메뉴 건너뛰기




Volumn 17, Issue 2, 2012, Pages 211-232

Targeting of EPH receptor tyrosine kinases for anticancer therapy

Author keywords

Eph; Receptor tyrosine kinase inhibitors; Somatic mutations; Tumor promoter; Tumor suppressor; Tumor targeting antibodies

Indexed keywords

AZURIN; BAFETINIB; BOSUTINIB; CHEMOKINE RECEPTOR CXCR4; DASATINIB; DISINTEGRIN; EPHRIN RECEPTOR; EPHRIN RECEPTOR A1; EPHRIN RECEPTOR A2; EPHRIN RECEPTOR A3; EPHRIN RECEPTOR A4; EPHRIN RECEPTOR A5; EPHRIN RECEPTOR A7; EPHRIN RECEPTOR B1; EPHRIN RECEPTOR B2; EPHRIN RECEPTOR B4; EPHRIN RECEPTOR B6; EPIDERMAL GROWTH FACTOR RECEPTOR; JI 101; MONOCLONAL ANTIBODY; NCK PROTEIN; NILOTINIB; NVP BHG712; PACLITAXEL; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; RITUXIMAB; STROMELYSIN 2; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT;

EID: 84861524407     PISSN: 08939675     EISSN: 21626448     Source Type: Journal    
DOI: 10.1615/CritRevOncog.v17.i2.60     Document Type: Article
Times cited : (12)

References (223)
  • 1
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: Bidirectional signaling and beyond
    • Pasquale EB. Eph receptors and ephrins in cancer: bidirectional signaling and beyond. Nat Rev Cancer. 2010;10(3):165-180.
    • (2010) Nat Rev Cancer , vol.10 , Issue.3 , pp. 165-180
    • Pasquale, E.B.1
  • 2
    • 48849108415 scopus 로고    scopus 로고
    • Eph, a protein family coming of age: More confusion, insight, or complexity?
    • Lackmann M, Boyd AW. Eph, a protein family coming of age: more confusion, insight, or complexity? Sci Signal. 2008;1(15):re2.
    • (2008) Sci Signal , vol.1 , Issue.15
    • Lackmann, M.1    Boyd, A.W.2
  • 3
    • 51349144056 scopus 로고    scopus 로고
    • Eph/ephrin signaling and function in oncogenesis: Lessons from embryonic development
    • Janes PW, Adikari S, Lackmann M. Eph/ephrin signaling and function in oncogenesis: lessons from embryonic development. Curr Cancer Drug Targets. 2008;8(6):473-479.
    • (2008) Curr Cancer Drug Targets , vol.8 , Issue.6 , pp. 473-479
    • Janes, P.W.1    Adikari, S.2    Lackmann, M.3
  • 4
    • 41549139097 scopus 로고    scopus 로고
    • Eph-ephrin signaling in adult tissues and cancer
    • Merlos-Suárez A, Batlle E. Eph-ephrin signaling in adult tissues and cancer. Curr Opin Cell Biol. 2008;20(2):194-200.
    • (2008) Curr Opin Cell Biol , vol.20 , Issue.2 , pp. 194-200
    • Merlos-Suárez, A.1    Batlle, E.2
  • 5
    • 41149084179 scopus 로고    scopus 로고
    • Eph-ephrin bidirectional signaling in physiology and disease
    • Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell. 2008;133(1):38-52.
    • (2008) Cell , vol.133 , Issue.1 , pp. 38-52
    • Pasquale, E.B.1
  • 6
    • 4444227124 scopus 로고    scopus 로고
    • Eph/ephrin signaling in morphogenesis, neural development and plasticity
    • Klein R. Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr Opin Cell Biol. 2004;16(5):580-589.
    • (2004) Curr Opin Cell Biol , vol.16 , Issue.5 , pp. 580-589
    • Klein, R.1
  • 7
    • 5044240692 scopus 로고    scopus 로고
    • Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly
    • Poliakov A, Cotrina M, Wilkinson DG. Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev Cell. 2004;7(4):465-480.
    • (2004) Dev Cell , vol.7 , Issue.4 , pp. 465-480
    • Poliakov, A.1    Cotrina, M.2    Wilkinson, D.G.3
  • 8
    • 0033278641 scopus 로고    scopus 로고
    • Protein tyrosine kinase cDNAs from amphioxus, hagfish, and lamprey: Isoform duplications around the divergence of cyclostomes and gnathostomes
    • Suga H, Hoshiyama D, Kuraku S, Katoh K, Kubokawa K, Miyata T. Protein tyrosine kinase cDNAs from amphioxus, hagfish, and lamprey: isoform duplications around the divergence of cyclostomes and gnathostomes. J Mol Evol. 1999;49(5):601-608.
    • (1999) J Mol Evol , vol.49 , Issue.5 , pp. 601-608
    • Suga, H.1    Hoshiyama, D.2    Kuraku, S.3    Katoh, K.4    Kubokawa, K.5    Miyata, T.6
  • 10
    • 0036668277 scopus 로고    scopus 로고
    • Eph family functions from an evolutionary perspective
    • Drescher U. Eph family functions from an evolutionary perspective. Curr Opin Genet Dev. 2002;12(4):397-402.
    • (2002) Curr Opin Genet Dev , vol.12 , Issue.4 , pp. 397-402
    • Drescher, U.1
  • 11
    • 34250223116 scopus 로고    scopus 로고
    • Regulation of angiogenesis by Eph-ephrin interactions
    • Kuijper S, Turner CJ, Adams RH. Regulation of angiogenesis by Eph-ephrin interactions. Trends Cardiovasc Med. 2007;17(5):145-151.
    • (2007) Trends Cardiovasc Med , vol.17 , Issue.5 , pp. 145-151
    • Kuijper, S.1    Turner, C.J.2    Adams, R.H.3
  • 12
    • 18844392603 scopus 로고    scopus 로고
    • EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics
    • Ireton RC, Chen J. EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics. Curr Cancer Drug Targets. 2005;5(3):149-157.
    • (2005) Curr Cancer Drug Targets , vol.5 , Issue.3 , pp. 149-157
    • Ireton, R.C.1    Chen, J.2
  • 16
    • 34249329249 scopus 로고    scopus 로고
    • Paradoxes of the EphB4 receptor in cancer
    • Noren NK, Pasquale EB. Paradoxes of the EphB4 receptor in cancer. Cancer Res. 2007; 67(9): 3994-3997.
    • (2007) Cancer Res , vol.67 , Issue.9 , pp. 3994-3997
    • Noren, N.K.1    Pasquale, E.B.2
  • 17
    • 9244260551 scopus 로고    scopus 로고
    • The role of ephrins and Eph receptors in cancer
    • Surawska H, Ma PC, Salgia R. The role of ephrins and Eph receptors in cancer. Cytokine Growth Factor Rev. 2004;15(6):419-433.
