Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity

Cancer Immunology, Immunotherapy

Volumn 57, Issue 12, 2008, Pages 1861-1869

  Yamaguchi, Shinjiro ^a   Tatsumi, Tomohide ^a,b   Takehara, Tetsuo ^a   Sasakawa, Akira ^a   Hikita, Hayato ^a   Kohga, Keisuke ^a   Uemura, Akio ^a   Sakamori, Ryotaro ^a   Ohkawa, Kazuyoshi ^a   Hayashi, Norio ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Cancer immunotherapy; Dendritic cells; Innate immunity; Liver tumor

Indexed keywords

ANTIBODY; CD4 ANTIBODY; CD8 ANTIBODY; DENDRITIC CELL VACCINE; EPHRIN A2; GANGLIOSIDE GM1 ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNIZATION; CANCER PREVENTION; CELL ACTIVITY; CELL ASSAY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; FEMALE; IN VIVO STUDY; INNATE IMMUNITY; LIVER CELL; LIVER TUMOR; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBPOPULATION; METASTASIS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROVOCATION TEST; TUMOR IMMUNITY;

ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; IMMUNITY, INNATE; KILLER CELLS, NATURAL; LIVER NEOPLASMS; LYMPHOCYTES; MICE; RECEPTOR, EPHA2;

EID: 52549126804     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-008-0514-5     Document Type: Article

References (34)

