prendergast, M.A.2    Gibson, D.A.3    Rogers, D.T.4    Blanchard, J.A.5    Holley, R.C.6
  • 157
    • 32544442698 scopus 로고    scopus 로고
    • Neramexane (Merz Pharmaceuticals/Forest Laboratories)
    • Rammes G, Schierloh A. Neramexane (Merz Pharmaceuticals/Forest Laboratories). Drugs 2006; 9: 128-35.
    • (2006) Drugs , vol.9 , pp. 128-135
    • Rammes, G.1    Schierloh, A.2
  • 158
    • 27744477334 scopus 로고    scopus 로고
    • Effects of a metabotropic, mGlu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats
    • McMillen BA, Crawford MS, Kulers CM, Williams HL. Effects of a metabotropic, mGlu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats. Alcohol Alcohol 2005; 40: 494-7.
    • (2005) Alcohol Alcohol , vol.40 , pp. 494-497
    • McMillen, B.A.1    Crawford, M.S.2    Kulers, C.M.3    Williams, H.L.4
  • 159
    • 33749166779 scopus 로고    scopus 로고
    • Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala
    • Zhao Y, Dayas CV, Aujla H, Baptista MA, Martin-Fardon R, Weiss F. Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala. J Neurosci 2006; 26: 9967-74.
    • (2006) J Neurosci , vol.26 , pp. 9967-9974
    • Zhao, Y.1    Dayas, C.V.2    Aujla, H.3    Baptista, M.A.4    Martin-Fardon, R.5    Weiss, F.6
  • 161
    • 37449009393 scopus 로고    scopus 로고
    • Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice
    • Farook JM, Morrell DJ, Lewis B, Littleton JM, Barron S. Topiramate (Topamax) reduces conditioned abstinence behaviours and handling-induced convulsions (HIC) after chronic administration of alcohol in Swiss-Webster mice. Alcohol Alcohol 2007; 42: 296-300.
    • (2007) Alcohol Alcohol , vol.42 , pp. 296-300
    • Farook, J.M.1    Morrell, D.J.2    Lewis, B.3    Littleton, J.M.4    Barron, S.5
  • 162
    • 4544344682 scopus 로고    scopus 로고
    • An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence
    • Johnson BA. An overview of the development of medications including novel anticonvulsants for the treatment of alcohol dependence. Exp Opin Pharmacother 2004; 5: 1943-55.
    • (2004) Exp Opin Pharmacother , vol.5 , pp. 1943-1955
    • Johnson, B.A.1
  • 163
    • 0141681163 scopus 로고    scopus 로고
    • Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre
    • Harper C, Dixon G, Sheedy D, Garrick T. Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. Prog Neuropsychopharmacology Biol Psychiatry 2003; 27: 951-61.
    • (2003) Prog Neuropsychopharmacology Biol Psychiatry , vol.27 , pp. 951-961
    • Harper, C.1    Dixon, G.2    Sheedy, D.3    Garrick, T.4
  • 165
    • 0027376701 scopus 로고
    • The kindling hypothesis: Further evidence from a U.S. national study of alcoholic men
    • Booth BM, Blow FC. The kindling hypothesis: further evidence from a U.S. national study of alcoholic men. Alcohol Alcohol 1993; 28: 593-8.
    • (1993) Alcohol Alcohol , vol.28 , pp. 593-598
    • Booth, B.M.1    Blow, F.C.2
  • 166
    • 0041442797 scopus 로고    scopus 로고
    • Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients
    • Duka T, Townshend JM, Collier K, Stephens DN. Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients. Alcohol Clin Exp Res 2003; 27: 1563-72.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 1563-1572
    • Duka, T.1    Townshend, J.M.2    Collier, K.3    Stephens, D.N.4
  • 167
    • 0022444420 scopus 로고
    • Implications of cognitive impairment for the treatment of alcoholism
    • McCrady BS, Smith DE. Implications of cognitive impairment for the treatment of alcoholism. Alcohol Clin Exp Res 1986; 10: 145-9.
    • (1986) Alcohol Clin Exp Res , vol.10 , pp. 145-149
    • McCrady, B.S.1    Smith, D.E.2
  • 169
    • 0034820542 scopus 로고    scopus 로고
    • Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain
    • Al Qatari M, Khan S, Harris B, Littleton J. Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin Exp Res; 2001: 1276-83.
