Second-order fear conditioning prevented by blocking NMDA receptors in amygdala

Nature

Volumn 388, Issue 6641, 1997, Pages 471-474

  Gewirtz, Jonathan C ^a   Davis, Michael ^a  

^a YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ARTICLE; CONDITIONING; CONTROLLED STUDY; FEAR; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REINFORCEMENT;

2-AMINO-5-PHOSPHONOVALERATE; AMYGDALA; ANIMALS; CONDITIONING, CLASSICAL; FEAR; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; STARTLE REACTION;

ANIMALIA;

EID: 0030802884     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/41325     Document Type: Article

References (30)

1. Bannerman, D. M., Good, M. A., Butcher, S. P., Ramsey, M. & Morris, R. G. M. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378, 182-186 (1995).
2. Hatfield, T. & Gallagher, M. Taste-potentiated odor conditioning: Impairment produced by infusion of an N-methyl-D-aspartate antagonist into basolateral amygdala. Behav. Neurosci. 109, 663-668 (1995).
3. Kim, J. J., DeCola, J. P., Landeira-Fernandez, J. & Fanselow, M. S. N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning. Behav. Neurosci. 105, 125-133 (1991).
4. Kim, M. & McGaugh, J. L. Effects of intra-amygdala injections of NMDA receptor antagonists on acquisition and retention of inhibitory avoidance. Brain Res. 585, 35-48 (1992).
5. Izquierdo, I. & Medina, J. H. Correlation between the pharmacology of long-term potentiation and the pharmacology of memory. Neurobiol. Learn. Mem. 63, 19-32 (1995).
6. Miserendino, M. J. D., Sananes, C. B., Melia, K. R. & Davis, M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345, 716-718 (1990).
7. Burns, L. H., Everitt, B. J. & Robbins, T. W. Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 impairs acquisition but not performance of discriminated approach to an appetitive CS. Behav. Neural Biol. 61, 242-250 (1994).
8. Staubli, U., Thibault, O., DiLorenzo, M. & Lynch, G. Antagonism of NMDA receptors impairs acquisition but not retention of olfactory memory. Behav. Neurosci. 103, 54-60 (1989).
9. Servatius, R. J. & Shors, T. J. Early acquisition, but not retention, of the classically conditioned eyeblink response is N-methyl-D-aspartate (NMDA) receptor dependent. Behav. Neurosci. 110, 1040-1048 (1996).
10. Saucier, D. & Cain, D. P. Spatial learning without NMDA receptor-dependent long-term potentiation. Nature 378, 186-189 (1995).
11. Keith, J. R. & Rudy, J. W. Why NMDA-receptor-dependent long-term potentiation may not be a mechanism of learning and memory: Reappraisal of the NMDA-receptor blockade strategy. Psychobiology 18, 251-257 (1990).
12. Caramanos, Z. & Shapiro, M. L. Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: Memory impairments depend on familiarity with the environment, drug dose, and training duration. Behav. Neurosci. 108, 30-43 (1994).
13. Campeau, S., Miserendino, M. J. D. & Davis, M. Intra-amygdala infusion of N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus. Behav. Neurosci. 106, 569-574 (1992).
14. Fanselow, M. S. & Kim, J. J. Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala. Behav. Neurosci. 108, 210-212 (1994).
15. Li, X. F., Phillips, R. & LeDoux, J. E. NMDA and non-NMDA receptors contribute to synaptic transmission between the medial geniculate body and the lateral nucleus of the amygdala. Exp. Brain Res. 105, 87-100 (1995).
16. Maren, S., Aharonov, G., Stote, D. L. & Fanselow, M. S. N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditioned fear in rats. Behav. Neurosci. 110, 1365-1374 (1996).
17. Pavlov, I. P. Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex (Dover, New York, 1927).
18. Rescorla, R. A. Pavlovian Second-order Conditioning: Studies in Associative Learning (Erlbaum, Hillsdale, NJ, 1980).
19. Kim, M., Campeau, S., Falls, W. A. & Davis, M. Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks expression of fear-potentiated startle. Behav. Neural Biol. 59, 5-8 (1993).
20. Campeau, S. & Davis, M. Involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J. Neurosci. 15, 2301-2311 (1995).
21. Romanski, L. M., Clugnet, M.-C., Bordi, F. & LeDoux, J. E. Somatosensory and auditory convergence in the lateral nucleus of the amygdala. Behav. Neurosci. 107, 444-450 (1993).
22. Campeau, S. et al. Induction of the c-fos proto-oncogene in the rat amygdala during unconditioned and conditioned fear. Brain Res. 565, 349-352 (1991).
23. Falls, W. F., Miserendino, M. J. D. & Davis, M. Extinction of fear-potentiated startle: Blockade by infusion of an NMDA antagonist into the amygdala. J. Neurosci. 12, 854-863 (1992).
24. Campeau, S. & Davis, M. Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli. J. Neurosci. 15, 2312-2327 (1995).
25. Romanski, L. M. & LeDoux, J. E. Equipotentiality of thalamo-amygdala and thalamo-cortico-amygdala circuits in auditory fear conditioning. J. Neurosci. 12, 4501-4509 (1992).
26. Li, X. F., Stutzmann, G. E. & LeDoux, J. E. Convergent but temporally separated inputs to lateral amygdala neurons from the auditory thalamus and auditory cortex use different postsynaptic receptors: In vivo intracellular and extracellular recordings in fear conditioning pathways. Learn. Mem. 3, 229-242 (1996).
27. Hatfield, T., Han, J.-S., Conley, M., Gallagher, M. & Holland, P. C. Neurotoxic lesions of basolateral, but not central, amygdala interfere with Pavlovian second-order conditioning and reinforcer devaluation effects. J. Neurosci. 16, 5256-5265 (1996).
28. Everitt, B. J. & Robbins, T. W. in The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction (ed. Aggleton, J. P.) 401-429 (Wiley-Liss, New York, 1992).
29. Willick, M. L. & Kokkinides, L. Cocaine enhances the expression of fear-potentiated startle: Evaluation of state-dependent extinction and the shock-sensitization of acoustic startle. Behav. Neurosci. 109, 929-938 (1995).
30. Cassella, J. V. & Davis, M. The design and calibration of a startle measurement system. Physiol. Behav. 36, 377-383 (1986).