메뉴 건너뛰기




Volumn 27, Issue 51, 2007, Pages 14205-14215

The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of rap GTPases

Author keywords

Dendritic spine; Ephrin; Growth cone collapse; Hippocampus; Integrin; Tyrosine kinase

Indexed keywords

CELL PROTEIN; EPHRIN A1; EPHRIN RECEPTOR A5; GUANOSINE TRIPHOSPHATASE; INTEGRIN; PDZ PROTEIN; PROTEIN TYROSINE KINASE; RAP1 PROTEIN; RAP2 PROTEIN; SPAR PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; EPHRIN A4; EPHRIN RECEPTOR A4; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; SPAR PROTEIN, HUMAN;

EID: 38449105906     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2746-07.2007     Document Type: Article
Times cited : (70)

References (65)
  • 1
    • 3543044348 scopus 로고    scopus 로고
    • EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway
    • Aoki M, Yamashita T, Tohyama M (2004) EphA receptors direct the differentiation of mammalian neural precursor cells through a mitogen-activated protein kinase-dependent pathway. J Biol Chem 279:32643-32650.
    • (2004) J Biol Chem , vol.279 , pp. 32643-32650
    • Aoki, M.1    Yamashita, T.2    Tohyama, M.3
  • 2
    • 5444230311 scopus 로고    scopus 로고
    • Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors
    • Arthur WT, Quilliam LA, Cooper JA (2004) Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors. J Cell Biol 167:111-122.
    • (2004) J Cell Biol , vol.167 , pp. 111-122
    • Arthur, W.T.1    Quilliam, L.A.2    Cooper, J.A.3
  • 3
    • 34548228572 scopus 로고    scopus 로고
    • alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits
    • Beg AA, Sommer JE, Martin JH, Scheiffele P (2007) alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. Neuron 55:768-778.
    • (2007) Neuron , vol.55 , pp. 768-778
    • Beg, A.A.1    Sommer, J.E.2    Martin, J.H.3    Scheiffele, P.4
  • 4
    • 0034254923 scopus 로고    scopus 로고
    • The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin
    • Boettner B, Govek EE, Cross J, Van Aelst L (2000) The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin. Proc Natl Acad Sci USA 97:9064-9069.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9064-9069
    • Boettner, B.1    Govek, E.E.2    Cross, J.3    Van Aelst, L.4
  • 5
    • 15044359236 scopus 로고    scopus 로고
    • Linking Rap to cell adhesion
    • Bos JL (2005) Linking Rap to cell adhesion. Curr Opin Cell Biol 17:123-128.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 123-128
    • Bos, J.L.1
  • 6
    • 34748829242 scopus 로고    scopus 로고
    • The EphA4 receptor regulates dendritic spine remodeling by affecting beta1 integrin signaling pathways
    • Bourgin C, Murai KK, Richter M, Pasquale EB (2007) The EphA4 receptor regulates dendritic spine remodeling by affecting beta1 integrin signaling pathways. J Cell Biol 178:1295-1307.
    • (2007) J Cell Biol , vol.178 , pp. 1295-1307
    • Bourgin, C.1    Murai, K.K.2    Richter, M.3    Pasquale, E.B.4
  • 7
    • 0033601747 scopus 로고    scopus 로고
    • The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain
    • Buchert M, Schneider S, Meskenaite V, Adams MT, Canaani E, Baechi T, Moelling K, Hovens CM (1999) The junction-associated protein AF-6 interacts and clusters with specific Eph receptor tyrosine kinases at specialized sites of cell-cell contact in the brain. J Cell Biol 144:361-371.
    • (1999) J Cell Biol , vol.144 , pp. 361-371
    • Buchert, M.1    Schneider, S.2    Meskenaite, V.3    Adams, M.T.4    Canaani, E.5    Baechi, T.6    Moelling, K.7    Hovens, C.M.8
  • 8
    • 0037329747 scopus 로고    scopus 로고
    • Cellular functions of the Rap1 GTP-binding protein: A pattern emerges
    • Caron E (2003) Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. J Cell Sci 116:435-440.
