메뉴 건너뛰기




Volumn 23, Issue 3, 2012, Pages 127-138

SOCS3 in immune regulation of inflammatory bowel disease and inflammatory bowel disease-related cancer

Author keywords

CRC; IBD; Immune regulation; SOCS3; STAT3

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 6; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA;

EID: 84861660536     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2012.04.005     Document Type: Review
Times cited : (48)

References (140)
  • 1
    • 2442563304 scopus 로고    scopus 로고
    • Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
    • Loftus E.V. Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences. Gastroenterology 2004, 126:1504-1517.
    • (2004) Gastroenterology , vol.126 , pp. 1504-1517
    • Loftus, E.V.1
  • 2
    • 33750609696 scopus 로고    scopus 로고
    • Recent trends in the epidemiology of inflammatory bowel diseases: up or down?
    • Lakatos P.L. Recent trends in the epidemiology of inflammatory bowel diseases: up or down?. World Journal of Gastroenterology 2006, 12:6102-6108.
    • (2006) World Journal of Gastroenterology , vol.12 , pp. 6102-6108
    • Lakatos, P.L.1
  • 4
    • 77950353786 scopus 로고    scopus 로고
    • Homeostasis and inflammation in the intestine
    • Garrett W.S., Gordon J.I., Glimcher L.H. Homeostasis and inflammation in the intestine. Cell 2010, 140:859-870.
    • (2010) Cell , vol.140 , pp. 859-870
    • Garrett, W.S.1    Gordon, J.I.2    Glimcher, L.H.3
  • 5
    • 79960826132 scopus 로고    scopus 로고
    • Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients
    • Latiano A., Palmieri O., Latiano T., Corritore G., Bossa F., Martino G., et al. Investigation of multiple susceptibility loci for inflammatory bowel disease in an Italian cohort of patients. PLoS One 2011, 6:e22688.
    • (2011) PLoS One , vol.6
    • Latiano, A.1    Palmieri, O.2    Latiano, T.3    Corritore, G.4    Bossa, F.5    Martino, G.6
  • 6
  • 8
    • 21844476213 scopus 로고    scopus 로고
    • The pathophysiologic rationale for biological therapies in inflammatory bowel disease
    • Gordon J.N., Di Sabatino A., Macdonald T.T. The pathophysiologic rationale for biological therapies in inflammatory bowel disease. Current Opinion in Gastroenterology 2005, 21:431-437.
    • (2005) Current Opinion in Gastroenterology , vol.21 , pp. 431-437
    • Gordon, J.N.1    Di Sabatino, A.2    Macdonald, T.T.3
  • 9
    • 35348940762 scopus 로고    scopus 로고
    • Defensins and Paneth cells in inflammatory bowel disease
    • Shi J. Defensins and Paneth cells in inflammatory bowel disease. Inflammatory Bowel Diseases 2007, 13:1284-1292.
    • (2007) Inflammatory Bowel Diseases , vol.13 , pp. 1284-1292
    • Shi, J.1
  • 10
    • 1642376424 scopus 로고    scopus 로고
    • Microbial biogeography along an estuarine salinity gradient: combined influences of bacterial growth and residence time
    • Crump B.C., Hopkinson C.S., Sogin M.L., Hobbie J.E. Microbial biogeography along an estuarine salinity gradient: combined influences of bacterial growth and residence time. Applied and Environment Microbiology 2004, 70:1494-1505.
    • (2004) Applied and Environment Microbiology , vol.70 , pp. 1494-1505
    • Crump, B.C.1    Hopkinson, C.S.2    Sogin, M.L.3    Hobbie, J.E.4
  • 12
    • 78651225855 scopus 로고    scopus 로고
    • Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
    • Momozawa Y., Mni M., Nakamura K., Coppieters W., Almer S., Amininejad L., et al. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nature Genetics 2011, 43:43-47.
    • (2011) Nature Genetics , vol.43 , pp. 43-47
    • Momozawa, Y.1    Mni, M.2    Nakamura, K.3    Coppieters, W.4    Almer, S.5    Amininejad, L.6
  • 13
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: a meta-analysis
    • Eaden J.A., Abrams K.R., Mayberry J.F. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 2001, 48:526-535.
    • (2001) Gut , vol.48 , pp. 526-535
    • Eaden, J.A.1    Abrams, K.R.2    Mayberry, J.F.3
  • 14
    • 4844228230 scopus 로고    scopus 로고
    • Review article: colorectal carcinoma and inflammatory bowel disease
    • Eaden J. Review article: colorectal carcinoma and inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 2004, 20(Suppl. 4):24-30.
    • (2004) Alimentary Pharmacology and Therapeutics , vol.20 , Issue.SUPPL. 4 , pp. 24-30
    • Eaden, J.1
  • 15
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    • Saleh M., Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nature Reviews Immunology 2011, 11:9-20.
    • (2011) Nature Reviews Immunology , vol.11 , pp. 9-20
    • Saleh, M.1    Trinchieri, G.2
  • 17
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis
    • Sartor R.B. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nature Clinical Practice Gastroenterology and Hepatology 2006, 3:390-407.
    • (2006) Nature Clinical Practice Gastroenterology and Hepatology , vol.3 , pp. 390-407
    • Sartor, R.B.1
  • 18
    • 0036138686 scopus 로고    scopus 로고
    • Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared
    • Rhodes J.M., Campbell B.J. Inflammation and colorectal cancer: IBD-associated and sporadic cancer compared. Trends in Molecular Medicine 2002, 8:10-16.
