The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells

Cancer Research

Volumn 70, Issue 3, 2010, Pages 1141-1153

  Truitt, Luke ^a   Freywald, Tanya ^a   DeCoteau, John ^b   Sharfe, Nigel ^c   Freywald, Andrew ^a  

^a UNIVERSITY OF REGINA   (Canada)

^b ROYAL UNIVERSITY HOSPITAL   (Canada)

^c HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; ACTIN; CBL PROTEIN; EPHRIN RECEPTOR B4; EPHRIN RECEPTOR B6;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER INVASION; CELL ADHESION; CELL FUNCTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION;

ACTINS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL ADHESION; CELL LINE; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETON; FIBRONECTINS; HUMANS; NEOPLASM INVASIVENESS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, EPHB4; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 76249132650     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1710     Document Type: Article

References (49)

1. Castano J, Davalos V, Schwartz S, Jr., Arango D. EPH receptors in cancer. Histol Histopathol 2008;23:1011-23.
2. Campbell TN, Robbins SM. The Eph receptor/ephrin system: an emerging player in the invasion game. Curr Issues Mol Biol 2008;10:61-6.
3. Pasquale EB. Eph-ephrin bidirectional signaling in physiology and disease. Cell 2008;133:38-52.
4. Pasquale EB. Eph receptor signalling casts a wide net on cell behaviour. Nat Rev Mol Cell Biol 2005;6:462-75.
5. Holmberg J, Genander M, Halford MM, et al. EphB receptors coordinate migration and proliferation in the intestinal stem cell niche. Cell 2006;125:1151-63.
6. Konstantinova I, Nikolova G, Ohara-Imaizumi M, et al. EphA-Ephrin-A-mediated β cell communication regulates insulin secretion from pancreatic islets. Cell 2007;129:359-70.
7. Zhao C, Irie N, Takada Y, et al. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab 2006;4:111-21.
8. Klein R. Bidirectional modulation of synaptic functions by Eph/ephrin signaling. Nat Neurosci 2009;12:15-20.
9. Aasheim HC, Patzke S, Hjorthaug HS, Finne EF. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Biochim Biophys Acta 2005;1723:1-7.
10. Gurniak CB, Berg LJ. A new member of the Eph family of receptors that lacks protein tyrosine kinase activity. Oncogene 1996;13:777-86.
11. Matsuoka H, Iwata N, Ito M, et al. Expression of a kinase-defective Eph-like receptor in the normal human brain. Biochem Biophys Res Commun 1997;235:487-92.
12. Fox BP, Kandpal RP. Transcriptional silencing of EphB6 receptor tyrosine kinase in invasive breast carcinoma cells and detection of methylated promoter by methylation specific PCR. Biochem Biophys Res Commun 2006;340:268-76.
13. Nakada M, Niska JA, Tran NL, McDonough WS, Berens ME. EphB2/ R-Ras signaling regulates glioma cell adhesion, growth, and invasion. Am J Pathol 2005;167:565-76.
14. Guo DL, Zhang J, Yuen ST, et al. Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. Carcinogenesis 2006;27:454-64.
15. Cortina C, Palomo-Ponce S, Iglesias M, et al. EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells. Nat Genet 2007;39:1376-83.
16. Oshima T, Akaike M, Yoshihara K, et al. Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer. Int J Oncol 2008;33:573-7.
17. Masood R, Kumar SR, Sinha UK, et al. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. Int J Cancer 2006;119:1236-48.
18. Alam SM, Fujimoto J, Jahan I, Sato E, Tamaya T. Overexpression of ephrinB2 and EphB4 in tumor advancement of uterine endometrial cancers. Ann Oncol 2007;18:485-90.
19. Noren NK, Pasquale EB. Paradoxes of the EphB4 receptor in cancer. Cancer Res 2007;67:3994-7.
20. Hafner C, Bataille F, Meyer S, et al. Loss of EphB6 expression in metastatic melanoma. Int J Oncol 2003;23:1553-9.
21. Tang XX, Evans AE, Zhao H, et al. High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas. Clin Cancer Res 1999;5:1491-6.
