메뉴 건너뛰기




Volumn 21, Issue 4, 2005, Pages 401-407

Recent advances in the genetics of inflammatory bowel disease

Author keywords

Card15; Crohn's disease; Genetic polymorphisms; Inflammatory bowel disease; Linkage analysis

Indexed keywords

BETA CATENIN; CARNITINE; CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; GUANYLATE KINASE; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MULTIDRUG RESISTANCE PROTEIN 1; MURAMYL DIPEPTIDE; ORGANIC CATION TRANSPORTER; PEPTIDOGLYCAN; PROTEIN DLG5; PROTEIN OCTN1; PROTEIN OCTN2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 21844473558     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (62)

References (111)
  • 1
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and pathogenesis
    • Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 1998; 115:182-205.
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 2
    • 0037148940 scopus 로고    scopus 로고
    • Genes, microbes, and T cells - New therapeutic targets in Crohn's disease
    • Elson CO. Genes, microbes, and T cells - new therapeutic targets in Crohn's disease. N Engl J Med 2002; 346:614-616.
    • (2002) N Engl J Med , vol.346 , pp. 614-616
    • Elson, C.O.1
  • 3
    • 0000651358 scopus 로고
    • Familial occurrences of ulcerative colitis, region enteritis and ileocolitis
    • Kirsner JB, Spencer JA. Familial occurrences of ulcerative colitis, region enteritis and ileocolitis. Ann Intern Med 1963; 59:133-144.
    • (1963) Ann Intern Med , vol.59 , pp. 133-144
    • Kirsner, J.B.1    Spencer, J.A.2
  • 4
    • 1842455329 scopus 로고    scopus 로고
    • Genetics of inflammatory bowel disease: Progress and prospects
    • Mathew CG, Lewis CM. Genetics of inflammatory bowel disease: progress and prospects. Hum Mol Genet 2004; 13:R161-R168.
    • (2004) Hum Mol Genet , vol.13
    • Mathew, C.G.1    Lewis, C.M.2
  • 5
    • 1042288640 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Crohn's disease and the success of NODern genetics
    • Newman B, Siminovitch K. Inflammatory bowel disease: Crohn's disease and the success of NODern genetics. Clin Invest Med 2003; 26:303-314.
    • (2003) Clin Invest Med , vol.26 , pp. 303-314
    • Newman, B.1    Siminovitch, K.2
  • 6
    • 13344259990 scopus 로고    scopus 로고
    • Mapping of a susceptibility locus for Crohn's disease on chromosome 16
    • Hugot JP, Laurent-Puig P, Gower-Rousseau C, et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature 1996; 379:821-823.
    • (1996) Nature , vol.379 , pp. 821-823
    • Hugot, J.P.1    Laurent-Puig, P.2    Gower-Rousseau, C.3
  • 7
    • 16044373177 scopus 로고    scopus 로고
    • Two-stage genome-wide search in inflammatory bowel disease: Evidence for susceptiblity loci on chromosomes 3, 7 and 12
    • Satsangi J, Parkes M, Louis E, et al. Two-stage genome-wide search in inflammatory bowel disease: evidence for susceptiblity loci on chromosomes 3, 7 and 12. Nat Genet 1996; 14:199-202.
    • (1996) Nat Genet , vol.14 , pp. 199-202
    • Satsangi, J.1    Parkes, M.2    Louis, E.3
  • 8
    • 13144261748 scopus 로고    scopus 로고
    • Identification of novel susceptibility loci for inflammatory bowel disease on chromomes 1p, 3q and 4q: Evidence for epistasis between 1p and IBD1
    • Cho JH, Nicolae DL, Gold LH, et al. Identification of novel susceptibility loci for inflammatory bowel disease on chromomes 1p, 3q and 4q: evidence for epistasis between 1p and IBD1. Proc Natl Acad Sci USA 1998; 95:7502-7507.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7502-7507
    • Cho, J.H.1    Nicolae, D.L.2    Gold, L.H.3
  • 9
    • 17144456849 scopus 로고    scopus 로고
    • Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16
    • Curran ME, Lau KF, Hampe J, et al. Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16. Gastroenterology 1998; 115:1066-1071.
    • (1998) Gastroenterology , vol.115 , pp. 1066-1071
    • Curran, M.E.1    Lau, K.F.2    Hampe, J.3
  • 10
    • 0032231756 scopus 로고    scopus 로고
    • Linkage and association between inflammatory bowel disease and a locus on chromosome 12
    • Duerr RH, Barmada MM, Zhang L, et al. Linkage and association between inflammatory bowel disease and a locus on chromosome 12. Am J Hum Genet 1998; 63:95-100.
    • (1998) Am J Hum Genet , vol.63 , pp. 95-100
    • Duerr, R.H.1    Barmada, M.M.2    Zhang, L.3
  • 11
    • 0033358425 scopus 로고    scopus 로고
    • A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort
    • Hampe J, Schreiber S, Shaw SH, et al. A genomewide analysis provides evidence for novel linkages in inflammatory bowel disease in a large European cohort. Am J Hum Genet 1999; 64:808-816.
    • (1999) Am J Hum Genet , vol.64 , pp. 808-816
    • Hampe, J.1    Schreiber, S.2    Shaw, S.H.3
  • 12
    • 0033358520 scopus 로고    scopus 로고
    • Linkage of inflammatory bowel disease to human chromosome 6p
    • Hampe J, Shaw SH, Saiz R, et al. Linkage of inflammatory bowel disease to human chromosome 6p. Am J Hum Genet 1999; 65:1647-1655.