    • (2003) J Cell Sci , vol.116 , pp. 435-440
    • Caron, E.1
  • 9
    • 13444254038 scopus 로고    scopus 로고
    • Regulation of cortical dendrite development by Rap1 signaling
    • Chen Y, Wang PY, Ghosh A (2005) Regulation of cortical dendrite development by Rap1 signaling. Mol Cell Neurosci 28:215-228.
    • (2005) Mol Cell Neurosci , vol.28 , pp. 215-228
    • Chen, Y.1    Wang, P.Y.2    Ghosh, A.3
  • 11
    • 33646799095 scopus 로고    scopus 로고
    • Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion
    • Dail M, Richter M, Godement P, Pasquale EB (2006) Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J Cell Sci 119:1244-1254.
    • (2006) J Cell Sci , vol.119 , pp. 1244-1254
    • Dail, M.1    Richter, M.2    Godement, P.3    Pasquale, E.B.4
  • 12
    • 0032500633 scopus 로고    scopus 로고
    • BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein
    • Deguchi M, Hata Y, Takeuchi M, Ide N, Hirao K, Yao I, Irie M, Toyoda A, Takai Y (1998) BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. J Biol Chem 273:26269-26272.
    • (1998) J Biol Chem , vol.273 , pp. 26269-26272
    • Deguchi, M.1    Hata, Y.2    Takeuchi, M.3    Ide, N.4    Hirao, K.5    Yao, I.6    Irie, M.7    Toyoda, A.8    Takai, Y.9
  • 13
    • 34247615569 scopus 로고    scopus 로고
    • Bidirectional Eph-ephrin signaling during axon guidance
    • Egea J, Klein R (2007) Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol 17:230-238.
    • (2007) Trends Cell Biol , vol.17 , pp. 230-238
    • Egea, J.1    Klein, R.2
  • 14
    • 7244242394 scopus 로고    scopus 로고
    • The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
    • Enserink JM, Price LS, Methi T, Mahic M, Sonnenberg A, Bos JL, Tasken K (2004) The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. J Biol Chem 279:44889-44896.
    • (2004) J Biol Chem , vol.279 , pp. 44889-44896
    • Enserink, J.M.1    Price, L.S.2    Methi, T.3    Mahic, M.4    Sonnenberg, A.5    Bos, J.L.6    Tasken, K.7
  • 16
    • 0031014969 scopus 로고    scopus 로고
    • Rapid Ca2+-mediated activation of Rap1 in human platelets
    • Franke B, Akkerman JW, Bos JL (1997) Rapid Ca2+-mediated activation of Rap1 in human platelets. EMBO J 16:252-259.
    • (1997) EMBO J , vol.16 , pp. 252-259
    • Franke, B.1    Akkerman, J.W.2    Bos, J.L.3
  • 18
    • 33846136109 scopus 로고    scopus 로고
    • Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons
    • Fu Z, Lee SH, Simonetta A, Hansen J, Sheng M, Pak DT (2007b) Differential roles of Rap1 and Rap2 small GTPases in neurite retraction and synapse elimination in hippocampal spiny neurons. J Neurochem 100:118-131.
    • (2007) J Neurochem , vol.100 , pp. 118-131
    • Fu, Z.1    Lee, S.H.2    Simonetta, A.3    Hansen, J.4    Sheng, M.5    Pak, D.T.6
  • 19
    • 0032952586 scopus 로고    scopus 로고
    • The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation
    • Gao Q, Srinivasan S, Boyer SN, Wazer DE, Band V (1999) The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Mol Cell Biol 19:733-744.
    • (1999) Mol Cell Biol , vol.19 , pp. 733-744
    • Gao, Q.1    Srinivasan, S.2    Boyer, S.N.3    Wazer, D.E.4    Band, V.5
  • 22
    • 0033845946 scopus 로고    scopus 로고
    • Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons
    • Helmbacher F, Schneider-Maunoury S, Topilko P, Tiret L, Charnay P (2000) Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development 127:3313-3324.
    • (2000) Development , vol.127 , pp. 3313-3324
    • Helmbacher, F.1    Schneider-Maunoury, S.2    Topilko, P.3    Tiret, L.4    Charnay, P.5
  • 26
    • 33751343894 scopus 로고    scopus 로고
    • Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors
    • Kayser MS, McClelland AC, Hughes EG, Dalva MB (2006) Intracellular and trans-synaptic regulation of glutamatergic synaptogenesis by EphB receptors. J Neurosci 26:12152-12164.
