Conditioning factors in drug abuse: Can they explain compulsion?

Journal of Psychopharmacology

Volumn 12, Issue 1, 1998, Pages 15-22

  O'Brien, Charles P ^a   Childress, Anna Rose ^a   Ehrman, Ronald ^a   Robbins, Steven J ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Addiction; Conditioning; Craving; Dependence

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; COMPULSION; CONDITIONING; DRUG DEPENDENCE; HUMAN; LEARNING; MOTIVATION; NONHUMAN; PRIORITY JOURNAL; RELAPSE; REMISSION; REVIEW; SYMPTOM; WITHDRAWAL SYNDROME;

ALCOHOLS; ANESTHETICS, LOCAL; COCAINE; CONDITIONING (PSYCHOLOGY); GANGLIONIC STIMULANTS; HUMANS; IMPULSE CONTROL DISORDERS; LEARNING; NARCOTICS; NICOTINE; SUBSTANCE-RELATED DISORDERS;

EID: 0031914485     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119801200103     Document Type: Review

References (63)

1. Abrams D B, Monti P M, Carey K B, Pinto R P, Jacobus S I (1988) Reactivity to smoking cues and relapse: two studies of discriminant validity. Behav Res Ther 26: 225-233
2. Baker T B, Morse E, Sherman J (1987) The motivation to use drugs. A psychobiological analysis of urges. In Rivers C (ed.) The Nebraska symposium on motivation: alcohol use and abuse. University of Nebraska Press, Lincoln, NE, pp. 257-323
3. Berger S P, Hall S, Mickalian J D, Reid M S, Crawford C A, Delucchi K, Carr K, Hall S (1996) Haloperidol antagonism of cue-elicited cocaine craving. Lancet 347: 504-508
4. Childress A R with NIDA contractors (1993) Cue extinction: inservice training curriculum. NIH Pub. No. 93-3692. US Government Printing Office, Washington, DC
5. Childress A R, McLellan A T, O'Brien C P (1984) Measurement and extinction of conditioned withdrawal-like responses in opiate dependent patients. NIDA Research Monograph 49. US Government Printing Office, Washington, DC, pp. 212-219
6. Childress A R, McLellan A T, O'Brien C P (1986a) Abstinent opiate abusers exhibit conditioned craving, conditioned withdrawal and reduction in both through extinction. Br J Addict 81: 644-660
7. Childress A R, McLellan A T, O'Brien C P (1986b) Conditioned responses in a methadone population: a comparison of laboratory, clinic and natural setting. J Substance Abuse Treat 3: 173-179
8. Childress A R, McLellan A T, Ehrman R, O'Brien C P (1987) Extinction of conditioned responses in abstinent cocaine or opioid users. NIDA Research Monograph 76. US Government Printing Office, Washington, DC, pp. 189-195
9. Childress A R, Ehrman R N, McLellan A T, O'Brien C P (1988) Conditioned craving and arousal in cocaine addiction: a preliminary report. NIDA Research Monograph 81. US Government Printing Office, Washington, DC, pp. 74-80
10. Childress A R, Hole A V, Ehrman R N, Robbins S J, McLellan A T, O'Brien C P (1993a) Cue reactivity and cue reactivity interventions in drug dependence. NIDA Research Monograph 137. US Government Printing Office, Washington, DC, pp. 73-95
11. Childress A R, Kung H, Mallison R T, Alavi A, Mozley D, Fitzgerald J, Kushner S, O'Brien C P (1993b) Brain correlates of induced cocaine craving. Paper presented at 23rd Annual Meeting of the Society for Neuroscience, Washington, DC, 762.8
12. Childress A R, Mozley D, Fitzgerald J, Reivich M, Jaggi J, O'Brien C P (1994) Regional brain blood flow during cue-induced cocaine craving. Paper presented at 24th Annual Meeting of the Society for Neuroscience, Miami Beach, FL, 666.2
13. Childress A, Mozley D, Fitzgerald J, Reivich M, Jaggi J, O'Brien C P (1995) Limbic activation during cue-induced cocaine craving. Paper presented at 25th Annual Meeting of the Society for Neuroscience, San Diego, CA, 767.1
14. Childress A E, McElgin W, Mozley D, Reivich M, O'Brien C P (1996) Brain correlates of cue induced cocaine and opiate craving. Paper presented at 26th Annual Meeting of the Society for Neuroscience, Washington, DC, 365.5
15. Dawe S, Powell J, Richards D, Gossop M, Marks I, Strang J, Gray J A (1993) Does post-withdrawal cue exposure improve outcome in opiate addiction? a controlled trial. Addiction 88: 1233-1245
