Chronic ethanol increases N-Methyl-D-aspartate-stimulated nitric oxide formation but not receptor density in cultured cortical neurons

Molecular Pharmacology

Volumn 51, Issue 5, 1997, Pages 733-740

  Chandler, L Judson ^a   Sutton, Greg ^a   Norwood, Dean ^a   Sumners, Colin ^b   Crews, Fulton T ^c  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; N METHYL DEXTRO ASPARTIC ACID; NITRIC OXIDE;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOL WITHDRAWAL; ANIMAL TISSUE; ARTICLE; FEMALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY;

EID: 0031010080     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.51.5.733     Document Type: Article

References (40)

1. Moncada, S., and A. Higgs. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329:2002-2012 (1993).
2. Chandler, L. J., N. J. Guzman, C. Sumners, and F. T. Crews. Magnesium and zinc potentiate ethanol inhibition of N-methyl-D-aspartate-stimulated nitric oxide synthase in cortical neurons. J. Pharmacol. Exp. Ther. 271: 67-75 (1994).
3. Collingridge, G. L., and R. A. Lester. Excitatory amino acids in the vertebrate central nervous system. Pharmacol. Rev. 41:143-210 (1989).
4. Dawson, T. M., and S. H. Snyder. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J. Neurosci. 14:5247-5159 (1994).
5. Crews, F., T., L. Morrow, H. Criswell, and G. Breese. Ethanol effects on ion channels. Int. Rev. Neurobiol. 39:283-367 (1996).
6. Iorio, K. R., L. Reinlib, B. Tabakoff, and P. L. Hoffman. Chronic exposure of cerebral granule cells to ethanol results in increased N-methyl-D-aspartate receptor function. Mol. Pharmacol. 41:1142-1148 (1992).
7. Hu, X.-J., and M. K. Ticku. Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons. Mol. Brain Res. 30:347-356 (1995).
8. Chandler, L. J., H. Newsom, C. Sumner, and F. Crews. Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. J. Neurochem. 60:1578-1581 (1993).
9. Crews, F. T., and L. J. Chandler. Excitotoxicity and the neuropathology of ethanol, in Alcohol Induced Brain Damage (W. Hunt and S. J. Nixon, eds.). National Institutes of Health, Bethesda, MD, NIH publication no. 93-3549, 355-371 (1993).
10. Khanna, J. M., G. S. Morato, G. Shah, A. Chau, and H. Kalant. Inhibition of nitric oxide synthesis impairs rapid tolerance to ethanol. Brain Res. Bull. 32:43-47 (1993).
11. Khanna, J. M., G. S. Morato, A. Chau, and G. Shah. Influence of nitric oxide synthase inhibition on the development of rapid tolerance to ethanol. Brain. Res. Bull. 37:599-604 (1995).
12. Adams, M. L., J. B. Forman, J. M. Kalicki, E. R. Meyer, B. Sewing, and T. J. Cicero. Antagonism of alcohol-induced suppression of rat testosterone secretion by an inhibitor of nitric oxide synthase. Alcohol. Clin. Exp. Res. 17:660-664 (1993).
13. Adams, M. L., B. N. Sewing, J. Chen, E. R. Meyer, and T. J. Cicero. Nitric oxide-related agents alter alcohol withdrawal in male rats. Alcohol. Clin. Exp. Res. 19:195-199 (1995).
14. Chou, Y.-C., W. G. Lutke, and C. Sumners. Characterization of glucocorticoid type II receptors in neuronal and glial cultures from rat brain. J. Neuroendocrinol. 2:29-38 (1990).
15. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T. Nature (Lond.) 227:680-685 (1970).
16. Williams, K., M. A. Dichter, and P. B. Molinoff. Up-regulation of N-methyl-D-aspartate receptors on cultured cortical neurons after exposure to antagonists. Mol. Pharmacol. 42:147-151 (1992).
17. Wang, Y.-H., T. Z. Bosy, R. P. Yasuda, D. R. Grayson, S. Vicini, T. Pizzorusso, and B. B. Wolfe. Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain ontogenic profile in the cerebellum. J. Neurochem. 65:176-183 (1995).
