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Volumn 132, Issue 1, 2007, Pages 384-396

Sustained IL-6/STAT-3 Signaling in Cholangiocarcinoma Cells Due to SOCS-3 Epigenetic Silencing

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; INTERLEUKIN 6; PROTEIN MCL 1; SMALL INTERFERING RNA; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRICHOSTATIN A; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

EID: 33846200831     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.10.037     Document Type: Article
Times cited : (187)

References (57)
  • 1
    • 0037698899 scopus 로고    scopus 로고
    • Cholangiocarcinoma: current concepts and insights
    • Gores G.J. Cholangiocarcinoma: current concepts and insights. Hepatology 37 (2003) 961-969
    • (2003) Hepatology , vol.37 , pp. 961-969
    • Gores, G.J.1
  • 3
    • 0034905260 scopus 로고    scopus 로고
    • Late development of bile duct cancer in patients who had biliary-enteric drainage for benign disease: a follow-up study of more than 1,000 patients
    • Tocchi A., Mazzoni G., Liotta G., Lepre L., Cassini D., and Miccini M. Late development of bile duct cancer in patients who had biliary-enteric drainage for benign disease: a follow-up study of more than 1,000 patients. Ann Surg 234 (2001) 210-214
    • (2001) Ann Surg , vol.234 , pp. 210-214
    • Tocchi, A.1    Mazzoni, G.2    Liotta, G.3    Lepre, L.4    Cassini, D.5    Miccini, M.6
  • 5
    • 26044444704 scopus 로고    scopus 로고
    • Role of inflammation in pancreatic carcinogenesis and the implications for future therapy
    • Garcea G., Dennison A.R., Steward W.P., and Berry D.P. Role of inflammation in pancreatic carcinogenesis and the implications for future therapy. Pancreatology 5 (2005) 514-529
    • (2005) Pancreatology , vol.5 , pp. 514-529
    • Garcea, G.1    Dennison, A.R.2    Steward, W.P.3    Berry, D.P.4
  • 6
    • 31144461664 scopus 로고    scopus 로고
    • Helicobacter infection and gastric neoplasia
    • Peek Jr. R.M., and Crabtree J.E. Helicobacter infection and gastric neoplasia. J Pathol 208 (2006) 233-248
    • (2006) J Pathol , vol.208 , pp. 233-248
    • Peek Jr., R.M.1    Crabtree, J.E.2
  • 7
    • 3042599473 scopus 로고    scopus 로고
    • Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
    • Itzkowitz S.H., and Yio X. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 287 (2004) G7-G17
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • Itzkowitz, S.H.1    Yio, X.2
  • 8
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 9
    • 11244335567 scopus 로고    scopus 로고
    • Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy
    • Sirica A.E. Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. Hepatology 41 (2005) 5-15
    • (2005) Hepatology , vol.41 , pp. 5-15
    • Sirica, A.E.1
  • 12
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 4 (2004) 11-22
    • (2004) Nat Rev Cancer , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 13
    • 0031912084 scopus 로고    scopus 로고
    • Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker
    • Goydos J.S., Brumfield A.M., Frezza E., Booth A., Lotze M.T., and Carty S.E. Marked elevation of serum interleukin-6 in patients with cholangiocarcinoma: validation of utility as a clinical marker. Ann Surg 227 (1998) 398-404
    • (1998) Ann Surg , vol.227 , pp. 398-404
    • Goydos, J.S.1    Brumfield, A.M.2    Frezza, E.3    Booth, A.4    Lotze, M.T.5    Carty, S.E.6
  • 14
    • 0032714310 scopus 로고    scopus 로고
    • Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line
    • Park J., Tadlock L., Gores G.J., and Patel T. Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. Hepatology 30 (1999) 1128-1133
    • (1999) Hepatology , vol.30 , pp. 1128-1133
    • Park, J.1    Tadlock, L.2    Gores, G.J.3    Patel, T.4
  • 15
    • 0027942090 scopus 로고
    • Interleukin-6 functions as an autocrine growth factor in a cholangiocarcinoma cell line
    • Okada K., Shimizu Y., Nambu S., Higuchi K., and Watanabe A. Interleukin-6 functions as an autocrine growth factor in a cholangiocarcinoma cell line. J Gastroenterol Hepatol 9 (1994) 462-467
    • (1994) J Gastroenterol Hepatol , vol.9 , pp. 462-467
    • Okada, K.1    Shimizu, Y.2    Nambu, S.3    Higuchi, K.4    Watanabe, A.5
  • 17
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge D.R., Hurt E.M., and Farrar W.L. The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer 41 (2005) 2502-2512
    • (2005) Eur J Cancer , vol.41 , pp. 2502-2512
    • Hodge, D.R.1    Hurt, E.M.2    Farrar, W.L.3
  • 18
    • 32944479992 scopus 로고    scopus 로고
    • Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells
    • Isomoto H., Kobayashi S., Werneburg N.W., Bronk S.F., Guicciardi M.E., Frank D.A., and Gores G.J. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 42 (2005) 1329-1338
