-
1
-
-
20344396123
-
Eph receptor signalling casts a wide net on cell behaviour
-
Pasquale E.B. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6 (2005) 462-475
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 462-475
-
-
Pasquale, E.B.1
-
2
-
-
0031922119
-
The ephrins and Eph receptors in neural development
-
Flanagan J.G., and Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu Rev Neurosci 21 (1998) 309-345
-
(1998)
Annu Rev Neurosci
, vol.21
, pp. 309-345
-
-
Flanagan, J.G.1
Vanderhaeghen, P.2
-
3
-
-
0036303033
-
Mechanism and function of Eph and ephrin signaling
-
Kullander K., and Klein R. Mechanism and function of Eph and ephrin signaling. Nat Rev Mol Cell Biol 3 (2002) 475-486
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 475-486
-
-
Kullander, K.1
Klein, R.2
-
5
-
-
0029851690
-
Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
-
Holland S.J., Gale N.W., Mbamalu G., Yancopoulos G.D., Henkemeyer M., and Pawson T. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands. Nature 383 (1996) 722-725
-
(1996)
Nature
, vol.383
, pp. 722-725
-
-
Holland, S.J.1
Gale, N.W.2
Mbamalu, G.3
Yancopoulos, G.D.4
Henkemeyer, M.5
Pawson, T.6
-
6
-
-
15844429889
-
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis
-
Gale N.W., Holland S.J., Valenzuela D.M., Flenniken A., Pan L., Ryan T.E., Henkemeyer M., Strebhardt K., Hirai H., and Wilkinson D.G. Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. Neuron 17 (1996) 9-19
-
(1996)
Neuron
, vol.17
, pp. 9-19
-
-
Gale, N.W.1
Holland, S.J.2
Valenzuela, D.M.3
Flenniken, A.4
Pan, L.5
Ryan, T.E.6
Henkemeyer, M.7
Strebhardt, K.8
Hirai, H.9
Wilkinson, D.G.10
-
7
-
-
0028110068
-
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
-
Davis S., Gale N.W., Aldrich T.H., Maisonpierre P.C., Lhotak V., Pawson T., Goldfarb M., and Yancopoulos G.D. Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity. Science 266 (1994) 816-819
-
(1994)
Science
, vol.266
, pp. 816-819
-
-
Davis, S.1
Gale, N.W.2
Aldrich, T.H.3
Maisonpierre, P.C.4
Lhotak, V.5
Pawson, T.6
Goldfarb, M.7
Yancopoulos, G.D.8
-
8
-
-
25144472138
-
Eph receptor signalling; dimerisation just isn't enough
-
Vearing C.J., and Lackmann M. Eph receptor signalling; dimerisation just isn't enough. Growth Factors 23 (2005) 67-76
-
(2005)
Growth Factors
, vol.23
, pp. 67-76
-
-
Vearing, C.J.1
Lackmann, M.2
-
9
-
-
34247615569
-
Bidirectional Eph-ephrin signaling during axon guidance
-
Egea J., and Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol 17 5 (2007) 230-238
-
(2007)
Trends Cell Biol
, vol.17
, Issue.5
, pp. 230-238
-
-
Egea, J.1
Klein, R.2
-
10
-
-
0025014008
-
A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein
-
Holzman L.B., Marks R.M., and Dixit V.M. A novel immediate-early response gene of endothelium is induced by cytokines and encodes a secreted protein. Mol Cell Biol 10 (1990) 5830-5838
-
(1990)
Mol Cell Biol
, vol.10
, pp. 5830-5838
-
-
Holzman, L.B.1
Marks, R.M.2
Dixit, V.M.3
-
11
-
-
0031787110
-
Ephrin-A1 is expressed at sites of vascular development in the mouse
-
McBride J.L., and Ruiz J.C. Ephrin-A1 is expressed at sites of vascular development in the mouse. Mech Dev 77 (1998) 201-204
-
(1998)
Mech Dev
, vol.77
, pp. 201-204
-
-
McBride, J.L.1
Ruiz, J.C.2
-
12
-
-
0034468383
-
Eph receptors and ephrin ligands. Essential mediators of vascular development
-
Adams R.H., and Klein R. Eph receptors and ephrin ligands. Essential mediators of vascular development. Trends Cardiovasc Med 10 5 (2000) 183-188