    • (2002) Trends in Molecular Medicine , vol.8 , pp. 10-16
    • Rhodes, J.M.1    Campbell, B.J.2
  • 20
    • 33646697347 scopus 로고    scopus 로고
    • The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability
    • Babon J.J., McManus E.J., Yao S., DeSouza D.P., Mielke L.A., Sprigg N.S., et al. The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. Molecular Cell 2006, 22:205-216.
    • (2006) Molecular Cell , vol.22 , pp. 205-216
    • Babon, J.J.1    McManus, E.J.2    Yao, S.3    DeSouza, D.P.4    Mielke, L.A.5    Sprigg, N.S.6
  • 26
    • 0033570054 scopus 로고    scopus 로고
    • CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling
    • Aman M.J., Migone T.S., Sasaki A., Ascherman D.P., Zhu M., Soldaini E., et al. CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling. Journal of Biological Chemistry 1999, 274:30266-30272.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 30266-30272
    • Aman, M.J.1    Migone, T.S.2    Sasaki, A.3    Ascherman, D.P.4    Zhu, M.5    Soldaini, E.6
  • 27
    • 0033544899 scopus 로고    scopus 로고
    • SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
    • Ram P.A., Waxman D.J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. Journal of Biological Chemistry 1999, 274:35553-35561.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 35553-35561
    • Ram, P.A.1    Waxman, D.J.2
  • 28
    • 0346121599 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling and immunity
    • Kubo M., Hanada T., Yoshimura A. Suppressors of cytokine signaling and immunity. Nature Immunology 2003, 4:1169-1176.
    • (2003) Nature Immunology , vol.4 , pp. 1169-1176
    • Kubo, M.1    Hanada, T.2    Yoshimura, A.3
  • 30
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • Schmitz J., Weissenbach M., Haan S., Heinrich P.C., Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. Journal of Biological Chemistry 2000, 275:12848-12856.
    • (2000) Journal of Biological Chemistry , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 32
    • 0033558088 scopus 로고    scopus 로고
    • Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
    • De Sepulveda P., Okkenhaug K., Rose J.L., Hawley R.G., Dubreuil P., Rottapel R. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO Journal 1999, 18:904-915.
    • (1999) EMBO Journal , vol.18 , pp. 904-915
    • De Sepulveda, P.1    Okkenhaug, K.2    Rose, J.L.3    Hawley, R.G.4    Dubreuil, P.5    Rottapel, R.6
  • 33
    • 1842478134 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling
    • Bayle J., Letard S., Frank R., Dubreuil P., De Sepulveda P. Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling. Journal of Biological Chemistry 2004, 279:12249-12259.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 12249-12259
    • Bayle, J.1    Letard, S.2    Frank, R.3    Dubreuil, P.4    De Sepulveda, P.5
  • 34
    • 1542328234 scopus 로고    scopus 로고
    • The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer
    • Greten F.R., Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Letters 2004, 206:193-199.
    • (2004) Cancer Letters , vol.206 , pp. 193-199
    • Greten, F.R.1    Karin, M.2
  • 37
    • 70349756909 scopus 로고    scopus 로고
    • The immunopathogenesis of Crohn's disease: a three-stage model
    • Sewell G.W., Marks D.J., Segal A.W. The immunopathogenesis of Crohn's disease: a three-stage model. Current Opinion in Immunology 2009, 21:506-513.
    • (2009) Current Opinion in Immunology , vol.21 , pp. 506-513
    • Sewell, G.W.1    Marks, D.J.2    Segal, A.W.3
  • 41
    • 34447521412 scopus 로고    scopus 로고
    • The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells
    • Ziesche E., Bachmann M., Kleinert H., Pfeilschifter J., Muhl H. The interleukin-22/STAT3 pathway potentiates expression of inducible nitric-oxide synthase in human colon carcinoma cells. Journal of Biological Chemistry 2007, 282:16006-16015.
    • (2007) Journal of Biological Chemistry , vol.282 , pp. 16006-16015
    • Ziesche, E.1    Bachmann, M.2    Kleinert, H.3    Pfeilschifter, J.4    Muhl, H.5
  • 43
    • 78649690842 scopus 로고    scopus 로고
    • Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease
    • Ouyang W. Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease. Cytokine and Growth Factor Reviews 2010, 21:435-441.
    • (2010) Cytokine and Growth Factor Reviews , vol.21 , pp. 435-441
    • Ouyang, W.1
  • 44
    • 78649757427 scopus 로고    scopus 로고
    • Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
    • Witte E., Witte K., Warszawska K., Sabat R., Wolk K. Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Cytokine and Growth Factor Reviews 2010, 21:365-379.
    • (2010) Cytokine and Growth Factor Reviews , vol.21 , pp. 365-379
    • Witte, E.1    Witte, K.2    Warszawska, K.3    Sabat, R.4    Wolk, K.5
  • 45
    • 33646552450 scopus 로고    scopus 로고
    • IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis
    • Wolk K., Witte E., Wallace E., Docke W.D., Kunz S., Asadullah K., et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. European Journal of Immunology 2006, 36:1309-1323.
