Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment

Molecular Brain Research

Volumn 58, Issue 1-2, 1998, Pages 221-224

  Kalluri, Haviryaji S G ^a   Mehta, Ashok K ^a   Ticku, Maharaj K ^a  

^a University of Texas Health Science Center at San Antonio   (United States)

Author keywords

Chronic ethanol treatment; NMDA receptor subunit; Up regulation

Indexed keywords

ALCOHOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POLYPEPTIDE;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; IMMUNOBLOTTING; LONG TERM EXPOSURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT;

ALCOHOLISM; ANIMALS; CEREBRAL CORTEX; HIPPOCAMPUS; MACROMOLECULAR SUBSTANCES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RNA, MESSENGER; SUBSTANCE WITHDRAWAL SYNDROME; UP-REGULATION;

EID: 0032528124     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(98)00112-0     Document Type: Article

References (22)

1. X. Chen, M.L. Michaelis, E.K. Michaelis, Effects of chronic ethanol treatment on the expression of calcium transport carriers and NMDA/glutamate receptor proteins in brain synaptic membranes, J. Neurochem. 69 (1997) 1559-1569.
2. P. Follesa, M.K. Ticku, Chronic ethanol treatment differentially regulates NMDA receptor subunit mRNA expression in rat brain, Mol. Brain Res. 29 (1995) 99-106.
3. P. Follesa, M.K. Ticku, Chronic ethanol-mediated up-regulation of the N-methyl-D-aspartate receptor polypeptide subunits in mouse cortical neurons in culture, J. Biol. Chem. 271 (1996) 13297-13299.
4. K.A. Grant, P. Valverius, M. Hudspith, B. Tabakoff, Ethanol withdrawal seizures and the NMDA receptor complex, Eur. J. Pharmacol. 176 (1990) 289-296.
5. K. Gulya, K.A. Grant, P. Valverius, P.L. Hoffman, B. Tabakoff, Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal, Brain Res. 547 (1991) 129-134.
6. P.L. Hoffman, C.S. Rabe, F. Moses, B. Tabakoff, N-Methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production, J. Neurochem. 52 (1989) 1937-1940.
7. X.-J. Hu, M.K. Ticku, Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons, Mol. Brain Res. 30 (1995) 347-356.
8. X.-J. Hu, P. Follesa, M.K. Ticku, Chronic ethanol treatment produces a selective upregulation of the NMDA receptor subunit gene expression in mammalian cultured cortical neurons, Mol. Brain Res. 36 (1996) 211-218.
9. K.R. Iorio, L. Reinlib, B. Tabakoff, P.L. Hoffman, Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function, Mol. Pharmacol. 41 (1992) 1142-1148.
10. T. Ishii, K. Moriyoshi, H. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi, C. Akazawa, R. Shigemoto, N. Mizuno, M. Masu, S. Nakanishi, Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits, J. Biol. Chem. 268 (1993) 2836-2843.
11. M. Kumari, M.K. Ticku, Ethanol and regulation of the NMDA receptor subunits in fetal cortical neurons, J. Neurochem. 70 (1998) 1467-1473.
12. T. Kutsuwada, N. Kashiwabuchi, H. Mori, K. Sakimura, E. Kushiya, K. Araki, H. Meguro, H. Masaki, T. Kumanishi, M. Arakawa, M. Mishina, Molecular diversity of the NMDA receptor channel, Nature 358 (1992) 36-41.
13. U.K. Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227 (1970) 680-685.
14. D.J. Laurie, P.H. Seeburg, Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA, J. Neurosci. 14 (1994) 3180-3194.
15. D.M. Lovinger, G. White, F.F. Weight, Ethanol inhibits NMDA activated ion channels in hippocampal neurons, Science 243 (1989) 1721-1724.
16. A.K. Mehta, M.K. Ticku, Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites, Brain Res. 489 (1989) 93-100.
17. H. Mori, M. Mishina, Structure and function of the NMDA receptor channel, Neuropharmacology 34 (1995) 1219-1237.
18. L.D. Snell, B. Tabakoff, P.L. Hoffman, Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion, Brain Res. 602 (1993) 91-98.
19. H. Towbin, T. Staehelin, J. Gordon, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc. Natl. Acad. Sci. USA 76 (1979) 4350-4354.
20. L. Trevisan, L.W. Fitzgerald, N. Brose, G.P. Gasic, S.F. Heinemann, R.S. Duiman, E.J. Nestler, Chronic ingestion of ethanol up-regulates NMDAR1 receptor subunit immunoreactivity in rat hippocampus, J. Neurochem. 62 (1994) 1635-1638.
21. Y. Wang, T.Z. Bosy, R.P. Yasuda, D.R. Grayson, S. Vicini, T. Pizzorusso, B.B. Wolfe, Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum, J. Neurochem. 65 (1995) 176-183.
22. G. White, D.M. Lovinger, F.F. Weight, Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron, Brain Res. 507 (1990) 332-336.