Epigenetic alterations in cholangiocarcinoma-sustained IL-6/STAT3 signaling in Cholangio- carcinoma due to SOCS3 epigenetic silencing

Digestion

Volumn 79, Issue SUPPL. 1, 2009, Pages 2-8

  Isomoto, Hajime ^a  

^a NAGASAKI UNIVERSITY HOSPITAL   (Japan)

Author keywords

Carcinogenesis; Cholangiocarcinoma; DNA hypermethylation; Epigenetics; Interleukin 6; Signal transducers and activators of transcription 3; Suppressor of cytokine signaling 3

Indexed keywords

INTERLEUKIN 6; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

APOPTOSIS; BILE DUCT CARCINOMA; CARCINOGENESIS; CONFERENCE PAPER; CPG ISLAND; DNA METHYLATION; EPIGENETICS; FEEDBACK SYSTEM; GENE SILENCING; HUMAN; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION;

BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CHOLANGIOCARCINOMA; DNA METHYLATION; EPIGENESIS, GENETIC; GENES, TUMOR SUPPRESSOR; HUMANS; INTERLEUKIN-6; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 58549089179     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000167859     Document Type: Conference Paper

References (47)

1. Lazaridis KN, Gores GJ: Cholangiocarcinoma. Gastroenterology 2005;128:1655-166.
2. Gores GJ: Cholangiocarcinoma: current concepts and insights. Hepatology 2003;37: 961-969.
3. Shaib YH, El-Serag HB: The epidemiology of cholangiocarcinoma. Semin Liver Dis 2004; 24:115-125.
4. Sandhu DS, Shire AM, Roberts LR: Epigenetic DNA hypermethylation in cholangiocarcinoma: potential roles in pathogenesis, diagnosis and identification of treatment targets. Liver Int 2008;28:12-27.
5. Khan SA, Davidson BR, Goldin R, Pereira SP, Rosenberg WM, Taylor-Robinson SD, Thillainayagam AV, Thomas HC, Thursz MR, Wasan H; British Society of Gastroenterology: Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document. Gut 2002;51(suppl 6):VI1-VI9.
6. Tischoff I, Wittekind C, Tannapfel A: Role of epigenetic alterations in cholangiocarcinoma. J Hepatobiliary Pancreat Surg 2006;13:274-279.
7. Kang YK, Kim WH, Lee HW, Lee HK, Kim YI: Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma. Lab Invest 1999;79:477-483.
8. Yoshida S, Todoroki T, Ichikawa Y, Hanai S, Suzuki H, Hori M, Fukao K, Miwa M, Uchida K: Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers. Cancer Res 1995;55:2756-2760.
9. Hahn SA, Bartsch D, Schroers A, Galehdari H, Becker M, Ramaswamy A, Schwarte-Waldhoff I, Maschek H, Schmiegel W: Mutations of the DPC4/Smad4 gene in biliary tract carcinoma. Cancer Res 1998;58:1124-1126.
10. Shiraishi K, Okita K, Kusano N, Harada T, Kondoh S, Okita S, Ryozawa S, Ohmura R, Noguchi T, Iida Y, Akiyama T, Oga A, Fukumoto Y, Furuya T, Kawauchi S, Sasaki K: A comparison of DNA copy number changes detected by comparative genomic hybridization in malignancies of the liver, biliary tract and pancreas. Oncology 2001;60:151-161.
11. Kawaki J, Miyazaki M, Ito H, Nakagawa K, Shimizu H, Yoshidome H, Uzawa K, Tanzawa H, Nakajima N: Allelic loss in human intrahepatic cholangiocarcinoma: correlation between chromosome 8p22 and tumor progression. Int J Cancer 2000;88:228-231.
12. Roth SY, Denu JM, Allis CD: Histone acetyltransferases. Annu Rev Biochem 2001;70:81-120.
13. Thiagalingam S, Cheng KH, Lee HJ, Mineva N, Thiagalingam A, Ponte JF: Histone deacetylases: unique players in shaping the epigenetic histone code. Ann NY Acad Sci 2003;983:84-100.
14. Baylin SB, Ohm JE: Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 2006;6:107-116.
15. Konishi K, Issa JP: Targeting aberrant chromatin structure in colorectal carcinomas. Cancer J 2007;13:49-55.
16. Pandolfi PP: Histone deacetylases and transcriptional therapy with their inhibitors. Cancer Chemother Pharmacol 2001;48(suppl 1):S17-S19.
17. Bird A: DNA methylation patterns and epigenetic memory. Genes Dev 2002;16:6-21.
18. Cooper DN, Gerber-Huber S: DNA methylation and CpG suppression. Cell Differ 1985; 17:199-205.
19. Riggs AD, Pfeifer GP: X-chromosome inactivation and cell memory. Trends Genet 1992;8:169-174.
20. Razin A, Cedar H: DNA methylation and genomic imprinting. Cell 1994;77:473-476.
21. Clouaire T, Stancheva I: Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin? Cell Mol Life Sci 2008;65:1509-1522.
22. Herman JG, Baylin SB: Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-2054.