-
(2000)
Trends Cardiovasc Med
, vol.10
, Issue.5
, pp. 183-188
-
-
Adams, R.H.1
Klein, R.2
-
13
-
-
0032577446
-
Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4
-
Wang H.U., Chen Z.F., and Anderson D.J. Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4. Cell 93 (1998) 741-753
-
(1998)
Cell
, vol.93
, pp. 741-753
-
-
Wang, H.U.1
Chen, Z.F.2
Anderson, D.J.3
-
14
-
-
0034693857
-
Eph receptors and ephrin ligands: embryogenesis to tumorigenesis
-
Dodelet V.C., and Pasquale E.B. Eph receptors and ephrin ligands: embryogenesis to tumorigenesis. Oncogene 19 49 (2000) 5614-5619
-
(2000)
Oncogene
, vol.19
, Issue.49
, pp. 5614-5619
-
-
Dodelet, V.C.1
Pasquale, E.B.2
-
15
-
-
30344440869
-
Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly
-
Foo S.S., Turner C.J., Adams S., Compagni A., Aubyn D., Kogata N., Lindblom P., Shani M., Zicha D., and Adams R.H. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 124 1 (2006) 161-173
-
(2006)
Cell
, vol.124
, Issue.1
, pp. 161-173
-
-
Foo, S.S.1
Turner, C.J.2
Adams, S.3
Compagni, A.4
Aubyn, D.5
Kogata, N.6
Lindblom, P.7
Shani, M.8
Zicha, D.9
Adams, R.H.10
-
16
-
-
34249329249
-
Paradoxes of the EphB4 receptor in cancer
-
Noren N.K., and Pasquale E.B. Paradoxes of the EphB4 receptor in cancer. Cancer Res. 67 9 (2007) 3994-3997
-
(2007)
Cancer Res.
, vol.67
, Issue.9
, pp. 3994-3997
-
-
Noren, N.K.1
Pasquale, E.B.2
-
17
-
-
0023607638
-
A novel putative tyrosine kinase receptor encoded by the eph gene
-
Hirai H., Maru Y., Hagiwara K., Nishida J., and Takaku F. A novel putative tyrosine kinase receptor encoded by the eph gene. Science 238 (1987) 1717-1720
-
(1987)
Science
, vol.238
, pp. 1717-1720
-
-
Hirai, H.1
Maru, Y.2
Hagiwara, K.3
Nishida, J.4
Takaku, F.5
-
18
-
-
34147163066
-
EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets
-
Konstantinova I., Nikolova G., Ohara-Imaizumi M., Meda P., Kucera T., Zarbalis K., Wurst W., Nagamatsu S., and Lammert E. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129 2 (2007) 359-370
-
(2007)
Cell
, vol.129
, Issue.2
, pp. 359-370
-
-
Konstantinova, I.1
Nikolova, G.2
Ohara-Imaizumi, M.3
Meda, P.4
Kucera, T.5
Zarbalis, K.6
Wurst, W.7
Nagamatsu, S.8
Lammert, E.9
-
19
-
-
33746528704
-
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
-
Zhao C., Irie N., Takada Y., Shimoda K., Miyamoto T., Nishiwaki T., Suda T., and Matsuo K. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 4 2 (2006) 111-121
-
(2006)
Cell Metab
, vol.4
, Issue.2
, pp. 111-121
-
-
Zhao, C.1
Irie, N.2
Takada, Y.3
Shimoda, K.4
Miyamoto, T.5
Nishiwaki, T.6
Suda, T.7
Matsuo, K.8
-
20
-
-
0035924322
-
Crystal structure of an Eph receptor-ephrin complex
-
Himanen J.P., Rajashankar K.R., Lackmann M., Cowan C.A., Henkemeyer M., and Nikolov D.B. Crystal structure of an Eph receptor-ephrin complex. Nature 414 (2001) 933-938
-
(2001)
Nature
, vol.414
, pp. 933-938
-
-
Himanen, J.P.1
Rajashankar, K.R.2
Lackmann, M.3
Cowan, C.A.4
Henkemeyer, M.5
Nikolov, D.B.6
-
21
-
-
11144354644
-
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling
-
In this study, the authors characterize structurally and functionally an unusual intrasubclass Eph/ephrin interaction. The overall conclusion is that the total bidirectional signals transduced into opposing cells are a combination of all Eph-ephrin interactions - both intrasubclass and intersubclass. Thus, even interactions that are of lower affinity could significantly affect cell behavior depending on the number/density of interacting molecules.