    • (2006) European Journal of Immunology , vol.36 , pp. 1309-1323
    • Wolk, K.1    Witte, E.2    Wallace, E.3    Docke, W.D.4    Kunz, S.5    Asadullah, K.6
  • 46
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J., Phesse T.J., von Burstin V.A., Putoczki T., Bennecke M., Bateman T., et al. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 2009, 15:91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5    Bateman, T.6
  • 48
    • 76649144503 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair
    • Linke A., Goren I., Bosl M.R., Pfeilschifter J., Frank S. The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair. Journal of Investigative Dermatology 2010, 130:876-885.
    • (2010) Journal of Investigative Dermatology , vol.130 , pp. 876-885
    • Linke, A.1    Goren, I.2    Bosl, M.R.3    Pfeilschifter, J.4    Frank, S.5
  • 49
    • 76649145431 scopus 로고    scopus 로고
    • Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1
    • Linke A., Goren I., Bosl M.R., Pfeilschifter J., Frank S. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1. Journal of Investigative Dermatology 2010, 130:866-875.
    • (2010) Journal of Investigative Dermatology , vol.130 , pp. 866-875
    • Linke, A.1    Goren, I.2    Bosl, M.R.3    Pfeilschifter, J.4    Frank, S.5
  • 50
    • 34447629700 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon
    • Rigby R.J., Simmons J.G., Greenhalgh C.J., Alexander W.S., Lund P.K. Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon. Oncogene 2007, 26:4833-4841.
    • (2007) Oncogene , vol.26 , pp. 4833-4841
    • Rigby, R.J.1    Simmons, J.G.2    Greenhalgh, C.J.3    Alexander, W.S.4    Lund, P.K.5
  • 51
    • 33144482986 scopus 로고    scopus 로고
    • Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-kappaB-dependent manner
    • Smith M.F., Novotny J., Carl V.S., Comeau L.D. Helicobacter pylori and toll-like receptor agonists induce syndecan-4 expression in an NF-kappaB-dependent manner. Glycobiology 2006, 16:221-229.
    • (2006) Glycobiology , vol.16 , pp. 221-229
    • Smith, M.F.1    Novotny, J.2    Carl, V.S.3    Comeau, L.D.4
  • 52
    • 79954591379 scopus 로고    scopus 로고
    • Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation
    • White G.E., Cotterill A., Addley M.R., Soilleux E.J., Greaves D.R. Suppressor of cytokine signalling protein SOCS3 expression is increased at sites of acute and chronic inflammation. Journal of Molecular Histology 2010, 42:137-151.
    • (2010) Journal of Molecular Histology , vol.42 , pp. 137-151
    • White, G.E.1    Cotterill, A.2    Addley, M.R.3    Soilleux, E.J.4    Greaves, D.R.5
  • 53
    • 0033233214 scopus 로고    scopus 로고
    • LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages
    • Bode J.G., Nimmesgern A., Schmitz J., Schaper F., Schmitt M., Frisch W., et al. LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Letters 1999, 463:365-370.
    • (1999) FEBS Letters , vol.463 , pp. 365-370
    • Bode, J.G.1    Nimmesgern, A.2    Schmitz, J.3    Schaper, F.4    Schmitt, M.5    Frisch, W.6
  • 54
    • 0037443661 scopus 로고    scopus 로고
    • Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3
    • Niemand C., Nimmesgern A., Haan S., Fischer P., Schaper F., Rossaint R., et al. Activation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3. Journal of Immunology 2003, 170:3263-3272.
    • (2003) Journal of Immunology , vol.170 , pp. 3263-3272
    • Niemand, C.1    Nimmesgern, A.2    Haan, S.3    Fischer, P.4    Schaper, F.5    Rossaint, R.6
  • 55
    • 23944488874 scopus 로고    scopus 로고
    • Salmonella pathogenicity island 2-dependent expression of suppressor of cytokine signaling 3 in macrophages
    • Uchiya K., Nikai T. Salmonella pathogenicity island 2-dependent expression of suppressor of cytokine signaling 3 in macrophages. Infection and Immunity 2005, 73:5587-5594.
    • (2005) Infection and Immunity , vol.73 , pp. 5587-5594
    • Uchiya, K.1    Nikai, T.2
  • 56
    • 0035877256 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
    • Dalpke A.H., Opper S., Zimmermann S., Heeg K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. Journal of Immunology 2001, 166:7082-7089.
    • (2001) Journal of Immunology , vol.166 , pp. 7082-7089
    • Dalpke, A.H.1    Opper, S.2    Zimmermann, S.3    Heeg, K.4
  • 57
    • 0035712854 scopus 로고    scopus 로고
    • CpG-oligonucleotides in vaccination: signaling and mechanisms of action
    • Dalpke A., Zimmermann S., Heeg K. CpG-oligonucleotides in vaccination: signaling and mechanisms of action. Immunobiology 2001, 204:667-676.
    • (2001) Immunobiology , vol.204 , pp. 667-676
    • Dalpke, A.1    Zimmermann, S.2    Heeg, K.3
  • 58
    • 44449140105 scopus 로고    scopus 로고
    • Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo
    • Liu Y., Stewart K.N., Bishop E., Marek C.J., Kluth D.C., Rees A.J., et al. Unique expression of suppressor of cytokine signaling 3 is essential for classical macrophage activation in rodents in vitro and in vivo. Journal of Immunology 2008, 180:6270-6278.
