The neuroprotective effect of the forebrain-selective NMDA antagonist CP101,606 upon focal ischemic brain damage caused by acute subdural hematoma in the rat

Journal of Neurotrauma

Volumn 14, Issue 6, 1997, Pages 409-417

  Tsuchida, Eiji ^a   Rice, Melody ^a   Bullock, Ross ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute subdural hematoma; Ischemic brain damage; NMDA antagonist; Rat

Indexed keywords

4 (3 PHOSPHONOALLYL) 2 PIPERAZINECARBOXYLIC ACID; 4 PHOSPHONOMETHYLPIPECOLIC ACID; 6,7 DICHLORO 5 NITRO 2,3 QUINOXALINEDIONE; DEXTROMETHORPHAN; DIZOCILPINE; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; SIPATRIGINE; TRAXOPRODIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG SELECTIVITY; FOREBRAIN; MALE; NEUROPROTECTION; NONHUMAN; RAT; SUBDURAL HEMATOMA;

EID: 0030832277     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.1997.14.409     Document Type: Article

References (43)

1. ADAMS, J.H., GRAHAM, D.I., and GENNARELLI, T.A. (1983). Head injury in man and experimental animals: Neuropathology. Acta Neurochir. Suppl. 32, 15-30.
2. BOUMA G.J., MUIZELAAR, J.P., STRINGER, W.A., CHOI, S.C., FATOUROS, P., and YOUNG, H.F. (1992). Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography. J. Neurosurg. 77, 360-368.
3. BRIERLEY, J.B., MELDRUM, B.S., and BROWN, A.W. (1973). The threshold and neuropathology of cerebral "anoxic-ischemic" cell change. Arch. Neurol. 29, 367-374.
4. BULLOCK, R., and FUJISAWA, H. (1992). The role of glutamate antagonists for the treatment of CNS injury. J. Neurotrauma 9, S443-462.
5. BULLOCK, R., and TEASDALE, G. (1990). Surgical management of traumatic intracranial hematomas, in: Handbook of Clinical Neurology. Head Injury, Vol. 57. R. Braakman (ed). Elsevier, Amsterdam, pp. 249-297.
6. BULLOCK, R., BUTCHER, S.P., CHEN, M.H., KENDALL, L., and MCCULLOCH, J. (1991). Extracellular glutamate concentration correlates with the extent of blood flow reduction after subdural hematoma in the rat. J. Neurosurg. 74, 794-802.
7. CHEN, M.H., BULLOCK, R., GRAHAM, D.I., MILLER, J.D., and MCCULLOCH, J. (1991). Ischemic neuronal damage after acute subdural hematoma in the rat: effects of pretreatment with a glutamate antagonist. J. Neurosurg. 74, 944-950.
8. CHENARD, B.L., BORDNER, T.W., CHAMBERS, L.K., COLLINS, M.A., et al. (1995). (1S,2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phyenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-Methyl-D-aspartate responses. J. Med. Chem. 38, 3138-3145.
9. 125Iodo-MK801 binding after subdural hematoma in the rat: an in vivo autoradiographic study. J. Neurosurg. (in press)
10. DI, X., BULLOCK, R., WATSON, J., FATOUROS, P., et al. (1996). The effect of CP101,606, a novel NR2B subunit anagonist of the NMDA receptor, upon the volume of ischemic brain damage and brain cytotoxic edema following middle cerebral artery occlusion in the feline brain. Stroke. (submitted).
11. DUHAIME, A.C., GENNARELLI, L.M., and BOARDMAN, C. (1996a). Neuroprotection by Dextromethorphan in acute experimental subdural hematoma in the rat. J. Neurotrauma 13, 79-84.
12. DUHAIME, A.C., GENNARELLI, L.M., and YACHNIS, A. (1996b). Acute subdural hematoma: is the blood itself toxic? J. Neurotrauma 11, 669-678.
13. GENNARELLI, T.A., SPIELMAN, G.M., LANGFITT, T.W., GILDENBERG, P.L., HARRINGTON, T., JANE, J.A., MARSHALL, L.F., MILLER, J.D., and PITTS, L.H. (1982). Influence of the type of intracranial lesion on outcome severe head injury. A multicenter study using a new classification system. J. Neurosurg. 56, 26-32.
14. GOTTI, B., DUVERGER, D., BERTIN, D. et al. (1988). Ifenprodil and SL 82075 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. J. Pharmacol. Exp. Ther. 247, 1211-1221.
15. GRAHAM, D.I., ADAMS, J.H., and DOYLE, D. (1978). Ischemic brain damage in fatal non-missile head injuries. J. Neurol. Sci. 39, 213-234.
16. GRAHAM, S.H., CHEN, J., LAN, J. et al. (1994). Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J. Pharmacol. Exp. Ther. 269, 854-859.
17. GROTTA, J. (1994). Safety and tolerability of the glutamate antagonist CGS 19755 in acute stroke patients. Stroke 25, 255.
18. HASELSBERGER, K., PUCHER, R., and AUER, L.M. (1988). Prognosis after acute subdural or epidural hemorrhage. Acta. Neurochir. (Wien), 111-116.
19. INGLIS, F., KURODA, Y., and BULLOCK, R. (1992). Glucose hypermetabolism after acute subdural hematoma is ameliorated by a competitive NMDA antagonist. J. Neurotrauma 9, 75-84.
