메뉴 건너뛰기




Volumn 27, Issue 11, 2003, Pages 1724-1735

The Neurotoxicity Induced by Ethanol Withdrawal in Mature Organotypic Hippocampal Slices Might Involve Cross-Talk between Metabotropic Glutamate Type 5 Receptors and N-Methyl-D-Aspartate Receptors

Author keywords

Acamprosate; Ethanol Withdrawal; Hippocampus; mGluR5; NMDAR

Indexed keywords

2 METHYL 6 (2 PHENYLVINYL)PYRIDINE; 7 (HYDROXYIMINO)CYCLOPROPA[B]CHROMEN 1A CARBOXYLATE ETHYL ESTER; ACAMPROSATE; ALCOHOL; CARBOXYLIC ACID DERIVATIVE; DIZOCILPINE; ESTER DERIVATIVE; ISOPROTEIN; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; POLYPEPTIDE; PROPIDIUM IODIDE; SODIUM DERIVATIVE; STAUROSPORINE; UNCLASSIFIED DRUG;

EID: 10744224826     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000093601.33119.E3     Document Type: Article
Times cited : (91)

References (58)
  • 1
    • 0030957787 scopus 로고    scopus 로고
    • Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins
    • Abdel-Hamid KM, Tymianski M (1997) Mechanisms and effects of intracellular calcium buffering on neuronal survival in organotypic hippocampal cultures exposed to anoxia/aglycemia or to excitotoxins. J Neurosci 17:3538-3553.
    • (1997) J Neurosci , vol.17 , pp. 3538-3553
    • Abdel-Hamid, K.M.1    Tymianski, M.2
  • 2
    • 0034706061 scopus 로고    scopus 로고
    • Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: A role for metabotropic glutamate receptors
    • Adamchik Y, Baskys A (2000) Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors. Neuroscience 99:731-736.
    • (2000) Neuroscience , vol.99 , pp. 731-736
    • Adamchik, Y.1    Baskys, A.2
  • 4
    • 0025748026 scopus 로고
    • Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA receptors
    • Aniksztejn L, Bregestovski P, Ben-Ari Y (1991) Selective activation of quisqualate metabotropic receptor potentiates NMDA but not AMPA receptors. Eur J Pharmacol 205:327-328.
    • (1991) Eur J Pharmacol , vol.205 , pp. 327-328
    • Aniksztejn, L.1    Bregestovski, P.2    Ben-Ari, Y.3
  • 5
    • 0034332480 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus
    • Awad H, Hubert GW, Smith Y, Levey AI, Conn PJ (2000) Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci 20:7871-7879.
    • (2000) J Neurosci , vol.20 , pp. 7871-7879
    • Awad, H.1    Hubert, G.W.2    Smith, Y.3    Levey, A.I.4    Conn, P.J.5
  • 7
    • 0034948146 scopus 로고    scopus 로고
    • Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission
    • Battaglia G, Bruno V, Pisani A, Centonze D, Catania MV, Calabresi P, Nicoletti F (2001) Selective blockade of type-1 metabotropic glutamate receptors induces neuroprotection by enhancing gabaergic transmission. Mol Cell Neurosci 17:1071-1083.
    • (2001) Mol Cell Neurosci , vol.17 , pp. 1071-1083
    • Battaglia, G.1    Bruno, V.2    Pisani, A.3    Centonze, D.4    Catania, M.V.5    Calabresi, P.6    Nicoletti, F.7
  • 8
    • 0027520283 scopus 로고
    • The metabotropic glutamate receptor (mGluR1a) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction
    • Baude A, Nusser Z, Roberts JDB, Mulvihill E, McIlhinney RAJ, Somogyi P (1993) The metabotropic glutamate receptor (mGluR1a) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Neuron 11:771-787.