    • (1999) Am J Hum Genet , vol.65 , pp. 1647-1655
    • Hampe, J.1    Shaw, S.H.2    Saiz, R.3
  • 13
    • 0033228538 scopus 로고    scopus 로고
    • A genome-wide search identifies potential new susceptibility loci for Crohn's disease
    • Ma Y, Ohmen JD, Li Z, et al. A genome-wide search identifies potential new susceptibility loci for Crohn's disease. Inflamm Bowel Dis 1999; 5:271-278.
    • (1999) Inflamm Bowel Dis , vol.5 , pp. 271-278
    • Ma, Y.1    Ohmen, J.D.2    Li, Z.3
  • 14
    • 0033910870 scopus 로고    scopus 로고
    • Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
    • Rioux JD, Silverberg MS, Daly MJ, et al. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet 2000; 66:1863-1870.
    • (2000) Am J Hum Genet , vol.66 , pp. 1863-1870
    • Rioux, J.D.1    Silverberg, M.S.2    Daly, M.J.3
  • 15
    • 0033927387 scopus 로고    scopus 로고
    • High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12
    • Duerr RH, Barmada MM, Zhang L, et al. High-density genome scan in Crohn disease shows confirmed linkage to chromosome 14q11-12. Am J Hum Genet 2000; 66:1857-1862.
    • (2000) Am J Hum Genet , vol.66 , pp. 1857-1862
    • Duerr, R.H.1    Barmada, M.M.2    Zhang, L.3
  • 16
    • 0033659830 scopus 로고    scopus 로고
    • The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease
    • Parkes M, Barmada MM, Satsangi J, et al. The IBD2 locus shows linkage heterogeneity between ulcerative colitis and Crohn disease. Am J Hum Genet 2000; 67:1605-1610.
    • (2000) Am J Hum Genet , vol.67 , pp. 1605-1610
    • Parkes, M.1    Barmada, M.M.2    Satsangi, J.3
  • 17
    • 0035004413 scopus 로고    scopus 로고
    • International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16
    • IBD International Genetics Consortium. International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16. Am J Hum Genet 2001; 68:1165-1171.
    • (2001) Am J Hum Genet , vol.68 , pp. 1165-1171
  • 18
    • 0035125464 scopus 로고    scopus 로고
    • Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease
    • Hampe J, Lynch NJ, Daniels S, et al. Fine mapping of the chromosome 3p susceptibility locus in inflammatory bowel disease. Gut 2001; 48:191-197.
    • (2001) Gut , vol.48 , pp. 191-197
    • Hampe, J.1    Lynch, N.J.2    Daniels, S.3
  • 19
    • 18644376169 scopus 로고    scopus 로고
    • Evidence for an inflammatory bowel disease locus on chromosome 3p26: Linkage, transmission/disequilibrium and partitioning of linkage
    • Duerr RH, Barmada MM, Zhang L, et al. Evidence for an inflammatory bowel disease locus on chromosome 3p26: linkage, transmission/disequilibrium and partitioning of linkage. Hum Mol Genet 2002; 11:2599-2606.
    • (2002) Hum Mol Genet , vol.11 , pp. 2599-2606
    • Duerr, R.H.1    Barmada, M.M.2    Zhang, L.3
  • 20
    • 0036875821 scopus 로고    scopus 로고
    • Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci
    • Williams CN, Kocher K, Lander ES, et al. Using a genome-wide scan and meta-analysis to identify a novel IBD locus and confirm previously identified IBD loci. Inflamm Bowel Dis 2002; 8:375-381.
    • (2002) Inflamm Bowel Dis , vol.8 , pp. 375-381
    • Williams, C.N.1    Kocher, K.2    Lander, E.S.3
  • 21
    • 0037299313 scopus 로고    scopus 로고
    • Genome-wide search in Finnish families with inflammatory bowel disease provides evidence for novel susceptibility loci
    • Paavola-Sakki P, Ollikainen V, Helio T, et al. Genome-wide search in Finnish families with inflammatory bowel disease provides evidence for novel susceptibility loci. Eur J Hum Genet 2003; 11:112-120.
    • (2003) Eur J Hum Genet , vol.11 , pp. 112-120
    • Paavola-Sakki, P.1    Ollikainen, V.2    Helio, T.3
  • 22
    • 10744227039 scopus 로고    scopus 로고
    • The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants
    • van Heel D, Dechairo BM, Dawson G, et al. The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants. Hum Mol Genet 2003; 12:2569-2575.
    • (2003) Hum Mol Genet , vol.12 , pp. 2569-2575
    • Heel, D.1    Dechairo, B.M.2    Dawson, G.3
  • 23
    • 32644488003 scopus 로고    scopus 로고
    • A genome scan in 260 inflammatory bowel disease-affected relative pairs
    • Barmada MM, Brant SR, Nicolae DL, et al. A genome scan in 260 inflammatory bowel disease-affected relative pairs. Inflamm Bowel Dis 2004; 66: 1863-1870.
    • (2004) Inflamm Bowel Dis , vol.66 , pp. 1863-1870
    • Barmada, M.M.1    Brant, S.R.2    Nicolae, D.L.3
  • 24
    • 3042657319 scopus 로고    scopus 로고
    • Genome wide scan in a Flemish inflammatory bowel disease population: Support for the IBD4 locus, population heterogeneity, and epistasis
    • Vermeire S, Rutgeerts P, Van Steen K, et al. Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and epistasis. Gut 2004; 53:980-986.