20. KLUN, B., and FETTICH, M. (1984). Factors influencing the outcome in acute subdural haematoma. Acta Neurochir. (Wien) 71, 171-178.
21. KOEK, W., and COLPAERT, F.C. (1989). Selective blockade of N-methyl-D-aspartate (NMDA)-induced convulsions by NMDA antagonists and putative glycine antagonists: Relationship with phencyclidine-like behavioral effects. J. Pharmacol. Exp. Ther. 252, 349-357.
22. KOEK, W., WOODS, J.H., and WINGER, G.D. (1988). MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. J. Pharmacol. Exp. Ther. 245, 969-974.
23. KOENIG, J.F.R., and KLIPPEL, R.A. (1963). The Rat Brain. A Stereotactic Atlas. Forebrain and Lower Parts of the Brain Stem. Williams & Wilkins, Baltimore, MD.
24. KURODA, Y., and BULLOCK, R. (1992). Failure of cerebral blood flow-metabolism coupling after acute subdural hematoma in the rat. Neurosurgery 31, 1062-1071.
25. KURODA, Y., INGLIS, F.M., MILLER, J.D., MCCULLOCH, J., GRAHAM, D.I., and BULLOCK, R. (1992). Transient glucose hypermetabolism after acute subdural hematoma in the rat. J. Neurosurg. 76, 471-477.
26. KURODA, Y., FUJISAWA, H., STREBEL, S., GRAHAM, D.I., and BULLOCK, R. (1994). Effect of neuroprotective N-methyl-D-aspartate anagonists on increased intracranial pressure: Studies in the rat acute subdural hematoma model. Neurosurgery 35, 106-112.
27. LEACH, M.J., SWAN, J.H., EISENTHAL, D., et al. (1993). BW 619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24, 1063-1067.
28. MACPHERSON, P., and GRAHAM, D.I. (1978). Correlation between angiographic findings and the ischemia of head injury. J. Neurol. Neurosurg. Psychiatry 41, 122-127.
29. MENNITI, F., CHENARD, B., COLLINS, M., DUCAT, M., SHALABY, I., and WHITE, F. (1996). CP101,606, a potent neuroprotectant selective for forebrain neurons. Eur. J. Pharmacol. (in press).
30. MILLER, J.D., BULLOCK, R., GRAHAM, D.I., CHEN, M.H., and TEASDALE, G.M. (1990). Ischemic brain damage in a model of acute subdural hematoma. Neurosurgery 27, 433-439.
31. MILLER, J.D., BUTTERWORTH, J.F., GUDEMAN, S.K. et al. (1981). Further experience in the management of severe head injury. J. Neurosurg. 54, 289-299.
32. OSBORNE, K.A., SHIGENO, T., BALARSKY, A.M., et al. (1990). Quantitative assessment of early brain damage in a rat model of focal cerebral ischemia. J. Neurol. Neurosurg. Psychiatry 50, 402-410.
33. PHUENPATHOM, N., CHOOMUANG, M., and RATANALERT, S. (1993). Outcome and outcome prediction in acute subdural hematoma. Surg. Neurol. 40, 22-25.
34. SALVANT, J.B., and MUIZELAAR, J.P. (1993). Changes in cerebral blood flow and metabolism related to the presence of subdural hematoma. Neurosurgery 33, 387-393.
35. SEELIG, J.M., BECKER, D.P., MILLER, J.D., GREENBERG, R.P., WARD, J.D., and CHOI, S.C. (1981). Traumatic acute subdural hematoma. Major mortality reduction in comatose patients treated within four hours. N. Engl. J. Med. 304, 1511-1518.
36. SHEMKIN, H.A. (1982). Acute subdural hematoma. Review of 39 consecutive cases with high incidence of cortical artery rupture. J. Neurosurg. 57, 254-257.
37. SMITH, S.E., LEKIEFFRE, D., SOWINSKI, P., et al. (1993). Cerebroprotective effect of BW619C89 after focal or global cerebral ischaemia inthe rat. NeuroReport 4, 1339-1342.
38. STONE, J.L., RIFAI, M.H.S., SUGAR, O., LANG, R.G.R., OLDERSHAW, J.B., and MOODY, R.A. (1983). Subdural hematoma. I. Acute subdural hematoma: progress in definition, clinical pathology, and therapy. Surg Neurol 19, 216-231.
39. STONE, J.L., LOWE, R.J., JONASSON, O., et al. (1986). Acute subdural hematoma: direct admission to a trauma center yield improved results. J. Trauma 26, 445-450.
40. TSUCHIDA, E., and BULLOCK, R. (1995). The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA 1021 on ischemic brain damage cused by acute subdural hematoma in the rat. J. Neurotrauma 12, 279-288.
41. TSUCHIDA, E., HARMS, J., WOODWARD, J., and BULLOCK, R. (1996). A use-dependent sodium channel antagonist, 619C89, in reduction of ischemic brain damage and glutamate release after acute subdural hematoma in the rat. J. Neurosurg. 85, 104-111.
42. WAGSTAFF, A., TEASDALE, G.M., CLIFTON, G., and STEWART, L. (1995). The cerebral hemodynamic and metabolic effects of the noncompetitive NMDA antagonist CNS 1102 in humans with severe head injury. Ann. N.Y. Acad. Sci. 765, 332-333.
43. WILBERGER, J.E., HARRIS, M., and DIAMOND, D.L. (1991). Acute subdural hematoma: morbidity, mortality, and operative timing. J. Neurosurg. 74, 212-218.