    • (1993) Neuron , vol.11 , pp. 771-787
    • Baude, A.1    Nusser, Z.2    Roberts, J.D.B.3    Mulvihill, E.4    McIlhinney, R.A.J.5    Somogyi, P.6
  • 9
    • 0035853489 scopus 로고    scopus 로고
    • The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures
    • Blaabjerg M, Kristensen BW, Bonde C, Zimmer J (2001) The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain Res 898:91-104.
    • (2001) Brain Res , vol.898 , pp. 91-104
    • Blaabjerg, M.1    Kristensen, B.W.2    Bonde, C.3    Zimmer, J.4
  • 10
    • 0030627444 scopus 로고    scopus 로고
    • Expression of c-FOS protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine
    • Bouchenafa O, Littleton JM (1998) Expression of c-FOS protein immunoreactivity in rat brain during ethanol withdrawal is prevented by nifedipine. Alcohol 15:71-76.
    • (1998) Alcohol , vol.15 , pp. 71-76
    • Bouchenafa, O.1    Littleton, J.M.2
  • 13
    • 0034078492 scopus 로고    scopus 로고
    • Group-I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cells
    • Chuang SC, Bianchi R, Wong RK (2000) Group-I mGluR activation turns on a voltage-gated inward current in hippocampal pyramidal cells. J Neurophysiol 83:2844-2853.
    • (2000) J Neurophysiol , vol.83 , pp. 2844-2853
    • Chuang, S.C.1    Bianchi, R.2    Wong, R.K.3
  • 14
    • 0033958458 scopus 로고    scopus 로고
    • Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze
    • Cole JC, Littleton JM, Little HJ (2000) Acamprosate, but not naltrexone, inhibits conditioned abstinence behaviour associated with repeated ethanol administration and exposure to a plus-maze. Psychopharmacology 147:403-411.
    • (2000) Psychopharmacology , vol.147 , pp. 403-411
    • Cole, J.C.1    Littleton, J.M.2    Little, H.J.3
  • 15
    • 0037345627 scopus 로고    scopus 로고
    • Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods
    • Dahchour A, De Witte P (2003) Effects of acamprosate on excitatory amino acids during multiple ethanol withdrawal periods. Alcohol Clin Exp Res 27:465-470.
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 465-470
    • Dahchour, A.1    De Witte, P.2
  • 16
    • 0032891904 scopus 로고    scopus 로고
    • Gender-selective effects of ethanol dependence on NMDA receptor subunit expression in cerebral cortex, hippocampus, and hypothalamus
    • Devaud LL, Morrow AL (1999) Gender-selective effects of ethanol dependence on NMDA receptor subunit expression in cerebral cortex, hippocampus, and hypothalamus. Eur J Pharmacol 369:331-334.
    • (1999) Eur J Pharmacol , vol.369 , pp. 331-334
    • Devaud, L.L.1    Morrow, A.L.2
  • 17
    • 0032569521 scopus 로고    scopus 로고
    • Immunohistochemical localization of the mGluR1β metabotropic glutamate receptor in the adult forebrain: Evidence for a different distribution of splice variants
    • Ferraguti F, Conquet F, Corti C, Grandes P, Kuhn R, Knoepfel T (1998) Immunohistochemical localization of the mGluR1β metabotropic glutamate receptor in the adult forebrain: evidence for a different distribution of splice variants. J Comp Neurol 400:391-407.
    • (1998) J Comp Neurol , vol.400 , pp. 391-407
    • Ferraguti, F.1    Conquet, F.2    Corti, C.3    Grandes, P.4    Kuhn, R.5    Knoepfel, T.6
  • 18
    • 0036462446 scopus 로고    scopus 로고
    • Allosteric modulators of group-I metabotropic glutamate receptors: Novel subtype-selective ligands and therapeutic perspectives
    • Gasparini F, Kuhn R, Pin JP (2002) Allosteric modulators of group-I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives. Curr Opin Pharmacol 2:43-49.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 43-49
    • Gasparini, F.1    Kuhn, R.2    Pin, J.P.3
  • 20
    • 0022647607 scopus 로고
    • Effects of ethanol on stimulated inositol phospholipid hydrolysis in rat brain
    • Gonzales RA, Theiss C, Crews FT (1986) Effects of ethanol on stimulated inositol phospholipid hydrolysis in rat brain. J Pharmacol Exp Ther 237:92-98.