-
Himanen J.P., Chumley M.J., Lackmann M., Li C., Barton W.A., Jeffrey P.D., Vearing C., Geleick D., Feldheim D.A., Boyd A.W., et al. Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. Nat Neurosci 7 5 (2004) 501-509. In this study, the authors characterize structurally and functionally an unusual intrasubclass Eph/ephrin interaction. The overall conclusion is that the total bidirectional signals transduced into opposing cells are a combination of all Eph-ephrin interactions - both intrasubclass and intersubclass. Thus, even interactions that are of lower affinity could significantly affect cell behavior depending on the number/density of interacting molecules.
-
(2004)
Nat Neurosci
, vol.7
, Issue.5
, pp. 501-509
-
-
Himanen, J.P.1
Chumley, M.J.2
Lackmann, M.3
Li, C.4
Barton, W.A.5
Jeffrey, P.D.6
Vearing, C.7
Geleick, D.8
Feldheim, D.A.9
Boyd, A.W.10
-
22
-
-
34247606362
-
Crystal structure of the human ephrin-A5 ectodomain
-
Nikolov D., Li C., Lackmann M., Jeffrey P., and Himanen J. Crystal structure of the human ephrin-A5 ectodomain. Protein Sci 16 5 (2007) 996-1000
-
(2007)
Protein Sci
, vol.16
, Issue.5
, pp. 996-1000
-
-
Nikolov, D.1
Li, C.2
Lackmann, M.3
Jeffrey, P.4
Himanen, J.5
-
23
-
-
23944480844
-
Crystal structure of the ephrin-B1 ectodomain: implications for receptor recognition and signaling
-
Nikolov D.B., Li C., Barton W.A., and Himanen J.P. Crystal structure of the ephrin-B1 ectodomain: implications for receptor recognition and signaling. Biochemistry 44 33 (2005) 10947-10953
-
(2005)
Biochemistry
, vol.44
, Issue.33
, pp. 10947-10953
-
-
Nikolov, D.B.1
Li, C.2
Barton, W.A.3
Himanen, J.P.4
-
24
-
-
33748781688
-
Structural and biophysical characterization of the EphB4/ephrinB2 protein-protein interaction and receptor specificity
-
Chrencik J.E., Brooun A., Kraus M.L., Recht M.I., Kolatkar A.R., Han G.W., Seifert J.M., Widmer H., Auer M., and Kuhn P. Structural and biophysical characterization of the EphB4/ephrinB2 protein-protein interaction and receptor specificity. J Biol Chem 281 38 (2006) 28185-28192
-
(2006)
J Biol Chem
, vol.281
, Issue.38
, pp. 28185-28192
-
-
Chrencik, J.E.1
Brooun, A.2
Kraus, M.L.3
Recht, M.I.4
Kolatkar, A.R.5
Han, G.W.6
Seifert, J.M.7
Widmer, H.8
Auer, M.9
Kuhn, P.10
-
25
-
-
1542364449
-
Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen
-
Smith F.M., Vearing C., Lackmann M., Treutlein H., Himanen J., Chen K., Saul A., Nikolov D., and Boyd A.W. Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen. J Biol Chem 279 10 (2004) 9522-9531
-
(2004)
J Biol Chem
, vol.279
, Issue.10
, pp. 9522-9531
-
-
Smith, F.M.1
Vearing, C.2
Lackmann, M.3
Treutlein, H.4
Himanen, J.5
Chen, K.6
Saul, A.7
Nikolov, D.8
Boyd, A.W.9
-
26
-
-
22544434364
-
Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3
-
Day B., To C., Himanen J.P., Smith F.M., Nikolov D.B., Boyd A.W., and Lackmann M. Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3. J Biol Chem 280 28 (2005) 26526-26532
-
(2005)
J Biol Chem
, vol.280
, Issue.28
, pp. 26526-26532
-
-
Day, B.1
To, C.2
Himanen, J.P.3