    • (2004) Gut , vol.53 , pp. 980-986
    • Vermeire, S.1    Rutgeerts, P.2    Van Steen, K.3
  • 25
    • 13944273766 scopus 로고    scopus 로고
    • The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction
    • Pierik M, Yang H, Barmada MM, et al. The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction. Inflamm Bowel Dis 2005; 11:1-7.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 1-7
    • Pierik, M.1    Yang, H.2    Barmada, M.M.3
  • 26
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 27
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 28
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe J, Cuthbert A, Croucher PJ, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 2001; 357:1925-1928.
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.3
  • 29
    • 0036201577 scopus 로고    scopus 로고
    • CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
    • Lesage S, Zouali H, Cezard JP, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet 2002; 70:845-857.
    • (2002) Am J Hum Genet , vol.70 , pp. 845-857
    • Lesage, S.1    Zouali, H.2    Cezard, J.P.3
  • 30
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 2002; 122:867-874.
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1    Fisher, S.A.2    Mirza, M.M.3
  • 31
    • 0036202336 scopus 로고    scopus 로고
    • The molecular classification of the clinical manifestations of Crohn's disease
    • Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology 2002; 122:854-866.
    • (2002) Gastroenterology , vol.122 , pp. 854-866
    • Ahmad, T.1    Armuzzi, A.2    Bunce, M.3
  • 32
    • 18444381172 scopus 로고    scopus 로고
    • CARD15 genetic variation in a Quebec population: Prevalence, genotype-phenotype relationship, and haplotype structure
    • Vermeire S, Wild G, Kocher K, et al. CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Am J Hum Genet 2002; 71:74-83.
    • (2002) Am J Hum Genet , vol.71 , pp. 74-83
    • Vermeire, S.1    Wild, G.2    Kocher, K.3
  • 33
    • 0037221395 scopus 로고    scopus 로고
    • Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan
    • Bonen DK, Ogura Y, Nicolae DL, et al. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 2003; 124:140-146.
    • (2003) Gastroenterology , vol.124 , pp. 140-146
    • Bonen, D.K.1    Ogura, Y.2    Nicolae, D.L.3
  • 34
    • 0035049790 scopus 로고    scopus 로고
    • The IBD1 locus for susceptibility to Crohn's disease has a greater impact in Ashkenazi Jews with early onset disease
    • Akolkar PN, Gulvani-Akolkar B, Lin X-Y, et al. The IBD1 locus for susceptibility to Crohn's disease has a greater impact in Ashkenazi Jews with early onset disease. Am J Gastroenterol 2001; 96:1127-1132.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1127-1132
    • Akolkar, P.N.1    Gulvani-Akolkar, B.2    Lin, X.-Y.3
  • 35
    • 0038136125 scopus 로고    scopus 로고
    • CARD15/NOD2 risk alleles in the development of Crohn's disease in the Australian population
    • Cavanaugh JA, Adams KE, Quak EJ, et al. CARD15/NOD2 risk alleles in the development of Crohn's disease in the Australian population. Ann Hum Genet 2003; 67:35-41.
    • (2003) Ann Hum Genet , vol.67 , pp. 35-41
    • Cavanaugh, J.A.1    Adams, K.E.2    Quak, E.J.3
  • 36
    • 10744221095 scopus 로고    scopus 로고
    • CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease
    • Newman B, Silverberg MS, Gu X, et al. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. Am J Gastroenterol 2004; 99:306-315.
    • (2004) Am J Gastroenterol , vol.99 , pp. 306-315
    • Newman, B.1    Silverberg, M.S.2    Gu, X.3
  • 37
    • 0036306951 scopus 로고    scopus 로고
    • Lack of common NOD2 variants in Japanese patients with Crohn's disease
    • Inoue N, Tamura K, Kinouchi Y, et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002; 123:86-91.
    • (2002) Gastroenterology , vol.123 , pp. 86-91
    • Inoue, N.1    Tamura, K.2    Kinouchi, Y.3
  • 38
    • 0037373316 scopus 로고    scopus 로고
    • A novel NOD2/CARD15 haplotype conferring risk for Crohn Disease in Ashkenazi Jews
    • Sugimura K, Taylor KD, Lin YC, et al. A novel NOD2/CARD15 haplotype conferring risk for Crohn Disease in Ashkenazi Jews. Am J Hum Genet 2003; 72:509-519.
    • (2003) Am J Hum Genet , vol.72 , pp. 509-519
    • Sugimura, K.1    Taylor, K.D.2    Lin, Y.C.3
  • 39
    • 0027404560 scopus 로고
    • Familial empirical risks for inflammatory bowel disease: Differences between Jews and non-Jews
    • Yang H, McElree C, Roth MP, et al. Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut 1993; 34: 517-524.
    • (1993) Gut , vol.34 , pp. 517-524
    • Yang, H.1    McElree, C.2    Roth, M.P.3
  • 40
    • 1842592102 scopus 로고    scopus 로고
    • Crohn disease: Frequency and nature of CARD15 mutations in Ashkenazi and Sephardi/Oriental Jewish families
    • Tukel T, Shalata A, Present D, et al. Crohn Disease: Frequency and Nature of CARD15 Mutations in Ashkenazi and Sephardi/Oriental Jewish Families. Am J Hum Genet 2004; 74:623-636.
    • (2004) Am J Hum Genet , vol.74 , pp. 623-636
    • Tukel, T.1    Shalata, A.2    Present, D.3
  • 41
    • 0842321799 scopus 로고    scopus 로고
    • Failure to replicate the association of the novel NOD2/CARD15 haplotype (S268P-JW1) to Crohn's disease in the Jewish Israeli population
    • Karban A, Eliakim R. Failure to replicate the association of the novel NOD2/CARD15 haplotype (S268P-JW1) to Crohn's disease in the Jewish Israeli population. Gastroenterology 2004; 126:624-625.