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 92-98
    • Gonzales, R.A.1    Theiss, C.2    Crews, F.T.3
  • 21
    • 0035155762 scopus 로고    scopus 로고
    • Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor
    • Grosshans DR, Browning MD (2001) Protein kinase C activation induces tyrosine phosphorylation of the NR2A and NR2B subunits of the NMDA receptor. J Neurochem 76:737-744.
    • (2001) J Neurochem , vol.76 , pp. 737-744
    • Grosshans, D.R.1    Browning, M.D.2
  • 24
    • 0027320589 scopus 로고
    • Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in the rat hippocampal slices
    • Harvey J, Collingridge GL (1993) Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in the rat hippocampal slices. Br J Pharmacol 109:1085-1090.
    • (1993) Br J Pharmacol , vol.109 , pp. 1085-1090
    • Harvey, J.1    Collingridge, G.L.2
  • 25
    • 0032528124 scopus 로고    scopus 로고
    • Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment
    • Kalluri HSG, Mehta AK, Ticku MK (1998) Up-regulation of NMDA receptor subunits in rat brain following chronic ethanol treatment. Mol Brain Res 58:221-224.
    • (1998) Mol Brain Res , vol.58 , pp. 221-224
    • Kalluri, H.S.G.1    Mehta, A.K.2    Ticku, M.K.3
  • 27
    • 0041344635 scopus 로고    scopus 로고
    • Co-stimulation of mGluR5 and NMDA receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons
    • Kotecha SA, Jackson MF, Al-Mahrouki AA, Roder JC, Orser BA, MacDonald JF (2003) Co-stimulation of mGluR5 and NMDA receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons. J Biol Chem 278:27742-27749.
    • (2003) J Biol Chem , vol.278 , pp. 27742-27749
    • Kotecha, S.A.1    Jackson, M.F.2    Al-Mahrouki, A.A.3    Roder, J.C.4    Orser, B.A.5    MacDonald, J.F.6
  • 28
    • 0035898280 scopus 로고    scopus 로고
    • Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate
    • Lahtinen H, Autere A-M, Paalasmaa P, Lauri SE, Kaila K (2001) Post-insult activity is a major cause of delayed neuronal death in organotypic hippocampal slices exposed to glutamate. Neuroscience 105:131-137.
    • (2001) Neuroscience , vol.105 , pp. 131-137
    • Lahtinen, H.1    Autere, A.-M.2    Paalasmaa, P.3    Lauri, S.E.4    Kaila, K.5
  • 29
    • 0034702259 scopus 로고    scopus 로고
    • Regulation of distinct AMPA receptor phosphorylation sites during bi-directional synaptic plasticity
    • Lee HK, Barbarosle M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bi-directional synaptic plasticity. Nature 405:955-959.
    • (2000) Nature , vol.405 , pp. 955-959
    • Lee, H.K.1    Barbarosle, M.2    Kameyama, K.3    Bear, M.F.4    Huganir, R.L.5
  • 32
    • 0035882474 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function
    • Mannaioni G, Marino MJ, Valenti O, Traynelis SF, Conn JP (2001) Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. J Neurosci 20:5925-5934.
    • (2001) J Neurosci , vol.20 , pp. 5925-5934
    • Mannaioni, G.1    Marino, M.J.2    Valenti, O.3    Traynelis, S.F.4    Conn, J.P.5
  • 33
    • 0034816006 scopus 로고    scopus 로고
    • Treatment of alcohol-dependent outpatients with acamprosate: A clinical review
    • Mason BJ (2001) Treatment of alcohol-dependent outpatients with acamprosate: a clinical review. J Clin Psychiatry (Suppl 20) 62:42-48.
