Acamprosate inhibits the binding and neurotoxic effects of trans-ACPD, suggesting a novel site of action at metabotropic glutamate receptors

Alcoholism: Clinical and Experimental Research

Volumn 26, Issue 12, 2002, Pages 1779-1793

  Harris, Barton R ^a,b   Prendergast, Mark A ^b   Gibson, D Alex ^a,b   Rogers, D Trent ^b   Blanchard, John A ^a,b   Holley, Robert C ^a,b   Fu, May C ^b   Hart, Stewart R ^a,b   Pedigo, Norman W ^a   Littleton, John M ^b  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Acamprosate; Metabotropic Glutamate Receptor; N Methyl D Aspartate Receptor; SIB 1893; Trans ACPD

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; ACAMPROSATE; GLUTAMIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; PROPIDIUM IODIDE;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; BRAIN SLICE; CEREBELLUM; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; FEMALE; HIPPOCAMPUS; MALE; NEUROPROTECTION; NEUROTOXICITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 12244265522     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2002.tb02484.x     Document Type: Article

References (67)

1. Abdel-Hamid KM, Tymianski M (1997) Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins. J Neurosci 17:3538-3553.
2. 2+ channels in cultured rat mesencephalic neurons. Naunyn Schmiedebergs Arch Pharmacol 362:440-443.
3. al Qatari M, Bouchenafa O, Littleton J (1998) Mechanism of action of acamprosate. Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex. Alcohol Clin Exp Res 22:810-814.
4. al Qatari M, Khan S, Harris B, Littleton J (2001) Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain. Alcohol Clin Exp Res 25:1276-1283.
5. Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ (2000) Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci 20:7871-7879.
6. 3H]glutamate binding sites in rat hippocampal membranes. J Neurochem 36:811-820.
7. B receptors in nucleus accumbens neurons. Alcohol Clin Exp Res 22:183-191.
8. Biala G, Kotlinska J (1999) Blockade of the acquisition of ethanol-induced conditioned place preference by N-methyl-D-aspartate receptor antagonists. Alcohol Alcohol 34:175-182.
9. Blaabjerg M, Kristensen BW, Bonde C, Zimmer J (2001) The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain Res 898:91-104.
10. Bruno V, Battaglia G, Copani A, Casabona G, Storto M, Gerevini VDG, Ngomba R, Nicoletti F (1998) Metabotropic glutamate receptors and neurodegeneration, in Progress in Brain Res, vol 116, pp 209-221. Elsevier Science BV, Amsterdam, The Netherlands.
11. Bruno V, Battaglia G, Copani A, D'Onofrio M, Di Iorio P, De Blasi A, Melchiorri D, Flor PJ, Nicoletti F (2001) Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. J Cereb Blood Flow Metab 21:1013-1033.
12. Cartmell J, Schoepp DD (2000) Regulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem 75:889-907.
13. Catania MV, De Socarraz H, Penney JB, Young AB (1994) Metabotropic glutamate receptor heterogeneity in rat brain. Mol Pharmacol 45:626-636.
14. Chiamulera C, Epping-Jordan MP, Zocchi A, Marcon C, Cottiny C, Tacconi S, Corsi M, Orzi F, Conquet F (2001) Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 4:873-874.
15. 3H]aspartate in human cerebellum. J Neurochem 47:1463-1468.
16. Dahchour A, De Witte P (2000) Ethanol and amino acids in the central nervous system: Assessment of the pharmacological actions of acamprosate. Prog Neurobiol 60:343-362.
17. Dahchour A, De Witte P, Bolo N, Nedelec JF, Muzet M, Durbin P, Macher JP (1998) Central effects of acamprosate. Part I. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats. Psychiatry Res 82:107-114.
18. Foster AC, Fagg G (1984) Acidic amino acid binding sites in mammalian neuronal membranes: Their characteristics and relationship to synaptic receptors. Brain Res Rev 7:103-164.
19. Foster AC, Wong EH (1987) The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain. Br J Pharmacol 91:403-409.