    • (2004) Cytokine Growth Factor Rev , vol.15 , Issue.6 , pp. 419-433
    • Surawska, H.1    Ma, P.C.2    Salgia, R.3
  • 18
    • 79952111485 scopus 로고    scopus 로고
    • Of Ephs and ephrins: Companies target guidance molecules in cancer
    • Garber K. Of Ephs and ephrins: companies target guidance molecules in cancer. J Natl Cancer Inst. 2010;102(22):1692-1694.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.22 , pp. 1692-1694
    • Garber, K.1
  • 19
    • 63849221730 scopus 로고    scopus 로고
    • Eph receptors in breast cancer: Roles in tumor promotion and tumor suppression
    • Vaught D, Brantley-Sieders DM, Chen J. Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast Cancer Res. 2008;10(6):217.
    • (2008) Breast Cancer Res , vol.10 , Issue.6 , pp. 217
    • Vaught, D.1    Brantley-Sieders, D.M.2    Chen, J.3
  • 20
    • 57749121465 scopus 로고    scopus 로고
    • The EphA2 receptor and ephrinA1 ligand in solid tumors: Function and therapeutic targeting
    • Wykosky J, Debinski W. The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res. 2008;6(12):1795-1806.
    • (2008) Mol Cancer Res , vol.6 , Issue.12 , pp. 1795-1806
    • Wykosky, J.1    Debinski, W.2
  • 21
    • 35548948069 scopus 로고    scopus 로고
    • Cell-cell signaling via Eph receptors and ephrins
    • Himanen J-P, Saha N, Nikolov DB. Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol. 2007;19(5):534-542.
    • (2007) Curr Opin Cell Biol , vol.19 , Issue.5 , pp. 534-542
    • Himanen, J.-P.1    Saha, N.2    Nikolov, D.B.3
  • 22
    • 0031559401 scopus 로고    scopus 로고
    • Eph Nomenclature Committee
    • Unified nomenclature for Eph family receptors and their ligands, the ephrins
    • Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. Cell. 1997;90:403-404.
    • (1997) Cell , vol.90 , pp. 403-404
  • 24
    • 15744397834 scopus 로고    scopus 로고
    • EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish
    • Cooke JE, Kemp HA, Moens CB. EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafish. Curr Biol. 2005;15(6):536-542.
    • (2005) Curr Biol , vol.15 , Issue.6 , pp. 536-542
    • Cooke, J.E.1    Kemp, H.A.2    Moens, C.B.3
  • 25
    • 73649128536 scopus 로고    scopus 로고
    • Structural characterization of the EphA4- Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity
    • Qin H, Noberini R, Huan X, Shi J, Pasquale EB, Song J. Structural characterization of the EphA4- Ephrin-B2 complex reveals new features enabling Eph-ephrin binding promiscuity. J Biol Chem. 2009;285(1):644-654.
    • (2009) J Biol Chem , vol.285 , Issue.1 , pp. 644-654
    • Qin, H.1    Noberini, R.2    Huan, X.3    Shi, J.4    Pasquale, E.B.5    Song, J.6
  • 26
    • 0036455140 scopus 로고    scopus 로고
    • Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro
    • Takemoto M, Fukuda T, Sonoda R, Murakami F, Tanaka H, Yamamoto N. Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro. Eur J Neurosci. 2002;16(6):1168-1172.
    • (2002) Eur J Neurosci , vol.16 , Issue.6 , pp. 1168-1172
    • Takemoto, M.1    Fukuda, T.2    Sonoda, R.3    Murakami, F.4    Tanaka, H.5    Yamamoto, N.6
  • 29
    • 0030962317 scopus 로고    scopus 로고
    • The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling
    • Labrador JP, Brambilla R, Klein R. The N-terminal globular domain of Eph receptors is sufficient for ligand binding and receptor signaling. EMBO J. 1997;16(13):3889-3897.
    • (1997) EMBO J , vol.16 , Issue.13 , pp. 3889-3897
    • Labrador, J.P.1    Brambilla, R.2    Klein, R.3
  • 30
  • 31
    • 1442358805 scopus 로고    scopus 로고
    • Recruitment of Eph receptors into signaling clusters does not require ephrin contact
    • Wimmer-Kleikamp SH, Janes PW, Squire A, Bastiaens PI, Lackmann M. Recruitment of Eph receptors into signaling clusters does not require ephrin contact. J Cell Biol. 2004;164(5): 661-666.
    • (2004) J Cell Biol , vol.164 , Issue.5 , pp. 661-666
    • Wimmer-Kleikamp, S.H.1    Janes, P.W.2    Squire, A.3    Bastiaens, P.I.4    Lackmann, M.5
  • 32
    • 77950516909 scopus 로고    scopus 로고
    • An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly
    • Seiradake E, Harlos K, Sutton G, Aricescu AR, Jones EY. An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly. Nat Struct Mol Biol. 2010;17(4):398-402.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.4 , pp. 398-402
    • Seiradake, E.1    Harlos, K.2    Sutton, G.3    Aricescu, A.R.4    Jones, E.Y.5
  • 34
    • 33749346713 scopus 로고    scopus 로고
    • A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
    • Wiesner S, Wybenga-Groot LE, Warner N, Lin H, Pawson T, Forman-Kay JD, Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J. 2006;25(19):4686-4696.
    • (2006) EMBO J , vol.25 , Issue.19 , pp. 4686-4696
    • Wiesner, S.1    Wybenga-Groot, L.E.2    Warner, N.3    Lin, H.4    Pawson, T.5    Forman-Kay, J.D.6    Sicheri, F.7
  • 35
    • 0035929146 scopus 로고    scopus 로고
    • Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region
    • Wybenga-Groot LE, Baskin B, Ong SH, Tong J, Pawson T, Sicheri F. Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell. 2001;106(6):745-757.
    • (2001) Cell , vol.106 , Issue.6 , pp. 745-757
    • Wybenga-Groot, L.E.1    Baskin, B.2    Ong, S.H.3    Tong, J.4    Pawson, T.5    Sicheri, F.6
  • 36
    • 0037213432 scopus 로고    scopus 로고
    • Eph signaling: A structural view
    • Himanen JP, Nikolov DB. Eph signaling: a structural view. Trends Neurosci. 2003;26(1):46-51.
    • (2003) Trends Neurosci , vol.26 , Issue.1 , pp. 46-51
    • Himanen, J.P.1    Nikolov, D.B.2
  • 37
    • 0034659510 scopus 로고    scopus 로고
    • Topographic mapping: Organising by repulsion and competion?
    • Wilkinson D. Topographic mapping: organising by repulsion and competion? Curr Biol. 2000; 10(12):R447-R451.
    • (2000) Curr Biol , vol.10 , Issue.12
    • Wilkinson, D.1
  • 38
    • 0034054851 scopus 로고    scopus 로고
    • Eph receptors and ephrins: Regulators of guidance and assembly
    • Wilkinson DG. Eph receptors and ephrins: regulators of guidance and assembly. Int Rev Cytol. 2000;196:177-244.
    • (2000) Int Rev Cytol , vol.196 , pp. 177-244
    • Wilkinson, D.G.1
  • 41
    • 77957244402 scopus 로고    scopus 로고
    • Ephrins and Eph receptors in stem cells and cancer
    • Genander M, Frisén J. Ephrins and Eph receptors in stem cells and cancer. Curr Opin Cell Biol. 2010;22(5):611-616.
