Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

Journal of Biological Chemistry

Volumn 283, Issue 43, 2008, Pages 29461-29472

  Noberini, Roberta ^a,b   Koolpe, Mitchell ^a   Peddibhotla, Satyamaheshwar ^c   Dahl, Russell ^a   Su, Ying ^a   Cosford, Nicholas D P ^a   Roth, Gregory P ^c   Pasquale, Elena B ^a,d  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c Burnham Institute for Medical Research at Lake Nona   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; BIOCHEMISTRY; CELL GROWTH; CHEMICAL REACTIONS; ENZYME ACTIVITY; MOLECULES; PHOSPHORYLATION;

BENZOIC ACID DERIVATIVES; BINDING POCKETS; CANCER.; CELL PERIPHERIES; CELL VIABILITIES; COMPETITIVE INHIBITORS; EPHRIN BINDINGS; EPHRIN LIGANDS; EXTRACELLULAR DOMAINS; GROWTH CONE COLLAPSES; HEPATOCELLULAR; HIGH AFFINITIES; HIGH THROUGHPUTS; IMMUNOSORBENT ASSAYS; IN CELLS; ISOMERIC COMPOUNDS; LIGAND BINDINGS; NERVE INJURIES; PATHOLOGICAL PROCESSES; PEPTIDE LIGANDS; POTENT COMPOUNDS; PROSTATE CANCER CELLS; RECEPTOR FUNCTIONS; RECEPTOR TYROSINE KINASES; SMALL MOLECULES; THERAPEUTIC APPLICATIONS;

LIGANDS;

2,5 DIMETHYLPYRROLYL BENZOIC ACID; EPHRIN; EPHRIN A2; EPHRIN A4; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; ISOMER; LIGAND BINDING; MOLECULAR WEIGHT; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; DRUG DESIGN; EPHRIN-A2; EPHRIN-A4; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIGANDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPHA2; RECEPTOR, EPHA4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 57649178194     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M804103200     Document Type: Article

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