    • (2008) Journal of Immunology , vol.180 , pp. 6270-6278
    • Liu, Y.1    Stewart, K.N.2    Bishop, E.3    Marek, C.J.4    Kluth, D.C.5    Rees, A.J.6
  • 59
    • 79957673711 scopus 로고    scopus 로고
    • IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer
    • Neurath M.F., Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine and Growth Factor Reviews 2011, 22:83-89.
    • (2011) Cytokine and Growth Factor Reviews , vol.22 , pp. 83-89
    • Neurath, M.F.1    Finotto, S.2
  • 60
    • 0037097509 scopus 로고    scopus 로고
    • Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation
    • Berlato C., Cassatella M.A., Kinjyo I., Gatto L., Yoshimura A., Bazzoni F. Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. Journal of Immunology 2002, 168:6404-6411.
    • (2002) Journal of Immunology , vol.168 , pp. 6404-6411
    • Berlato, C.1    Cassatella, M.A.2    Kinjyo, I.3    Gatto, L.4    Yoshimura, A.5    Bazzoni, F.6
  • 62
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K., Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine and Growth Factor Reviews 2002, 13:357-368.
    • (2002) Cytokine and Growth Factor Reviews , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 63
    • 0037600741 scopus 로고    scopus 로고
    • IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    • Yasukawa H., Ohishi M., Mori H., Murakami M., Chinen T., Aki D., et al. IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nature Immunology 2003, 4:551-556.
    • (2003) Nature Immunology , vol.4 , pp. 551-556
    • Yasukawa, H.1    Ohishi, M.2    Mori, H.3    Murakami, M.4    Chinen, T.5    Aki, D.6
  • 64
    • 33645527599 scopus 로고    scopus 로고
    • Gene delivery of SOCS3 protects mice from lethal endotoxic shock
    • Fang M., Dai H., Yu G., Gong F. Gene delivery of SOCS3 protects mice from lethal endotoxic shock. Cellular and Molecular Immunology 2005, 2:373-377.
    • (2005) Cellular and Molecular Immunology , vol.2 , pp. 373-377
    • Fang, M.1    Dai, H.2    Yu, G.3    Gong, F.4
  • 65
    • 77952865796 scopus 로고    scopus 로고
    • Phagocyte partnership during the onset and resolution of inflammation
    • Soehnlein O., Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nature Reviews Immunology 2010, 10:427-439.
    • (2010) Nature Reviews Immunology , vol.10 , pp. 427-439
    • Soehnlein, O.1    Lindbom, L.2
  • 66
    • 33847375865 scopus 로고    scopus 로고
    • Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade
    • Ehlting C., Lai W.S., Schaper F., Brenndorfer E.D., Matthes R.J., Heinrich P.C., et al. Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. Journal of Immunology 2007, 178:2813-2826.
    • (2007) Journal of Immunology , vol.178 , pp. 2813-2826
    • Ehlting, C.1    Lai, W.S.2    Schaper, F.3    Brenndorfer, E.D.4    Matthes, R.J.5    Heinrich, P.C.6
  • 67
    • 71649101015 scopus 로고    scopus 로고
    • Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation
    • Dagvadorj J., Naiki Y., Tumurkhuu G., Noman A.S., Iftakhar E., Khuda I., et al. Tumor necrosis factor-a augments lipopolysaccharide-induced suppressor of cytokine signalling 3 (SOCS-3) protein expression by preventing the degradation. Immunology 2010, 129:97-104.
    • (2010) Immunology , vol.129 , pp. 97-104
    • Dagvadorj, J.1    Naiki, Y.2    Tumurkhuu, G.3    Noman, A.S.4    Iftakhar, E.5    Khuda, I.6
  • 69
    • 0036681955 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction
    • Hortner M., Nielsch U., Mayr L.M., Johnston J.A., Heinrich P.C., Haan S. Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. Journal of Immunology 2002, 169:1219-1227.
    • (2002) Journal of Immunology , vol.169 , pp. 1219-1227
    • Hortner, M.1    Nielsch, U.2    Mayr, L.M.3    Johnston, J.A.4    Heinrich, P.C.5    Haan, S.6
  • 70
    • 1342346569 scopus 로고    scopus 로고
    • SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
    • Kimura A., Kinjyo I., Matsumura Y., Mori H., Mashima R., Harada M., et al. SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. Journal of Biological Chemistry 2004, 279:6905-6910.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 6905-6910
    • Kimura, A.1    Kinjyo, I.2    Matsumura, Y.3    Mori, H.4    Mashima, R.5    Harada, M.6
  • 72
    • 27744536534 scopus 로고    scopus 로고
    • Transdifferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by T cells
    • Iking-Konert C., Ostendorf B., Sander O., Jost M., Wagner C., Joosten L., et al. Transdifferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by T cells. Annals of the Rheumatic Diseases 2005, 64:1436-1442.
    • (2005) Annals of the Rheumatic Diseases , vol.64 , pp. 1436-1442
    • Iking-Konert, C.1    Ostendorf, B.2    Sander, O.3    Jost, M.4    Wagner, C.5    Joosten, L.6
  • 73
    • 34848898431 scopus 로고    scopus 로고
    • Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells
    • Matsumura Y., Kobayashi T., Ichiyama K., Yoshida R., Hashimoto M., Takimoto T., et al. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells. Journal of Immunology 2007, 179:2170-2179.
