Indoleamine 2,3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation

Journal of Immunology

Volumn 164, Issue 7, 2000, Pages 3596-3599

  Hwu, Patrick ^a   Du, Mark X ^b   Lapointe, Réjean ^a   Do, My ^a   Taylor, Milton W ^b   Young, Howard A ^c  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INDIANA UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; INDOLEAMINE 2,3 DIOXYGENASE; INTERFERON; LIGAND; MESSENGER RNA; TRYPTOPHAN;

AMINO ACID METABOLISM; ARTICLE; CELL ACTIVATION; DENDRITIC CELL; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; PRIORITY JOURNAL; REGULATORY MECHANISM; T LYMPHOCYTE;

EID: 0034176031     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.7.3596     Document Type: Article

References (13)

1. Banchereau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
2. Rissoan, M. C., V. Soumelis, N. Kadowaki, G. Grouard, F. Briere, R. de Waal Malefyt, and Y. Liu. 1999. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283:1183.
3. Sallusto, F., and A. Lanzavecchia. 1999. Mobilizing dendritic cells for tolerance, priming, and chronic inflammation. J. Exp. Med. 189:611.
4. Taylor, M. W., and G. Feng. 1991. Relationship between interferon-γ, indoleamine 2,3-dioxygenase, and tryptophan catabolism. FASEB J. 5:2516.
5. Munn, D. H., M. Zhou, J. Attwood, I. Bondarev, S. Conway, B. Marshall, C. Brown, and A. Mellor. 1998. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281:1191.
6. Munn, D. H., E. Shafizadeh, J. Attwood, I. Bondarev, A. Pashine, and A. Mellor. 1999. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J. Exp. Med. 189:1363.
7. + leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J. Leukocyte Biol. 59:208.
8. Xu, H., M. Kramer, H. Spengler, and J. Peters. 1995. Dendritic cells differentiated from human monocytes through a combination of IL-4, GM-CSF and IFN-γ exhibit phenotype and function of blood dendritic cells. Adv. Exp. Med. Biol. 378:75.
9. Ye, J., J. Ortaldo, K. Conlon, R. Winkler-Pickelt, and H. A. Young. 1995. Cellular and molecular mechanisms of IFN-γ production induced by IL-2 and IL-12 in a human NK cell line. J. Leukocyte Biol. 58:225.
10. Yong, S., and S. Lau. 1979. Rapid separation of tryptophan, kynurenines, and indoles using reversed-phase high-performance liquid chromatography. J. Chromatogr. 175:343.
11. + T cells. J. Exp. Med. 186:239.
12. Boehme, S. A., and M Lenardo. 1993. Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle. Ear. J. Immunol. 23:1552.
13. + T cells. J. Exp. Med. 185:2133.