    • (2004) Gastroenterology , vol.126 , pp. 624-625
    • Karban, A.1    Eliakim, R.2
  • 42
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    • Ogura Y, Inohara N, Benito A. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 2001; 276:4812-4818.
    • (2001) J Biol Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3
  • 43
    • 0037379915 scopus 로고    scopus 로고
    • TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD 15) gene in human intestinal epithelial cells
    • Rosenstiel P, Fantini M, Brautigam K, et al. TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD 15) gene in human intestinal epithelial cells. Gastroenterology 2003; 124:1001-1009.
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Brautigam, K.3
  • 44
    • 0037380969 scopus 로고    scopus 로고
    • CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells
    • Hisamatsu T, Suzuki M, Reinecker H-C, et al. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 2003; 124:999-1000.
    • (2003) Gastroenterology , vol.124 , pp. 999-1000
    • Hisamatsu, T.1    Suzuki, M.2    Reinecker, H.-C.3
  • 45
    • 0038109983 scopus 로고    scopus 로고
    • Crohn's disease and the NOD2 gene: A role for paneth cells
    • Lala S, Ogura Y, Osborne C. Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 2003; 125:47-57.
    • (2003) Gastroenterology , vol.125 , pp. 47-57
    • Lala, S.1    Ogura, Y.2    Osborne, C.3
  • 46
    • 0036828844 scopus 로고    scopus 로고
    • Induction of Nod2 in myelomoncytic and intestinal epithelial cells via nuclear factor-κB activation
    • Gutierrez O, Pipaon C, Inohara N, et al. Induction of Nod2 in myelomoncytic and intestinal epithelial cells via nuclear factor-κB activation. J Biol Chem 2002; 277:41701-41705.
    • (2002) J Biol Chem , vol.277 , pp. 41701-41705
    • Gutierrez, O.1    Pipaon, C.2    Inohara, N.3
  • 47
    • 0035859020 scopus 로고    scopus 로고
    • Plant pathogens and integrated defence responses to infection
    • Dang JL, Jones JD. Plant pathogens and integrated defence responses to infection. Nature 2001; 411:826-833.
    • (2001) Nature , vol.411 , pp. 826-833
    • Dang, J.L.1    Jones, J.D.2
  • 48
    • 0036160150 scopus 로고    scopus 로고
    • Nods. A family of cytosolic proteins that regulate the host response to pathogens
    • Inohara N, Ogura Y, Nunez G. Nods. A family of cytosolic proteins that regulate the host response to pathogens. Curr Opin Microbiol 2002; 5:76-80.
    • (2002) Curr Opin Microbiol , vol.5 , pp. 76-80
    • Inohara, N.1    Ogura, Y.2    Nunez, G.3
  • 49
    • 0036532316 scopus 로고    scopus 로고
    • Intracellular vs extracellular recognition of pathogens - Common concepts in mammals and flies
    • Girardin SE, Sansonetti PJ, Philpott DJ. Intracellular vs extracellular recognition of pathogens - common concepts in mammals and flies. Trends Microbiol 2002; 10:193-199.
    • (2002) Trends Microbiol , vol.10 , pp. 193-199
    • Girardin, S.E.1    Sansonetti, P.J.2    Philpott, D.J.3
  • 50
    • 0034307339 scopus 로고    scopus 로고
    • The toll receptor family and microbial recognition
    • Medzhitov R, Janeway C. The toll receptor family and microbial recognition. Trends Microbiol 2000; 8:452-456.
    • (2000) Trends Microbiol , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway, C.2
  • 51
    • 0037460116 scopus 로고    scopus 로고
    • Recognition of pathogen-associated molecular patterns by TLR family
    • Akira S, Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol Lett 2003; 85:85-95.
    • (2003) Immunol Lett , vol.85 , pp. 85-95
    • Akira, S.1    Hemmi, H.2
  • 52
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2: Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease. J Biol Chem 2003; 278:5509-5512.
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 53
    • 0012722659 scopus 로고    scopus 로고
    • Nod 2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J, et al. Nod 2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003; 278:8869-8872.
    • (2003) J Biol Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 54
    • 7644234401 scopus 로고    scopus 로고
    • hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells
    • Vavricka SR, Musch MW, Chang JE, et al. hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology 2004; 127:1401-1409.
    • (2004) Gastroenterology , vol.127 , pp. 1401-1409
    • Vavricka, S.R.1    Musch, M.W.2    Chang, J.E.3
  • 56
    • 0032524908 scopus 로고    scopus 로고
    • RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis
    • Inohara N, del Peso L, Koseki T, et al. RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J Biol Chem 1998; 273:12296-12300.
    • (1998) J Biol Chem , vol.273 , pp. 12296-12300
    • Inohara, N.1    Del Peso, L.2    Koseki, T.3
  • 57
    • 0034623225 scopus 로고    scopus 로고
    • An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways
    • Inohara N, Kosecki T, Lin J, et al. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 2000; 275:27823-27831.
    • (2000) J Biol Chem , vol.275 , pp. 27823-27831
    • Inohara, N.1    Kosecki, T.2    Lin, J.3
  • 58
    • 0037075551 scopus 로고    scopus 로고
    • RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
    • Kobayashi K, Inohara N, Hernandez LD, et al. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 2002; 416:194-199.