    • (2007) Journal of Immunology , vol.179 , pp. 2170-2179
    • Matsumura, Y.1    Kobayashi, T.2    Ichiyama, K.3    Yoshida, R.4    Hashimoto, M.5    Takimoto, T.6
  • 74
    • 10744223693 scopus 로고    scopus 로고
    • SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    • Croker B.A., Metcalf D., Robb L., Wei W., Mifsud S., DiRago L., et al. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 2004, 20:153-165.
    • (2004) Immunity , vol.20 , pp. 153-165
    • Croker, B.A.1    Metcalf, D.2    Robb, L.3    Wei, W.4    Mifsud, S.5    DiRago, L.6
  • 75
    • 0034176031 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation
    • Hwu P., Du M.X., Lapointe R., Do M., Taylor M.W., Young H.A. Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. Journal of Immunology 2000, 164:3596-3599.
    • (2000) Journal of Immunology , vol.164 , pp. 3596-3599
    • Hwu, P.1    Du, M.X.2    Lapointe, R.3    Do, M.4    Taylor, M.W.5    Young, H.A.6
  • 76
    • 21044458270 scopus 로고    scopus 로고
    • Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant
    • Orabona C., Belladonna M.L., Vacca C., Bianchi R., Fallarino F., Volpi C., et al. Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant. Journal of Immunology 2005, 174:6582-6586.
    • (2005) Journal of Immunology , vol.174 , pp. 6582-6586
    • Orabona, C.1    Belladonna, M.L.2    Vacca, C.3    Bianchi, R.4    Fallarino, F.5    Volpi, C.6
  • 78
    • 33746875244 scopus 로고    scopus 로고
    • IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells
    • Strengell M., Lehtonen A., Matikainen S., Julkunen I. IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells. Journal of Leukocyte Biology 2006, 79:1279-1285.
    • (2006) Journal of Leukocyte Biology , vol.79 , pp. 1279-1285
    • Strengell, M.1    Lehtonen, A.2    Matikainen, S.3    Julkunen, I.4
  • 79
    • 33746190828 scopus 로고    scopus 로고
    • Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo
    • Li Y., Chu N., Rostami A., Zhang G.X. Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro and in vivo. Journal of Immunology 2006, 177:1679-1688.
    • (2006) Journal of Immunology , vol.177 , pp. 1679-1688
    • Li, Y.1    Chu, N.2    Rostami, A.3    Zhang, G.X.4
  • 81
    • 49249132865 scopus 로고    scopus 로고
    • Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins
    • Dimitriou I.D., Clemenza L., Scotter A.J., Chen G., Guerra F.M., Rottapel R. Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. Immunological Reviews 2008, 224:265-283.
    • (2008) Immunological Reviews , vol.224 , pp. 265-283
    • Dimitriou, I.D.1    Clemenza, L.2    Scotter, A.J.3    Chen, G.4    Guerra, F.M.5    Rottapel, R.6
  • 83
    • 45549102525 scopus 로고    scopus 로고
    • Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes
    • Zhang X., Jin J., Peng X., Ramgolam V.S., Markovic-Plese S. Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. Journal of Immunology 2008, 180:6988-6996.
    • (2008) Journal of Immunology , vol.180 , pp. 6988-6996
    • Zhang, X.1    Jin, J.2    Peng, X.3    Ramgolam, V.S.4    Markovic-Plese, S.5
  • 84
    • 78650341401 scopus 로고    scopus 로고
    • Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma
    • Hausding M., Tepe M., Ubel C., Lehr H.A., Rohrig B., Hohn Y., et al. Induction of tolerogenic lung CD4+ T cells by local treatment with a pSTAT-3 and pSTAT-5 inhibitor ameliorated experimental allergic asthma. International Immunology 2011, 23:1-15.
    • (2011) International Immunology , vol.23 , pp. 1-15
    • Hausding, M.1    Tepe, M.2    Ubel, C.3    Lehr, H.A.4    Rohrig, B.5    Hohn, Y.6
  • 88
    • 33644536099 scopus 로고    scopus 로고
    • IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3
    • Owaki T., Asakawa M., Kamiya S., Takeda K., Fukai F., Mizuguchi J., et al. IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3. Journal of Immunology 2006, 176:2773-2780.
    • (2006) Journal of Immunology , vol.176 , pp. 2773-2780
    • Owaki, T.1    Asakawa, M.2    Kamiya, S.3    Takeda, K.4    Fukai, F.5    Mizuguchi, J.6
  • 89
    • 33751568890 scopus 로고    scopus 로고
    • IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways
    • Owaki T., Asakawa M., Fukai F., Mizuguchi J., Yoshimoto T. IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. Journal of Immunology 2006, 177:7579-7587.
    • (2006) Journal of Immunology , vol.177 , pp. 7579-7587
    • Owaki, T.1    Asakawa, M.2    Fukai, F.3    Mizuguchi, J.4    Yoshimoto, T.5
  • 90
    • 0036533474 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance
    • Egwuagu C.E., Yu C.R., Zhang M., Mahdi R.M., Kim S.J., Gery I. Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. Journal of Immunology 2002, 168:3181-3187.
    • (2002) Journal of Immunology , vol.168 , pp. 3181-3187
    • Egwuagu, C.E.1    Yu, C.R.2    Zhang, M.3    Mahdi, R.M.4    Kim, S.J.5    Gery, I.6
  • 91
    • 0141996324 scopus 로고    scopus 로고
    • SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit
    • Yamamoto K., Yamaguchi M., Miyasaka N., Miura O. SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. Biochemical and Biophysical Research Communications 2003, 310:1188-1193.
