Protein geranylgeranylation regulates the balance between Th 17 cells and Foxp3+ regulatory T cells

International Immunology

Volumn 21, Issue 6, 2009, Pages 679-689

  Kagami, Shin Ichiro ^a,b   Owada, Takayoshi ^b   Kanari, Hiroko ^a   Saito, Yukari ^b   Suto, Akira ^a,b   Ikeda, Kei ^b   Hirose, Koichi ^b   Watanabe, Norihiko ^b   Iwamoto, Itsuo ^c   Nakajima, Hiroshi ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

^c ASAHI GENERAL HOSPITAL   (Japan)

Author keywords

SOCS3; Statin; T cells; Tolerance

Indexed keywords

GGTI 298; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INTERLEUKIN 17; INTERLEUKIN 6; N [[5 [(2 AMINO 3 MERCAPTOPROPYL)AMINO][1,1' BIPHENYL] 2 YL]CARBONYL]METHIONINE METHYL ESTER; SIMVASTATIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTION FACTOR FOXP3; TRANSFERASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IMMUNOMODULATION; INTERFERON PRODUCTION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN GERANYLGERANYLATION; PROTEIN MODIFICATION; REGULATORY T LYMPHOCYTE; TH17 CELL;

ANIMALS; BENZAMIDES; CELL DIFFERENTIATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; INTERLEUKIN-17; INTERLEUKIN-6; METHIONINE; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; PEPTIDE FRAGMENTS; PRENYLATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SEVERE COMBINED IMMUNODEFICIENCY; SIMVASTATIN; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 66249138469     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxp037     Document Type: Article

References (34)

1. Murphy, K. M., Ouyang, W., Farrar, J. D. et al. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18:451.
2. Steinman, L. 2007. A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13:139.
3. McGeachy, M. J. and Cua, D. J. 2008. Th17 cell differentiation: The long and winding road. Immunity 28:445.
4. Dong, C. 2008. TH17 cells in development: An updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8:337.
5. + regulatory T cells. Immunol. Rev. 212:60.
6. + natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212:8.
7. Bettelli, E., Carrier, Y., Gao, W. et al. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441:235.
8. Mangan, P. R., Harrington, L. E., O'Quinn, D. B. et al. 2006. Transforming growth factor-β induces development of the TH17 lineage. Nature 441:231.
9. Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M. and Stockinger, B. 2006. TGF-β in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24:179.
10. Laurence, A., Tato, C. M., Davidson, T. S. et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26:371.
11. Liao, J. K. and Laufs, U. 2005. Pleiotropic effects of statins. Annu. Rev. Pharmacol. Toxicol. 45:89.
12. Greenwood, J., Steinman, L. and Zamvil, S. S. 2006. Statin therapy and autoimmune disease: From protein prenylation to immunomodulation. Nat. Rev. Immunol. 6:358.
13. Youssef, S., Stüve, O., Patarroyo, J. C. et al. 2002. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420:78.
14. Aktas, O., Waiczies, S., Smorodchenko, A. et al. 2003. Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin. J. Exp. Med. 197:725.
15. Vollmer, T., Key, L., Durkalski, V. et al. 2004. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet 363:1607.
16. McCarey, D. W., McInnes, I. B., Madhok, R. et al. 2004. Trial of Atorvastatin in Rheumatoid Arthritis (TARA): Double-blind, randomized placebo-controlled trial. Lancet 363:2015.
17. + lymphocytes. J. Immunol. 180:6988.
18. Zhang, F. L. and Casey, P. J. 1996. Protein prenylation: Molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:241.
19. Etienne-Manneville, S. and Hall, A. 2002. Rho GTPases in cell biology. Nature 420:629.
20. Dunn, S. E., Youssef, S., Goldstein, M. J. et al. 2006. Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. J. Exp. Med. 203:401.
21. lo thymocytes in vivo. Science 250:1720.
22. + T cells. J. Exp. Med. 205:1369.
23. Suzuki, K., Nakajima, H., Ikeda, K. et al. 2003. IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-α production in mast cells. J. Exp. Med. 198:1717.
24. Fantini, M. C., Rizzo, A., Fina, D. et al. 2007. IL-21 regulates experimental colitis by modulating the balance between Treg and Th17 cells. Eur. J. Immunol. 37:3155.
25. Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L. and Powrie, F. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190:995.
26. van de Donk, N. W., Kamphuis, M. M., van Kessel, B., Lokhorst, H. M. and Bloem, A. C. 2003. Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. Blood 102:3354.
27. Yoshimura, A., Naka, T. and Kubo, M. 2007. SOCS proteins, cytokine signalling and immune regulation. Nat. Rev. Immunol. 7:454.
28. Chen, Z., Laurence, A., Kanno, Y. et al. 2006. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl Acad. Sci. USA 103:8137.
29. Huang, K. C., Chen, C. W., Chen, J. C. and Lin, W. W. 2003. Statins induce suppressor of cytokine signaling-3 in macrophages. FEBS Lett. 555:385.
30. + T cells. Atherosclerosis 197:829.
31. Neurath, M. F., Weigmann, B., Finotto, S. et al. 2002. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J. Exp. Med. 6:1129.
32. Elson, C. O., Cong, Y., Weaver, C. T. et al. 2007. Monoclonal antiinterleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132:2359.
33. Yang, X. O., Nurieva, R., Martinez, G. J. et al. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29:44.
34. Zhou, L., Lopes, J. E., Chong, M. M. et al. 2008. TGF-β-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORγt function. Nature 453:236.