    • (2002) Nature , vol.416 , pp. 194-199
    • Kobayashi, K.1    Inohara, N.2    Hernandez, L.D.3
  • 59
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005; 307:731-734. The data in this article reveal CARD15 to be essential for detection of bacterial MDP and reveal impaired induction of intestinal cryptdins/defensins as a possible mechanism whereby CARD15 mutations predispose to CD.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 60
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • Watanabe T, Kitani A, Murray PJ, et al. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 2004; 5:800-808. The data provided in this article provide the first indication of an intersection between toll-like receptor 2 and CARD15 signaling and identify CARD15 inhibition of TLR2 activity as a possible mechanism whereby CARD15 regulates cell responses to bacterial pathogens.
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3
  • 61
    • 13244277880 scopus 로고    scopus 로고
    • Nod 2 mutation in Crohn's disease potentiates NF-κB activity and IL-Iβ processing
    • Maeda S, Hsu L-C, Liu H, et al. Nod 2 mutation in Crohn's disease potentiates NF-κB activity and IL-Iβ processing. Science 2005; 307:734-738. In this article, mice carrying a germline CARD15 mutant allele are used to demonstrate that CARD15 may act as a positive regulator of NF-κB activation.
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1    Hsu, L.-C.2    Liu, H.3
  • 62
    • 12444259829 scopus 로고    scopus 로고
    • Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture
    • Uehara A, Yang S, Fujimoto Y, et al. Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cell Microbiol 2005; 7:53-61.
    • (2005) Cell Microbiol , vol.7 , pp. 53-61
    • Uehara, A.1    Yang, S.2    Fujimoto, Y.3
  • 63
    • 11144289688 scopus 로고    scopus 로고
    • The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO
    • Abbott DW, Wilkins A, Asara JM, et al. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr Biol 2004; 14:2217-2227.
    • (2004) Curr Biol , vol.14 , pp. 2217-2227
    • Abbott, D.W.1    Wilkins, A.2    Asara, J.M.3
  • 64
    • 0032732928 scopus 로고    scopus 로고
    • Defensins and innate host defence of the gastrointestinal tract
    • Bevins CL, Martin-Porter E, Ganz T. Defensins and innate host defence of the gastrointestinal tract. Gut 1999; 45:911-915.
    • (1999) Gut , vol.45 , pp. 911-915
    • Bevins, C.L.1    Martin-Porter, E.2    Ganz, T.3
  • 65
    • 7244257312 scopus 로고    scopus 로고
    • NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal-defensin expression
    • Wehkamp J, Harder J, Weichenthal M, et al. NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal-defensin expression. Gut 2004; 53:1658-1664.
    • (2004) Gut , vol.53 , pp. 1658-1664
    • Wehkamp, J.1    Harder, J.2    Weichenthal, M.3
  • 66
    • 0034785352 scopus 로고    scopus 로고
    • Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
    • Rioux JD, Daly MJ, Silverberg MS, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet 2001; 29:223-228.
    • (2001) Nat Genet , vol.29 , pp. 223-228
    • Rioux, J.D.1    Daly, M.J.2    Silverberg, M.S.3
  • 67
    • 0037383554 scopus 로고    scopus 로고
    • Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease
    • Mirza MM, Fisher SA, King K, et al. Genetic evidence for interaction of the 5q31 cytokine locus and the CARD15 gene in Crohn disease. Am J Hum Genet 2003; 72:1018-1022.
    • (2003) Am J Hum Genet , vol.72 , pp. 1018-1022
    • Mirza, M.M.1    Fisher, S.A.2    King, K.3
  • 68
    • 0037622913 scopus 로고    scopus 로고
    • Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31
    • Armuzzi A, Ahmad T, Ling KL, et al. Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31. Gut 2003; 52:1133-1139.
    • (2003) Gut , vol.52 , pp. 1133-1139
    • Armuzzi, A.1    Ahmad, T.2    Ling, K.L.3
  • 69
    • 0038389762 scopus 로고    scopus 로고
    • IBD5 is a general risk factor for inflammatory bowel disease: Replication of association with Crohn disease and identification of a novel association with ulcerative colitis
    • Giallourakis C, Stoll M, Miller K, et al. IBD5 is a general risk factor for inflammatory bowel disease: replication of association with Crohn disease and identification of a novel association with ulcerative colitis. Am J Hum Genet 2003; 73:205-211.
    • (2003) Am J Hum Genet , vol.73 , pp. 205-211
    • Giallourakis, C.1    Stoll, M.2    Miller, K.3
  • 70
    • 0142138025 scopus 로고    scopus 로고
    • Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease
    • Negoro K, McGovern DP, Kinouchi Y, et al. Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease. Gut 2003; 52:541-546.
    • (2003) Gut , vol.52 , pp. 541-546
    • Negoro, K.1    McGovern, D.P.2    Kinouchi, Y.3
  • 71
    • 2442585704 scopus 로고    scopus 로고
    • Functional variants of OCTN cation transporter genes are associated with Crohn's Disease
    • Peltekova VD, Wintle RF, Rubin LA, et al. Functional variants of OCTN cation transporter genes are associated with Crohn's Disease. Nat Genet 2004; 36:471-475. This article reports on the discovery of gene variants in the SLC22A4 and SLC22A5 genes that are associated with Crohn disease, impair function/expression of the OCTN1 and OCTN2 transporters encoded by these genes, and interact with CARD15 variants to confer risk for CD.