    • (2005) Hepatology , vol.42 , pp. 1329-1338
    • Isomoto, H.1    Kobayashi, S.2    Werneburg, N.W.3    Bronk, S.F.4    Guicciardi, M.E.5    Frank, D.A.6    Gores, G.J.7
  • 19
    • 20444452357 scopus 로고    scopus 로고
    • Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells
    • Kobayashi S., Werneburg N.W., Bronk S.F., Kaufmann S.H., and Gores G.J. Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. Gastroenterology 128 (2005) 2054-2065
    • (2005) Gastroenterology , vol.128 , pp. 2054-2065
    • Kobayashi, S.1    Werneburg, N.W.2    Bronk, S.F.3    Kaufmann, S.H.4    Gores, G.J.5
  • 21
    • 0142250392 scopus 로고    scopus 로고
    • Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence
    • Trikha M., Corringham R., Klein B., and Rossi J.F. Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: a review of the rationale and clinical evidence. Clin Cancer Res 9 (2003) 4653-4665
    • (2003) Clin Cancer Res , vol.9 , pp. 4653-4665
    • Trikha, M.1    Corringham, R.2    Klein, B.3    Rossi, J.F.4
  • 22
    • 0038320035 scopus 로고    scopus 로고
    • Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
    • Almasan A., and Ashkenazi A. Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy. Cytokine Growth Factor Rev 14 (2003) 337-348
    • (2003) Cytokine Growth Factor Rev , vol.14 , pp. 337-348
    • Almasan, A.1    Ashkenazi, A.2
  • 23
    • 0036892964 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling: relevance to gastrointestinal function and disease
    • Greenhalgh C.J., Miller M.E., Hilton D.J., and Lund P.K. Suppressors of cytokine signaling: relevance to gastrointestinal function and disease. Gastroenterology 123 (2002) 2064-2081
    • (2002) Gastroenterology , vol.123 , pp. 2064-2081
    • Greenhalgh, C.J.1    Miller, M.E.2    Hilton, D.J.3    Lund, P.K.4
  • 24
    • 0346121599 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling and immunity
    • Kubo M., Hanada T., and Yoshimura A. Suppressors of cytokine signaling and immunity. Nat Immunol 4 (2003) 1169-1176
    • (2003) Nat Immunol , vol.4 , pp. 1169-1176
    • Kubo, M.1    Hanada, T.2    Yoshimura, A.3
  • 28
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • Schmitz J., Weissenbach M., Haan S., Heinrich P.C., and Schaper F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J Biol Chem 275 (2000) 12848-12856
    • (2000) J Biol Chem , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 29
    • 0345603004 scopus 로고    scopus 로고
    • The CpG island searcher: a new WWW resource
    • Takai D., and Jones P.A. The CpG island searcher: a new WWW resource. In Silico Biol 3 (2003) 235-240
    • (2003) In Silico Biol , vol.3 , pp. 235-240
    • Takai, D.1    Jones, P.A.2
  • 31
  • 32
    • 27144433826 scopus 로고    scopus 로고
    • Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
    • Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., Yamamoto J., Kubo T., and Yoshikawa H. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene 24 (2005) 6406-6417
    • (2005) Oncogene , vol.24 , pp. 6406-6417
    • Niwa, Y.1    Kanda, H.2    Shikauchi, Y.3    Saiura, A.4    Matsubara, K.5    Kitagawa, T.6    Yamamoto, J.7    Kubo, T.8    Yoshikawa, H.9
  • 33
    • 7644228433 scopus 로고    scopus 로고
    • CpG island methylation in gastroenterologic neoplasia: a maturing field
    • Rashid A., and Issa J.P. CpG island methylation in gastroenterologic neoplasia: a maturing field. Gastroenterology 127 (2004) 1578-1588
    • (2004) Gastroenterology , vol.127 , pp. 1578-1588
    • Rashid, A.1    Issa, J.P.2
  • 34
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman J.G., and Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349 (2003) 2042-2054
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 37
    • 0026788159 scopus 로고
    • Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells
    • Shimizu Y., Demetris A.J., Gollin S.M., Storto P.D., Bedford H.M., Altarac S., Iwatsuki S., Herberman R.B., and Whiteside T.L. Two new human cholangiocarcinoma cell lines and their cytogenetics and responses to growth factors, hormones, cytokines or immunologic effector cells. Int J Cancer 52 (1992) 252-260
    • (1992) Int J Cancer , vol.52 , pp. 252-260
    • Shimizu, Y.1    Demetris, A.J.2    Gollin, S.M.3    Storto, P.D.4    Bedford, H.M.5    Altarac, S.6    Iwatsuki, S.7    Herberman, R.B.8    Whiteside, T.L.9
  • 38
    • 0032951127 scopus 로고    scopus 로고
    • Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase
    • Park J., Gores G.J., and Patel T. Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase. Hepatology 29 (1999) 1037-1043
    • (1999) Hepatology , vol.29 , pp. 1037-1043
    • Park, J.1    Gores, G.J.2    Patel, T.3
  • 39