    • (2001) J Clin Psychiatry (Suppl 20) , vol.62 , pp. 42-48
    • Mason, B.J.1
  • 34
    • 0036797201 scopus 로고    scopus 로고
    • Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus
    • Mayer S, Harris BR, Gibson DA, Blanchard JA, Prendergast MA, Holley RC, Littleton J (2002) Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcohol Clin Exp Res 26:1468-1478.
    • (2002) Alcohol Clin Exp Res , vol.26 , pp. 1468-1478
    • Mayer, S.1    Harris, B.R.2    Gibson, D.A.3    Blanchard, J.A.4    Prendergast, M.A.5    Holley, R.C.6    Littleton, J.7
  • 35
    • 0032223783 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors in the plasticity of excitatory responses in the hippocampus
    • Merlin LR (1998) Metabotropic glutamate receptors in the plasticity of excitatory responses in the hippocampus. Adv Exp Med Biol 446:131-144.
    • (1998) Adv Exp Med Biol , vol.446 , pp. 131-144
    • Merlin, L.R.1
  • 36
    • 0026335391 scopus 로고
    • Chronic ethanol exposure increases levels of protein kinase C-8 and -E and protein kinase C-mediated phosphorylation in cultured neural cells
    • Messing RO, Petersen PJ, Henrich CJ (1991) Chronic ethanol exposure increases levels of protein kinase C-8 and -E and protein kinase C-mediated phosphorylation in cultured neural cells. J Biol Chem 266:23428-23432.
    • (1991) J Biol Chem , vol.266 , pp. 23428-23432
    • Messing, R.O.1    Petersen, P.J.2    Henrich, C.J.3
  • 37
    • 0031915098 scopus 로고    scopus 로고
    • Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes
    • Minami K, Gereau RW IV, Minami M, Heinemann SF, Harris RA (1998) Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Mol Pharmacol 53:148-156.
    • (1998) Mol Pharmacol , vol.53 , pp. 148-156
    • Minami, K.1    Gereau IV, R.W.2    Minami, M.3    Heinemann, S.F.4    Harris, R.A.5
  • 38
    • 0026763141 scopus 로고
    • Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin
    • Monyer H, Giffard RG, Hartley DM, Dugan LL, Goldberg MP, Choi DW (1992) Oxygen or glucose deprivation-induced neuronal injury in cortical cell cultures is reduced by tetanus toxin. Neuron 8:967-973.
    • (1992) Neuron , vol.8 , pp. 967-973
    • Monyer, H.1    Giffard, R.G.2    Hartley, D.M.3    Dugan, L.L.4    Goldberg, M.P.5    Choi, D.W.6
  • 39
    • 0035197286 scopus 로고    scopus 로고
    • mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors
    • Movsesyan VA, O'Leary DM, Fan L, Bao W, Mullins PGM, Knoblach SM, Faden AI (2001) mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 296:41-47.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 41-47
    • Movsesyan, V.A.1    O'Leary, D.M.2    Fan, L.3    Bao, W.4    Mullins, P.G.M.5    Knoblach, S.M.6    Faden, A.I.7
  • 40
    • 0027529578 scopus 로고
    • Time course of synaptic development in hippocampal organotypic cultures
    • Müller D, Buchs P-A, Stoppini L (1993) Time course of synaptic development in hippocampal organotypic cultures. Dev Brain Res 71:93-100.
    • (1993) Dev Brain Res , vol.71 , pp. 93-100
    • Müller, D.1    Buchs, P.-A.2    Stoppini, L.3
  • 42
    • 0033638723 scopus 로고    scopus 로고
    • Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
    • O'Leary DM, Movsesyan V, Vicini S, Faden AI (2000) Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism. Br J Pharmacol 131:1429-1437.
    • (2000) Br J Pharmacol , vol.131 , pp. 1429-1437
    • O'Leary, D.M.1    Movsesyan, V.2    Vicini, S.3    Faden, A.I.4
  • 43
    • 0029808496 scopus 로고    scopus 로고
    • Protein kinase C: Molecular and cellular targets for the action of ethanol
    • Pandey SC (1996) Protein kinase C: molecular and cellular targets for the action of ethanol. Alcohol Clin Exp Res 20:67A-71A.
