Magnesium-dependent inhibition of n-methyl-o-aspartate receptor-mediated synaptic transmission by ethanol

Journal of Pharmacology and Experimental Therapeutics

Volumn 287, Issue 3, 1998, Pages 1015-1019

  Calton, Jeffrey L ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CENTRAL DEPRESSANT AGENT; GLUTAMIC ACID; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; IN VITRO STUDY; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT; SYNAPTIC TRANSMISSION; ANIMAL TISSUE; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; NONHUMAN; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY; VOLTAGE CLAMP;

AMYGDALA; ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DRUG SYNERGISM; ETHANOL; GLUTAMIC ACID; MAGNESIUM; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION;

EID: 0032252740     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Aggleton JP (1992) The Amygdala: Neuroblological Aspects of Emotion, Memory, and Mental Dysfunction, Wiley-Liss, New York.
2. Altura BM, Altura BT and Gupta RK (1991) Alcohol intoxication results in rapid loss in free magnesium in brain and disturbances in brain bioenergetics: relation to cerebrovasospasm, alcohol-induced strokes, and barbiturate anesthesia-induced deaths. Magnes Trace Elem 10:122-135.
3. Calton JL, Moore SD and Wilson WA (1996) Voltage dependent ethanol effect on NMDA transmission in basolateral amygdala. Soc Neurosci Abstr 22:467.
4. Carlen PL, Gurevich N and Durand D (1982) Ethanol in low doses augment? calcium-mediated mechanisms measured intracellularly in hippocampal neurons. Science 215:306-309.
5. Chu B, Anantharam V and Treistman SN (1995) Ethanol inhibition of recombinant heteromeric NMDA channels in the presence and absence of modulators. J Neurochem 65:140-148.
6. Fanselow MS and Kim JJ (1994) Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5phosphonovaleric acid to the basolateral amygdala. Behav Neurosci 108:210-212.
7. Gean PW (1992) Ethanol inhibits epileptiform activity and NMDA receptormediated synaptic transmission in rat amygdaloid slices. Brain Res Bull 28:417-421.
8. Gean PW, Chang FC, Huang CC, Lin JH and Way LJ (1993a) Long-term enhancement of EPSP and NMDA receptor-mediated synaptic transmission in the amygdala. Brain Res Bull 31:7-11.
9. Gean PW, Chang FC and Huang CR (1993b) Use-dependent modification of a slow NMDA receptor-mediated synaptic potential in rat amygdalar slices. J Neurose' Res 34:635-641.
10. Grover CA, Frye GD and Griffith WH (1994) Acute tolerance to ethanol inhibition o~ NMDA-mediated EPSPs in the CA1 region of the rat hippocampus. Brain Res 642: 70-76.
11. Koob GF, Rassnick S, Heinrichs S and Weiss F (1994) Alcohol, the reward systerr and dependence. EXS 71:103-114.
12. LeDoux JE (1993) Emotional memory: In search of systems and synapses. Ann NY AcadSci 702:149-157.
13. Lovinger DM, White G and Weight FF (1989) Ethanol inhibits NMDA-activated ior current in hippocampal neurons. Science 243:1721-1724.
14. Martin D, Morrisett RA, Bian XP, Wilson WA and Swartzwelder HS (1991) Ethanol inhibition of NMDA mediated depolarizations is increased in the presence of Mg2 + . Brain Res 546:227-234.
15. Michaelis ML and Michaelis EK (1994) Effects of ethanol on NMDA receptors in brain: Possibilities for Mg(2+)-ethanol interactions. Alcohol Clin Exp Res 18; 1069-1075.
16. Miyakawa H, Ross WN, Jaffe D, Callaway JC, Lasser-Ross N, Lisman JE and Johnston D (1992) Synaptically activated increases in Ca2+ concentration in hippocampal CA1 pyramidal cells are primarily due to voltage-gated Ca2+ channels. Neuron 9:1163-1173.
17. Moore SD, Madamba SG and Siggins GR (1990) Ethanol diminishes a voltagedependent K+ current, the M-current, in CA1 hippocampal pyramidal neurons in vitro. Brain Res 516:222-228.
18. Morrisett RA, Martin D, Getting TA, Lewis DV, Wilson WA and Swartzwelder HS (1991) Ethanol and magnesium ions inhibit N-methyl-D-aspartate-mediated synaptic potentials in an interactive manner. Neuropharmacology 30:1173-1178.
19. Morrisett RA and Swartzwelder HS (1993) Attenuation of hippocampal long-term potentiation by ethanol: a patch-clamp analysis of glutamatergic and GABAergic mechanisms. J Neurosci 13:2264-2272.
20. Nie Z, Madamba SG and Siggins GR (1994) Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms. J Pharmacol Exp Ther 271:1566-1573.
21. Peoples RW, White G, Lovinger DM and Weight FF (1997) Ethanol inhibition of N-methyl-D-aspartate-activated current in mouse hippocampal neurones: whole-cell patch-clamp analysis. Br J Pharmacol 122:1035-1042.
22. Rainnie DG, Asprodini EK and Shinnick-Gallagher P (1991a) Excitatory transmission in the basolateral amygdala. J Neurophyslol 66:986-998.
23. Rainnie DG, Asprodini EK and Shinnick-Gallagher P (1991b) Inhibitory transmission in the basolateral amygdala. J Neurophysiol 66:999-1009.
24. Rassnick S, Heinrichs SC, Britton KT and Koob GF (1993) Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res 605:25-32.
25. Schummers J, Bentz S and Browning MD (1997) Ethanol's inhibition of LTP may not be mediated solely via direct effects on the NMDA receptor. Alcohol Clin Exp Res 21:404-408.
26. Siggins GR, Bloom FE, French ED, Madamba SG, Mancillas J, Pittman QJ and Rogers J (1987a) Electrophysiology of ethanol on central neurons. Ann NY Acad Sci 492:350-366.
27. Siggins GR, Pittman QJ and French ED (1987b) Effects of ethanol on CA1 and CA3 pyramidal cells in the hippocampal slice preparation: An intracellular study. Brain Res 414:22-34.
28. Washburn MS and Moises HC (1992) Electrophysiological and morphological properties of rat basolateral amygdaloid neurons in vitro. J Neurosci 12:4066-4079.
29. Weight FF, Lovinger DM, White G and Peoples RW (1991) Alcohol and anesthetic actions on excitatory amino acid-activated ion channels. Ann NY Acad Sci 625: 97-107.
30. White G, Lovinger DM and Weight FF (1990) Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuron. Brain Res 507:332-336.