Chronic ethanol upregulates NMDA and AMPA, but not kainate receptor subunit proteins in rat primary cortical cultures

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 2, 1999, Pages 363-370

  Chandler, L Judson ^a   Norwood, Dean ^a   Sutton, Greg ^a  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

AMPA; Chronic Ethanol; Glutamine; Kainate; NMDA

Indexed keywords

ALCOHOL; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; EXCITATORY AMINO ACID RECEPTOR; GLUTAMINE; KAINIC ACID; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR PROTEIN; RECEPTOR SUBUNIT;

ALCOHOL WITHDRAWAL; ALCOHOLISM; ANIMAL CELL; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; FEMALE; NERVE CELL CULTURE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SYNAPTIC TRANSMISSION;

EID: 0033058120     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04123.x     Document Type: Article

References (36)

1. Seeburg PH: The molecular biology of mammalian glutamate receptor channels. Trends Pharmacol Sci 14:297-303, 1993
2. Crews FT, Morrow AL, Criswell H, Breese G: Effects of ethanol on ion channels. Int Rev Neurobiol 39:283-367, 1996
3. Lovinger DM: Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: Relation to the actions of ifenprodil. J Pharmacol Exp Ther 274:164-172, 1995
4. Masood K, Wu C, Brauneis U, Weight FF: Differential ethanol sensitivity of recombinant N-methyl-D-aspartate receptor subunits. Mol Pharmacol 54:324-329, 1994
5. Iorio KA, Reinlib L, Tabakoff B, Hoffman PL: Chronic exposure of cerebellar granule cells to ethanol results in increased NMDA receptor function. Mol Pharmacol 41:1142-1148, 1992
6. Smothers CT, Mrotek JJ, Lovinger DM: Chronic ethanol exposure leads to a selective enhancement of N-methyl-D-aspartate receptor function in cultured hippocampal neurons. J Pharmacol Exp Ther 283:1214-1222, 1997
7. Ahern KB, Lustig HS, Greenberg DA: Enhancement of NMDA toxicity and calcium responses by chronic ethanol. Neurosci Lett 165:211-214, 1994
8. Blevins T, Mirshahi T, Woodward JJ: Increased agonist and antagonist sensitivity of N-methyl-D-aspartate-stimulated calcium flux in cultured neurons following chronic ethanol exposure. Neurosci Lett 200:214-218, 1995
9. Hu X-J, Ticku MK: Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons. Mol Brain Res 3:347-356, 1995
10. Chandler LJ, Sutton G, Norwood D, Sumners C, Crews FT: Chronic ethanol increases N-methyl-D-aspartate stimulated nitric oxide formation but not receptor density in cultured cortical neurons. Mol Pharmacol 51:733-740, 1997
11. Navamani M, Morgan M, Williams RJ: Ethanol modulates N-methyl-D-aspartate-evoked arachidonic acid release from neurons. Eur J Pharmacol 340:27-34, 1997
12. Iorio KR, Tabakoff B, Hoffman PL: Glutamate-induced neurotoxicity is increased in cerebellar granule cells exposed chronically to ethanol. Eur J Pharmacol 248:209-212, 1993
13. Chandler LJ, Newson H, Sumners C, Crews FT: Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons. J Neurochem 60:1578-1581, 1993
14. Grant KA, Valverius P, Hudspith M, Tabakoff B: Ethanol withdrawal seizures and the NMDA receptor complex. Eur J Pharmacol 176:289-296, 1990
15. Gulya K, Grant KA, Valverius P, Hoffman PL, Tabakoff B: Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal. Brain Res 547:129-134, 1991
16. Snell LD, Tabakoff B, Hoffman PL: Radioligand binding to the NMDA receptor/ionphore complex: Alterations by ethanol in vitro and chronic in vivo ethanol ingestion. Brain Res 602:91-98, 1993
17. Trevisan L, Fitzgerald LW, Brose N, Gasic GP: Chronic ingestion of ethanol upregulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus. J Neurochem 62:1635-1638, 1994
18. Follesa P, Ticku MK: Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture. J Biol Chem 271:13297-13299, 1996
19. Carter LA, Belfnap JK, Crabbe JC, Janowsky A: Allosteric regulation of the N-methyl-D-aspartate receptor linked ion channel complex and effects of ethanol in ethanol-withdrawal seizure prone and -resistant mice. J Neurochem 1995:213-219, 1995
20. Rudolph JG, Walker DW, Iimuro Y, Thurman RG, Crews FT: NMDA receptor binding in adult rat brain after several chronic ethanol treatment protocols. Alcohol Clin Exp Res 21:1508-1519, 1997
21. 3H]MK-801 binding sites following chronic ethanol consumption. Alcohol Clin Exp Res 18:1004-1008, 1994
22. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T. Nature 227, 1970
23. Follesa P, Ticku MK: NMDA receptor upregulation: Molecular studies in cultured mouse cortical neurons after chronic antagonist exposure. J Neurosci 16:2172-2178, 1996
24. Wang Y-H, Bosy TZ, Yasuda RP, Grayson DR, Vicini S, Pizzorusso T, Wolfe BB: Characterization of NMDA receptor subunit-specific antibodies: Distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum. J Neurochem 65:176-183, 1995
25. Dildy-Mayfield JE, Harris RA: Ethanol inhibits kainate responses of glutamate receptors in Xenopus oocytes: Role of calcium and protein kinase C. J Neurosci 15:3162-3171, 1995
26. Didly-Mayfield JE, Harris RA: Comparison of ethanol sensitivity of brain kainate, α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid, and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 262:487-494, 1992
27. Martin D, Tayyeb MI, Swartzwelder HS: Ethanol inhibition of AMPA and kainate receptor-mediated depolarizations of hippocampal area CA1. Alcohol Clin Exp Res 19:1312-1316, 1995
28. Lovinger DM: High ethanol sensitivity of recombinant AMPA-type glutamate receptors expressed in mammalian cells. Neurosci Lett 159:83-87, 1993
29. Weight FF, Peoples RW, Wright JM, Lovinger DM, White G: Ethanol action on excitatory amino acid activated ion channels. Alcohol Alcohol 2:353-358, 1993
30. Chandler LJ, Guzman NJ, Sumners C, Crews FT: Magnesium and zinc potentiates ethanol inhibition of N-methyl-D-aspartate-stimulated nitric oxide synthase in cortical neurons. J Pharmacol Exp Ther 271:67-75, 1994
31. Ortiz J, Fitzgerald LW, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman RS, Nestler EJ: Biochemical actions of chronic ethanol exposure in the mesolimbic dopmaine system. Synapse 21:289-298, 1995
32. Breese CR, Freedman R, Leonard SS: Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res 674:82-90, 1995
33. Hamberger AC, Chiang GH, Nylen ES, Scheff SW, Cotman CW: Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res 168:513-530, 1979
34. Bradford HF, Ward HK, Thomas AJ: Glutamine - A major substrate for nerve endings. J Neurochem 30:1453-1459, 1978
35. 2+ concentrations. J Neurochem 44:1724-1731, 1985
36. Goldberg MP, Monyer H, Choi DW: Hypoxic neuronal injury in vitro depends on extracellular glutamine. Neurosci Lett 94:52-57, 1988