18. Charness, M. E., A. S. Gordon, and I. Diamond. Ethanol modulation of opiate receptors in cultured neural cells. Science (Washington D. C.) 222: 12461248 (1983).
19. Fitzgerald, L. W., M. E. Charlton, R. S. Duman, and E. J. Nestler. Regulation of neuronal nitric oxide synthase by chronic ethanol ingestion. Synapse 21:93-95 (1995).
20. Ahern, K. B., H. S. Lustig, and D. A. Greenberg. Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol. Neurosci Lett. 165:211-214 (1994).
21. Grant, K. A., P. Valverius, M. Hudspith, and B. Tabakoff. Ethanol withdrawal seizures and the NMDA receptor complex. Eur. J. Pharmacol. 176:289-296 (1990).
22. Morrisett, R. A., A. H. Rezvani, D. Overstreet, D. S. Janowsky, W. A. Wilson, and H. S. Swartzwelder. MK-801 potently inhibits alcohol withdrawal seizures in rats. Eur. J. Pharmacol. 176:103-105 (1990).
23. Liljequist, S. The competitive NMDA receptor antagonist, CGP 39551, inhibits ethanol withdrawal seizure. Eur. J. Pharmacol. 192:197-198 (1991).
24. Gulya, K., K. A. Grant, P. Valverius, P. L. Hoffman, and B. Tabakoff. Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res. 547:129-134 (1991).
25. Snell, L. D., B. Tabakoff, and P. L. Hoffman. Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion. Brain Res. 602:91-98 (1993).
26. 3H]MK-801 binding sites following chronic ethanol consumption. Alcohol. Clin. Exp. Res. 18:1004-1008 (1994).
27. Carter, L. A., J. K. Belnap, J. C. Crabbe, and A. Janowsky. Allosteric regulation of the N-methyl-D-aspartate receptor-linked ion channel complex and effects of ethanol-withdrawal seizure-prone and-resistant mice. J. Neurochem. 64:213-219 (1995).
28. Trevisan, L., L. W. Fitzgerald, N. Brose, G. P. Gasic, S. F. Heinemann, R. S. Duman, and E. J. Nestler. Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J. Neurochem. 62:1635-1638 (1994).
29. Follesa, P., and M. K. Ticku. Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain. Mol. Brain Res. 29:99-106 (1995).
30. Ortiz, J., L. W. Fitzgerald, M. Charlton, S. Lane, L. Trevisan, X. Guitart, W. Shoemaker, R. S. Duman, and E. J. Nestler. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 21:289-298 (1995).
31. Seeberg, P. H. The molecular biology of mammalian glutamate receptor channels. Trends Pharmacol. Sci. 14:297-303 (1993).
32. Masood, K., C. Wu, C. Y. Brauneis, and F. F. Weight. Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol. Pharmacol. 45:324-329 (1994).
33. Nakanishi, S. Molecular diversity of glutamate receptors and implications for brain function. Science (Washington D. C.) 258:597-603 (1992).
34. Koltchine, V., V. Anantharam, A. Wilson, H. Bayley, and S. N. Treistman. Homomeric assemblies of NMDAR1 splice variants are sensitive to ethanol. Neurosci. Lett. 152:13-16 (1993).
35. Kumar, K. N., N. Tilakaratne, P. S. Johnson, A. E. Allen, and E. K. Michaelis. Isolation of the NMDA receptor complex and cloning of cDNA for the glutamate-binding subunit. Nature (Lond.) 354:70-73 (1991).
36. 2+ block of NMDA-receptor channels as a mechanism of modulation. Nature (Lond.) 356:521-523 (1992).
37. 2+-dependent phosphatase. Nature (Lond.) 369:235-239 (1994).
38. Wang, Y. T., and M. W. Salter. Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature (Lond.) 369:233-235 (1994).
39. Wang, L.-Y., B. A. Orser, D. L. Brautigan, and J. F. MacDonald. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature (Lond.) 369:230-232 (1994).
40. 2+-independent reduction of N-methyl-D-aspartate channel activity by protein tyrosine phosphatase. Proc. Natl. Acad. Aci. USA 93:1721-1725 (1996).