    • (2001) Alcohol Clin Exp Res , pp. 1276-1283
    • Al Qatari, M.1    Khan, S.2    Harris, B.3    Littleton, J.4
  • 170
    • 34249093924 scopus 로고    scopus 로고
    • Pathologically-activated therapeutics for neuroprotection: Mechanism of NMDA receptor block by memantine and S-nitrosylation
    • Lipton SA. Pathologically-activated therapeutics for neuroprotection: mechanism of NMDA receptor block by memantine and S-nitrosylation. Curr Drug Targets 2007; 8: 621-32.
    • (2007) Curr Drug Targets , vol.8 , pp. 621-632
    • Lipton, S.A.1
  • 171
    • 26244462973 scopus 로고    scopus 로고
    • Neuroprotective effects of topiramate after hypoxiaischemia in newborn piglets
    • Schubert S, Brandl U, Brodhun M, Ulrich C, Spaltmann J, Fiedler N, et al. Neuroprotective effects of topiramate after hypoxiaischemia in newborn piglets. Brain Res 2005; 1058: 129-36.
    • (2005) Brain Res , vol.1058 , pp. 129-136
    • Schubert, S.1    Brandl, U.2    Brodhun, M.3    Ulrich, C.4    Spaltmann, J.5    Fiedler, N.6
  • 172
    • 10744224826 scopus 로고    scopus 로고
    • The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors
    • Harris BR, Gibson DA, Prendergast MA, Blanchard JA, Holley RC, Hart SR, et al. The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors. Alcohol Clin Exp Res 2003; 27: 1724-35.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 1724-1735
    • Harris, B.R.1    Gibson, D.A.2    Prendergast, M.A.3    Blanchard, J.A.4    Holley, R.C.5    Hart, S.R.6
  • 173
    • 0346505342 scopus 로고    scopus 로고
    • Review of NMDA antagonist-induced neurotoxicity and implications for clinical development
    • Low SJ, Roland CL. Review of NMDA antagonist-induced neurotoxicity and implications for clinical development. Int J Clin Pharmacol Ther 2004; 42: 1-14.
    • (2004) Int J Clin Pharmacol Ther , vol.42 , pp. 1-14
    • Low, S.J.1    Roland, C.L.2
  • 174
    • 0032467053 scopus 로고    scopus 로고
    • Glutamate in CNS disorders as a target for drug development: An update
    • Parsons CG, Danysz W, Quack G. Glutamate in CNS disorders as a target for drug development: an update. Drug News Perspect 1998; 11: 523-69.
    • (1998) Drug News Perspect , vol.11 , pp. 523-569
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 175
    • 0031983728 scopus 로고    scopus 로고
    • Ethanol and Nmethyl-D-aspartate receptor complex interactions: A detailed drug discrimination study in the rat
    • Hundt W, Danysz W, Holter SM, Spanagel R. Ethanol and Nmethyl-D-aspartate receptor complex interactions: a detailed drug discrimination study in the rat. Psychopharmacology (Berl) 1998; 135: 44-51.
    • (1998) Psychopharmacology (Berl) , vol.135 , pp. 44-51
    • Hundt, W.1    Danysz, W.2    Holter, S.M.3    Spanagel, R.4
  • 176
    • 0028987875 scopus 로고
    • Polyamine regulation of N-methyl-Daspartate receptor channels
    • Rock DM, Macdonald RL. Polyamine regulation of N-methyl-Daspartate receptor channels. Annu Rev Pharmacol Toxicol 1995; 35: 463-82.
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 463-482
    • Rock, D.M.1    Macdonald, R.L.2
  • 177
    • 0030474273 scopus 로고    scopus 로고
    • Polyamine analogue regulation of NMDA MK-801 binding: A structure-activity study
    • Bergeron RJ, Weimar WR, Wu Q, Feng Y, McManis JS. Polyamine analogue regulation of NMDA MK-801 binding: a structure-activity study. J Med Chem 1996; 39: 5257-66.