    • (2006) J Neurosci , vol.26 , pp. 12152-12164
    • Kayser, M.S.1    McClelland, A.C.2    Hughes, E.G.3    Dalva, M.B.4
  • 27
    • 1542344841 scopus 로고    scopus 로고
    • Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins
    • Kelley GG, Reks SE, Smrcka AV (2004) Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. Biochem J 378:129-139.
    • (2004) Biochem J , vol.378 , pp. 129-139
    • Kelley, G.G.1    Reks, S.E.2    Smrcka, A.V.3
  • 28
    • 0025368594 scopus 로고
    • Genetic analysis of the Kirsten-ras-revertant 1 gene: Potentiation of its tumor suppressor activity by specific point mutations
    • Kitayama H, Matsuzaki T, Ikawa Y, Noda M (1990) Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations. Proc Natl Acad Sci USA 87:4284-4288.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4284-4288
    • Kitayama, H.1    Matsuzaki, T.2    Ikawa, Y.3    Noda, M.4
  • 29
    • 0035137449 scopus 로고    scopus 로고
    • Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo
    • Kullander K, Mather NK, Diella F, Dottori M, Boyd AW, Klein R (2001) Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Neuron 29:73-84.
    • (2001) Neuron , vol.29 , pp. 73-84
    • Kullander, K.1    Mather, N.K.2    Diella, F.3    Dottori, M.4    Boyd, A.W.5    Klein, R.6
  • 31
    • 0030867994 scopus 로고    scopus 로고
    • A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion
    • Li Y, Maher P, Schubert D (1997) A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Neuron 19:453-463.
    • (1997) Neuron , vol.19 , pp. 453-463
    • Li, Y.1    Maher, P.2    Schubert, D.3
  • 32
    • 1942533655 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase
    • Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (2004) Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. J Biol Chem 279:15711-15714.
    • (2004) J Biol Chem , vol.279 , pp. 15711-15714
    • Machida, N.1    Umikawa, M.2    Takei, K.3    Sakima, N.4    Myagmar, B.E.5    Taira, K.6    Uezato, H.7    Ogawa, Y.8    Kariya, K.9
  • 33
    • 1842425828 scopus 로고    scopus 로고
    • The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes
    • McLeod SJ, Shum AJ, Lee RL, Takei F, Gold MR (2004) The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes. J Biol Chem 279:12009-12019.
    • (2004) J Biol Chem , vol.279 , pp. 12009-12019
    • McLeod, S.J.1    Shum, A.J.2    Lee, R.L.3    Takei, F.4    Gold, M.R.5
  • 34
    • 0037314984 scopus 로고    scopus 로고
    • Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
    • Murai KK, Nguyen LN, Irie F, Yamaguchi Y, Pasquale EB (2003) Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling. Nat Neurosci 6:153-160.
    • (2003) Nat Neurosci , vol.6 , pp. 153-160
    • Murai, K.K.1    Nguyen, L.N.2    Irie, F.3    Yamaguchi, Y.4    Pasquale, E.B.5
  • 35
    • 0036911338 scopus 로고    scopus 로고
    • Adaptor protein Crk is required for Ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells
    • Nagashima K, Endo A, Ogita H, Kawana A, Yamagishi A, Kitabatake A, Matsuda M, Mochizuki N (2002) Adaptor protein Crk is required for Ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells. Mol Biol Cell 13:4231-4242.
    • (2002) Mol Biol Cell , vol.13 , pp. 4231-4242
    • Nagashima, K.1    Endo, A.2    Ogita, H.3    Kawana, A.4    Yamagishi, A.5    Kitabatake, A.6    Matsuda, M.7    Mochizuki, N.8
  • 36
    • 1842828975 scopus 로고    scopus 로고
    • Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins
    • Noren NK, Pasquale EB (2004) Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins. Cell Signal 16:655-666.
    • (2004) Cell Signal , vol.16 , pp. 655-666
    • Noren, N.K.1    Pasquale, E.B.2
  • 39
    • 0032966750 scopus 로고    scopus 로고
    • Eph receptors and ephrins in neural development
    • O'Leary DD, Wilkinson DG (1999) Eph receptors and ephrins in neural development. Curr Opin Neurobiol 9:65-73.