20. Garaschuk OV, Kovalchuk YN, Krishtal OA (1992) Trans-ACPD selectively inhibits excitability of hippocampal CA1 neurones. Eur J Pharmacol 212:305-306.
21. Gasparini F, Kuhn R, Pin JP (2002) Allosteric modulators of group-I metabotropic glutamate receptors: Novel subtype-selective ligands and therapeutic perspectives. Curr Opin Pharmacol 2:43-49.
22. Grant KA, Valverius P, Hudspith M, Tabakoff B (1990) Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol 176:289-296.
23. Harris BR, Blanchard JA, Holley RC, Gibson DA, Ha LB, Littleton JM (2001a) Putative interactions between acamprosate and metabotropic glutamate receptors in ethanol withdrawal (abstract). Soc Neurosci 27:Program No. 980.20.
24. Harris BR, Rogers DT, Littleton JM (2001b) Acamprosate and metabotropic glutamate receptors: A molecular match (abstract)? Alcohol Clin Exp Res 25:143.A.
25. Hermans E, Challiss J (2001) Structural, signaling and regulatory properties of the group I metabotropic glutamate receptors: Prototypic family C G-protein coupled receptors J Biochem 359:465-484.
26. Herrero I, Miras-Portugal MT, Sanchez-Prieto J (1992) Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation. Nature 360:163-166.
27. Koob GF, Mason BJ, De Witte P, Littleton J, Siggins GR (2002) Potential neuroprotective effects of acamprosate. Alcohol Clin Exp Res 26:586-592.
28. Lahtinen H, Autere A, Paalasmaa P, Lauri SE, Kaila K (2001) Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate. Neuroscience 105:131-137.
29. Littleton J (1995) Acamprosate in alcohol dependence: How does it work? Addiction 90:1179-1188.
30. Madamba SG, Schweitzer P, Zieglgänsberger W, Siggins GR (1996) Acamprosate (calcium acetylhomotaurinate) enhances the NMDA receptor component of excitatory transmission in rat hippocampal CA1 neurons in vitro. Alcohol Clin Exp Res 20:651-658.
31. Manev RM, Gabellini N, Manev H (1993) Polyamines modulate the function of transfected glutamate receptor mGluRla. Neuroreport 4:830-832.
32. Martín M, Sanz JM, Cubero A (1993) Characterization of metabotropic glutamate receptors coupled to a pertussis toxin sensitive G-protein in bovine brain coated vesicles. FEBS Lett 316:191-196.
33. Mason BJ (2001) Treatment of alcohol-dependent outpatients with acamprosate: A clinical review. J Clin Psychiatry 62(Suppl 20):42-48.
34. Mayer S, Harris B, Gibson DA, Blanchard J, Prendergast MA, Holley RC, Littleton J (2002) Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat. Alcohol Clin Exp Res 26:665-662.
35. McDonald JW, Schoepp DD (1992) The metabotropic glutamate receptor agonist 1S, 3R-ACPD selectively potentiates N-methyl-D-aspartate-induced brain injury. Eur J Pharmacol 215:353-354.
36. Monyer H, Giffard RG, Hartley DM, Dugan LL, Goldberg MP, Choi DW (1992) Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin. Neuron 8:967-973.
37. D-aspartate receptors. J Pharmacol Exp Ther 296:41-47.
38. Naassila K, Hammoumi S, Legrand E, Durbin P, Daoust M (1998) Mechanism of action of acamprosate. Part I. Characterization of spermidine sensitive acamprosate binding site in rat brain. Alcohol Clin Exp Res 22:802-809.
39. Nagy J, Müller F, Lászlo L (2001) Cytotoxic effect of alcohol-withdrawal on primary cultures of cortical neurons. Drug Alcohol Depend 61:155-162.
40. Netzeband JG, Schneeloch JR, Trotter C, Caguioa-Aquino JN, Gruol DL (2002) Chronic ethanol treatment and withdrawal alter ACPD-evoked calcium signals in developing Purkinje neurons. Alcohol Clin Exp Res 26:386-393.
41. Nicoletti F, Bruno V, Catania MV, Battaglia G, Copani A, Barbagallo G, Ceña V, Sanchez-Prieto J, Spano PF, Pizzi M (1999) Group-I metabotropic glutamate receptors: Hypotheses to explain their dual role in neurotoxicity and neuroprotection. Neuropharmacology 38:1477-1484.