    • (1996) J Med Chem , vol.39 , pp. 5257-5266
    • Bergeron, R.J.1    Weimar, W.R.2    Wu, Q.3    Feng, Y.4    McManis, J.S.5
  • 178
    • 0025328067 scopus 로고
    • Polyamines regulate glycine interaction with the N-methyl-D-aspartate receptor
    • Ransom RW, Deschenes NL. Polyamines regulate glycine interaction with the N-methyl-D-aspartate receptor. Synapse 1990; 5: 294-8.
    • (1990) Synapse , vol.5 , pp. 294-298
    • Ransom, R.W.1    Deschenes, N.L.2
  • 179
    • 0032510322 scopus 로고    scopus 로고
    • Molecular features associated with polyamine modulation of NMDA receptors
    • Lewin AH, Sun G, Fudala L, Navarro H, Zhou LM, Popik P, et al. Molecular features associated with polyamine modulation of NMDA receptors. J Med Chem 1998; 41: 988-95.
    • (1998) J Med Chem , vol.41 , pp. 988-995
    • Lewin, A.H.1    Sun, G.2    Fudala, L.3    Navarro, H.4    Zhou, L.M.5    Popik, P.6
  • 180
    • 0027082483 scopus 로고
    • Effects of mono-, di-, and triamines on the Nmethyl-D-aspartate receptor complex: A model of the polyamine recognition site
    • Romano C, Williams K, DePriest S, Seshadri R, Marshall GR, Israel M, et al. Effects of mono-, di-, and triamines on the Nmethyl-D-aspartate receptor complex: a model of the polyamine recognition site. Mol Pharmacol 1992; 41: 785-92.
    • (1992) Mol Pharmacol , vol.41 , pp. 785-792
    • Romano, C.1    Williams, K.2    DePriest, S.3    Seshadri, R.4    Marshall, G.R.5    Israel, M.6
  • 181
    • 0026751798 scopus 로고
    • Interaction of long chain n-alkyl diamines with the NMDA receptor complex
    • Berger ML, Seifriz I, Letschnig M, Schodl C, Noe CR. Interaction of long chain n-alkyl diamines with the NMDA receptor complex. Neurosci Lett 1992; 142: 85-8.
    • (1992) Neurosci Lett , vol.142 , pp. 85-88
    • Berger, M.L.1    Seifriz, I.2    Letschnig, M.3    Schodl, C.4    Noe, C.R.5
  • 182
    • 0037064234 scopus 로고    scopus 로고
    • Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil
    • Gibson DA, Harris BR, Rogers DT, Littleton JM. Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain Res 2002; 952: 71-7.
    • (2002) Brain Res , vol.952 , pp. 71-77
    • Gibson, D.A.1    Harris, B.R.2    Rogers, D.T.3    Littleton, J.M.4
  • 183
    • 0030040402 scopus 로고    scopus 로고
    • Agmatine treatment is neuroprotective in rodent brain injury models
    • Gilad GM, Salame K, Rabey JM, Gilad VH. Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci 1996; 58: 41-6.
    • (1996) Life Sci , vol.58 , pp. 41-46
    • Gilad, G.M.1    Salame, K.2    Rabey, J.M.3    Gilad, V.H.4
  • 184
    • 0035991288 scopus 로고    scopus 로고
    • Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in rats
    • Morgan AD, Campbell UC, Fons RD, Carroll ME. Effects of agmatine on the escalation of intravenous cocaine and fentanyl self-administration in rats. Pharmacol Biochem Behav 2002; 72: 873-80.
    • (2002) Pharmacol Biochem Behav , vol.72 , pp. 873-880
    • Morgan, A.D.1    Campbell, U.C.2    Fons, R.D.3    Carroll, M.E.4
  • 185
    • 0036385125 scopus 로고    scopus 로고
    • A review of chemical agents in the pharmacotherapy of addiction
    • Levi MS, Borne RF. A review of chemical agents in the pharmacotherapy of addiction. Curr Med Chem 2002; 9: 1807-18.
    • (2002) Curr Med Chem , vol.9 , pp. 1807-1818
    • Levi, M.S.1    Borne, R.F.2
  • 186
    • 0035237167 scopus 로고    scopus 로고
    • Ibogaine as a glutamate antagonist: Relevance to its putative antiaddictive properties
    • Skolnick P. Ibogaine as a glutamate antagonist: relevance to its putative antiaddictive properties. Alkaloids Chem Biol 2001; 56: 55-62.
