Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: Correlation with restricted localisation of NR2B subunit in dorsal horn

Neuropharmacology

Volumn 38, Issue 5, 1999, Pages 611-623

  Boyce, S ^a   Wyatt, A ^a   Webb, J K ^a   O'Donnell, R ^a   Mason, G ^a   Rigby, M ^a   Sirinathsinghji, D ^a   Hill, R G ^a   Rupniak, N M J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Hyperalgesia; N methyl D aspartate; Neuropathic pain; NR2B antagonists

Indexed keywords

3 AMINO 1 HYDROXY 4 METHYL 2 PYRROLIDINONE; 4 BENZYL ALPHA (4 HYDROXYPHENYL) BETA METHYL 1 PIPERIDINEPROPANOL; 7 CHLORO 4 HYDROXY 3 (3 PHENOXYPHENYL) 2 QUINOLONE; DIZOCILPINE; GABAPENTIN; IFENPRODIL; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; TRAXOPRODIL; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; IMMUNOCHEMISTRY; IMMUNOCYTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MOTOR DYSFUNCTION; NEURALGIA; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; RAT; RECEPTOR DENSITY; SPINAL CORD DORSAL HORN;

ACETIC ACIDS; AMINES; ANIMALS; ANTICONVULSANTS; CYCLOHEXANECARBOXYLIC ACIDS; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; MALE; MOTOR ACTIVITY; PAIN MEASUREMENT; PHENOLS; PIPERIDINES; PYRROLIDINONES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD; TRIAZINES;

EID: 0032987252     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(98)00218-4     Document Type: Article

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