Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes

Journal of Immunology

Volumn 180, Issue 10, 2008, Pages 6988-6996

  Zhang, Xin ^a   Jin, Jianping ^b   Peng, Xueyan ^c   Ramgolam, Vinod S ^a   Markovic Plese, Silva ^a,d  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 6; JANUS KINASE; MEVALONIC ACID; RELATED ORPHAN NUCLEAR HORMONE RECEPTOR C; RETINOIC ACID; SIMVASTATIN; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; SUPPRESSOR OF CYTOKINE SIGNALING 7; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CELL RECEPTOR; IMMUNOLOGIC FACTOR; NUCLEAR PROTEIN; SOCS3 PROTEIN, HUMAN; SOCS7 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING;

ARTICLE; CD4+ T LYMPHOCYTE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG MECHANISM; DRUG TARGETING; GENE; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HUMAN; IL 23 GENE; IL 6 GENE; IMMUNOMODULATION; MONOCYTE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TH17 CELL; BIOSYNTHESIS; DNA MICROARRAY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; MALE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION; T LYMPHOCYTE SUBPOPULATION; WESTERN BLOTTING;

BLOTTING, WESTERN; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-17; MALE; MONOCYTES; MULTIPLE SCLEROSIS; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIMVASTATIN; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTE SUBSETS;

EID: 45549102525     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.10.6988     Document Type: Article

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