    • (2010) Curr Opin Cell Biol , vol.22 , Issue.5 , pp. 611-616
    • Genander, M.1    Frisén, J.2
  • 42
    • 11244299992 scopus 로고    scopus 로고
    • Ephrin signaling in vivo: Look both ways
    • Davy A, Soriano P. Ephrin signaling in vivo: look both ways. Dev Dyn. 2005;232(1):1-10.
    • (2005) Dev Dyn , vol.232 , Issue.1 , pp. 1-10
    • Davy, A.1    Soriano, P.2
  • 43
    • 34247615569 scopus 로고    scopus 로고
    • Bidirectional Eph-ephrin signaling during axon guidance
    • Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007;17(5):230-238.
    • (2007) Trends Cell Biol , vol.17 , Issue.5 , pp. 230-238
    • Egea, J.1    Klein, R.2
  • 44
    • 7244245371 scopus 로고    scopus 로고
    • A relative signaling model for the formation of a topographic neural map
    • Reber M, Burrola P, Lemke G. A relative signaling model for the formation of a topographic neural map. Nature. 2004;431(7010):847-853.
    • (2004) Nature , vol.431 , Issue.7010 , pp. 847-853
    • Reber, M.1    Burrola, P.2    Lemke, G.3
  • 46
    • 77949412667 scopus 로고    scopus 로고
    • Restriction of receptor movement alters cellular response: Physical force sensing by EphA2
    • Salaita K, Nair PM, Petit RS, Neve RM, Das D, Gray JW, Groves JT. Restriction of receptor movement alters cellular response: physical force sensing by EphA2. Science. 2010;327(5971):1380-1385.
    • (2010) Science , vol.327 , Issue.5971 , pp. 1380-1385
    • Salaita, K.1    Nair, P.M.2    Petit, R.S.3    Neve, R.M.4    Das, D.5    Gray, J.W.6    Groves, J.T.7
  • 48
    • 0036045804 scopus 로고    scopus 로고
    • EphrinA1- induced cytoskeletal re-organization requires FAK and p130(cas)
    • Carter N, Nakamoto T, Hirai H, Hunter T. EphrinA1- induced cytoskeletal re-organization requires FAK and p130(cas). Nat Cell Biol. 2002;4(8): 565-573.
    • (2002) Nat Cell Biol , vol.4 , Issue.8 , pp. 565-573
    • Carter, N.1    Nakamoto, T.2    Hirai, H.3    Hunter, T.4
  • 50
    • 0036500192 scopus 로고    scopus 로고
    • Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signaling
    • Lawrenson ID, Wimmer-Kleikamp SH, Lock P, Schoenwaelder SM, Down M, Boyd AW, Alewood PF, Lackmann M. Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3- expressing 293T and melanoma cells by CrkII and Rho-mediated signaling. J Cell Sci. 2002;115(Pt 5):1059-1072.
    • (2002) J Cell Sci , vol.115 , Issue.Pt 5 , pp. 1059-1072
    • Lawrenson, I.D.1    Wimmer-Kleikamp, S.H.2    Lock, P.3    Schoenwaelder, S.M.4    Down, M.5    Boyd, A.W.6    Alewood, P.F.7    Lackmann, M.8
  • 51
    • 25144472138 scopus 로고    scopus 로고
    • Eph receptor signaling; dimerisation just isn't enough
    • Vearing CJ, Lackmann M. Eph receptor signaling; dimerisation just isn't enough. Growth Factors. 2005;23(1):67-76.
    • (2005) Growth Factors , vol.23 , Issue.1 , pp. 67-76
    • Vearing, C.J.1    Lackmann, M.2
  • 52
    • 0037450709 scopus 로고    scopus 로고
    • Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion
    • Tanaka M, Kamo T, Ota S, Sugimura H. Association of Dishevelled with Eph tyrosine kinase receptor and ephrin mediates cell repulsion. EMBO J. 2003;22(4):847-858.
    • (2003) EMBO J , vol.22 , Issue.4 , pp. 847-858
    • Tanaka, M.1    Kamo, T.2    Ota, S.3    Sugimura, H.4
  • 53
    • 0028170817 scopus 로고
    • Receptor protein-tyrosine kinases and their signal transduction pathways
    • van der Geer P, Hunter T, Lindberg RA. Receptor protein-tyrosine kinases and their signal transduction pathways. Annu Rev Cell Biol. 1994;10:251-337.
    • (1994) Annu Rev Cell Biol , vol.10 , pp. 251-337
    • van der Geer, P.1    Hunter, T.2    Lindberg, R.A.3
  • 55
    • 70249086591 scopus 로고    scopus 로고
    • Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor
    • Noren NK, Yang NY, Silldorff M, Mutyala R, Pasquale EB. Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor. Biochem J. 2009;422(3):433-442.
    • (2009) Biochem J , vol.422 , Issue.3 , pp. 433-442
    • Noren, N.K.1    Yang, N.Y.2    Silldorff, M.3    Mutyala, R.4    Pasquale, E.B.5
  • 56
    • 22544434364 scopus 로고    scopus 로고
    • Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3
    • Day B, To C, Himanen JP, Smith FM, Nikolov DB, Boyd AW, Lackmann M. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. J Biol Chem. 2005;280(28):26526-26532.
    • (2005) J Biol Chem , vol.280 , Issue.28 , pp. 26526-26532
    • Day, B.1    To, C.2    Himanen, J.P.3    Smith, F.M.4    Nikolov, D.B.5    Boyd, A.W.6    Lackmann, M.7
  • 58
    • 0032031705 scopus 로고    scopus 로고
    • Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
    • Stein E, Lane AA, Cerretti DP, Schoecklmann HO, Schroff AD, Van Etten RL, Daniel TO. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev. 1998;12(5):667-678.
    • (1998) Genes Dev , vol.12 , Issue.5 , pp. 667-678
    • Stein, E.1    Lane, A.A.2    Cerretti, D.P.3    Schoecklmann, H.O.4    Schroff, A.D.5    van Etten, R.L.6    Daniel, T.O.7
  • 59
    • 0037040281 scopus 로고    scopus 로고
    • The kinasenull EphB6 receptor undergoes transphosphorylation in a complex with EphB1
    • Freywald A, Sharfe N, Roifman CM. The kinasenull EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J Biol Chem. 2002; 277(6):3823-3828.
    • (2002) J Biol Chem , vol.277 , Issue.6 , pp. 3823-3828
    • Freywald, A.1    Sharfe, N.2    Roifman, C.M.3
  • 60
    • 76249132650 scopus 로고    scopus 로고
    • The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells
    • Truitt L, Freywald T, DeCoteau J, Sharfe N, Freywald A. The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res. 2010;70(3):1141-1153.
    • (2010) Cancer Res , vol.70 , Issue.3 , pp. 1141-1153
    • Truitt, L.1    Freywald, T.2    Decoteau, J.3    Sharfe, N.4    Freywald, A.5
  • 61
    • 42649146180 scopus 로고    scopus 로고
    • Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays
    • Warner N, Wybenga-Groot LE, Pawson T. Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays. FEBS J. 2008;275(10):2561-2573.
    • (2008) FEBS J , vol.275 , Issue.10 , pp. 2561-2573
    • Warner, N.1    Wybenga-Groot, L.E.2    Pawson, T.3
  • 62
    • 77956849819 scopus 로고    scopus 로고
    • Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries
    • Bush JO, Soriano P. Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries. Genes Dev. 2010; 24(18):2068-2080.