Smith, F.M.4
Nikolov, D.B.5
Boyd, A.W.6
Lackmann, M.7
-
27
-
-
0032493828
-
Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization
-
Lackmann M., Oates A.C., Dottori M., Smith F.M., Do C., Power M., Kravets L., and Boyd A.W. Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization. J Biol Chem 273 (1998) 20228-20237
-
(1998)
J Biol Chem
, vol.273
, pp. 20228-20237
-
-
Lackmann, M.1
Oates, A.C.2
Dottori, M.3
Smith, F.M.4
Do, C.5
Power, M.6
Kravets, L.7
Boyd, A.W.8
-
28
-
-
30344442873
-
The many faces of SAM
-
Qiao F., and Bowie J.U. The many faces of SAM. Sci STKE 286 (2005) re7
-
(2005)
Sci STKE
, vol.286
-
-
Qiao, F.1
Bowie, J.U.2
-
29
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103 (2000) 211-225
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
30
-
-
0033786922
-
Protein tyrosine kinase structure and function
-
Hubbard S.R., and Till J.H. Protein tyrosine kinase structure and function. Annu Rev Biochem 69 (2000) 373-398
-
(2000)
Annu Rev Biochem
, vol.69
, pp. 373-398
-
-
Hubbard, S.R.1
Till, J.H.2
-
31
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M., and Kuriyan J. The conformational plasticity of protein kinases. Cell 109 (2002) 275-282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
32
-
-
0034796263
-
Theme and variations: juxtamembrane regulation of receptor protein kinases
-
Hubbard S.R. Theme and variations: juxtamembrane regulation of receptor protein kinases. Mol Cell 8 (2001) 481-487
-
(2001)
Mol Cell
, vol.8
, pp. 481-487
-
-
Hubbard, S.R.1
-
33
-
-
0035929146
-
Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region
-
Wybenga-Groot L.E., Baskin B., Ong S.H., Tong J., Pawson T., and Sicheri F. Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell 106 (2001) 745-757
-
(2001)
Cell
, vol.106
, pp. 745-757
-
-
Wybenga-Groot, L.E.1
Baskin, B.2
Ong, S.H.3
Tong, J.4
Pawson, T.5
Sicheri, F.6
-
34
-
-
33749346713
-
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases
-
The authors report a detailed study of Eph kinase activation utilizing a combination of mutational analysis, X-ray crystallography and NMR spectroscopy on the auto-inhibited and active forms of EphB2 and EphA4. Their results suggest that a change in interlobe dynamics, rather than a transition to a static active conformation, underlies Eph RTK activation.
-
Wiesner S., Wybenga-Groot L.E., Warner N., Lin H., Pawson T., Forman-Kay J.D., and Sicheri F. A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases. EMBO J 25 (2006) 4686-4696. The authors report a detailed study of Eph kinase activation utilizing a combination of mutational analysis, X-ray crystallography and NMR spectroscopy on the auto-inhibited and active forms of EphB2 and EphA4. Their results suggest that a change in interlobe dynamics, rather than a transition to a static active conformation, underlies Eph RTK activation.
-
(2006)
EMBO J
, vol.25
, pp. 4686-4696
-
-
Wiesner, S.1
Wybenga-Groot, L.E.2
Warner, N.3
Lin, H.4
Pawson, T.5
Forman-Kay, J.D.6
Sicheri, F.7
-
35
-
-
0037122898
-
Can Eph receptors stimulate the mind?
