SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit

Biochemical and Biophysical Research Communications

Volumn 310, Issue 4, 2003, Pages 1188-1193

  Yamamoto, Koh ^a   Yamaguchi, Mitsuko ^a   Miyasaka, Nobuyuki ^a   Miura, Osamu ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

IL 12; IL 12R 2; SOCS 3; STAT4; Th1; Th2

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; MUTANT PROTEIN; PROTEIN; RECEPTOR SUBUNIT; STAT4 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BETA CHAIN; BINDING SITE; CONTROLLED STUDY; DNA TRANSCRIPTION; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TH1 CELL;

EID: 0141996324     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.09.140     Document Type: Article

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