    • (2010) Genes Dev , vol.24 , Issue.18 , pp. 2068-2080
    • Bush, J.O.1    Soriano, P.2
  • 64
    • 0034714357 scopus 로고    scopus 로고
    • Regulated cleavage of a contact-mediated axon repellent
    • Hattori M, Osterfield M, Flanagan JG. Regulated cleavage of a contact-mediated axon repellent. Science. 2000;289(5483):1360-1365.
    • (2000) Science , vol.289 , Issue.5483 , pp. 1360-1365
    • Hattori, M.1    Osterfield, M.2    Flanagan, J.G.3
  • 65
    • 79954990986 scopus 로고    scopus 로고
    • Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map
    • Yoo S, Kim Y, Noh H, Lee H, Park E, Park S. Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map. EMBO J. 2011;30(8):1593-1607.
    • (2011) EMBO J , vol.30 , Issue.8 , pp. 1593-1607
    • Yoo, S.1    Kim, Y.2    Noh, H.3    Lee, H.4    Park, E.5    Park, S.6
  • 66
    • 34249861061 scopus 로고    scopus 로고
    • Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord
    • Kida YS, Sato T, Miyasaka KY, Suto A, Ogura T. Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Proc Natl Acad Sci U S A. 2007;104(16):6708-6713.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.16 , pp. 6708-6713
    • Kida, Y.S.1    Sato, T.2    Miyasaka, K.Y.3    Suto, A.4    Ogura, T.5
  • 67
    • 0037101649 scopus 로고    scopus 로고
    • Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse
    • Jurney WM, Gallo G, Letourneau PC, McLoon SC. Rac1-mediated endocytosis during ephrin-A2- and semaphorin 3A-induced growth cone collapse. J Neurosci. 2002;22(14):6019-6028.
    • (2002) J Neurosci , vol.22 , Issue.14 , pp. 6019-6028
    • Jurney, W.M.1    Gallo, G.2    Letourneau, P.C.3    McLoon, S.C.4
  • 68
    • 0141839882 scopus 로고    scopus 로고
    • Racdependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
    • Marston DJ, Dickinson S, Nobes CD. Racdependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat Cell Biol. 2003;5(10):879-888.
    • (2003) Nat Cell Biol , vol.5 , Issue.10 , pp. 879-888
    • Marston, D.J.1    Dickinson, S.2    Nobes, C.D.3
  • 69
    • 0141839883 scopus 로고    scopus 로고
    • EphBephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
    • Zimmer M, Palmer A, Kohler J, Klein R. EphBephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol. 2003;5(10):869-878.
    • (2003) Nat Cell Biol , vol.5 , Issue.10 , pp. 869-878
    • Zimmer, M.1    Palmer, A.2    Kohler, J.3    Klein, R.4
  • 70
    • 33751095631 scopus 로고    scopus 로고
    • Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells
    • Lauterbach J, Klein R. Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells. J Neurosci. 2006;26(45):11575-11581.
    • (2006) J Neurosci , vol.26 , Issue.45 , pp. 11575-11581
    • Lauterbach, J.1    Klein, R.2
  • 73
    • 57649221000 scopus 로고    scopus 로고
    • Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion
    • Lin KT, Sloniowski S, Ethell DW, Ethell IM. Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J Biol Chem. 2008;283(43):28969-28979.
    • (2008) J Biol Chem , vol.283 , Issue.43 , pp. 28969-28979
    • Lin, K.T.1    Sloniowski, S.2    Ethell, D.W.3    Ethell, I.M.4
  • 74
    • 1642422313 scopus 로고    scopus 로고
    • Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2
    • Pascall JC, Brown KD. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. Biochem Biophys Res Commun. 2004;317(1):244-252.
    • (2004) Biochem Biophys Res Commun , vol.317 , Issue.1 , pp. 244-252
    • Pascall, J.C.1    Brown, K.D.2
  • 75
    • 38449105906 scopus 로고    scopus 로고
    • The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases
    • Richter M, Murai KK, Bourgin C, Pak DT, Pasquale EB. The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. J Neurosci. 2007;27(51): 14205-14215.
    • (2007) J Neurosci , vol.27 , Issue.51 , pp. 14205-14215
    • Richter, M.1    Murai, K.K.2    Bourgin, C.3    Pak, D.T.4    Pasquale, E.B.5
  • 76
    • 34047268925 scopus 로고    scopus 로고
    • Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-kinase-dependent Rac1 activation
    • Zhuang G, Hunter S, Hwang Y, Chen J. Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-kinase-dependent Rac1 activation. J Biol Chem. 2007;282(4): 2683-2694.
    • (2007) J Biol Chem , vol.282 , Issue.4 , pp. 2683-2694
    • Zhuang, G.1    Hunter, S.2    Hwang, Y.3    Chen, J.4
  • 79
    • 1842828975 scopus 로고    scopus 로고
    • Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins
    • Noren NK, Pasquale EB. Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal. 2004;16(6):655-666.
    • (2004) Cell Signal , vol.16 , Issue.6 , pp. 655-666
    • Noren, N.K.1    Pasquale, E.B.2
  • 80
    • 0029867243 scopus 로고    scopus 로고
    • A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn
    • Ellis C, Kasmi F, Ganju P, Walls E, Panayotou G, Reith AD. A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. Oncogene. 1996;12(8):1727-1736.
    • (1996) Oncogene , vol.12 , Issue.8 , pp. 1727-1736
    • Ellis, C.1    Kasmi, F.2    Ganju, P.3    Walls, E.4    Panayotou, G.5    Reith, A.D.6
  • 81
    • 0037047122 scopus 로고    scopus 로고
    • Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred
    • Prevost N, Woulfe D, Tanaka T, Brass LF. Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. Proc Natl Acad Sci U S A. 2002;99(14):9219-9224.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.14 , pp. 9219-9224
    • Prevost, N.1    Woulfe, D.2    Tanaka, T.3    Brass, L.F.4
  • 82
    • 0032554762 scopus 로고    scopus 로고
    • Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region
    • Zisch AH, Kalo MS, Chong LD, Pasquale EB. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region. Oncogene. 1998; 16(20):2657-2670.
    • (1998) Oncogene , vol.16 , Issue.20 , pp. 2657-2670
    • Zisch, A.H.1    Kalo, M.S.2    Chong, L.D.3    Pasquale, E.B.4
  • 83
    • 65649096506 scopus 로고    scopus 로고
    • SRC family kinases are required for limb trajectory selection by spinal motor axons
    • Kao TJ, Palmesino E, Kania A. SRC family kinases are required for limb trajectory selection by spinal motor axons. J Neurosci. 2009;29(17):5690-5700.
    • (2009) J Neurosci , vol.29 , Issue.17 , pp. 5690-5700
    • Kao, T.J.1    Palmesino, E.2    Kania, A.3
  • 84
    • 0035811562 scopus 로고    scopus 로고
    • Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor
    • Yu HH, Zisch AH, Dodelet VC, Pasquale EB. Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor. Oncogene. 2001;20(30):3995-4006.