16. Drobes D J, Tiffany S T (1997) Induction of smoking urge through imaginal and in vivo procedures: physiological and self-report manifestations. J Abnorm Psychol 106: 15-25
17. Droungas A, Ehrman R, Childress A R, O'Brien C P (1995) Effect of smoking cues and cigarette availability on craving and smoking behavior. Addict Behav 20: 657-673
18. Drummond D C, Glautier S (1994) A controlled trial of cue exposure treatment in alcohol dependence. J Cons Clin Psychol 62: 809-817
19. Drummond D C, Cooper T, Glautier S P (1990) Conditioned learning in alcohol dependence: implications for cue exposure treatment. Br J Addict 85: 725-743
20. Ehrman R N, Robbins S J, Childress A R, O'Brien C P (1992a) Conditioned responses to cocaine-related stimuli in cocaine abuse patients. Psychopharmacology 107: 523-529
21. Ehrman R, Ternes J, O'Brien C P, McLellan A T (1992b) Conditioned tolerance in human opiate addicts. Psychopharmacology 108: 218-224
22. Ehrman R N, Robbins S J, Cornish J W, Childress A R, O'Brien C P (1996) Failure of ritanserin to block cocaine cue reactivity. Drug Alcohol Depend 42: 167-174
23. Grant S, London E D, Newlin D B, Villemagne V L, Liu X, Contoreggi C, Phillips R L, Kimes A S, Margolin A (1996) Activation of memory circuits during cue-elicited cocaine craving. Proc Natl Acad Sci USA 93: 12040-12045
24. Holman R B, Snape B M, Widdowson P S (1987) Naloxone elicits dose-dependent changes in alcohol-induced increases in endogenous dopamine release from rat striatum. Alcohol 1: 737-741
25. Jaffe J H, Cascella N G, Kumo K M, Sherer M A (1989) Cocaine-induced cocaine craving. Psychopharmacology 97: 59-64
26. Kalivas P W, Duffy P (1990) Effect of acute and daily cocaine treatment on extracellular dopamine in the nucleus accumbens. Synapse 5: 48-58
27. Kaplan R F, Meyer R E, Stoebel C F (1983) Alcohol dependence and responsivity to an ethanol stimulus as predictors of alcohol consumption. Br J Addict 78: 259-267
28. Ludwig A M, Wikler A, Stark L H (1974) The first drink: psychobiological aspects of craving. Archs Gen Psychiat 30: 539-547
29. Martin W, Jasinski D (1969) Physiological parameters of morphine dependence in man - tolerance, early abstinence and protracted abstinence. J Psychiat Res 7: 9-17
30. McLellan A T, Luborsky L, Woody G E, O'Brien C P (1983) Predicting response to alcohol and drug abuse treatment: role of psychiatric severity. Archs Gen Psychiat 40: 620-625
31. Niaura R S, Rosenhow D J, Binkoff J A, Monti P M, Pedraza M, Abrams D B (1988) Relevance of cue reactivity to understanding alcohol and smoking relapse. J Abnorm Psychol 97: 133-152
32. Niaura R S, Abrams D B, Demuth B, Pinto R P, Monti P M (1989) Responses to smoking-related stimuli and early relapse to smoking. Addict Behav 14: 419-428
33. O'Brien C P, McLellan A T (1996) Myths about the treatment of addiction. Lancet 347: 237-240
34. O'Brien C P, Chaddock B, Woody G, Greenstein R (1974) Systematic extinction of narcotic drug use using narcotic antagonists. Psychosom Med 36: 458
35. O'Brien C P, O'Brien T J, Mintz J (1975) Conditioning of narcotic abstinence symptoms in human subjects. Drug Alcohol Depend 1: 115-123
36. O'Brien C P, Testa T, O'Brien T J, Brady J P, Wells B (1977) Conditioned narcotic withdrawal in humans. Science 195: 1000-1001
37. O'Brien C P, Greenstein R, Ternes J, McLellan A T, Grabowski J (1980) Unreinforced self-injections: effects on rituals and outcome in heroin addicts. NIDA Research Monograph 27. US Government Printing Office, Washington, DC, pp. 275-281
38. O'Brien C P, Ehrman R, Ternes J (1986) Classical conditioning in human opioid dependence. In Goldberg S R, Stolerman I P (eds), Behavioral analysis of drug dependence. Academic Press, Orlando, FL, pp. 329-356
39. O'Brien C P, Childress A R, McLellan A T, Ehrman R (1990) Integrating systematic cue exposure with standard treatment in recovering drug dependent patients. Addict Behav 15: 355-365