    • (2003) Biochemical and Biophysical Research Communications , vol.310 , pp. 1188-1193
    • Yamamoto, K.1    Yamaguchi, M.2    Miyasaka, N.3    Miura, O.4
  • 92
    • 20144372087 scopus 로고    scopus 로고
    • Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression
    • Takatori H., Nakajima H., Kagami S., Hirose K., Suto A., Suzuki K., et al. Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. Journal of Immunology 2005, 174:4105-4112.
    • (2005) Journal of Immunology , vol.174 , pp. 4105-4112
    • Takatori, H.1    Nakajima, H.2    Kagami, S.3    Hirose, K.4    Suto, A.5    Suzuki, K.6
  • 93
  • 94
    • 33645849231 scopus 로고    scopus 로고
    • Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1
    • Kinjyo I., Inoue H., Hamano S., Fukuyama S., Yoshimura T., Koga K., et al. Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. Journal of Experimental Medicine 2006, 203:1021-1031.
    • (2006) Journal of Experimental Medicine , vol.203 , pp. 1021-1031
    • Kinjyo, I.1    Inoue, H.2    Hamano, S.3    Fukuyama, S.4    Yoshimura, T.5    Koga, K.6
  • 96
    • 77953293952 scopus 로고    scopus 로고
    • Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    • Durant L., Watford W.T., Ramos H.L., Laurence A., Vahedi G., Wei L., et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity 2010, 32:605-615.
    • (2010) Immunity , vol.32 , pp. 605-615
    • Durant, L.1    Watford, W.T.2    Ramos, H.L.3    Laurence, A.4    Vahedi, G.5    Wei, L.6
  • 97
    • 33745190069 scopus 로고    scopus 로고
    • SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
    • Wong P.K., Egan P.J., Croker B.A., O'Donnell K., Sims N.A., Drake S., et al. SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. Journal of Clinical Investigation 2006, 116:1571-1581.
    • (2006) Journal of Clinical Investigation , vol.116 , pp. 1571-1581
    • Wong, P.K.1    Egan, P.J.2    Croker, B.A.3    O'Donnell, K.4    Sims, N.A.5    Drake, S.6
  • 99
  • 102
    • 79957809530 scopus 로고    scopus 로고
    • Human beta-defensin-2 enhances IFN-gamma and IL-10 production and suppresses IL-17 production in T cells
    • Kanda N., Kamata M., Tada Y., Ishikawa T., Sato S., Watanabe S. Human beta-defensin-2 enhances IFN-gamma and IL-10 production and suppresses IL-17 production in T cells. Journal of Leukocyte Biology 2011, 89:935-944.
    • (2011) Journal of Leukocyte Biology , vol.89 , pp. 935-944
    • Kanda, N.1    Kamata, M.2    Tada, Y.3    Ishikawa, T.4    Sato, S.5    Watanabe, S.6
  • 104
    • 34547901394 scopus 로고    scopus 로고
    • Deficient SOCS3 expression in CD4+ CD25+ FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function
    • Pillemer B.B., Xu H., Oriss T.B., Qi Z., Ray A. Deficient SOCS3 expression in CD4+ CD25+ FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. European Journal of Immunology 2007, 37:2082-2089.
    • (2007) European Journal of Immunology , vol.37 , pp. 2082-2089
    • Pillemer, B.B.1    Xu, H.2    Oriss, T.B.3    Qi, Z.4    Ray, A.5
  • 106
    • 66249138469 scopus 로고    scopus 로고
    • Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells
    • Kagami S., Owada T., Kanari H., Saito Y., Suto A., Ikeda K., et al. Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. International Immunology 2009, 21:679-689.
    • (2009) International Immunology , vol.21 , pp. 679-689
    • Kagami, S.1    Owada, T.2    Kanari, H.3    Saito, Y.4    Suto, A.5    Ikeda, K.6
  • 108
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan S.R., Landers C.J., Yang H., Lodes M.J., Cong Y., Papadakis K.A., et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 2005, 128:2020-2028.
    • (2005) Gastroenterology , vol.128 , pp. 2020-2028
    • Targan, S.R.1    Landers, C.J.2    Yang, H.3    Lodes, M.J.4    Cong, Y.5    Papadakis, K.A.6
  • 109
    • 70350093622 scopus 로고    scopus 로고
    • An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice
    • e1741
    • Kobayashi K., Qiao S.W., Yoshida M., Baker K., Lencer W.I., Blumberg R.S. An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice. Gastroenterology 2009, 137:1746-1756. e1741.
    • (2009) Gastroenterology , vol.137 , pp. 1746-1756
    • Kobayashi, K.1    Qiao, S.W.2    Yoshida, M.3    Baker, K.4    Lencer, W.I.5    Blumberg, R.S.6
  • 111
    • 15844373147 scopus 로고    scopus 로고
    • Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease
    • Nishiwaki T., Ina K., Goto H., Watanabe O., Tsuzuki T., Furuta R., et al. Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease. Journal of Gastroenterology 2005, 40:128-136.