23. Esteller M, Corn PG, Baylin SB, Herman JG: A gene hypermethylation profile of human cancer. Cancer Res 2001;61:3225-3229.
24. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-707.
25. Lee S, Kim WH, Jung HY, Yang MH, Kang GH: Aberrant CpG island methylation of multiple genes in intrahepatic cholangiocarcinoma. Am J Pathol 2002;161:1015-1122.
26. Tozawa T, Tamura G, Honda T, Nawata S, Kimura W, Makino N, Kawata S, Sugai T, Suto T, Motoyama T: Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients. Cancer Sci 2004;95:736-740.
27. Ahrendt SA, Eisenberger CF, Yip L, Rashid A, Chow JT, Pitt HA, Sidransky D: Chromosome 9p21 loss and p16 inactivation in primary sclerosing cholangitis-associated cholangiocarcinoma. J Surg Res 1999;84:88-93.
28. Yang B, House MG, Guo M, Herman JG, Clark DP: Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. Mod Pathol 2005;18:412-420.
29. Klump B, Hsieh CJ, Dette S, Holzmann K, Kiebetalich R, Jung M, Sinn U, Ortner M, Porschen R, Gregor M: Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease. Clin Cancer Res 2003;9:1773-1778.
30. Koga Y, Kitajima Y, Miyoshi A, Sato K, Kitahara K, Soejima H, Miyazaki K: Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers. Ann Surg Oncol 2005;12:354-363.
31. Hong SM, Choi J, Ryu K, Ro JY, Yu E: Promoter hypermethylation of the p16 gene and loss of its protein expression is correlated with tumor progression in extrahepatic bile duct carcinomas. Arch Pathol Lab Med 2006;130:33-38.
32. Tannapfel A, Sommerer F, Benicke M, Weinans L, Katalinic A, Geissler F, Uhlmann D, Hauss J, Wittekind C: Genetic and epigenetic alterations of the INK4a-ARF pathway in cholangiocarcinoma. J Pathol 2002;197:624-631.
33. Foja S, Goldberg M, Schagdarsurengin U, Dammann R, Tannapfel A, Ballhausen WG: Promoter methylation and loss of coding exons of the fragile histidine triad (FHIT) gene in intrahepatic cholangiocarcinomas. Liver Int 2005;25:1202-1208.
34. Wong N, Li L, Tsang K, Lai PB, To KF, Johnson PJ: Frequent loss of chromosome 3p and hypermethylation of RASSF1A in cholangiocarcinoma. J Hepatol 2002;37:633-639.
35. Raveh T, Kimchi A: DAP kinase-a proapoptotic gene that functions as a tumor suppressor. Exp Cell Res 2001;264:185-192.
36. Liu XF, Zhu SG, Zhang H, Xu Z, Su HL, Li SJ, Zhou XT: The methylation status of the TMS1/ASC gene in cholangiocarcinoma and its clinical significance. Hepatobiliary Pancreat Dis Int 2006;5:449-453.
37. Tischoff I, Markwarth A, Witzigmann H, Uhlmann D, Hauss J, Mirmohammadsadegh A, Wittekind C, Hengge UR, Tannapfel A: Allele loss and epigenetic inactivation of 3p21.3 in malignant liver tumors. Int J Cancer 2005;115:684-689.
38. Fishel R, Kolodner RD: Identification of mismatch repair genes and their role in the development of cancer. Curr Opin Genet Dev 1995;5:382-395.
39. Kane MF, Loda M, Gaida GM, Lipman J, Mishra R, Goldman H, Jessup JM, Kolodner R: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997;57:808-811.
40. Abraham SC, Lee JH, Boitnott JK, Argani P, Furth EE, Wu TT: Microsatellite instability in intraductal papillary neoplasms of the biliary tract. Mod Pathol 2002;15:1309-1317.
41. Limpaiboon T, Khaenam P, Chinnasri P, Soonklang M, Jearanaikoon P, Sripa B, Pairojkul C, Bhudhisawasdi V: Promoter hypermethylation is a major event of hMLH1 gene inactivation in liver fluke related cholangiocarcinoma. Cancer Lett 2005;217:213-219.
42. Casorelli I, Russo MT, Bignami M: Role of mismatch repair and MGMT in response to anticancer therapies. Anticancer Agents Med Chem 2008;8:368-380.
43. Stemmler MP: Cadherins in development and cancer. Mol Biosyst 2008;4:835-850.
44. Kubo M, Hanada T, Yoshimura A: Suppressors of cytokine signaling and immunity. Nat Immunol 2003;4:1169-1176.
45. Isomoto H, Mott JL, Kobayashi S, Werneburg NW, Bronk SF, Haan S, Gores GJ: Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing. Gastroenterology 2007;132:384-396.
46. Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, Gores GJ: Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology 2005;42:1329-1338.
47. Heinrich PC, Behrmann I, Haan S, Hermanns HM, Müller-Newen G, Schaper F: Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003;374:1-20.