Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4467-4470

  Choi, Yongmun ^a,b   Syeda, Farisa ^c,d   Walker, John R ^d   Finerty Jr , Patrick J ^d   Cuerrier, Dominic ^c,d   Wojciechowski, Amy ^a,b   Liu, Qingsong ^a,b   Dhe Paganon, Sirano ^c,d   Gray, Nathanael S ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Eph kinase; Ephrin; Type II kinase inhibitor

Indexed keywords

EPHRIN RECEPTOR; EPHRIN RECEPTOR A3; EPHRIN RECEPTOR A7; EPHRIN RECEPTOR B2; NILOTINIB; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; STRUCTURE ANALYSIS;

ADENOSINE TRIPHOSPHATE; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHORYLATION; RECEPTORS, EPH FAMILY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 67649996707     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.05.029     Document Type: Article

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