    • (2004) Nat Genet , vol.36 , pp. 471-475
    • Peltekova, V.D.1    Wintle, R.F.2    Rubin, L.A.3
  • 72
    • 0032935034 scopus 로고    scopus 로고
    • Novel membrane transporter OCTN1 mediates multispecific, bidirectional and pH-dependent transport of organic cations
    • Yabuuchi H, Tamai I, Nezu J, et al. Novel membrane transporter OCTN1 mediates multispecific, bidirectional and pH-dependent transport of organic cations. J Pharmacol Exp Ther 1999; 289:768-773.
    • (1999) J Pharmacol Exp Ther , vol.289 , pp. 768-773
    • Yabuuchi, H.1    Tamai, I.2    Nezu, J.3
  • 73
    • 0035132434 scopus 로고    scopus 로고
    • A molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2
    • Oshashi R, Tamai I, Nezu J, et al. A molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2. Mol Pharmacol 2001; 59:358-366.
    • (2001) Mol Pharmacol , vol.59 , pp. 358-366
    • Oshashi, R.1    Tamai, I.2    Nezu, J.3
  • 74
    • 0033921479 scopus 로고    scopus 로고
    • Structure of renal organic anion and cation transporters
    • Burckhardt G, Wolff NA. Structure of renal organic anion and cation transporters. Am J Physiol Renal Physiol 2000; 278:F853-F866.
    • (2000) Am J Physiol Renal Physiol , vol.278
    • Burckhardt, G.1    Wolff, N.A.2
  • 75
    • 14944356373 scopus 로고    scopus 로고
    • A risk haplotype in the solute carrier family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease
    • Newman B, Gu X, Wintle RF, et al. A risk haplotype in the solute carrier family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. Gastroenterology 2005; 128:260-269.
    • (2005) Gastroenterology , vol.128 , pp. 260-269
    • Newman, B.1    Gu, X.2    Wintle, R.F.3
  • 76
    • 12744274602 scopus 로고    scopus 로고
    • Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease
    • Yamazaki K, Takazoe M, Tanaka T, et al. Association analysis of SLC22A4, SLC22A5 and DLG5 in Japanese patients with Crohn disease. J Hum Genet 2004; 49:664-668.
    • (2004) J Hum Genet , vol.49 , pp. 664-668
    • Yamazaki, K.1    Takazoe, M.2    Tanaka, T.3
  • 77
    • 0344364566 scopus 로고    scopus 로고
    • An intronic SNP in a RUNXI binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis
    • Tokuhiro S, Yamada R, Chang X, et al. An intronic SNP in a RUNXI binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat Genet 2003; 35:341-348.
    • (2003) Nat Genet , vol.35 , pp. 341-348
    • Tokuhiro, S.1    Yamada, R.2    Chang, X.3
  • 78
    • 13444292850 scopus 로고    scopus 로고
    • SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population
    • Newman B, Wintle RF, van Oene M, et al. SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population. Arthritis Rheum 2005; 52:425-429.
    • (2005) Arthritis Rheum , vol.52 , pp. 425-429
    • Newman, B.1    Wintle, R.F.2    Van Oene, M.3
  • 79
    • 0034842137 scopus 로고    scopus 로고
    • Carnitine transport by organic cation transporters and systemic carnitine deficiency
    • Lahjouji K, Mitchell GA, Qureshi IA. Carnitine transport by organic cation transporters and systemic carnitine deficiency. Mol Genet Metab 2001; 73:287-297.
    • (2001) Mol Genet Metab , vol.73 , pp. 287-297
    • Lahjouji, K.1    Mitchell, G.A.2    Qureshi, I.A.3
  • 80
    • 0023013994 scopus 로고
    • Metabolic induction of experimental ulcerative colitis by inhibition of fatty acid oxidation
    • Roediger WE, Nance S. Metabolic induction of experimental ulcerative colitis by inhibition of fatty acid oxidation. Br J Exp Pathol 1986; 67:773-782.
    • (1986) Br J Exp Pathol , vol.67 , pp. 773-782
    • Roediger, W.E.1    Nance, S.2
  • 81
    • 2442519456 scopus 로고    scopus 로고
    • Genetic variation in DLG5 is associated with inflammatory bowel disease
    • Stoll M, Corneliussen B, Costello CM, et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 2004; 36:476-480. In this article, linkage disequilibrium mapping is used successfully to identify DLG5 variants as susceptibility alleles for IBD.
    • (2004) Nat Genet , vol.36 , pp. 476-480
    • Stoll, M.1    Corneliussen, B.2    Costello, C.M.3
  • 82
    • 0031840135 scopus 로고    scopus 로고
    • Identification of a novel human homolog of the Drosophila dig, P-dlg, specifically expressed in the gland tissues and interacting with p55
    • Nakamura H, Sudo T, Tsuiki H, et al. Identification of a novel human homolog of the Drosophila dig, P-dlg, specifically expressed in the gland tissues and interacting with p55. FEBS Lett 1998; 433:63-67.
    • (1998) FEBS Lett , vol.433 , pp. 63-67
    • Nakamura, H.1    Sudo, T.2    Tsuiki, H.3
  • 83
    • 0010677685 scopus 로고    scopus 로고
    • The cloning, genomic organization and tissue expression profile of the human DLG5 gene
    • Shah G, Brugada R, Gonzalez O, et al. The cloning, genomic organization and tissue expression profile of the human DLG5 gene. BMC Genomics 2002; 3:6.
    • (2002) BMC Genomics , vol.3 , pp. 6
    • Shah, G.1    Brugada, R.2    Gonzalez, O.3
  • 84
    • 0037821783 scopus 로고    scopus 로고
    • Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact
    • Wakabayashi M, Ito T, Mitsushima M, et al. Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. J Biol Chem 2003; 278:21709-21714.