40. O'Malley S S, Jaffe A J, Chang G, Schottenfeld R S, Meyer R E, Rounsaville B (1992) Naltrexone and coping skills therapy for alcohol dependence. Archs Gen Psychiat 49: 881-887
41. Post R M, Lockfeld A, Squillace K M, Contel N R (1981) Drug-environment interaction: context dependency of cocaine-induced behavioral sensitization. Life Sci 28: 755-760
42. Post R M, Weiss S R B, Pert A, Uhde T W (1987) Chronic cocaine administration: sensitization and kindling effects. In Fisher S, Raskin A, Uhlenhuth E (eds), Cocaine: clinical and biobehavioral aspects. Oxford University Press, New York
43. Powell J, Gray J, Bradley B (1993) Subjective craving for opiates: Evaluation of a cue exposure protocol for use with detoxified opiate addicts. Br J Clin Psychol 32: 39-53
44. Rickard-Figueroa K, Zeichner A (1985) Assessment of smoking urge and its concomitants under an environmental smoking cue manipulation. Addict Behav 10: 249-256
45. Robbins S J, Ehrman R N (1992) Designing studies of drug conditioning in humans. Psychopharmacology 106: 143-153
46. Robbins S J, Ehrman R N, Childress A R, O'Brien C P (1992) Using cue reactivity to screen medications for cocaine abuse: a test of amantadine hydrochloride. Addict Behav 17: 491-499
47. Robbins S J, Ehrman R N, Childress A R, O'Brien C P (1996) Relationships among physiological and self-report responses produced by cocaine-related cues. Addict Behav 22: 1-11
48. Sherman J E, Jorenby M S, Baker T B (1988) Classical conditioning with alcohol: acquired preferences and aversions, tolerance and urges/craving. In Wilkinson D A, Chaudron D (eds), Theories of alcoholism. Addiction Research Foundation, Toronto, pp. 173-237
49. Siegel S (1975) Evidence from rats that morphine tolerance is a learned response. J Comp Physiol Psychol 89: 498-506
50. Siegel S (1979) The role of conditioning in drug tolerance and addiction. In Keehn J D (ed.), Psychopathology in animals: research and treatment implication. Academic Press, New York, pp. 143-168
51. Siegel S, MacRae J (1984) Environmental specificity of tolerance. Trends Neurosci 7: 140-142
52. Siegel S, Hinson R, Krank M (1978) The role of predrug signals in morphine analgesic tolerance: support for a Pavlovian conditioning model of tolerance. J Exp Psychol: Anim Behav Proc 4: 188-196
53. Stewart J (1984) Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area. Pharmac Biochem Behav 20: 917-923
54. Stewart J, deWit H, Eikelboom R (1984) The role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants. Psychol Rev 91: 251-268
55. Ternes J W, O'Brien C P, Grabowski J, Wellerstein H, Jordan-Hayes J (1980) Conditioned drug responses to naturalistic stimuli: problems of drug dependence. NIDA Research Monograph 27. US Government Printing Office, Washington DC, pp. 282-288
56. Tiffany S T, Drobes D J (1990) Imagery and smoking urges: the manipulation of affective content. Addict Behav 15: 531-539
57. Volpicelli J, Alterman A, Hayashida M, Muentz L, O'Brien C (1990) Naltrexone and the treatment of alcohol dependence. In: Reid L, (ed.), Opioids, bulimia and alcoholism. Springer, New York, pp. 195-214
58. Volpicelli J R, Alterman A I, Hayashida M, O'Brien C P (1992) Naltrexone in the treatment of alcohol dependence. Archs Gen Psychiat 49: 876-880
59. Weiss F, Lorang M T, Bloom F E, Koob G F (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmac Exp Ther 267: 250-267
60. Whitelaw R B, Markou A, Robbins T, Everitt B J (1996) Excitotoxic lesions of the basolateral amygdala impair the acquisition of cocaine-seeking behaviour under a second-order schedule of reinforcement. Psychopharmacology 127: 213-224
61. Wikler A (1965) Conditioning factors in opiate addiction and relapse. In Willner D I, Kassenbaum, G G (eds), Narcotics. McGraw-Hill, New York, pp. 85-100
62. Wikler A, Pescor F (1967) Classical conditioning of a morphine abstinence phenomenon, reinforcement of opioid-drinking behavior and relapse in morphine-addicted rats. Psychopharmacologia 10: 255-284
63. Wise R A (1996) Neurobiology of addiction. Curr Opin Neurobiol 6: 243-251