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 65-73
    • O'Leary, D.D.1    Wilkinson, D.G.2
  • 40
    • 0344443828 scopus 로고    scopus 로고
    • Targeted protein degradation and synapse remodeling by an inducible protein kinase
    • Pak DT, Sheng M (2003) Targeted protein degradation and synapse remodeling by an inducible protein kinase. Science 302:1368-1373.
    • (2003) Science , vol.302 , pp. 1368-1373
    • Pak, D.T.1    Sheng, M.2
  • 41
    • 0035797521 scopus 로고    scopus 로고
    • Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP
    • Pak DT, Yang S, Rudolph-Correia S, Kim E, Sheng M (2001) Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP. Neuron 31:289-303.
    • (2001) Neuron , vol.31 , pp. 289-303
    • Pak, D.T.1    Yang, S.2    Rudolph-Correia, S.3    Kim, E.4    Sheng, M.5
  • 42
    • 0027378333 scopus 로고
    • Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells
    • Park S, Jove R (1993) Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells. J Biol Chem 268:25728-25734.
    • (1993) J Biol Chem , vol.268 , pp. 25728-25734
    • Park, S.1    Jove, R.2
  • 43
    • 20344396123 scopus 로고    scopus 로고
    • Eph receptor signalling casts a wide net on cell behaviour
    • Pasquale EB (2005) Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 6:462-475.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 462-475
    • Pasquale, E.B.1
  • 44
    • 22544457474 scopus 로고    scopus 로고
    • Downregulation of Rap1 activity is involved in ephrinB1-induced cell contraction
    • Riedl JA, Brandt DT, Batlle E, Price LS, Clevers H, Bos JL (2005) Downregulation of Rap1 activity is involved in ephrinB1-induced cell contraction. Biochem J 389:465-469.
    • (2005) Biochem J , vol.389 , pp. 465-469
    • Riedl, J.A.1    Brandt, D.T.2    Batlle, E.3    Price, L.S.4    Clevers, H.5    Bos, J.L.6
  • 45
    • 0025886681 scopus 로고
    • Role of the sigma receptor in the inhibition of [3H]-noradrenaline uptake in brain synaptosomes and adrenal chromaffin cells
    • Rogers C, Lemaire S (1991) Role of the sigma receptor in the inhibition of [3H]-noradrenaline uptake in brain synaptosomes and adrenal chromaffin cells. Br J Pharmacol 103:1917-1922.
    • (1991) Br J Pharmacol , vol.103 , pp. 1917-1922
    • Rogers, C.1    Lemaire, S.2
  • 46
    • 0034697252 scopus 로고    scopus 로고
    • Phosphorylation of the p190 RhoGAP N-terminal domain by c-Src results in a loss of GTP binding activity
    • Roof RW, Dukes BD, Chang JH, Parsons SJ (2000) Phosphorylation of the p190 RhoGAP N-terminal domain by c-Src results in a loss of GTP binding activity. FEBS Lett 472:117-121.
    • (2000) FEBS Lett , vol.472 , pp. 117-121
    • Roof, R.W.1    Dukes, B.D.2    Chang, J.H.3    Parsons, S.J.4
  • 47
    • 0035998270 scopus 로고    scopus 로고
    • SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus
    • Roy BC, Kohu K, Matsuura K, Yanai H, Akiyama T (2002) SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus. Genes Cells 7:607-617.
    • (2002) Genes Cells , vol.7 , pp. 607-617
    • Roy, B.C.1    Kohu, K.2    Matsuura, K.3    Yanai, H.4    Akiyama, T.5
  • 50
    • 4344594485 scopus 로고    scopus 로고
    • The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity
    • Schwamborn JC, Puschel AW (2004) The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity. Nat Neurosci 7:923-929.
    • (2004) Nat Neurosci , vol.7 , pp. 923-929
    • Schwamborn, J.C.1    Puschel, A.W.2
  • 51
    • 0034916230 scopus 로고    scopus 로고
    • PDZ domains and the organization of supramolecular complexes
    • Sheng M, Sala C (2001) PDZ domains and the organization of supramolecular complexes. Annu Rev Neurosci 24:1-29.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 1-29
    • Sheng, M.1    Sala, C.2
  • 52
    • 0038561221 scopus 로고    scopus 로고
    • Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow
    • Shimonaka M, Katagiri K, Nakayama T, Fujita N, Tsuruo T, Yoshie O, Kinashi T (2003) Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J Cell Biol 161:417-427.