-
Murai K.K., and Pasquale E.B. Can Eph receptors stimulate the mind?. Neuron 33 (2002) 159-162
-
(2002)
Neuron
, vol.33
, pp. 159-162
-
-
Murai, K.K.1
Pasquale, E.B.2
-
36
-
-
0033635736
-
EphB receptors interact with NMDA receptors and regulate excitatory synapse formation
-
Dalva M.B. EphB receptors interact with NMDA receptors and regulate excitatory synapse formation. Cell 103 (2000) 945-956
-
(2000)
Cell
, vol.103
, pp. 945-956
-
-
Dalva, M.B.1
-
37
-
-
33751343894
-
Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors
-
Kayser M.S., McClelland A.C., Hughes E.G., and Dalva M.B. Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci 26 47 (2006) 12152-12164
-
(2006)
J Neurosci
, vol.26
, Issue.47
, pp. 12152-12164
-
-
Kayser, M.S.1
McClelland, A.C.2
Hughes, E.G.3
Dalva, M.B.4
-
38
-
-
0037033004
-
An ephrin mimetic peptide that selectively targets the EphA2 receptor
-
Koolpe M., Dail M., and Pasquale E.B. An ephrin mimetic peptide that selectively targets the EphA2 receptor. J Biol Chem 277 49 (2002) 46974-46979
-
(2002)
J Biol Chem
, vol.277
, Issue.49
, pp. 46974-46979
-
-
Koolpe, M.1
Dail, M.2
Pasquale, E.B.3
-
39
-
-
0347124700
-
Targeting the EphA4 receptor in the nervous system with biologically active peptides
-
Murai K.K., Nguyen L.N., Koolpe M., McLennan R., Krull C.E., and Pasquale E.B. Targeting the EphA4 receptor in the nervous system with biologically active peptides. Mol Cell Neurosci 24 4 (2003) 1000-1011
-
(2003)
Mol Cell Neurosci
, vol.24
, Issue.4
, pp. 1000-1011
-
-
Murai, K.K.1
Nguyen, L.N.2
Koolpe, M.3
McLennan, R.4
Krull, C.E.5
Pasquale, E.B.6
-
40
-
-
20344376236
-
EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity
-
The authors report the identification by phage display of peptides that bind selectively to different receptors of the EphB class, including EphB1, EphB2, and EphB4. Consistent with targeting the ephrin-binding site, the higher affinity peptides antagonize ephrin binding to the EphB receptors and the authors even optimize an EphB4-binding peptide with affinity comparable with that of the natural ligand, ephrin-B2.
-
Koolpe M., Burgess R., Dail M., and Pasquale E.B. EphB receptor-binding peptides identified by phage display enable design of an antagonist with ephrin-like affinity. J Biol Chem 280 17 (2005) 17301-17311. The authors report the identification by phage display of peptides that bind selectively to different receptors of the EphB class, including EphB1, EphB2, and EphB4. Consistent with targeting the ephrin-binding site, the higher affinity peptides antagonize ephrin binding to the EphB receptors and the authors even optimize an EphB4-binding peptide with affinity comparable with that of the natural ligand, ephrin-B2.
-
(2005)
J Biol Chem
, vol.280
, Issue.17
, pp. 17301-17311
-
-
Koolpe, M.1
Burgess, R.2
Dail, M.3
Pasquale, E.B.4
-
41
-
-
32044470909
-
Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity
-
In this study, the authors report the crystal structure of the EphB4 receptor in complex with a highly specific antagonistic peptide identified in [40], documenting that the peptide binds in the ephrin-binding surface channel of the receptor. Isothermal titration calorimetry reveals an interesting thermodynamic discrepancy between ephrin-B2 binding [24], which is an entropically driven process, and peptide binding, which is an enthalpically driven process.
-
Chrencik J.E., Brooun A., Recht M.I., Kraus M.L., Koolpe M., Kolatkar A.R., Bruce R.H., Martiny-Baron G., Widmer H., Pasquale E.B., and Kuhn P. Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity. Structure 14 2 (2006) 321-330. In this study, the authors report the crystal structure of the EphB4 receptor in complex with a highly specific antagonistic peptide identified in [40], documenting that the peptide binds in the ephrin-binding surface channel of the receptor. Isothermal titration calorimetry reveals an interesting thermodynamic discrepancy between ephrin-B2 binding [24], which is an entropically driven process, and peptide binding, which is an enthalpically driven process.