    • (2001) Oncogene , vol.20 , Issue.30 , pp. 3995-4006
    • Yu, H.H.1    Zisch, A.H.2    Dodelet, V.C.3    Pasquale, E.B.4
  • 85
    • 23644439618 scopus 로고    scopus 로고
    • A key role for Abl family kinases in EphA receptor-mediated growth cone collapse
    • Harbott LK, Nobes CD. A key role for Abl family kinases in EphA receptor-mediated growth cone collapse. Mol Cell Neurosci. 2005;30(1):1-11.
    • (2005) Mol Cell Neurosci , vol.30 , Issue.1 , pp. 1-11
    • Harbott, L.K.1    Nobes, C.D.2
  • 86
    • 0034960682 scopus 로고    scopus 로고
    • The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner
    • Gu C, Park S. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol Cell Biol. 2001;21(14):4579-4597.
    • (2001) Mol Cell Biol , vol.21 , Issue.14 , pp. 4579-4597
    • Gu, C.1    Park, S.2
  • 87
    • 2942605976 scopus 로고    scopus 로고
    • EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation
    • Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J. EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation. J Cell Sci. 2004;117(Pt 10):2037-2049.
    • (2004) J Cell Sci , vol.117 , Issue.Pt 10 , pp. 2037-2049
    • Brantley-Sieders, D.M.1    Caughron, J.2    Hicks, D.3    Pozzi, A.4    Ruiz, J.C.5    Chen, J.6
  • 88
    • 0242552912 scopus 로고    scopus 로고
    • Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol- 3 kinase pathway and promotes angiogenesis in adult vasculature
    • Maekawa H, Oike Y, Kanda S, Ito Y, Yamada Y, Kurihara H, Nagai R, Suda T. Ephrin-B2 induces migration of endothelial cells through the phosphatidylinositol- 3 kinase pathway and promotes angiogenesis in adult vasculature. Arterioscler Thromb Vasc Biol. 2003;23(11):2008-2014.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , Issue.11 , pp. 2008-2014
    • Maekawa, H.1    Oike, Y.2    Kanda, S.3    Ito, Y.4    Yamada, Y.5    Kurihara, H.6    Nagai, R.7    Suda, T.8
  • 93
    • 54049153684 scopus 로고    scopus 로고
    • EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line
    • Fukai J, Yokote H, Yamanaka R, Arao T, Nishio K, Itakura T. EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line. Mol Cancer Ther. 2008;7(9):2768-2778.
    • (2008) Mol Cancer Ther , vol.7 , Issue.9 , pp. 2768-2778
    • Fukai, J.1    Yokote, H.2    Yamanaka, R.3    Arao, T.4    Nishio, K.5    Itakura, T.6
  • 95
    • 1642423563 scopus 로고    scopus 로고
    • Ectopic EphA4 receptor induces posterior protrusions via FGF signaling in Xenopus embryos
    • Park EK, Warner N, Bong YS, Stapleton D, Maeda R, Pawson T, Daar IO. Ectopic EphA4 receptor induces posterior protrusions via FGF signaling in Xenopus embryos. Mol Biol Cell. 2004;15(4): 1647-1655.
    • (2004) Mol Biol Cell , vol.15 , Issue.4 , pp. 1647-1655
    • Park, E.K.1    Warner, N.2    Bong, Y.S.3    Stapleton, D.4    Maeda, R.5    Pawson, T.6    Daar, I.O.7
  • 96
    • 58149288204 scopus 로고    scopus 로고
    • Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway
    • Poliakov A, Cotrina ML, Pasini A, Wilkinson DG. Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway. J Cell Biol. 2008;183(5):933-947.
    • (2008) J Cell Biol , vol.183 , Issue.5 , pp. 933-947
    • Poliakov, A.1    Cotrina, M.L.2    Pasini, A.3    Wilkinson, D.G.4
  • 98
    • 74449091169 scopus 로고    scopus 로고
    • Cell adhesion and EGFR activation regulate EphA2 expression in cancer
    • Larsen AB, Stockhausen MT, Poulsen HS. Cell adhesion and EGFR activation regulate EphA2 expression in cancer. Cell Signal. 2010;22(4):636-644.
    • (2010) Cell Signal , vol.22 , Issue.4 , pp. 636-644
    • Larsen, A.B.1    Stockhausen, M.T.2    Poulsen, H.S.3
  • 102
    • 33751168256 scopus 로고    scopus 로고
    • EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling
    • Salvucci O, de la Luz Sierra M, Martina JA, McCormick PJ, Tosato G. EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling. Blood. 2006;108(9):2914-2922.
    • (2006) Blood , vol.108 , Issue.9 , pp. 2914-2922
    • Salvucci, O.1    de la Luz, S.M.2    Martina, J.A.3    McCormick, P.J.4    Tosato, G.5
  • 104
    • 0030891962 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of transmembrane ligands for Eph receptors
    • Bruckner K, Pasquale EB, Klein R. Tyrosine phosphorylation of transmembrane ligands for Eph receptors. Science. 1997;275(5306):1640-1643.
    • (1997) Science , vol.275 , Issue.5306 , pp. 1640-1643
    • Bruckner, K.1    Pasquale, E.B.2    Klein, R.3
  • 105
    • 0029851690 scopus 로고    scopus 로고
    • Bidirectional signaling through the EPH-family receptor Nuk and its transmembrane ligands
    • Holland SJ, Gale NW, Mbamalu G, Yancopoulos GD, Henkemeyer M, Pawson T. Bidirectional signaling through the EPH-family receptor Nuk and its transmembrane ligands. Nature. 1996;383(6602):722-725.
    • (1996) Nature , vol.383 , Issue.6602 , pp. 722-725
    • Holland, S.J.1    Gale, N.W.2    Mbamalu, G.3    Yancopoulos, G.D.4    Henkemeyer, M.5    Pawson, T.6
  • 107
    • 33645277094 scopus 로고    scopus 로고
    • Metalloproteinase/ Presenilin1 processing of ephrinB regulates EphBinduced Src phosphorylation and signaling
    • Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G, Robakis NK. Metalloproteinase/ Presenilin1 processing of ephrinB regulates EphBinduced Src phosphorylation and signaling. EMBO J. 2006;25(6):1242-1252.
    • (2006) EMBO J , vol.25 , Issue.6 , pp. 1242-1252
    • Georgakopoulos, A.1    Litterst, C.2    Ghersi, E.3    Baki, L.4    Xu, C.5    Serban, G.6    Robakis, N.K.7
  • 108
    • 70349569570 scopus 로고    scopus 로고
    • EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures
    • Salvucci O, Maric D, Economopoulou M, Sakakibara S, Merlin S, Follenzi A, Tosato G. EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures. Blood. 2009;114(8):1707-1716.
    • (2009) Blood , vol.114 , Issue.8 , pp. 1707-1716
    • Salvucci, O.1    Maric, D.2    Economopoulou, M.3    Sakakibara, S.4    Merlin, S.5    Follenzi, A.6    Tosato, G.7
  • 109
    • 0035855819 scopus 로고    scopus 로고
    • The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals
    • Cowan CA, Henkemeyer M. The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001;413(6852):174-179.