    • (2003) J Cell Biol , vol.161 , pp. 417-427
    • Shimonaka, M.1    Katagiri, K.2    Nakayama, T.3    Fujita, N.4    Tsuruo, T.5    Yoshie, O.6    Kinashi, T.7
  • 53
    • 0028152896 scopus 로고
    • Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines
    • Soans C, Holash JA, Pasquale EB (1994) Characterization of the expression of the Cek8 receptor-type tyrosine kinase during development and in tumor cell lines. Oncogene 9:3353-3361.
    • (1994) Oncogene , vol.9 , pp. 3353-3361
    • Soans, C.1    Holash, J.A.2    Pasquale, E.B.3
  • 54
    • 0038741814 scopus 로고    scopus 로고
    • Does Rap1 deserve a bad Rap?
    • Stork PJ (2003) Does Rap1 deserve a bad Rap? Trends Biochem Sci 28:267-275.
    • (2003) Trends Biochem Sci , vol.28 , pp. 267-275
    • Stork, P.J.1
  • 57
    • 0033573247 scopus 로고    scopus 로고
    • Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments
    • Torti M, Bertoni A, Canobbio I, Sinigaglia F, Lapetina EG, Balduini C (1999) Interaction of the low-molecular-weight GTP-binding protein rap2 with the platelet cytoskeleton is mediated by direct binding to the actin filaments. J Cell Biochem 75:675-685.
    • (1999) J Cell Biochem , vol.75 , pp. 675-685
    • Torti, M.1    Bertoni, A.2    Canobbio, I.3    Sinigaglia, F.4    Lapetina, E.G.5    Balduini, C.6
  • 58
    • 0033603578 scopus 로고    scopus 로고
    • Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion
    • Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N (1999) Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem 274:18463-18469.
    • (1999) J Biol Chem , vol.274 , pp. 18463-18469
    • Tsukamoto, N.1    Hattori, M.2    Yang, H.3    Bos, J.L.4    Minato, N.5
  • 60
    • 27844605053 scopus 로고    scopus 로고
    • Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6
    • Xie Z, Huganir RL, Penzes P (2005) Activity-dependent dendritic spine structural plasticity is regulated by small GTPase Rap1 and its target AF-6. Neuron 48:605-618.
    • (2005) Neuron , vol.48 , pp. 605-618
    • Xie, Z.1    Huganir, R.L.2    Penzes, P.3
  • 61
    • 25444434962 scopus 로고    scopus 로고
    • RA-RhoGAP, Rap-activated Rho GTPase-activating protein implicated in neurite outgrowth through Rho
    • Yamada T, Sakisaka T, Hisata S, Baba T, Takai Y (2005) RA-RhoGAP, Rap-activated Rho GTPase-activating protein implicated in neurite outgrowth through Rho. J Biol Chem 280:33026-33034.
    • (2005) J Biol Chem , vol.280 , pp. 33026-33034
    • Yamada, T.1    Sakisaka, T.2    Hisata, S.3    Baba, T.4    Takai, Y.5
  • 63
    • 0025084077 scopus 로고
    • Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors
    • Zafra F, Hengerer B, Leibrock J, Thoenen H, Lindholm D (1990) Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors. EMBO J 9:3545-3550.
    • (1990) EMBO J , vol.9 , pp. 3545-3550
    • Zafra, F.1    Hengerer, B.2    Leibrock, J.3    Thoenen, H.4    Lindholm, D.5
  • 64
    • 0037162696 scopus 로고    scopus 로고
    • Ras and Rap control AMPA receptor trafficking during synaptic plasticity
    • Zhu JJ, Qin Y, Zhao M, Van Aelst L, Malinow R (2002) Ras and Rap control AMPA receptor trafficking during synaptic plasticity. Cell 110:443-455.
    • (2002) Cell , vol.110 , pp. 443-455
    • Zhu, J.J.1    Qin, Y.2    Zhao, M.3    Van Aelst, L.4    Malinow, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.