-
(2006)
Structure
, vol.14
, Issue.2
, pp. 321-330
-
-
Chrencik, J.E.1
Brooun, A.2
Recht, M.I.3
Kraus, M.L.4
Koolpe, M.5
Kolatkar, A.R.6
Bruce, R.H.7
Martiny-Baron, G.8
Widmer, H.9
Pasquale, E.B.10
Kuhn, P.11
-
42
-
-
28544446811
-
Targeting protein-protein interactions for cancer therapy
-
Fry D.C., and Vassilev L.T. Targeting protein-protein interactions for cancer therapy. J Mol Med 83 12 (2005) 955-963
-
(2005)
J Mol Med
, vol.83
, Issue.12
, pp. 955-963
-
-
Fry, D.C.1
Vassilev, L.T.2
-
43
-
-
0033119320
-
Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons
-
Hornberger M.R., Dütting D., Ciossek T., Yamada T., Handwerker C., Lang S., Weth F., Huf J., Wessel R., and Logan C. Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron 22 (1999) 731-742
-
(1999)
Neuron
, vol.22
, pp. 731-742
-
-
Hornberger, M.R.1
Dütting, D.2
Ciossek, T.3
Yamada, T.4
Handwerker, C.5
Lang, S.6
Weth, F.7
Huf, J.8
Wessel, R.9
Logan, C.10
-
44
-
-
1242316215
-
EphA receptor tyrosine kinases interact with co-expressed ephrin-A ligands in cis
-
Yin Y., Yamashita Y., Noda H., Okafuji T., Go M.J., and Tanaka H. EphA receptor tyrosine kinases interact with co-expressed ephrin-A ligands in cis. Neurosci Res 48 (2004) 285-296
-
(2004)
Neurosci Res
, vol.48
, pp. 285-296
-
-
Yin, Y.1
Yamashita, Y.2
Noda, H.3
Okafuji, T.4
Go, M.J.5
Tanaka, H.6
-
45
-
-
17044377138
-
Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains
-
Marquardt T., Shirasaki R., Ghosh S., Andrews S.E., Carter N., Hunter T., and Pfaff S.L. Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domains. Cell 121 (2005) 127-139
-
(2005)
Cell
, vol.121
, pp. 127-139
-
-
Marquardt, T.1
Shirasaki, R.2
Ghosh, S.3
Andrews, S.E.4
Carter, N.5
Hunter, T.6
Pfaff, S.L.7
-
46
-
-
33344477193
-
Silencing of EphA3 through a cis interaction with ephrinA5
-
In this study, the authors use truncated versions of EphA3, single-amino acid point mutants of ephrinA5 and fluorescence resonance energy transfer technology to uncover a cis interaction between EphA3 and ephrinA5 that is independent of the established ligand-binding domain of EphA3 and involves, instead its FNIII region. This interaction is inhibitory blocking EphA3 activation and reducing the cellular response to A-ephrins presented in trans.
-
Carvalho R.F., Beutler M., Marler K.J., Knöll B., Becker-Barroso E., Heintzmann R., Ng T., and Drescher U. Silencing of EphA3 through a cis interaction with ephrinA5. Nat Neurosci 9 (2006) 322-330. In this study, the authors use truncated versions of EphA3, single-amino acid point mutants of ephrinA5 and fluorescence resonance energy transfer technology to uncover a cis interaction between EphA3 and ephrinA5 that is independent of the established ligand-binding domain of EphA3 and involves, instead its FNIII region. This interaction is inhibitory blocking EphA3 activation and reducing the cellular response to A-ephrins presented in trans.
