The suppressor of cytokine signaling (SOCS)-3 determines keratinocyte proliferative and migratory potential during skin repair

Journal of Investigative Dermatology

Volumn 130, Issue 3, 2010, Pages 876-885

  Linke, Andreas ^a   Goren, Itamar ^a   Bösl, Michael R ^b   Pfeilschifter, Josef ^a   Frank, Stefan ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 5; LORICRIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASEMENT MEMBRANE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKIN INJURY; TRANSGENIC MOUSE; WOUND; WOUND CLOSURE;

EID: 76649144503     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.344     Document Type: Article

References (43)

1. Alexander WS, Hilton DJ (2004) The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response. Annu Rev Immunol 22:503-529
2. Amendt C, Schirmacher P, Weber H et al. (1998) Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development. Oncogene 17:25-34
3. Apelqvist J, Larsson J, Agardh CD (1993) Long-term prognosis for diabetic patients with foot ulcers. J Intern Med 233:485-491
4. Asakura M, Kitakaze M, Takashima S et al. (2002) Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing HB-EGF: met allopro-teinase inhibitors as a new therapy. Nat Med 8:35-40
5. Barrandon Y, Green H (1987) Cell migration is essential for sustained growth of keratinocyte colonies: the role of transforming growth factor-alpha and epidermal growth factor. Cell 50:1131-1137
6. Blessing M, Nanney LB, King LE et al. (1993) Transgenic mice as a model to study the role of TGF-beta-related molecules in hair follicles. Genes Dev 7:204-215
7. Boukamp P, Petrussevska RT, Breitkreuz D et al. (1988) Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 106:761-771
8. Boulton AJM (2004) The diabetic foot: from art to science. The 18th Camillo Golgi lecture. Diabetologia 47:1343-1353
9. Carrington AL, Abbott CA, Griffiths J et al. (2001) A foot care program for diabetic unilateral lower limb amputees. Diabetes Care 24:216-221
10. Casatorres J, Navarro JM, Blessing M et al. (1994) Analysis of the control of expression and tissue specificity of the keratin 5 gene, characteristic of basal keratinocytes. Fundamental role of an AP-1 element. J Biol Chem 269:20489-20496
11. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
12. Eming SA, Krieg T, Davidson JM (2007) Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 127:514-525
13. Faglia E, Favales F, Morabito A (2001) New ulceration, new major amputation, and survival rates in diabetic subjects hospitalised for foot ulceration from 1990-1993: a 6.5-year follow-up. Diabetes Care 24:78-83
14. Frank S, Stallmeyer B, Kämpfer H et al. (1999) Nitric oxide triggers enhanced induction of vascular endothelial growth factor expression in cultured keratinocytes (HaCaT) and during cutaneous wound repair. FASEB J 13:2002-2014
15. Frank S, Stallmeyer B, Kämpfer H et al. (2000) Leptin enhances wound reepithelialization and constitutes a direct function of leptin in skin repair. J Clin Invest 106:501-509
16. Friedrich M, Holzmann R, Sterry W et al. (2003) Ultraviolet B radiation-mediated inhibition of interferon-gamma-induced keratinocyte activation is independent of interleukin-10 and other soluble mediators but associated with enhanced intracellular suppressors of cytokine-signaling expression. J Invest Dermatol 121:845-852
17. Gerdes J, Lemke H, Baisch H et al. (1984) Cell cycle analysis of a cell proliferation associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133:1710-1715
18. Goren I, Kämpfer H, Podda M et al. (2003) Leptin and wound inflammation in diabetic ob/ob mice: differential regulation of neutrophil and macro-phage influx and a potential role for the scab as a sink for inflammatory cells and mediators. Diabetes 52:2821-2832
19. Goren I, Linke A, Müller E et al. (2006) The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation. J Invest Dermatol 126:477-485
20. Goren I, Müller E, Schiefelbein D et al. (2007) Systemic anti-TNF-a treatment restores diabetes-impaired skin repair in ob/ob mice by inactivation of macrophages. J Invest Dermatol 127:2259-2267
21. Jeffcoate WJ, Harding KG (2003) Diabetic foot ulcers. Lancet 361:1545-1551
22. Kim BC, Kim HT, Park SH et al. (2003) Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta type II receptor expression. J Cell Physiol 195:331-336
23. Loot MA, Kenter SB, Au FL et al. (2002) Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF and PDGF-AB compared to controls. Eur J Cell Biol 81:153-160
24. Martin P (1997) Wound healing\-aiming for perfect skin regeneration. Science 276:75-81
25. Mehrel T, Hohl D, Rothnagel JA et al. (1990) Identification of a major keratinocyte cell envelope protein, loricrin. Cell 61:1103-1112
26. Neufang G, Fürstenberger G, Heidt M et al. (2001) Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin. Proc Natl Acad Sci USA 98:7629-7634
27. Pierce GF (2001) Inflammation in nonhealing diabetic wounds. The space-time continuum does matter. Am J Pathol 159:399-403
28. Pryce TD (1887) A case of perforating ulcers of both feet associated with diabetes and ataxic symptoms. Lancet 2:11-12
29. Reiber GE, Ledoux WR (2002) Epidemiology of diabetic foot ulcers and amputations: evidence for prevention. In The Evidence Base For Diabetes Care (Williams R, Herman W, Kinmonth AL, Wareham NJ, eds), Wiley: Chichester, 641-665
30. Sano S, Chan KS, Carbajal S et al. (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11:43-49
31. Sano S, Itami S, Takeda K et al. (1999) Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 18:4657-4668
32. Schweizer J, Winter H (1983) Keratin biosynthesis in normal mouse epithelia and in squamous cell carcinomas. J Biol Chem 258:13268-13272
33. Singer AK, Clark RAF (1999) Cutaneous wound healing. N Engl J Med 341:738-746
34. Smiell JM, Wieman TJ, Steed DL et al. (1999) Efficacy and safety of becaplermin (recombinant human platelet-derived growth factor-BB) in patients with non-healing, lower extremity diabetic ulcers: a combined analysis of four randomized studies. Wound Repair Regen 7:335-346
35. Stallmeyer B, Kämpfer H, Kolb N et al. (1999) The function of nitric oxide in wound repair: inhibition of inducible nitric oxide synthase severely impairs wound reepithelialization. J Invest Dermatol 113:1090-1098
36. Starr R, Willson TA, Viney EM et al. (1997) A family of cytokine-inducible inhibitors of signalling. Nature 387:917-921
37. Steven AC, Bisher ME, Roop DR et al. (1990) Biosynthetic pathways of filaggrin and loricrin\-two major proteins expressed by terminally differentiated epidermal keratinocytes. J Struct Biol 104:150-162
38. Tokumaru S, Sayama K, Shirakata Y et al. (2005a) Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37. J Immunol 175:4662-4668
39. Tokumaru S, Sayama K, Yamasaki K et al. (2005b) SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration. Biochem Biophys Res Commun 327:100-105
40. Wetzler C, Kämpfer H, Stallmeyer B et al. (2000) Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair. J Invest Dermatol 115:245-53
41. Wormald S, Hilton DJ (2004) Inhibitors of cytokine signal transduction. J Biol Chem 279:821-824
42. Yamasaki K, Hanakawa Y, Tokumaru S et al. (2003) Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes. J Invest Dermatol 120:571-580
43. Zhu BM, Ishida Y, Robinson GW et al. (2008) SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing. J Invest Dermatol 128:1821-1829