    • (2001) Nature , vol.413 , Issue.6852 , pp. 174-179
    • Cowan, C.A.1    Henkemeyer, M.2
  • 110
    • 60749086997 scopus 로고    scopus 로고
    • Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning
    • Xu NJ, Henkemeyer M. Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning. Nat Neurosci. 2009;12(3):268-276.
    • (2009) Nat Neurosci , vol.12 , Issue.3 , pp. 268-276
    • Xu, N.J.1    Henkemeyer, M.2
  • 111
    • 0033103887 scopus 로고    scopus 로고
    • EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains
    • Bruckner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg PH, Klein R. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999;22(3):511-524.
    • (1999) Neuron , vol.22 , Issue.3 , pp. 511-524
    • Bruckner, K.1    Pablo, L.J.2    Scheiffele, P.3    Herb, A.4    Seeburg, P.H.5    Klein, R.6
  • 112
    • 0033525063 scopus 로고    scopus 로고
    • The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. The Journal of Biological Chemistry
    • Lin D, Gish GD, Songyang Z, Pawson T. The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif. The Journal of Biological Chemistry.J Biol Chem 1999;274(6):3726-3733.
    • (1999) J Biol Chem , vol.274 , Issue.6 , pp. 3726-3733
    • Lin, D.1    Gish, G.D.2    Songyang, Z.3    Pawson, T.4
  • 114
    • 80054982789 scopus 로고    scopus 로고
    • A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses
    • Xu NJ, Sun S, Gibson JR, Henkemeyer M. A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses. Nat Neurosci. 2011;14(11):1421-1429.
    • (2011) Nat Neurosci , vol.14 , Issue.11 , pp. 1421-1429
    • Xu, N.J.1    Sun, S.2    Gibson, J.R.3    Henkemeyer, M.4
  • 117
    • 0036498380 scopus 로고    scopus 로고
    • Ephrin-As as receptors in topographic projections
    • Knoll B, Drescher U. Ephrin-As as receptors in topographic projections. Trends Neurosci. 2002;25(3):145-149.
    • (2002) Trends Neurosci , vol.25 , Issue.3 , pp. 145-149
    • Knoll, B.1    Drescher, U.2
  • 118
    • 0033385502 scopus 로고    scopus 로고
    • Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
    • Davy A, Gale NW, Murray EW, Klinghoffer RA, Soriano P, Feuerstein C, Robbins SM. Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev. 1999;13(23):3125-3135.
    • (1999) Genes Dev , vol.13 , Issue.23 , pp. 3125-3135
    • Davy, A.1    Gale, N.W.2    Murray, E.W.3    Klinghoffer, R.A.4    Soriano, P.5    Feuerstein, C.6    Robbins, S.M.7
  • 119
    • 0242352659 scopus 로고    scopus 로고
    • Ephrin signaling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signaling bind them?
    • Gauthier LR, Robbins SM. Ephrin signaling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signaling bind them? Life Sci. 2003;74(2-3):207-216.
    • (2003) Life Sci , vol.74 , Issue.2-3 , pp. 207-216
    • Gauthier, L.R.1    Robbins, S.M.2
  • 120
    • 0034676025 scopus 로고    scopus 로고
    • Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner
    • Davy A, Robbins SM. Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner. EMBO J. 2000;19(20):5396-5405.
    • (2000) EMBO J , vol.19 , Issue.20 , pp. 5396-5405
    • Davy, A.1    Robbins, S.M.2
  • 121
    • 44449118933 scopus 로고    scopus 로고
    • The Eph receptor/ ephrin system: An emerging player in the invasion game
    • Campbell TN, Robbins SM. The Eph receptor/ ephrin system: an emerging player in the invasion game. Curr Issues Mol Biol. 2008;10(1-2):61-66.
    • (2008) Curr Issues Mol Biol , vol.10 , Issue.1-2 , pp. 61-66
    • Campbell, T.N.1    Robbins, S.M.2
  • 122
    • 0034282516 scopus 로고    scopus 로고
    • Identification of a tumorspecific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules
    • Chiari R, Hames G, Stroobant V, Texier C, Maillere B, Boon T, Coulie PG. Identification of a tumorspecific shared antigen derived from an Eph receptor and presented to CD4 T cells on HLA class II molecules. Cancer Res. 2000;60(17):4855-4863.
    • (2000) Cancer Res , vol.60 , Issue.17 , pp. 4855-4863
    • Chiari, R.1    Hames, G.2    Stroobant, V.3    Texier, C.4    Maillere, B.5    Boon, T.6    Coulie, P.G.7
  • 123
    • 37249079132 scopus 로고    scopus 로고
    • Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: Role of the Eph receptors
    • Hess AR, Margaryan NV, Seftor EA, Hendrix MJ. Deciphering the signaling events that promote melanoma tumor cell vasculogenic mimicry and their link to embryonic vasculogenesis: Role of the Eph receptors. Dev Dyn. 2007;236(12):3283-3296.
    • (2007) Dev Dyn , vol.236 , Issue.12 , pp. 3283-3296
    • Hess, A.R.1    Margaryan, N.V.2    Seftor, E.A.3    Hendrix, M.J.4
  • 125
    • 0034619758 scopus 로고    scopus 로고
    • The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
    • Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene. 2000;19(52): 6043-6052.
    • (2000) Oncogene , vol.19 , Issue.52 , pp. 6043-6052
    • Ogawa, K.1    Pasqualini, R.2    Lindberg, R.A.3    Kain, R.4    Freeman, A.L.5    Pasquale, E.B.6
  • 127
    • 33746894693 scopus 로고    scopus 로고
    • Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer
    • Fournier MV, Martin KJ, Kenny PA, Xhaja K, Bosch I, Yaswen P, Bissell MJ. Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res. 2006;66(14):7095-7102.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7095-7102
    • Fournier, M.V.1    Martin, K.J.2    Kenny, P.A.3    Xhaja, K.4    Bosch, I.5    Yaswen, P.6    Bissell, M.J.7
  • 128
    • 33746646032 scopus 로고    scopus 로고
    • The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
    • Noren NK, Foos G, Hauser CA, Pasquale EB. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol. 2006;8(8):815-825.
    • (2006) Nat Cell Biol , vol.8 , Issue.8 , pp. 815-825
    • Noren, N.K.1    Foos, G.2    Hauser, C.A.3    Pasquale, E.B.4
  • 129
    • 33746929036 scopus 로고    scopus 로고
    • Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin
    • Guo H, Miao H, Gerber L, Singh J, Denning MF, Gilliam AC, Wang B. Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res. 2006;66(14):7050-7058.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 7050-7058
    • Guo, H.1    Miao, H.2    Gerber, L.3    Singh, J.4    Denning, M.F.5    Gilliam, A.C.6    Wang, B.7
  • 131
  • 133
    • 0035345024 scopus 로고    scopus 로고
    • Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer
    • Takai N, Miyazaki T, Fujisawa K, Nasu K, Miyakawa I. Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer. Oncol Rep. 2001;8(3):567-573.
    • (2001) Oncol Rep , vol.8 , Issue.3 , pp. 567-573
    • Takai, N.1    Miyazaki, T.2    Fujisawa, K.3    Nasu, K.4    Miyakawa, I.5
  • 135
    • 58149402919 scopus 로고    scopus 로고
    • Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features
    • Guan M, Xu C, Zhang F, Ye C. Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. Int J Cancer. 2009;124(1):88-94.