-
(2006)
Nat Neurosci
, vol.9
, pp. 322-330
-
-
Carvalho, R.F.1
Beutler, M.2
Marler, K.J.3
Knöll, B.4
Becker-Barroso, E.5
Heintzmann, R.6
Ng, T.7
Drescher, U.8
-
47
-
-
32344447055
-
Neural map specification by gradients
-
Flanagan J.G. Neural map specification by gradients. Curr Opin Neurobiol 16 (2006) 59-66
-
(2006)
Curr Opin Neurobiol
, vol.16
, pp. 59-66
-
-
Flanagan, J.G.1
-
48
-
-
33748302057
-
Repulsion or adhesion: receptors make the call
-
Halloran M.C., and Wolman M.A. Repulsion or adhesion: receptors make the call. Curr Opin Cell Biol 18 5 (2006) 533-540
-
(2006)
Curr Opin Cell Biol
, vol.18
, Issue.5
, pp. 533-540
-
-
Halloran, M.C.1
Wolman, M.A.2
-
49
-
-
1642422313
-
Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2
-
Pascall J.C., and Brown K.D. Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2. Biochem Biophys Res Commun 317 (2004) 244-252
-
(2004)
Biochem Biophys Res Commun
, vol.317
, pp. 244-252
-
-
Pascall, J.C.1
Brown, K.D.2
-
50
-
-
0034714357
-
Regulated cleavage of a contact-mediated axon repellent
-
The authors document for the first time that that ephrins are functionally cleaved by the metalloprotease ADAM10, a process essential for disrupting Eph/ephrin cell contacts in vivo.
-
Hattori M., Osterfield M., and Flanagan J.G. Regulated cleavage of a contact-mediated axon repellent. Science 289 (2000) 1360-1365. The authors document for the first time that that ephrins are functionally cleaved by the metalloprotease ADAM10, a process essential for disrupting Eph/ephrin cell contacts in vivo.
-
(2000)
Science
, vol.289
, pp. 1360-1365
-
-
Hattori, M.1
Osterfield, M.2
Flanagan, J.G.3
-
51
-
-
26844448800
-
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans
-
In this study, the authors report a detailed structure-function investigation of the ADAM10/EphA3/ephrin-A5(A2) interactions and suggest a simple mechanism, which ensures that only Eph-bound ephrins are recognized and cleaved to allow separation of the interacting cells. This is also the first study to document cleavage in trans (on the surface of the opposing cell) by an ADAM family metalloprotease.
-
Janes P.W., Saha N., Barton W.A., Kolev M.V., Wimmer-Kleikamp S.H., Nievergall E., Blobel C.P., Himanen J.P., Lackmann M., and Nikolov D.B. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell 123 (2005) 291-304. In this study, the authors report a detailed structure-function investigation of the ADAM10/EphA3/ephrin-A5(A2) interactions and suggest a simple mechanism, which ensures that only Eph-bound ephrins are recognized and cleaved to allow separation of the interacting cells. This is also the first study to document cleavage in trans (on the surface of the opposing cell) by an ADAM family metalloprotease.
-
(2005)
Cell
, vol.123
, pp. 291-304
-
-
Janes, P.W.1
Saha, N.2
Barton, W.A.3
Kolev, M.V.4
Wimmer-Kleikamp, S.H.5
Nievergall, E.6
Blobel, C.P.7
Himanen, J.P.8
Lackmann, M.9
Nikolov, D.B.10
-
52
-
-
33745731954
-
Crystal structures of VAP1 reveal ADAMs MDC domain architecture and its unique C-shaped scaffold
-
Takeda S., Igarashi T., Mori H., and Araki S. Crystal structures of VAP1 reveal ADAMs MDC domain architecture and its unique C-shaped scaffold. EMBO J 25 (2006) 2388-2396
-
(2006)
EMBO J
, vol.25
, pp. 2388-2396
-
-
Takeda, S.1
Igarashi, T.2
Mori, H.3
Araki, S.4
-
53
-
-
33645277094
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Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalling
-
In this study, the authors show that EphB stimulates a metalloproteinase cleavage of ephrinB2, producing a carboxy-terminal fragment that is further processed by PS1/gamma-secretase to produce an intracellular peptide, which binds Src and inhibits its association with the inhibitory kinase Csk. This is the first compelling evidence that the combined action of α-secretase activity and γ-secretase activity can mediate ephrin reverse signaling.
-
Georgakopoulos A., Litterst C., Ghersi E., Baki L., Xu C., Serban G., and Robakis N.K. Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalling. EMBO J 25 6 (2006) 1242-1252. In this study, the authors show that EphB stimulates a metalloproteinase cleavage of ephrinB2, producing a carboxy-terminal fragment that is further processed by PS1/gamma-secretase to produce an intracellular peptide, which binds Src and inhibits its association with the inhibitory kinase Csk. This is the first compelling evidence that the combined action of α-secretase activity and γ-secretase activity can mediate ephrin reverse signaling.
