Neuroprotective effects of topiramate after hypoxia-ischemia in newborn piglets

Brain Research

Volumn 1058, Issue 1-2, 2005, Pages 129-136

  Schubert, Susanne ^a   Brandl, Ulrich ^a   Brodhun, Michael ^b   Ulrich, Christiane ^a   Spaltmann, Jens ^a   Fiedler, Nico ^a   Bauer, Reinhard ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

Hypoxia Ischemia; Neuroprotection; Newborn; Piglet; Topiramate

Indexed keywords

DNA FRAGMENT; SODIUM CHLORIDE; TOPIRAMATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY OCCLUSION; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CAROTID ARTERY; CELL LOSS; COHORT ANALYSIS; CONTROLLED STUDY; DRUG DOSE REGIMEN; FRONTAL CORTEX; HYPOTENSION; HYPOXIA; MAINTENANCE DRUG DOSE; MONITORING; NEUROPROTECTION; NEWBORN; NICK END LABELING; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SEIZURE; STAINING; WHITE MATTER;

ANIMALS; ANIMALS, NEWBORN; ASPHYXIA NEONATORUM; BRAIN; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; FRUCTOSE; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; IN SITU NICK-END LABELING; INFANT, NEWBORN; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; SUS SCROFA; TREATMENT OUTCOME;

EID: 26244462973     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.07.061     Document Type: Article

References (22)

1. A.M. Brambrink, L.J. Martin, D.F. Hanley, K.J. Becker, R.C. Koehler, and R.J. Traystman Effects of the AMPA receptor antagonist NBQX on outcome of newborn pigs after asphyxic cardiac arrest J. Cereb. Blood Flow Metab. 19 1999 927 938
2. M. Brodhun, H. Fritz, B. Walter, I. Antonow-Schlorke, K. Reinhart, U. Zwiener, R. Bauer, and S. Patt Immunomorphological sequelae of severe brain injury induced by fluid-percussion in juvenile pigs-Effects of mild hypothermia Acta Neuropathol. (Berl) 101 2001 424 434
3. O. Cataltepe, R.C. Vannucci, D.F. Heitjan, and J. Towfighi Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat Pediatr. Res. 38 1995 251 257
4. U. Dirnagl, R.P. Simon, and J.M. Hallenbeck Ischemic tolerance and endogenous neuroprotection Trends Neurosci. 26 2003 248 254
5. A.J. du Plessis, and J.J. Volpe Perinatal brain injury in the preterm and term newborn Curr. Opin. Neurol. 15 2002 151 157
6. P.L. Follett, W. Deng, W. Dai, D.M. Talos, L.J. Massillon, P.A. Rosenberg, J.J. Volpe, and F.E. Jensen Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate J. Neurosci. 24 2004 4412 4420
7. K.A. Foster, P.B. Colditz, B.E. Lingwood, C. Burke, K.R. Dunster, and M.S. Roberts An improved survival model of hypoxia/ischaemia in the piglet suitable for neuroprotection studies Brain Res. 919 2001 122 231
8. J.L. Galinkin, C.D. Kurth, H. Shi, M.A. Priestley, A.W. Loepke, and P.C. Adamson The plasma pharmacokinetics and cerebral spinal fluid penetration of intravenous topiramate in newborn pigs Biopharm. Drug Dispos. 25 2004 265 271
9. T.A. Glauser, M.V. Miles, P. Tang, P. Clark, K. McGee, and D.R. Doose Topiramate pharmacokinetics in infants Epilepsia 40 1999 788 791
10. C. Glier, M. Dzietko, P. Bittigau, B. Jarosz, E. Korobowicz, and C. Ikonomidou Therapeutic doses of topiramate are not toxic to the developing rat brain Exp. Neurol. 187 2004 403 409
11. R. Gold, M. Schmied, G. Giegerich, H. Breitschopf, H.P. Hartung, K.V. Toyka, and H. Lassmann Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques Lab. Invest. 71 1994 219 225
12. M.V. Johnston, W.H. Trescher, A. Ishida, and W. Nakajima Neurobiology of hypoxic-ischemic injury in the developing brain Pediatr. Res. 49 2001 735 741
13. S. Koh, and F.E. Jensen Topiramate blocks perinatal hypoxia-induced seizures in rat pups Ann. Neurol. 50 2001 366 372
14. M.H. LeBlanc, L.A. Farias, O.B. Evans, V. Vig, E.E. Smith, and A.K. Markov Fructose-1,6-bisphosphate, when given immediately before reoxygenation, or before injury, does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig Crit. Care Med. 19 1991 75 83
15. Y. Liu, J.D. Barks, G. Xu, and F.S. Silverstein Topiramate extends the therapeutic window for hypothermia-mediated neuroprotection after stroke in neonatal rats Stroke 35 2004 1460 1465
16. A. Lorek, Y. Takei, E.B. Cady, J.S. Wyatt, J. Penrice, A.D. Edwards, D. Peebles, M. Wylezinska, H. Owen-Reece, and V. Kirkbride Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy Pediatr. Res. 36 1994 699 706
17. S.D. Mundle, X.Z. Gao, S. Khan, S.A. Gregory, H.D. Preisler, and A. Raza Two in situ labeling techniques reveal different patterns of DNA fragmentation during spontaneous apoptosis in vivo and induced apoptosis in vitro Anticancer Res. 15 1995 1895 1904
18. R.P. Shank, J.F. Gardocki, A.J. Streeter, and B.E. Maryanoff An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action Epilepsia 41 Suppl. 1 2000 S3 S9
19. S. Taverna, G. Sancini, M. Mantegazza, S. Franceschetti, and G. Avanzini Inhibition of transient and persistent Na+ current fractions by the new anticonvulsant topiramate J. Pharmacol. Exp. Ther. 288 1999 960 968
20. M. Viswanath, C. Palmer, and R.L. Roberts Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection Pediatr. Res. 48 2000 109 113
21. J.J. Volpe Perinatal brain injury: from pathogenesis to neuroprotection Ment. Retard. Dev. Disabil. Res. Rev. 7 2001 56 64
22. H.S. White, S.D. Brown, J.H. Woodhead, G.A. Skeen, and H.H. Wolf Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold Epilepsy Res. 28 1997 167 179