    • (2009) Int J Cancer , vol.124 , Issue.1 , pp. 88-94
    • Guan, M.1    Xu, C.2    Zhang, F.3    Ye, C.4
  • 138
    • 63949086165 scopus 로고    scopus 로고
    • Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival
    • Herath NI, Doecke J, Spanevello MD, Leggett BA, Boyd AW. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. Br J Cancer. 2009;100(7):1095-1102.
    • (2009) Br J Cancer , vol.100 , Issue.7 , pp. 1095-1102
    • Herath, N.I.1    Doecke, J.2    Spanevello, M.D.3    Leggett, B.A.4    Boyd, A.W.5
  • 139
    • 2442419137 scopus 로고    scopus 로고
    • Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application
    • Fox BP, Kandpal RP. Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem Biophys Res Commun. 2004;318(4):882-892.
    • (2004) Biochem Biophys Res Commun , vol.318 , Issue.4 , pp. 882-892
    • Fox, B.P.1    Kandpal, R.P.2
  • 141
    • 0033215506 scopus 로고    scopus 로고
    • Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells
    • Dottori M, Down M, Huttmann A, Fitzpatrick DR, Boyd AW. Cloning and characterization of EphA3 (Hek) gene promoter: DNA methylation regulates expression in hematopoietic tumor cells. Blood. 1999;94(7):2477-2486.
    • (1999) Blood , vol.94 , Issue.7 , pp. 2477-2486
    • Dottori, M.1    Down, M.2    Huttmann, A.3    Fitzpatrick, D.R.4    Boyd, A.W.5
  • 151
    • 27644466229 scopus 로고    scopus 로고
    • EphA2 as a novel molecular marker and target in glioblastoma multiforme
    • Wykosky J, Gibo DM, Stanton C, Debinski W. EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol Cancer Res. 2005;3(10):541-551.
    • (2005) Mol Cancer Res , vol.3 , Issue.10 , pp. 541-551
    • Wykosky, J.1    Gibo, D.M.2    Stanton, C.3    Debinski, W.4
  • 152
    • 1842732148 scopus 로고    scopus 로고
    • Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth
    • Noren NK, Lu M, Freeman AL, Koolpe M, Pasquale EB. Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc Natl Acad Sci U S A. 2004;101(15):5583-5588.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.15 , pp. 5583-5588
    • Noren, N.K.1    Lu, M.2    Freeman, A.L.3    Koolpe, M.4    Pasquale, E.B.5
  • 162
    • 0036568740 scopus 로고    scopus 로고
    • Ephrins are not only unattractive
    • Holmberg J, Frisen J. Ephrins are not only unattractive. Trends Neurosci. 2002;25(5):239-243.
    • (2002) Trends Neurosci , vol.25 , Issue.5 , pp. 239-243
    • Holmberg, J.1    Frisen, J.2
  • 165
    • 0035865227 scopus 로고    scopus 로고
    • Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth- muscle cells
    • Gale NW, Baluk P, Pan L, Kwan M, Holash J, DeChiara TM, McDonald DM, Yancopoulos GD. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth- muscle cells. Dev Biol. 2001;230(2):151-160.
    • (2001) Dev Biol , vol.230 , Issue.2 , pp. 151-160
    • Gale, N.W.1    Baluk, P.2    Pan, L.3    Kwan, M.4    Holash, J.5    Dechiara, T.M.6    McDonald, D.M.7    Yancopoulos, G.D.8
  • 166
    • 0035865049 scopus 로고    scopus 로고
    • Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization
    • Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA Jr, Anderson DJ. Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol. 2001;230(2):139-150.
    • (2001) Dev Biol , vol.230 , Issue.2 , pp. 139-150
    • Shin, D.1    Garcia-Cardena, G.2    Hayashi, S.3    Gerety, S.4    Asahara, T.5    Stavrakis, G.6    Isner, J.7    Folkman, J.8    Gimbrone Jr., M.A.9    Anderson, D.J.10
  • 167
    • 27744597086 scopus 로고    scopus 로고
    • Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression
    • Brantley-Sieders DM, Fang WB, Hicks DJ, Zhuang G, Shyr Y, Chen J. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression. FASEB J. 2005;19(13):1884-1886.
    • (2005) FASEB J , vol.19 , Issue.13 , pp. 1884-1886
    • Brantley-Sieders, D.M.1    Fang, W.B.2    Hicks, D.J.3    Zhuang, G.4    Shyr, Y.5    Chen, J.6
  • 168
    • 33751296587 scopus 로고    scopus 로고
    • Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice
    • Brantley-Sieders DM, Fang WB, Hwang Y, Hicks D, Chen J. Ephrin-A1 facilitates mammary tumor metastasis through an angiogenesis-dependent mechanism mediated by EphA receptor and vascular endothelial growth factor in mice. Cancer Res. 2006;66(21):10315-10324.
    • (2006) Cancer Res , vol.66 , Issue.21 , pp. 10315-10324
    • Brantley-Sieders, D.M.1    Fang, W.B.2    Hwang, Y.3    Hicks, D.4    Chen, J.5
  • 169
    • 18244382791 scopus 로고    scopus 로고
    • Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization
    • Hayashi S, Asahara T, Masuda H, Isner JM, Losordo DW. Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization. Circulation. 2005;111(17):2210-2218.
    • (2005) Circulation , vol.111 , Issue.17 , pp. 2210-2218
    • Hayashi, S.1    Asahara, T.2    Masuda, H.3    Isner, J.M.4    Losordo, D.W.5
  • 173
    • 0037093097 scopus 로고    scopus 로고
    • Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior
    • Carles-Kinch K, Kilpatrick KE, Stewart JC, Kinch MS. Antibody targeting of the EphA2 tyrosine kinase inhibits malignant cell behavior. Cancer Res. 2002;62(10):2840-2847.
    • (2002) Cancer Res , vol.62 , Issue.10 , pp. 2840-2847
    • Carles-Kinch, K.1    Kilpatrick, K.E.2    Stewart, J.C.3    Kinch, M.S.4
  • 179
    • 80054764457 scopus 로고    scopus 로고
    • Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody
    • Peng L, Oganesyan V, Damschroder MM, Wu H, Dall'acqua WF. Structural and functional characterization of an agonistic anti-human EphA2 monoclonal antibody. J Mol Biol. 2011;413(2):390-405.
    • (2011) J Mol Biol , vol.413 , Issue.2 , pp. 390-405
    • Peng, L.1    Oganesyan, V.2    Damschroder, M.M.3    Wu, H.4    Dall'acqua, W.F.5
  • 187
    • 37549047649 scopus 로고    scopus 로고
    • A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor expressing tumor cells
    • Wykosky J, Gibo DM, Debinski W. A novel, potent, and specific ephrinA1-based cytotoxin against EphA2 receptor expressing tumor cells. Mol Cancer Ther. 2007;6(12 Pt 1):3208-3218.