    • 0036105755 scopus 로고    scopus 로고
    • A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor
    • Hortner M., Nielsch U., Mayr L.M., Heinrich P.C., and Haan S. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur J Biochem 269 (2002) 2516-2526
    • (2002) Eur J Biochem , vol.269 , pp. 2516-2526
    • Hortner, M.1    Nielsch, U.2    Mayr, L.M.3    Heinrich, P.C.4    Haan, S.5
  • 40
    • 15444366416 scopus 로고    scopus 로고
    • Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3
    • Dunn S.L., Bjornholm M., Bates S.H., Chen Z., Seifert M., and Myers Jr. M.G. Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3. Mol Endocrinol 19 (2005) 925-938
    • (2005) Mol Endocrinol , vol.19 , pp. 925-938
    • Dunn, S.L.1    Bjornholm, M.2    Bates, S.H.3    Chen, Z.4    Seifert, M.5    Myers Jr., M.G.6
  • 42
    • 27544432516 scopus 로고    scopus 로고
    • Nonapoptotic functions of FADD-binding death receptors and their signaling molecules
    • Park S.M., Schickel R., and Peter M.E. Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol 17 (2005) 610-616
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 610-616
    • Park, S.M.1    Schickel, R.2    Peter, M.E.3
  • 43
    • 25844530426 scopus 로고    scopus 로고
    • Epigenetic changes in solid and hematopoietic tumors
    • Toyota M., and Issa J.P. Epigenetic changes in solid and hematopoietic tumors. Semin Oncol 32 (2005) 521-530
    • (2005) Semin Oncol , vol.32 , pp. 521-530
    • Toyota, M.1    Issa, J.P.2
  • 44
    • 0141537154 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    • Kang G.H., Lee H.J., Hwang K.S., Lee S., Kim J.H., and Kim J.S. Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol 163 (2003) 1551-1556
    • (2003) Am J Pathol , vol.163 , pp. 1551-1556
    • Kang, G.H.1    Lee, H.J.2    Hwang, K.S.3    Lee, S.4    Kim, J.H.5    Kim, J.S.6
  • 45
    • 0035955640 scopus 로고    scopus 로고
    • Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells
    • Hodge D.R., Xiao W., Clausen P.A., Heidecker G., Szyf M., and Farrar W.L. Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J Biol Chem 276 (2001) 39508-39511
    • (2001) J Biol Chem , vol.276 , pp. 39508-39511
    • Hodge, D.R.1    Xiao, W.2    Clausen, P.A.3    Heidecker, G.4    Szyf, M.5    Farrar, W.L.6
  • 48
    • 23944441266 scopus 로고    scopus 로고
    • Interleukin-6 regulation of prostate cancer cell growth
    • Culig Z., Steiner H., Bartsch G., and Hobisch A. Interleukin-6 regulation of prostate cancer cell growth. J Cell Biochem 95 (2005) 497-505
    • (2005) J Cell Biochem , vol.95 , pp. 497-505
    • Culig, Z.1    Steiner, H.2    Bartsch, G.3    Hobisch, A.4
  • 49
    • 3042819106 scopus 로고    scopus 로고
    • Phosphatidylinositide 3-kinase/AKT in radiation responses
    • Zhan M., and Han Z.C. Phosphatidylinositide 3-kinase/AKT in radiation responses. Histol Histopathol 19 (2004) 915-923
    • (2004) Histol Histopathol , vol.19 , pp. 915-923
    • Zhan, M.1    Han, Z.C.2
  • 51
    • 33746902024 scopus 로고    scopus 로고
    • Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes
    • Meng F., Yamagiwa Y., Ueno Y., and Patel T. Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes. J Hepatol 44 (2006) 1055-1065
    • (2006) J Hepatol , vol.44 , pp. 1055-1065
    • Meng, F.1    Yamagiwa, Y.2    Ueno, Y.3    Patel, T.4
  • 54
    • 21344474349 scopus 로고    scopus 로고
    • Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer
    • Horak P., Pils D., Haller G., Pribill I., Roessler M., Tomek S., Horvat R., Zeillinger R., Zielinski C., and Krainer M. Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer. Mol Cancer Res 3 (2005) 335-343
    • (2005) Mol Cancer Res , vol.3 , pp. 335-343
    • Horak, P.1    Pils, D.2    Haller, G.3    Pribill, I.4    Roessler, M.5    Tomek, S.6    Horvat, R.7    Zeillinger, R.8    Zielinski, C.9    Krainer, M.10
  • 55
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • Fulda S., Kufer M.U., Meyer E., van Valen F., Dockhorn-Dworniczak B., and Debatin K.M. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 20 (2001) 5865-5877
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    van Valen, F.4    Dockhorn-Dworniczak, B.5    Debatin, K.M.6
  • 56
    • 27144509196 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
    • Lyko F., and Brown R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 97 (2005) 1498-1506
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1498-1506
    • Lyko, F.1    Brown, R.2
  • 57
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: past, present and future
    • Yoo C.B., and Jones P.A. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5 (2006) 37-50
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2


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