    • (2005) Journal of Gastroenterology , vol.40 , pp. 128-136
    • Nishiwaki, T.1    Ina, K.2    Goto, H.3    Watanabe, O.4    Tsuzuki, T.5    Furuta, R.6
  • 115
    • 36048932040 scopus 로고    scopus 로고
    • SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis
    • Le Y., Zhu B.M., Harley B., Park S.Y., Kobayashi T., Manis J.P., et al. SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis. Immunity 2007, 27:811-823.
    • (2007) Immunity , vol.27 , pp. 811-823
    • Le, Y.1    Zhu, B.M.2    Harley, B.3    Park, S.Y.4    Kobayashi, T.5    Manis, J.P.6
  • 117
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
    • Grivennikov S.I., Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine and Growth Factor Reviews 2010, 21:11-19.
    • (2010) Cytokine and Growth Factor Reviews , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 118
    • 27144433826 scopus 로고    scopus 로고
    • Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
    • Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., et al. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene 2005, 24:6406-6417.
    • (2005) Oncogene , vol.24 , pp. 6406-6417
    • Niwa, Y.1    Kanda, H.2    Shikauchi, Y.3    Saiura, A.4    Matsubara, K.5    Kitagawa, T.6
  • 121
    • 58549089179 scopus 로고    scopus 로고
    • Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio-carcinoma due to SOCS3 epigenetic silencing
    • Isomoto H. Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in cholangio-carcinoma due to SOCS3 epigenetic silencing. Digestion 2009, 79(Suppl. 1):2-8.
    • (2009) Digestion , vol.79 , Issue.SUPPL. 1 , pp. 2-8
    • Isomoto, H.1
  • 122
    • 33646146734 scopus 로고    scopus 로고
    • Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production
    • Ogata H., Chinen T., Yoshida T., Kinjyo I., Takaesu G., Shiraishi H., et al. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. Oncogene 2006, 25:2520-2530.
    • (2006) Oncogene , vol.25 , pp. 2520-2530
    • Ogata, H.1    Chinen, T.2    Yoshida, T.3    Kinjyo, I.4    Takaesu, G.5    Shiraishi, H.6
  • 123
    • 33846200831 scopus 로고    scopus 로고
    • Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing
    • Isomoto H., Mott J.L., Kobayashi S., Werneburg N.W., Bronk S.F., Haan S., et al. Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing. Gastroenterology 2007, 132:384-396.
    • (2007) Gastroenterology , vol.132 , pp. 384-396
    • Isomoto, H.1    Mott, J.L.2    Kobayashi, S.3    Werneburg, N.W.4    Bronk, S.F.5    Haan, S.6
  • 124
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S., Karin E., Terzic J., Mucida D., Yu G.Y., Vallabhapurapu S., et al. IL-6 and stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 2009, 15:103-113.
    • (2009) Cancer Cell , vol.15 , pp. 103-113
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5    Vallabhapurapu, S.6
  • 125
    • 77149155643 scopus 로고    scopus 로고
    • Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
    • Li Y., de Haar C., Chen M., Deuring J., Gerrits M.M., Smits R., et al. Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut 2010, 59:227-235.
    • (2010) Gut , vol.59 , pp. 227-235
    • Li, Y.1    de Haar, C.2    Chen, M.3    Deuring, J.4    Gerrits, M.M.5    Smits, R.6
  • 126
    • 81855166109 scopus 로고    scopus 로고
    • Tumor-associated Macrophages (TAM) and inflammation in colorectal cancer
    • Erreni M., Mantovani A., Allavena P. Tumor-associated Macrophages (TAM) and inflammation in colorectal cancer. Cancer Microenvironment 2011, 4:141-154.
    • (2011) Cancer Microenvironment , vol.4 , pp. 141-154
    • Erreni, M.1    Mantovani, A.2    Allavena, P.3
  • 127
    • 39649120597 scopus 로고    scopus 로고
    • Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
    • Duluc D., Delneste Y., Tan F., Moles M.P., Grimaud L., Lenoir J., et al. Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood 2007, 110:4319-4330.
    • (2007) Blood , vol.110 , pp. 4319-4330
    • Duluc, D.1    Delneste, Y.2    Tan, F.3    Moles, M.P.4    Grimaud, L.5    Lenoir, J.6
  • 128
    • 33644775602 scopus 로고    scopus 로고
    • An oligonucleotide decoy for Stat3 activates the immune response of macrophages to breast cancer
    • Sun Z., Yao Z., Liu S., Tang H., Yan X. An oligonucleotide decoy for Stat3 activates the immune response of macrophages to breast cancer. Immunobiology 2006, 211:199-209.
    • (2006) Immunobiology , vol.211 , pp. 199-209
    • Sun, Z.1    Yao, Z.2    Liu, S.3    Tang, H.4    Yan, X.5
  • 129
    • 77953752609 scopus 로고    scopus 로고
    • Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses
    • Wang Y.C., He F., Feng F., Liu X.W., Dong G.Y., Qin H.Y., et al. Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. Cancer Research 2010, 70:4840-4849.
    • (2010) Cancer Research , vol.70 , pp. 4840-4849
    • Wang, Y.C.1    He, F.2    Feng, F.3    Liu, X.W.4    Dong, G.Y.5    Qin, H.Y.6
  • 130
    • 79959567446 scopus 로고    scopus 로고
    • Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction
    • Hiwatashi K., Tamiya T., Hasegawa E., Fukaya T., Hashimoto M., Kakoi K., et al. Suppression of SOCS3 in macrophages prevents cancer metastasis by modifying macrophage phase and MCP2/CCL8 induction. Cancer Letters 2011, 308:172-180.
