Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells

Developmental Biology

Volumn 230, Issue 2, 2001, Pages 151-160

  Gale, Nicholas W ^a   Baluk, Peter ^b   Pan, Li ^a   Kwan, Marilyn ^b   Holash, Jocelyn ^a   DeChiara, Thomas M ^a   McDonald, Donald M ^b   Yancopoulos, George D ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alpha smooth muscle actin; Angiogenesis; Artery; Capillary; CD31; Eph; Ephrin; PECAM; Pericyte; Receptor tyrosine kinase; Vasculogenesis; Vein

Indexed keywords

EPHRIN; EPHRIN B2; EPHRIN RECEPTOR; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTERY; ARTICLE; CAPILLARY; CONTROLLED STUDY; EMBRYO DEVELOPMENT; IMMUNOHISTOCHEMISTRY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR VASCULARIZATION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VEIN; VENULE;

EID: 0035865227     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.0112     Document Type: Article

References (22)

1. Roles of ephrinB ligands and EphB receptors in cardiovascular development: Demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis
2. Tyrosine phosphorylation of transmembrane ligands for Eph receptors
3. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
4. The ephrins and Eph receptors in neural development
5. Tumor Angiogenesis: Therapeutic implications
6. Ephrins and their receptors: A repulsive topic?
7. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development
8. Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
9. Tumor growth and neovascularization: An experimental model using the rabbit cornea
10. The characteristic structural features of the blood vessels of the Lewis lung carcinoma (a light microscopic and scanning electron microscopic study)
11. The angioarchitecture of the Lewis lung carcinoma in laboratory mice (a light microscopic and scanning electron microscopic study)
12. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
13. Studies on dipeptidyl(amino)peptidase IV (glycylproline naphthylamidase). II. Blood vessels
14. Neurotrophin-3: A neurotrophic factor related to NGF and BDNF
15. Emzymatic heterogeneity of the capillary bed of rat skeletal muscles
16. Mechanisms of angiogenesis
17. Arterial-specific expression of EphrinB2 in adult vascular endothelial and smooth muscle cells and at sites of neovascularization
18. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
19. Permeability-related changes revealed at endothelial cell borders in inflamed venules by lectin binding
20. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
21. Vasculogenesis, angiogenesis, and growth factors: Ephrins enter the fray at the border
22. Stromal cells expressing Ephrin-B2 promote the growth and sprouting of Ephrin-B2 positive endothelial cells