1. RM Steinman 1991 The dendritic cell system and its role in immunogenicity Annu Rev Immunol 9 271 296
2. DN Hart 1997 Dendritic cells: unique leukocyte populations which control the primary immune response Blood 90 3245 3287
3. CM Smith NS Wilson J Waithman JA Villadangos FR Carbone WR Heath GT Belz 2004 Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity Nat Immunol 5 1143 1148
4. DW O'Neill S Adams N Bhardwaj 2004 Manipulating dendritic cell biology for the active immunotherapy of cancer Blood 104 2235 2246
5. NC Fernandez A Lozier C Flament P Ricciardi-Castagnoli D Bellet M Suter M Perricaudet T Tursz E Maraskovsky L Zitvogel 1999 Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo Nat Med 5 405 411
6. F Gerosa B Baldani-Guerra C Nisii V Marchesini G Carra G Trinchieri 2002 Reciprocal activating interaction between natural killer cells and dendritic cells J Exp Med 195 327 333
7. G Miller S Lahrs RP Dematteo 2003 Overexpression of interleukin-12 enables dendritic cells to activate NK cells and confer systemic antitumor immunity FASEB J 17 728 730
8. D Piccioli S Sbrana E Melandri NM Valiante 2002 Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells J Exp Med 195 335 341
9. M Jinushi T Takehara T Kanto T Tatsumi V Groh T Spies T Miyagi T Suzuki Y Sasaki N Hayashi 2003 Critical role of MHC class I-related chain A and B expression on IFNα-stimulated dendritic cells in NK cell activation: Impairment in chronic hepatitis C virus infection J Immunol 170 1249 1256
10. T Kawano J Cui Y Koezuka Y Toura Y Kaneko K Motoki H Ueno R Nakagawa H Sato E Kondo H Koseki M Taniguchi 1997 CD1d-restricted and TCR-mediated activation of Vα14NKT cells by glycosylceramids Science 278 1626 1629
11. T Kawano J Cui Y Koezuka I Toura Y Kaneko H Sato E Kondo M Harada H Koseki Y Tanaka M Taniguchi 1998 Natural killer-like nonspecific tumor cell lysis mediated by specific ligand-activated Vα14NKT cells Proc Natl Acad Sci USA 95 5690 5693
12. H Kitamura K Iwakabe T Yahata S Nishimura A Ohta Y Ohmi M Sato K Takeda K Okumura L Van Kaer T Kawano M Taniguchi T Nishimura 1999 The natural killer T (NKT) cell-ligand-Galactosylceramide demonstrates immunopoteniating effects by inducing interleukin (IL)-12 production by dendritic cells and IL-12 receptor expression on NKT cells J Exp Med 189 1121 1128
13. RH Wiltrout 2000 Regulation and antimetastatic functions of liver-associated natural killer cells Immunol Rev 174 63 76
14. AP George AP Catherine 2005 Liver immunobiology Toxicol Pathol 33 52 62
15. DG Doherty C O'Farrelly 2000 Innate and adaptive lymphoid cells in human liver Immunol Rev 174 5 20
16. T Miyagi T Takehara T Tatsumi T Kanto T Suzuki M Jinushi Y Sugimoto Y Sasaki M Hori N Hayashi 2003 CD1d-mediated stimulation of natural killer T cells selectively activates hepatic natural killer T cells to eliminate experimentally disseminated hepatoma cells in murine liver Int J Cancer 106 81 89
17. R Nakagawa K Motoki H Ueno R Iijima H Nakamura E Kobayashi A Shimosaka Y Koezuka 1998 Treatment of hepatic metastasis of the colon 26 adenocarcinoma with a Galactosylceramide, KRN7000 Cancer Res 58 1202 1207
18. JI Mayordome T Zorina WJ Storkus L Zitvogel C Celluzzi LD Falo CJ Melief ST Ildstad WM Kast AB Deleo 1995 Bone marrow-derived dendritic cells pulsed with synthetic tumor peptide elicits protective and therapeutic antitumor immunity Nat Med 12 1297 1302
19. P Paglia C Chiodoni M Rodolfo MP Colombo 1996 Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo J Exp Med 183 317 322
20. JI Mayordomo DJ Loftus H Sakamoto CM De Cesare PM Appasamy MT Lotze WJ Storkus E Appella AB DeLeo 1996 Therapy of murine tumors with p53 wild-type and mutant sequence peptide-based vaccines J Exp Med 183 1357 1365
21. RM Olson NP Perencevich AW Malcolm JT Chaffey RE Wilson 1980 Patterns of recurrence following curative resection of adenocarcinoma of the colon and rectum Cancer 45 2969 2974
22. AW Malcolm NP Perencevich RM Olson JA Hanley JT Chaffey RE Wilson 1981 Analysis of recurrence patterns following curative resection for carcinoma of thecolon and rectum Surg Gynecol Obstet 152 131 136
23. M Ota H Shimada H Masui K Tanaka S Yamaguchi Y Ichikawa S Togo H Ike S Oki 2004 Adjuvant hepatic arterial infusion chemotherapy after curative resection for Dukes colorectal cancer: a pilot study Hepatogastroenterology 51 124 127
24. HT Arkenau K Rettig R Porschen 2005 Adjuvant chemotherapy in curative resected colon carcinoma: 5-fluorouracil/leucovorin versus high-dose 5- fluorouracil 24-h infusion versus high-dose 5-fluorouracil 24-h infusion Int J Colorectal Dis 20 258 261
25. A Hayashibe M Kameyama M Shinbo S Makimoto 2007 Clinical results on intra-arterial adjuvant chemotherapy for prevention of liver metastasis following curative resection of pancreatic cancer Ann Surg Oncol 14 190 194
26. KJ Liu CC Wang LT Chen AL Cheng DT Lin YC Wu WL Yu YM Hung HY Yang SH Juang J Whang-Peng 2004 Generation of carcinoembryonic antigen (CEA)- specific T-cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides Clin Cancer Res 10 2645 2651
27. N Sadanaga H Nagashima K Mashino K Tahara H Yamaguchi M Ohta T Fujie F Tanaka H Inoue K Takesako T Akiyoshi M Mori 2001 Dendritic cell vaccination with MAGE peptide is a novel therapeutic approach for gastrointestinal carcinomas Clin Cancer Res 7 2277 2284
28. JM Timmerman R Levy 1999 Dendritic cell vaccines for cancer immunotherapy Annu Rev Med 50 507 529
29. L Nevellino C Castelli G Parmiani 2005 A listing of human tumor antigens recognized by T cells: March 2004 update Cancer Immunol Immunother 54 187 207
30. M Simone RR Carlo L Mario N Donato 2004 Colorectal cancer vaccines: principles, results, and perspectives Gastroenterology 27 1821 1837
31. Y Oka A Tsuboi T Taguchi T Osaki T Kyo H Nakajima OA Elisseeva Y Oji M Kawakami K Ikegame N Hosen S Yoshihara Y Wu F Fujiki M Murukami T Masuda S Nishida T Shirakata S Nakatsuka A Sasaki K Udaka H Dohy K Aozasa S Noguchi I Kawase H Sugiyama 2004 Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression Pro Natl Acad Sci USA 138 13885 13890
32. S Yamaguchi T Tatsumi T Takehara R Sakamori A Uemura T Mizushima K Ohkawa N Hayashi 2007 Immunotherapy of murine colon cancer using receptor tyrosine kinase EphA2-derived peptide-pulsed dendritic cell vaccines Cancer 110 7 1469 1477
33. G Felazzo C Munz 2004 NK cell compartments and their activation by dendritic cells J Immunol 172 1333 1339
34. M Nieda M Okai A Tazbirkova H Lin A Yamamura K Ide R Abraham T Juji DJ Macfarlane AJ Nicol 2004 Therapeutic activation of Vα24 + Vβ11 + NKT cells in human subjects results in highly coordinates secondary activation of acquired and innate immunity Blood 103 383 389