-
(2006)
EMBO J
, vol.25
, Issue.6
, pp. 1242-1252
-
-
Georgakopoulos, A.1
Litterst, C.2
Ghersi, E.3
Baki, L.4
Xu, C.5
Serban, G.6
Robakis, N.K.7
-
55
-
-
20444365447
-
MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth
-
Domeniconi M., Zampieri N., Spencer T., Hilaire M., Mellado W., Chao M.V., and Filbin M.T. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron 46 6 (2005) 849-855
-
(2005)
Neuron
, vol.46
, Issue.6
, pp. 849-855
-
-
Domeniconi, M.1
Zampieri, N.2
Spencer, T.3
Hilaire, M.4
Mellado, W.5
Chao, M.V.6
Filbin, M.T.7
-
56
-
-
0141839883
-
EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion
-
In this study, the authors show that cell contact-induced EphB-ephrinB complexes are endocytosed during the retraction of cells and neuronal growth cones. The observed endocytosis, which is sufficient to promote cell detachment, occurs in a bidirectional manner and involves full-length receptor and ligand complexes.
-
Zimmer M., Palmer A., Köhler J., and Klein R. EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol 5 (2003) 869-878. In this study, the authors show that cell contact-induced EphB-ephrinB complexes are endocytosed during the retraction of cells and neuronal growth cones. The observed endocytosis, which is sufficient to promote cell detachment, occurs in a bidirectional manner and involves full-length receptor and ligand complexes.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 869-878
-
-
Zimmer, M.1
Palmer, A.2
Köhler, J.3
Klein, R.4
-
57
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0141839882
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Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion
-
The authors show endocytosis of activated Eph receptors and their bound, full-length ephrinB ligands in heterologous, nonneuronal cells. They also observe that both the internalization of the receptor-ligand complexes and the subsequent cell retraction events are dependent on actin polymerization, which in turn is dependent on Rac signalling within the receptor-expressing cells.
-
Marston D.J., Dickinson S., and Nobes C.D. Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat Cell Biol (2003) 879-888. The authors show endocytosis of activated Eph receptors and their bound, full-length ephrinB ligands in heterologous, nonneuronal cells. They also observe that both the internalization of the receptor-ligand complexes and the subsequent cell retraction events are dependent on actin polymerization, which in turn is dependent on Rac signalling within the receptor-expressing cells.
-
(2003)
Nat Cell Biol
, pp. 879-888
-
-
Marston, D.J.1
Dickinson, S.2
Nobes, C.D.3
-
58
-
-
20244369288
-
Vav family GEFs link activated Ephs to endocytosis and axon guidance
-
Cowan C.W., Shao Y.R., Sahin M., Shamah S.M., Lin M.Z., Greer P.L., Gao S., Griffith E.C., Brugge J.S., and Greenberg M.E. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron 46 2 (2005) 205-217
-
(2005)
Neuron
, vol.46
, Issue.2
, pp. 205-217
-
-
Cowan, C.W.1
Shao, Y.R.2
Sahin, M.3
Shamah, S.M.4
Lin, M.Z.5
Greer, P.L.6
Gao, S.7
Griffith, E.C.8
Brugge, J.S.9
Greenberg, M.E.10
-
59
-
-
33751095631
-
Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells
-
Lauterbach J., and Klein R. Release of full-length EphB2 receptors from hippocampal neurons to cocultured glial cells. J Neurosci 26 (2006) 11575-11581
-
(2006)
J Neurosci
, vol.26
, pp. 11575-11581
-
-
Lauterbach, J.1
Klein, R.2
-
60
-
-
34547957954
-
Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets
-
[Epub ahead of print]
-
Ethell I.M., and Ethell D.W. Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. J Neurosci Res (2007) [Epub ahead of print]
-
(2007)
J Neurosci Res
-
-
Ethell, I.M.1
Ethell, D.W.2
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