EphrinA1-induced cytoskeletal re-organization requires FAK and p130cas

Nature Cell Biology

Volumn 4, Issue 8, 2002, Pages 565-573

  Carter, Nigel ^a   Nakamoto, Tetsuya ^b   Hirai, Hisamaru ^b   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; EPHRIN; EPHRIN RECEPTOR; FOCAL ADHESION KINASE; LIGAND; PHOSPHOTYROSINE; PROTEIN P130;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL LINE; CELL SPREADING; CELL TYPE; CONTROLLED STUDY; CYTOSKELETON; EMBRYO; FIBROBLAST; MICROTUBULE; MORPHOGENESIS; MOUSE; NERVE CELL GROWTH; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; ACTINS; ANIMALS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CRK-ASSOCIATED SUBSTRATE PROTEIN; CYTOSKELETAL PROTEINS; CYTOSKELETON; EPHRIN-A1; EPHRIN-A2; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; MICE; MICE, KNOCKOUT; PAXILLIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHA2; RETINOBLASTOMA-LIKE PROTEIN P130; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TYROSINE;

ANIMALIA;

EID: 0036045804     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb823     Document Type: Article

References (54)

1. The Eph family of receptors
2. The ephrins and Eph receptors in neural development
3. Bidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
4. Tyrosine phosphorylation of transmembrane ligands for Eph receptors
5. Shared and distinct functions of RAGS and ELF-1 in guiding retinal axons
6. Tyrosine phosphorylation of transmembrane ligands for Eph receptors
7. Multiple roles of EPH receptors and ephrins in neural development
8. Eph receptors and neural plasticity
9. Excitory Eph receptors and adhesive ephrin ligands
10. Compartmentalised signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion
11. Ephrin-A5 modulates cell adhesion and morphology in an integrin dependent manner
12. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction
13. Ephrins stimulate or inhibit neurite outgrowth and survival as a function of neuronal cell type
14. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor
15. Signalling through focal adhesion kinase
16. Focal adhesion kinase: A regulator of focal adhesion dynamics and cell movement
17. Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration
18. Interaction between focal adhesion kinase and crk-associated tyrosine kinase substrate p130cas
19. Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas)
20. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
21. 1 integrins
22. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation
23. The EphA8 receptor regulates integrin activity through p110γ phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner
24. Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
25. An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein
26. Integrin activation by R-ras
27. 1 cytoplasmic domains
28. An Eph receptor regulates integrin activity through R-Ras
29. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A
30. Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway
31. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
32. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
33. cas as a mediator of focal adhesion kinase-promoted cell migration
34. Targetting Pyk2 to β1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells
35. Phosphospecific antibodies reveal focal adhesion kinase activation loop phosphorylation in nascent and mature focal adhesions and requirement for the autophosphorylation site
36. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
37. cas
38. cas, an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts
39. Characterisation of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases
40. Dimerisation mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase
41. Differential expression of cell surface molecules in prostate cancer cells
42. Increased expression of heparin binding EGF (HB-EGF), amphiregulin, TGFα and epiregulin in androgen-independent prostate cancer cell lines
43. Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression
44. Overexpression of the EphA2 Tyrosine Kinase in Prostate Cancer
45. Ephrin-A5 Induces Collapse of Growth Cones by Activating Rho and Rho Kinase
46. Growth Cone Collapse through Coincident loss of Actin Bundles and Leading Edge Actin without Actin Depolymerisation
47. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells
48. Complex formation between EphB2 and Src requires phosphorylation of tyrosine 611 in the EphB2 juxtamembrane region
49. Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor
50. Downregulation of the ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction
51. Signalling downstream of Eph receptors and ephrin ligands
52. Epha receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin
53. cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases
54. PRC1: A human mitotic spindle-associated CDK substrate protein required for cytokinesis