    • (2003) J Biol Chem , vol.278 , pp. 21709-21714
    • Wakabayashi, M.1    Ito, T.2    Mitsushima, M.3
  • 85
    • 0024267211 scopus 로고
    • Crohn's disease - A permeability disorder of the tight junction?
    • Hollander D. Crohn's disease - a permeability disorder of the tight junction? Gut 1988; 29:1621.
    • (1988) Gut , vol.29 , pp. 1621
    • Hollander, D.1
  • 86
    • 0025350323 scopus 로고
    • Abnormal intestinal permeability in Crohn's disease. A possible pathogenic factor
    • Olaison G, Sjodahl R, Tagesson C, et al. Abnormal intestinal permeability in Crohn's disease. A possible pathogenic factor. Scand J Gastroenterol 1990; 25:321-328.
    • (1990) Scand J Gastroenterol , vol.25 , pp. 321-328
    • Olaison, G.1    Sjodahl, R.2    Tagesson, C.3
  • 87
    • 0027293439 scopus 로고
    • Is small intestinal permeability really increased in relatives of patients with Crohn's disease?
    • May G, Sutherland L, Meddings JB. Is small intestinal permeability really increased in relatives of patients with Crohn's disease? Gastroenterology 1993; 104:1627-1632.
    • (1993) Gastroenterology , vol.104 , pp. 1627-1632
    • May, G.1    Sutherland, L.2    Meddings, J.B.3
  • 88
    • 0030823372 scopus 로고    scopus 로고
    • Clustering of increased small intestinal permeability in families with Crohn's disease
    • Peeters M, Geypens B, Claus D. Clustering of increased small intestinal permeability in families with Crohn's disease. Gastroenterology 1997; 113: 802-807.
    • (1997) Gastroenterology , vol.113 , pp. 802-807
    • Peeters, M.1    Geypens, B.2    Claus, D.3
  • 89
    • 11144354272 scopus 로고    scopus 로고
    • Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    • van Heel DA, Fisher SA, Kirby A, et al. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet 2004; 13:763-770. In this study, a meta-analysis of available IBD genome-wide screens is used to prioritize IBD loci meriting further genetic analysis and to identify several previously undetected susceptibility loci.
    • (2004) Hum Mol Genet , vol.13 , pp. 763-770
    • Van Heel, D.A.1    Fisher, S.A.2    Kirby, A.3
  • 90
    • 0031786405 scopus 로고    scopus 로고
    • A new structural model for P-glycoprotein
    • Jones PM, George AM. A new structural model for P-glycoprotein. J Membr Biol 1998; 166:133-147.
    • (1998) J Membr Biol , vol.166 , pp. 133-147
    • Jones, P.M.1    George, A.M.2
  • 91
    • 0042132423 scopus 로고
    • Expression of a multidrug-resistance gene in human tumors and tissues
    • Fojo AT, Ueda K, Slamon D, et al. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci USA 1987; 84:265-269.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 265-269
    • Fojo, A.T.1    Ueda, K.2    Slamon, D.3
  • 92
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 1998; 161:5733-5774.
    • (1998) J Immunol , vol.161 , pp. 5733-5774
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 93
    • 0037223561 scopus 로고    scopus 로고
    • Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis
    • Schwab M, Schaeffeler E, Marx C, et al. Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis. Gastroenterology 2003; 124:26-33.
    • (2003) Gastroenterology , vol.124 , pp. 26-33
    • Schwab, M.1    Schaeffeler, E.2    Marx, C.3
  • 94
    • 14944341671 scopus 로고    scopus 로고
    • Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis
    • Ho G, Nimmo E, Tanesa A, et al. Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis. Gastroenterology 2005; 128:288-296.
    • (2005) Gastroenterology , vol.128 , pp. 288-296
    • Ho, G.1    Nimmo, E.2    Tanesa, A.3
  • 95
    • 9144224852 scopus 로고    scopus 로고
    • MDR1 Ala893 polymorphism is associated with inflammatory bowel disease
    • Brant SR, Panhuysen CI, Nicolae D, et al. MDR1 Ala893 Polymorphism is Associated with Inflammatory Bowel Disease. Am J Hum Genet 2003; 73:1282-1292.
    • (2003) Am J Hum Genet , vol.73 , pp. 1282-1292
    • Brant, S.R.1    Panhuysen, C.I.2    Nicolae, D.3
  • 96
    • 0344197096 scopus 로고    scopus 로고
    • Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations
    • Croucher PJ, Mascheretti S, Foelsch UR, et al. Lack of association between the C3435T MDR1 gene polymorphism and inflammatory bowel disease in two independent Northern European populations. Gastroenterology 2003; 125:1919-1920.
    • (2003) Gastroenterology , vol.125 , pp. 1919-1920
    • Croucher, P.J.1    Mascheretti, S.2    Foelsch, U.R.3
  • 98
    • 0346100570 scopus 로고    scopus 로고
    • The C3435T MDR1 gene polymorphism is not associated with susceptibility for ulcerative colitis in Greek population
    • Gazouli M, Zacharatos P, Gorgoulis V, et al. The C3435T MDR1 gene polymorphism is not associated with susceptibility for ulcerative colitis in Greek population. Gastroenterology 2004; 126:367-369.
    • (2004) Gastroenterology , vol.126 , pp. 367-369
    • Gazouli, M.1    Zacharatos, P.2    Gorgoulis, V.3
  • 99
    • 0034190238 scopus 로고    scopus 로고
    • Intercellular adhesion molecule-1 (ICAM-1) expression and cell signalling cascades
    • Hubbard AK, Rothlein R. Intercellular adhesion molecule-1 (ICAM-1) expression and cell signalling cascades. Free Radio Biol Med 2000; 28:1379-1386.