    • (2007) Mol Cancer Ther , vol.6 , Issue.12 Pt 1 , pp. 3208-3218
    • Wykosky, J.1    Gibo, D.M.2    Debinski, W.3
  • 188
    • 80053976962 scopus 로고    scopus 로고
    • Molecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells
    • Sun XL, Xu ZM, Ke YQ, Hu CC, Wang SY, Ling GQ, Yan ZJ, Liu YJ, Song ZH, Jiang XD, Xu RX. Molecular targeting of malignant glioma cells with an EphA2-specific immunotoxin delivered by human bone marrow-derived mesenchymal stem cells. Cancer Lett. 2011;312(2): 168-177.
    • (2011) Cancer Lett , vol.312 , Issue.2 , pp. 168-177
    • Sun, X.L.1    Xu, Z.M.2    Ke, Y.Q.3    Hu, C.C.4    Wang, S.Y.5    Ling, G.Q.6    Yan, Z.J.7    Liu, Y.J.8    Song, Z.H.9    Jiang, X.D.10    Xu, R.X.11
  • 193
    • 0026500682 scopus 로고
    • Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines
    • Wicks IP, Wilkinson D, Salvaris E, Boyd AW. Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines. Proc Natl Acad Sci U S A. 1992;89(5):1611-1615.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.5 , pp. 1611-1615
    • Wicks, I.P.1    Wilkinson, D.2    Salvaris, E.3    Boyd, A.W.4
  • 195
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061-1068.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
  • 199
    • 64549133471 scopus 로고    scopus 로고
    • Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck
    • Kimura M, Kato Y, Sano D, Fujita K, Sakakibara A, Kondo N, Mikami Y, Tsukuda M. Soluble form of ephrinB2 inhibits xenograft growth of squamous cell carcinoma of the head and neck. Int J Oncol. 2009;34(2):321-327.
    • (2009) Int J Oncol , vol.34 , Issue.2 , pp. 321-327
    • Kimura, M.1    Kato, Y.2    Sano, D.3    Fujita, K.4    Sakakibara, A.5    Kondo, N.6    Mikami, Y.7    Tsukuda, M.8
  • 200
    • 33644783643 scopus 로고    scopus 로고
    • The soluble extracellular domain of EphB4 (sEphB4) antago nizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth
    • Kertesz N, Krasnoperov V, Reddy R, Leshanski L, Kumar SR, Zozulya S, Gill PS. The soluble extracellular domain of EphB4 (sEphB4) antago nizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood. 2006;107(6):2330-2338.
    • (2006) Blood , vol.107 , Issue.6 , pp. 2330-2338
    • Kertesz, N.1    Krasnoperov, V.2    Reddy, R.3    Leshanski, L.4    Kumar, S.R.5    Zozulya, S.6    Gill, P.S.7
  • 203
    • 3142677219 scopus 로고    scopus 로고
    • Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness
    • Duxbury MS, Ito H, Zinner MJ, Ashley SW, Whang EE. Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness. Biochem Biophys Res Commun. 2004;320(4): 1096-1102.
    • (2004) Biochem Biophys Res Commun , vol.320 , Issue.4 , pp. 1096-1102
    • Duxbury, M.S.1    Ito, H.2    Zinner, M.J.3    Ashley, S.W.4    Whang, E.E.5
  • 204
    • 10844277420 scopus 로고    scopus 로고
    • Immunocompetent mouse model of breast cancer for preclinical testing of EphA2-targeted therapy
    • Noblitt LW, Bangari DS, Shukla S, Mohammed S, Mittal SK. Immunocompetent mouse model of breast cancer for preclinical testing of EphA2-targeted therapy. Cancer Gene Ther. 2005; 12(1):46-53.
    • (2005) Cancer Gene Ther , vol.12 , Issue.1 , pp. 46-53
    • Noblitt, L.W.1    Bangari, D.S.2    Shukla, S.3    Mohammed, S.4    Mittal, S.K.5
  • 205
    • 4444257965 scopus 로고    scopus 로고
    • Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1
    • Noblitt LW, Bangari DS, Shukla S, Knapp DW, Mohammed S, Kinch MS, Mittal SK. Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1. Cancer Gene Ther. 2004;11(11):757-766.
    • (2004) Cancer Gene Ther , vol.11 , Issue.11 , pp. 757-766
    • Noblitt, L.W.1    Bangari, D.S.2    Shukla, S.3    Knapp, D.W.4    Mohammed, S.5    Kinch, M.S.6    Mittal, S.K.7
  • 210
    • 84857442694 scopus 로고    scopus 로고
    • Targeting Eph receptors with peptides and small molecules: Progress and challenges
    • doi:10.1016/j.semcdb. 2011.10.023
    • Noberini R, Lamberto I, Pasquale EB. Targeting Eph receptors with peptides and small molecules: Progress and challenges. Semin Cell Dev Biol. 2011; doi:10.1016/j.semcdb. 2011.10.023.
    • (2011) Semin Cell Dev Biol
    • Noberini, R.1    Lamberto, I.2    Pasquale, E.B.3
  • 212
    • 33947225176 scopus 로고    scopus 로고
    • Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: Rationale for patient selection
    • Huang F, Reeves K, Han X, Fairchild C, Platero S, Wong TW, Lee F, Shaw P, Clark E. Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection. Cancer Res. 2007;67(5):2226-2238.
    • (2007) Cancer Res , vol.67 , Issue.5 , pp. 2226-2238
    • Huang, F.1    Reeves, K.2    Han, X.3    Fairchild, C.4    Platero, S.5    Wong, T.W.6    Lee, F.7    Shaw, P.8    Clark, E.9
  • 213
    • 53049104807 scopus 로고    scopus 로고
    • Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signaling in pancreatic cancer
    • Chang Q, Jorgensen C, Pawson T, Hedley DW. Effects of dasatinib on EphA2 receptor tyrosine kinase activity and downstream signaling in pancreatic cancer. Br J Cancer. 2008;99(7):1074-1082.
    • (2008) Br J Cancer , vol.99 , Issue.7 , pp. 1074-1082
    • Chang, Q.1    Jorgensen, C.2    Pawson, T.3    Hedley, D.W.4
  • 219
    • 49749109122 scopus 로고    scopus 로고
    • Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients
    • Jin M, Komohara Y, Shichijo S, Yamanaka R, Nikawa J, Itoh K, Yamada A. Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. Cancer Sci. 2008; 99(8):1656-1662.
    • (2008) Cancer Sci , vol.99 , Issue.8 , pp. 1656-1662
    • Jin, M.1    Komohara, Y.2    Shichijo, S.3    Yamanaka, R.4    Nikawa, J.5    Itoh, K.6    Yamada, A.7
  • 220
    • 34648834393 scopus 로고    scopus 로고
    • Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines
    • Yamaguchi S, Tatsumi T, Takehara T, Sakamori R, Uemura A, Mizushima T, Ohkawa K, Storkus WJ, Hayashi N. Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines. Cancer. 2007;110(7):1469-1477.
    • (2007) Cancer , vol.110 , Issue.7 , pp. 1469-1477
    • Yamaguchi, S.1    Tatsumi, T.2    Takehara, T.3    Sakamori, R.4    Uemura, A.5    Mizushima, T.6    Ohkawa, K.7    Storkus, W.J.8    Hayashi, N.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.