    • (1996) Alcohol Clin Exp Res , vol.20
    • Pandey, S.C.1
  • 44
    • 0038240644 scopus 로고    scopus 로고
    • The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    • Patterson NE, Semenova S, Gasparini F, Markou A (2003) The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology 167:257-264.
    • (2003) Psychopharmacology , vol.167 , pp. 257-264
    • Patterson, N.E.1    Semenova, S.2    Gasparini, F.3    Markou, A.4
  • 46
    • 0033773037 scopus 로고    scopus 로고
    • Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro
    • Prendergast MA, Harris BR, Mayer S, Littleton JM (2000b) Chronic, but not acute, nicotine exposure attenuates ethanol withdrawal-induced hippocampal damage in vitro. Alcohol Clin Exp Res 24:1583-1592.
    • (2000) Alcohol Clin Exp Res , vol.24 , pp. 1583-1592
    • Prendergast, M.A.1    Harris, B.R.2    Mayer, S.3    Littleton, J.M.4
  • 49
    • 0033002026 scopus 로고    scopus 로고
    • Protection of excitotoxic neuronal death by gluconate through blockade of N-methyl-D-aspartate receptors
    • Sakaguchi T, Kuno M, Kawasaki K (1999) Protection of excitotoxic neuronal death by gluconate through blockade of N-methyl-D-aspartate receptors. Neuroscience 92:677-684.
    • (1999) Neuroscience , vol.92 , pp. 677-684
    • Sakaguchi, T.1    Kuno, M.2    Kawasaki, K.3
  • 50
    • 0030614698 scopus 로고    scopus 로고
    • Dual mode of N-methyl-D-aspartate-induced neuronal death in hippocampal slice cultures in relation to N-methyl-D-aspartate receptor properties
    • Sakaguchi T, Okada M, Kuno M, Kawasaki K (1997) Dual mode of N-methyl-D-aspartate-induced neuronal death in hippocampal slice cultures in relation to N-methyl-D-aspartate receptor properties. Neuroscience 76:411-423.
    • (1997) Neuroscience , vol.76 , pp. 411-423
    • Sakaguchi, T.1    Okada, M.2    Kuno, M.3    Kawasaki, K.4
  • 52
    • 0028129572 scopus 로고
    • Selective effects of ethanol exposure on metabotropic glutamate receptor and guanine nucleotide stimulated phospholipase C activity in primary cultures of astrocytes
    • Smith TL (1994) Selective effects of ethanol exposure on metabotropic glutamate receptor and guanine nucleotide stimulated phospholipase C activity in primary cultures of astrocytes. Alcohol 11:405-409.
    • (1994) Alcohol , vol.11 , pp. 405-409
    • Smith, T.L.1
  • 54
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini L, Buchs PA, Muller D (1991) A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37:173-182.
    • (1991) J Neurosci Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 55
    • 0033986985 scopus 로고    scopus 로고
    • Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal
    • Thomas MP, Morrisett RA (2000) Dynamics of NMDAR-mediated neurotoxicity during chronic ethanol exposure and withdrawal. Neuropharmacology 39:218-226.
    • (2000) Neuropharmacology , vol.39 , pp. 218-226
    • Thomas, M.P.1    Morrisett, R.A.2
  • 56
    • 0031959272 scopus 로고    scopus 로고
    • The role of glutamatergic neurotransmission in the pathophysiology of alcoholism
    • Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49:173-184.
    • (1998) Annu Rev Med , vol.49 , pp. 173-184
    • Tsai, G.1    Coyle, J.T.2
  • 58
    • 0021221206 scopus 로고
    • Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentate
    • Zimmer J, Gähwiler BH (1984) Cellular and connective organization of slice cultures of the rat hippocampus and fascia dentate. J Comp Neurol 228:432-446.
    • (1984) J Comp Neurol , vol.228 , pp. 432-446
    • Zimmer, J.1    Gähwiler, B.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.