    • (2001) Alkaloids Chem Biol , vol.56 , pp. 55-62
    • Skolnick, P.1
  • 187
    • 0035793446 scopus 로고    scopus 로고
    • Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex
    • Worthen DR, Gibson DA, Rogers DT, Bence AK, Fu M, Littleton JM, et al. Endogenous indoles as novel polyamine site ligands at the N-methyl-D-aspartate receptor complex. Brain Res 2001; 890: 343-6.
    • (2001) Brain Res , vol.890 , pp. 343-346
    • Worthen, D.R.1    Gibson, D.A.2    Rogers, D.T.3    Bence, A.K.4    Fu, M.5    Littleton, J.M.6
  • 188
    • 77950020507 scopus 로고    scopus 로고
    • Neuronal models for evaluation of proliferation in vitro using high content screening
    • Mundy WR, Radio NM, Freudenrich TM. Neuronal models for evaluation of proliferation in vitro using high content screening. Toxicol 2010; 270: 121-30.
    • (2010) Toxicol , vol.270 , pp. 121-130
    • Mundy, W.R.1    Radio, N.M.2    Freudenrich, T.M.3
  • 189
    • 0028057572 scopus 로고
    • Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol
    • Ahern KB, Lustig HS, Greenberg DA. Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol. Neurosci Lett 1994; 165: 211-4.
    • (1994) Neurosci Lett , vol.165 , pp. 211-214
    • Ahern, K.B.1    Lustig, H.S.2    Greenberg, D.A.3
  • 191
    • 49349093990 scopus 로고    scopus 로고
    • Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice
    • Farook JM, Krazem A, Lewis B, Morrell DJ, Littleton JM, Barron S. Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice. Physiol Behav 2008; 95: 267-70.
    • (2008) Physiol Behav , vol.95 , pp. 267-270
    • Farook, J.M.1    Krazem, A.2    Lewis, B.3    Morrell, D.J.4    Littleton, J.M.5    Barron, S.6
  • 193
    • 0001782605 scopus 로고
    • Increased preference for ethanol in rats following alcohol deprivation
    • Sinclair JD, Senter RJ. Increased preference for ethanol in rats following alcohol deprivation. Psychonomic Science 1967; 8: 11-2.
    • (1967) Psychonomic Science , vol.8 , pp. 11-12
    • Sinclair, J.D.1    Senter, R.J.2
  • 194
    • 0025255896 scopus 로고
    • New strategies in the search for anxiolytics
    • File SE. New strategies in the search for anxiolytics. Drug Des Deliv 1990; 5: 195-201.
    • (1990) Drug Des Deliv , vol.5 , pp. 195-201
    • File, S.E.1
  • 195
    • 0033958458 scopus 로고    scopus 로고
    • Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze
    • Cole JC, Littleton JM, Little HJ. Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology (Berl) 2000; 147: 403-11.
    • (2000) Psychopharmacology (Berl) , vol.147 , pp. 403-411
    • Cole, J.C.1    Littleton, J.M.2    Little, H.J.3
  • 197
    • 54249140161 scopus 로고    scopus 로고
    • Acute effects of acamprosate and MPEP on ethanol Drinkingin-the-Dark in male C57BL/6J mice
    • Gupta T, Syed YM, Revis AA, Miller SA, Martinez M, Cohn KA, et al. Acute effects of acamprosate and MPEP on ethanol Drinkingin-the-Dark in male C57BL/6J mice. Alcohol Clin Exp Res 2008; 32: 1992-8.
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 1992-1998
    • Gupta, T.1    Syed, Y.M.2    Revis, A.A.3    Miller, S.A.4    Martinez, M.5    Cohn, K.A.6
  • 199
    • 0032989907 scopus 로고    scopus 로고
    • Incidence of fetal alcohol syndrome in northeastern Manitoba
    • Williams R, Odaibo F, McGee J. Incidence of fetal alcohol syndrome in northeastern Manitoba. Can J Public Health 1999; 90: 192-4.