    • (2000) Free Radio Biol Med , vol.28 , pp. 1379-1386
    • Hubbard, A.K.1    Rothlein, R.2
  • 100
    • 0029150433 scopus 로고
    • Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease
    • Yang H, Vora DK, Targan SR, et al. Intercellular adhesion molecule 1 gene associations with immunologic subsets of inflammatory bowel disease. Gastroenterology 1995; 109:440-448.
    • (1995) Gastroenterology , vol.109 , pp. 440-448
    • Yang, H.1    Vora, D.K.2    Targan, S.R.3
  • 101
    • 6844259857 scopus 로고    scopus 로고
    • Analysis of ICAM-1 gene polymorphism in immunologie subsets of inflammatory bowel disease
    • Yang H. Analysis of ICAM-1 gene polymorphism in immunologie subsets of inflammatory bowel disease. Exp Clin Immunogenet 1997; 14:214-225.
    • (1997) Exp Clin Immunogenet , vol.14 , pp. 214-225
    • Yang, H.1
  • 102
    • 0035209986 scopus 로고    scopus 로고
    • Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status
    • Braun C, Zahn R, Martin K, et al. Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin Immunol 2001; 101:357-360.
    • (2001) Clin Immunol , vol.101 , pp. 357-360
    • Braun, C.1    Zahn, R.2    Martin, K.3
  • 103
    • 2442530967 scopus 로고    scopus 로고
    • Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1
    • Neville MJ, Dechairo BM, Walton R, et al. Inflammatory bowel disease is linked to 19p13 and associated with ICAM-1. Inflamm Bowel Dis 2004; 10:173-181.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 173-181
    • Neville, M.J.1    Dechairo, B.M.2    Walton, R.3
  • 104
    • 0032786521 scopus 로고    scopus 로고
    • HLA-DR and -DQ phenotypes in inflammatory bowel disease: A meta-analysis
    • Stokkers PC, Reitsma PH, Tytgat GN, et al. HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis. Gut 1999; 45:395-401.
    • (1999) Gut , vol.45 , pp. 395-401
    • Stokkers, P.C.1    Reitsma, P.H.2    Tytgat, G.N.3
  • 105
    • 0037239677 scopus 로고    scopus 로고
    • A population and family-based study of Canadian families reveals association of HLA DRB 1*0103 with colonic involvement in inflammatory bowel disease
    • Silverberg MS, Mirea L, Bull SB, et al. A population and family-based study of Canadian families reveals association of HLA DRB 1*0103 with colonic involvement in inflammatory bowel disease. Inflamm Bowel Dis 2003; 9:1-9.
    • (2003) Inflamm Bowel Dis , vol.9 , pp. 1-9
    • Silverberg, M.S.1    Mirea, L.2    Bull, S.B.3
  • 106
    • 2442710485 scopus 로고    scopus 로고
    • The contribution of HLA genes to IBD susceptibility and phenotype
    • Yap LM, Ahmad T, Jewell DP. The contribution of HLA genes to IBD susceptibility and phenotype. Best Pract Res Clin Gastroenterol 2004; 18: 577-596.
    • (2004) Best Pract Res Clin Gastroenterol , vol.18 , pp. 577-596
    • Yap, L.M.1    Ahmad, T.2    Jewell, D.P.3
  • 107
    • 0034464732 scopus 로고    scopus 로고
    • Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL
    • De La Concha EG, Fernandrez-Arquero M, Lopez-Nava G, et al. Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. Gastroenterology 2000; 119:1491-1495.
    • (2000) Gastroenterology , vol.119 , pp. 1491-1495
    • De La Concha, E.G.1    Fernandrez-Arquero, M.2    Lopez-Nava, G.3
  • 108
    • 18444395237 scopus 로고    scopus 로고
    • Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between OCT1 and NF-κB transcription factors
    • van Heel DA, Udalova IA, De Silva AP, et al. Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between OCT1 and NF-κB transcription factors. Hum Mol Genet 2002; 11:1281-1289.
    • (2002) Hum Mol Genet , vol.11 , pp. 1281-1289
    • Van Heel, D.A.1    Udalova, I.A.2    De Silva, A.P.3
  • 109
    • 10744233159 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    • Rachmilewitz D, Katakura K, Karmeli F, et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 2004; 126:520-528.
    • (2004) Gastroenterology , vol.126 , pp. 520-528
    • Rachmilewitz, D.1    Katakura, K.2    Karmeli, F.3
  • 110
    • 3242732415 scopus 로고    scopus 로고
    • Crohn's disease is associated with a toll-like receptor-9 polymorphism
    • Torok HP, Glas J, Tonenchi L, et al. Crohn's disease is associated with a toll-like receptor-9 polymorphism. Gastroenterology 2004; 127:365-366.
    • (2004) Gastroenterology , vol.127 , pp. 365-366
    • Torok, H.P.1    Glas, J.2    Tonenchi, L.3
  • 111
    • 0347917295 scopus 로고    scopus 로고
    • Functional annotation of a novel NFKB1 promoter Polymorphism that increases risk for ulcerative colitis
    • Karban AS, Okazaki T, Panhuysen CI, et al. Functional annotation of a novel NFKB1 promoter Polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 2004; 13:35-45.
    • (2004) Hum Mol Genet , vol.13 , pp. 35-45
    • Karban, A.S.1    Okazaki, T.2    Panhuysen, C.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.