22. Muller-Tidow C, Diederichs S, Bulk E, et al. Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer. Cancer Res 2005;65:1778-82.
23. Freywald A, Sharfe N, Roifman CM. The kinase-null EphB6 receptor undergoes transphosphorylation in a complex with EphB1. J Biol Chem 2002;277:3823-8.
24. Matsuoka H, Obama H, Kelly ML, Matsui T, Nakamoto M. Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J Biol Chem 2005;280:29355-63.
25. Freywald A, Sharfe N, Rashotte C, Grunberger T, Roifman CM. The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses. J Biol Chem 2003;6:6.
26. Sharfe N, Freywald A, Toro A, Roifman CM. Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells. J Immunol 2003;170:6024-32.
27. Sharfe N, Nikolic M, Cimpeon L, Van De Kratts A, Freywald A, Roifman CM. EphA and ephrin-A proteins regulate integrin-mediated T lymphocyte interactions. Mol Immunol 2008;45:1208-20.
28. Servitja JM, Marinissen MJ, Sodhi A, Bustelo XR, Gutkind JS. Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src. J Biol Chem 2003;278:34339-46.
29. Jin W, Yun C, Hobbie A, Martin MJ, Sorensen PH, Kim SJ. Cellular transformation and activation of the phosphoinositide-3-kinase-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-Src. Cancer Res 2007;67:3192-200.
30. McSherry EA, Donatello S, Hopkins AM, McDonnell S. Molecular basis of invasion in breast cancer. Cell Mol Life Sci 2007;64:3201-18.
31. Munthe E, Rian E, Holien T, Rasmussen A, Levy FO, Aasheim H. Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. FEBS Lett 2000;466:169-74.
32. Noren NK, Foos G, Hauser CA, Pasquale EB. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 2006;8:815-25.
33. Gallant ND, Michael KE, Garcia AJ. Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol Biol Cell 2005;16:4329-40.
34. Yamazaki D, Oikawa T, Takenawa T. Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion. J Cell Sci 2007;120:86-100.
35. Blystone SD. Integrating an integrin: a direct route to actin. Biochim Biophys Acta 2004;1692:47-54.
36. Himanen JP, Saha N, Nikolov DB. Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol 2007;19:534-42.
37. Sturz A, Bader B, Thierauch KH, Glienke J. EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration. Biochem Biophys Res Commun 2004;313:80-8.
38. Luo H, Wan X, Wu Y, Wu J. Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. J Immunol 2001;167:1362-70.
39. Swaminathan G, Tsygankov AY. The Cbl family proteins: ring leaders in regulation of cell signaling. J Cell Physiol 2006;209:21-43.
40. Miyoshi-Akiyama T, Aleman LM, Smith JM, Adler CE, Mayer BJ. Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor. Oncogene 2001;20:4058-69.
41. Zandy NL, Pendergast AM. Abl tyrosine kinases modulate cadherin-dependent adhesion upstream and downstream of Rho family GTPases. Cell Cycle 2008;7:444-8.
42. Zandy NL, Playford M, Pendergast AM. Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. Proc Natl Acad Sci U S A 2007;104:17686-91.
43. Huang X, Wu D, Jin H, Stupack D, Wang JY. Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. J Cell Biol 2008;183:711-23.
44. Kain KH, Gooch S, Klemke RL. Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene 2003;22:6071-80.
45. Cavallaro U, Christofori G. Cell adhesion in tumor invasion and metastasis: loss of the glue is not enough. Biochim Biophys Acta 2001;1552:39-45.
46. Kopfstein L, Christofori G. Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment. Cell Mol Life Sci 2006;63:449-68.
47. Guarino M. Epithelial-mesenchymal transition and tumour invasion. Int J Biochem Cell Biol 2007;39:2153-60.
48. Tse JC, Kalluri R. Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem 2007;101:816-29.
49. Dikic I, Schmidt MH. Malfunctions within the Cbl interactome uncouple receptor tyrosine kinases from destructive transport. Eur J Cell Biol 2007;86:505-12.