    • (1999) Can J Public Health , vol.90 , pp. 192-194
    • Williams, R.1    Odaibo, F.2    McGee, J.3
  • 201
    • 70049116800 scopus 로고    scopus 로고
    • The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt
    • Helfer JL, Goodlett CR, Greenough WT, Klintsova AY. The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt. Brain Res 2009; 1294: 1-11.
    • (2009) Brain Res , vol.1294 , pp. 1-11
    • Helfer, J.L.1    Goodlett, C.R.2    Greenough, W.T.3    Klintsova, A.Y.4
  • 202
    • 79952198463 scopus 로고    scopus 로고
    • Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats
    • Thomas JD, Idrus NM, Monk BR, Dominguez HD. Prenatal choline supplementation mitigates behavioral alterations associated with prenatal alcohol exposure in rats. Birth Defects Res A Clin Mol Teratol 2010; 88: 827-37.
    • (2010) Birth Defects Res A Clin Mol Teratol , vol.88 , pp. 827-837
    • Thomas, J.D.1    Idrus, N.M.2    Monk, B.R.3    Dominguez, H.D.4
  • 203
    • 0036840669 scopus 로고    scopus 로고
    • Novel antagonists of alcohol inhibition of l1-mediated cell adhesion: Multiple mechanisms of action
    • Wilkemeyer MF, Menkari CE, Charness ME. Novel antagonists of alcohol inhibition of l1-mediated cell adhesion: multiple mechanisms of action. Mol Pharmacol 2002; 62: 1053-60.
    • (2002) Mol Pharmacol , vol.62 , pp. 1053-1060
    • Wilkemeyer, M.F.1    Menkari, C.E.2    Charness, M.E.3
  • 204
    • 27744529221 scopus 로고    scopus 로고
    • Polyamines and apoptosis
    • Seiler N, Raul F. Polyamines and apoptosis. J Cell Mol Med 2005; 9: 623-42.
    • (2005) J Cell Mol Med , vol.9 , pp. 623-642
    • Seiler, N.1    Raul, F.2
  • 205
    • 0033996412 scopus 로고    scopus 로고
    • Developmental maturation of the N-methyl-D-aspartic acid receptor channel complex in postnatal rat brain
    • Sircar R. Developmental maturation of the N-methyl-D-aspartic acid receptor channel complex in postnatal rat brain. Int J Dev Neurosci 2000; 18: 121-31.
    • (2000) Int J Dev Neurosci , vol.18 , pp. 121-131
    • Sircar, R.1
  • 206
    • 0031730216 scopus 로고    scopus 로고
    • Ethanol inhibition of brain ornithine decarboxylase activity in the postnatal rat
    • Davidson M, Bedi K, Wilce P. Ethanol inhibition of brain ornithine decarboxylase activity in the postnatal rat. Neurotoxicol Teratol 1998; 20: 523-30.
    • (1998) Neurotoxicol Teratol , vol.20 , pp. 523-530
    • Davidson, M.1    Bedi, K.2    Wilce, P.3
  • 207
    • 0017342502 scopus 로고
    • Effects of late prenatal or early postnatal ethanol exposure on ornithine decarboxylase activity in brain and heart of developing rats
    • Thadani P, Slotkin T, Schanberg S. Effects of late prenatal or early postnatal ethanol exposure on ornithine decarboxylase activity in brain and heart of developing rats. Neuropharmacology 1977; 16: 289-93.
    • (1977) Neuropharmacology , vol.16 , pp. 289-293
    • Thadani, P.1    Slotkin, T.2    Schanberg, S.3
  • 208
    • 0028340993 scopus 로고
    • Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits
    • Williams K, Zappia A, Pritchett D, Shen Y, Molinoff P. Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. Mol Pharmacol 1994; 45: 803-9.
    • (1994) Mol Pharmacol , vol.45 , pp. 803-809
    • Williams, K.1    Zappia, A.2    Pritchett, D.3    Shen, Y.4    Molinoff, P.5
  • 209
    • 0036316216 scopus 로고    scopus 로고
    • Effect of prenatal and postnatal ethanol exposure on the developmental profile of mRNAs encoding NMDA receptor subunits in rat hippocampus
    • Naassila M, Daoust M. Effect of prenatal and postnatal ethanol exposure on the developmental profile of mRNAs encoding NMDA receptor subunits in rat hippocampus. J Neurochem 2002; 80: 850-60.