    • (2011) Cancer Letters , vol.308 , pp. 172-180
    • Hiwatashi, K.1    Tamiya, T.2    Hasegawa, E.3    Fukaya, T.4    Hashimoto, M.5    Kakoi, K.6
  • 131
    • 77956920766 scopus 로고    scopus 로고
    • Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells
    • Lechner M.G., Liebertz D.J., Epstein A.L. Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells. Journal of Immunology 2010, 185:2273-2284.
    • (2010) Journal of Immunology , vol.185 , pp. 2273-2284
    • Lechner, M.G.1    Liebertz, D.J.2    Epstein, A.L.3
  • 132
    • 79958066494 scopus 로고    scopus 로고
    • Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines
    • Lechner M.G., Megiel C., Russell S.M., Bingham B., Arger N., Woo T., et al. Functional characterization of human Cd33+ and Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines. Journal of Translational Medicine 2011, 9:90.
    • (2011) Journal of Translational Medicine , vol.9 , pp. 90
    • Lechner, M.G.1    Megiel, C.2    Russell, S.M.3    Bingham, B.4    Arger, N.5    Woo, T.6
  • 133
    • 79251535018 scopus 로고    scopus 로고
    • Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells
    • Medina-Echeverz J., Fioravanti J., Zabala M., Ardaiz N., Prieto J., Berraondo P. Successful colon cancer eradication after chemoimmunotherapy is associated with profound phenotypic change of intratumoral myeloid cells. Journal of Immunology 2011, 186:807-815.
    • (2011) Journal of Immunology , vol.186 , pp. 807-815
    • Medina-Echeverz, J.1    Fioravanti, J.2    Zabala, M.3    Ardaiz, N.4    Prieto, J.5    Berraondo, P.6
  • 134
    • 79960409792 scopus 로고    scopus 로고
    • Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors
    • Iwata-Kajihara T., Sumimoto H., Kawamura N., Ueda R., Takahashi T., Mizuguchi H., et al. Enhanced cancer immunotherapy using STAT3-depleted dendritic cells with high Th1-inducing ability and resistance to cancer cell-derived inhibitory factors. Journal of Immunology 2011, 187:27-36.
    • (2011) Journal of Immunology , vol.187 , pp. 27-36
    • Iwata-Kajihara, T.1    Sumimoto, H.2    Kawamura, N.3    Ueda, R.4    Takahashi, T.5    Mizuguchi, H.6
  • 135
    • 42049095495 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy
    • Zeng X., Kinsella T.J. Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy. Cancer Research 2008, 68:2384-2390.
    • (2008) Cancer Research , vol.68 , pp. 2384-2390
    • Zeng, X.1    Kinsella, T.J.2
  • 136
    • 78651403369 scopus 로고    scopus 로고
    • Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing
    • Zang Z.J., Ong C.K., Cutcutache I., Yu W., Zhang S.L., Huang D., et al. Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing. Cancer Research 2010, 71:29-39.
    • (2010) Cancer Research , vol.71 , pp. 29-39
    • Zang, Z.J.1    Ong, C.K.2    Cutcutache, I.3    Yu, W.4    Zhang, S.L.5    Huang, D.6
  • 137
    • 70349423483 scopus 로고    scopus 로고
    • Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    • Sinicrope F.A., Rego R.L., Ansell S.M., Knutson K.L., Foster N.R., Sargent D.J. Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology 2009, 137:1270-1279.
    • (2009) Gastroenterology , vol.137 , pp. 1270-1279
    • Sinicrope, F.A.1    Rego, R.L.2    Ansell, S.M.3    Knutson, K.L.4    Foster, N.R.5    Sargent, D.J.6
  • 138
    • 77950468866 scopus 로고    scopus 로고
    • Intratumoral CD8(+) T/FOXP3 (+) cell ratio is a predictive marker for survival in patients with colorectal cancer
    • Suzuki H., Chikazawa N., Tasaka T., Wada J., Yamasaki A., Kitaura Y., et al. Intratumoral CD8(+) T/FOXP3 (+) cell ratio is a predictive marker for survival in patients with colorectal cancer. Cancer Immunology, Immunotherapy 2010, 59:653-661.
    • (2010) Cancer Immunology, Immunotherapy , vol.59 , pp. 653-661
    • Suzuki, H.1    Chikazawa, N.2    Tasaka, T.3    Wada, J.4    Yamasaki, A.5    Kitaura, Y.6
  • 139
    • 84863717093 scopus 로고    scopus 로고
    • Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer
    • [Epub ahead of print]
    • Betts G., Jones E., Junaid S., El-Shanawany T., Scurr M., Mizen P., et al. Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut 2011, [Epub ahead of print].
    • (2011) Gut
    • Betts, G.1    Jones, E.2    Junaid, S.3    El-Shanawany, T.4    Scurr, M.5    Mizen, P.6
  • 140
    • 79959742164 scopus 로고    scopus 로고
    • Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer
    • Ladoire S., Martin F., Ghiringhelli F. Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer. Cancer Immunology, Immunotherapy 2010, 60:909-918.
    • (2010) Cancer Immunology, Immunotherapy , vol.60 , pp. 909-918
    • Ladoire, S.1    Martin, F.2    Ghiringhelli, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.