42. Oillet J, Nicolas F, Koziel V, Duval JL (1995) Analysis of glutamate receptors in primary cultured neurons from fetal rat forebrain. Neurochem Res 20:761-768.
43. O'Leary DM, Movsesyan V, Vicini S, Faden AI (2000) Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131:1429-1437.
44. Popp RL, Lovinger D (2000) Interaction of acamprosate with ethanol and spermine on NMDA receptors in primary cultured neurons. Eur J Pharmacol 394:221-231.
45. Rammes G, Mahal B, Putzke J, Parsons C, Spielmanns P, Pestel E, Spanagel R, Zieglgänsberger W, Schadrack J (2001) The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology 40:749-760.
46. Sacaan Al, Schoepp DD (1992) Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. Neurosci Lett 139:77-82.
47. Saivin S, Hulot T, Chabac S, Potgeiter A, Durbin P, Houin G (1998) Clinical pharmacokinetics of acamprosate. Clin Pharmacokinet 35:331-345.
48. Sakaguchi T, Kuno M, Kawasaki K (1999) Protection of excitotoxic neuronal death by gluconate through blockade of N-methyl-D-aspartate receptors. Neuroscience 92:677-684.
49. Sakaguchi T, Okada M, Kuno M, Kawasaki K (1997) Dual mode of n-methyl-d-aspartate induced neuronal death in hippocampal slice cultures in relation to n-methyl-d aspartate receptor properties. Neuroscience 76:411-423.
50. Schoepp DD (1993) The biochemical pharmacology of metabotropic glutamate receptors. Biochem Soc Trans 21:97-102.
51. Schoepp D, Bockaert J, Sladeczek F (1990) Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors. Trends Pharmacol Sci 11:508-515.
52. Schoepp DD, Conn JP (1993) Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol Sci 14:13-20.
53. Schoepp DD, Johnson BG, True RA, Monn JA (1991) Comparison of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) and 1R,3S-ACPD-stimulated brain phosphoinositide hydrolysis. Eur J Pharmacol 207:351-353.
54. 3H]glutamate receptor binding in membranes. Neurosci Lett 145:100-104.
55. 5 receptors and CNS disorders. Trends Pharmacol Sci 22:331-337.
56. Stoppini L, Buchs PA, Muller D (1991) A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37:173-182.
57. Thomas MP, Morrisett RA (2000) Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal. Neuropharmacology 39:218-226.
58. Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49:173-184.
59. Varney MA, Cosford NDP, Jachec C, Rao SP, Sacaan A, Lin F, Bleicher L, Santori EM, Flor PJ, Allgeier H, Gasparini F, Kuhn R, Hess SD, Velicelebi G, Johnson EC (1999) SIB-1757 and SIB-1893: Selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther 290:170-181.
60. Widdowson PS, Trainor A, Lock (1995) NMDS receptors in rat cerebellum and forebrain: Subtle differences in pharmacology and modulation. J Neurochem 64:651-661
61. Winter HC, Ueda T (1993) Glutamate uptake system in the presynaptic vesicle: Glutamic acid analogs as inhibitors and alternate substrates. Neurochem Res 18:79-85.
62. 3H]glutamate binding sites in the rat brain. J Neurochem 63:938-945.
63. Wroblewska B, Wroblewski JT, Pshenichkin S, Surin A, Sullivan SE, Neale JH (1997) N-acetylaspartylglutamate selectively activates mGluR 3 receptors in transfected cells. J Neurochem 69:174-181.
64. Wu JY, Jin H, Schloss JV, Faiman MD, Ningaraj NS, Foos T, Chen W (2001) Neurotoxic effect of acamprosate, N-acetyl homotaurine, in cultured neurons. J Biomed Sci 8:96-103.
65. Zahorodna A, Palucha A, Bijak M (1998) Comparison of the effects of low and high concentrations of group I metabotropic receptor agonists on field potentials in the hippocampal CA1 region in vitro. Pol J Pharmacol 50:291-298.
66. Zeise ML, Kasparov S, Capogna M, Ziegelgänsberger W (1993) Acamprosate (calcium acetylhomotaurinate) decreases postsynaptic potentials in the rat neocortex: Possible involvement of excitatory amino acid receptors. Eur J Pharmacol 231:47-52.
67. Zimmer J, Gähwiler BH (1984) Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentate. J Comp Neurol 228:432-446.