    • (2002) J Neurochem , vol.80 , pp. 850-860
    • Naassila, M.1    Daoust, M.2
  • 210
    • 0027405347 scopus 로고
    • Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
    • Williams K, Russell SL, Shen YM, Molinoff PB. Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 1993; 10: 267-78.
    • (1993) Neuron , vol.10 , pp. 267-278
    • Williams, K.1    Russell, S.L.2    Shen, Y.M.3    Molinoff, P.B.4
  • 211
    • 44349133893 scopus 로고    scopus 로고
    • Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures
    • Barron S, Mulholland PJ, Littleton JM, Prendergast MA. Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. Alcohol Clin Exp Res 2008; 32: 929-36.
    • (2008) Alcohol Clin Exp Res , vol.32 , pp. 929-936
    • Barron, S.1    Mulholland, P.J.2    Littleton, J.M.3    Prendergast, M.A.4
  • 214
    • 58549116306 scopus 로고    scopus 로고
    • Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats
    • Rubin MA, Wellmann KA, Lewis B, Overgaauw BJ, Littleton JM, Barron S. Difluoromethylornithine (DFMO) reduces deficits in isolation-induced ultrasonic vocalizations and balance following neonatal ethanol exposure in rats. Pharmacol Biochem Behav 2009; 92: 44-50.
    • (2009) Pharmacol Biochem Behav , vol.92 , pp. 44-50
    • Rubin, M.A.1    Wellmann, K.A.2    Lewis, B.3    Overgaauw, B.J.4    Littleton, J.M.5    Barron, S.6
  • 215
    • 77649274770 scopus 로고    scopus 로고
    • Agmatine reduces ultrasonic vocalization deficits in female rat pups exposed neonatally to ethanol
    • Wellmann K, Lewis B, Barron S. Agmatine reduces ultrasonic vocalization deficits in female rat pups exposed neonatally to ethanol. Neurotoxicol Teratol 2010; 32: 158-63.
    • (2010) Neurotoxicol Teratol , vol.32 , pp. 158-163
    • Wellmann, K.1    Lewis, B.2    Barron, S.3
  • 216
    • 34548511311 scopus 로고    scopus 로고
    • Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure
    • Lewis B, Wellmann KA, Barron S. Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure. Pharmacol Biochem Behav 2007; 88: 114-21.
    • (2007) Pharmacol Biochem Behav , vol.88 , pp. 114-121
    • Lewis, B.1    Wellmann, K.A.2    Barron, S.3
  • 217
    • 0042887031 scopus 로고    scopus 로고
    • Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats
    • Heyser CJ, Moc K, Koob, GF. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacol 2003; 28: 1463-71.
    • (2003) Neuropsychopharmacol , vol.28 , pp. 1463-1471
    • Heyser, C.J.1    Moc, K.2    Koob, G.F.3
  • 218
    • 12344309936 scopus 로고    scopus 로고
    • Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice
    • Gabriel KI, Cunningham CL. Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL/6J mice. Alcohol Clin Exp Res 2005; 29: 75-80.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 75-80
    • Gabriel, K.I.1    Cunningham, C.L.2
  • 220
    • 4043126243 scopus 로고    scopus 로고
    • The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats
    • Zakharova E, Malyshkin A, Kashkin V, Neznanova O, Sukhotina I, Danysz W, et al. The NMDA receptor channel blocker memantine and opioid receptor antagonist naltrexone inhibit the saccharin deprivation effect in rats. Behav Pharmacol 2004; 15: 273-8.
    • (2004) Behav Pharmacol , vol.15 , pp. 273-278
    • Zakharova, E.1    Malyshkin, A.2    Kashkin, V.3    Neznanova, O.4    Sukhotina, I.5    Danysz, W.6
  • 237
    • 23844450692 scopus 로고    scopus 로고
    • The excitatory amino acid transporters: Pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes
    • Bridges RJ, Esslinger CS. The excitatory amino acid transporters: pharmacological insights on substrate and inhibitor specificity of the EAAT subtypes. Pharmacol Ther 2005; 107:271-285.
    • (2005) Pharmacol Ther , vol.107 , pp. 271-285
    • Bridges, R.J.1    Esslinger, C.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.