A conditional feedback loop regulates Ras activity through EphA2

Cancer Cell

Volumn 8, Issue 2, 2005, Pages 111-118

  Macrae, Madhu ^a   Neve, Richard M ^b   Rodriguez Viciana, Pablo ^a   Haqq, Christopher ^a   Yeh, Jennifer ^a   Chen, Chira ^b   Gray, Joe W ^b,c   McCormick, Frank ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; EPHRIN A1; EPHRIN RECEPTOR A2; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; RAS PROTEIN;

ANIMAL CELL; ARTICLE; BREAST CANCER; CARCINOGENESIS; CONTROLLED STUDY; EMBRYO; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

EID: 23644451946     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2005.07.005     Document Type: Article

References (34)

1. E. Batlle, J.T. Henderson, H. Beghtel, M.M. van den Born, E. Sancho, G. Huls, J. Meeldijk, J. Robertson, M. van de Wetering, T. Pawson, and H. Clevers β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB Cell 111 2002 251 263
2. D.E. Bovenkamp, and P.A. Greer Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature DNA Cell Biol. 20 2001 203 213
3. P.A. Brittis, Q. Lu, and J.G. Flanagan Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target Cell 110 2002 223 235
4. H. Davies, G.R. Bignell, C. Cox, P. Stephens, S. Edkins, S. Clegg, J. Teague, H. Woffendin, M.J. Garnett, and W. Bottomley Mutations of the BRAF gene in human cancer Nature 417 2002 949 954
5. J. DeRisi, L. Penland, P.O. Brown, M.L. Bittner, P.S. Meltzer, M. Ray, Y. Chen, Y.A. Su, and J.M. Trent Use of a cDNA microarray to analyse gene expression patterns in human cancer Nat. Genet. 14 1996 457 460
6. V.C. Dodelet, and E.B. Pasquale Eph receptors and ephrin ligands: embryogenesis to tumorigenesis Oncogene 19 2000 5614 5619
7. D.J. Easty, B.A. Guthrie, K. Maung, C.J. Farr, R.A. Lindberg, R.J. Toso, M. Herlyn, and D.C. Bennett Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression Cancer Res. 55 1995 2528 2532
8. B. Knoll, and U. Drescher Ephrin-As as receptors in topographic projections Trends Neurosci. 25 2002 145 149
9. S.C. Kozma, M.E. Bogaard, K. Buser, S.M. Saurer, J.L. Bos, B. Groner, and N.E. Hynes The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231 Nucleic Acids Res. 15 1987 5963 5971
10. J.A. McCubrey, J.G. Shelton, L.S. Steelman, R.A. Franklin, T. Sreevalsan, and M. McMahon Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells Oncogene 23 2004 7810 7820
11. R. McLennan, and C.E. Krull Ephrin-As cooperate with EphA4 to promote trunk neural crest migration Gene Expr. 10 2002 295 305
12. H. Miao, B.R. Wei, D.M. Peehl, Q. Li, T. Alexandrou, J.R. Schelling, J.S. Rhim, J.R. Sedor, E. Burnett, and B. Wang Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway Nat. Cell Biol. 3 2001 527 530
13. H. Miao, C.H. Nickel, L.G. Cantley, L.A. Bruggeman, L.N. Bennardo, and B. Wang EphA kinase activation regulates HGF-induced epithelial branching morphogenesis J. Cell Biol. 162 2003 1281 1292
14. M. Nakamoto, and A.D. Bergemann Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis Microsc. Res. Tech. 59 2002 58 67
15. H. Ogata, H. Sato, J. Takatsuka, and L.M. De Luca Human breast cancer MDA-MB-231 cells fail to express the neurofibromin protein, lack its type I mRNA isoform and show accumulation of P-MAPK and activated Ras Cancer Lett. 172 2001 159 164
16. K. Ogawa, R. Pasqualini, R.A. Lindberg, R. Kain, A.L. Freeman, and E.B. Pasquale The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization Oncogene 19 2000 6043 6052
17. A. Palmer, and R. Klein Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function Genes Dev. 17 2003 1429 1450
18. A. Pandey, D.F. Lazar, A.R. Saltiel, and V.M. Dixit Activation of the Eck receptor protein tyrosine kinase stimulates phosphatidylinositol 3-kinase activity J. Biol. Chem. 269 1994 30154 30157
19. R.L. Pratt, and M.S. Kinch Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade Oncogene 21 2002 7690 7699
20. R.L. Pratt, and M.S. Kinch Ligand binding up-regulates EphA2 messenger RNA through the mitogen-activated protein/extracellular signal-regulated kinase pathway Mol. Cancer Res. 1 2003 1070 1076
21. M.A. Reynolds Microarray technology GEM microarrays and drug discovery J. Ind. Microbiol. Biotechnol. 28 2002 180 185
22. M.L. Samuels, M.J. Weber, J.M. Bishop, and M. McMahon Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase Mol. Cell. Biol. 13 1993 6241 6252
23. A. Schulze, K. Lehmann, H.B. Jefferies, M. McMahon, and J. Downward Analysis of the transcriptional program induced by Raf in epithelial cells Genes Dev. 15 2001 981 994
24. N. Sharfe, A. Freywald, A. Toro, H. Dadi, and C. Roifman Ephrin stimulation modulates T cell chemotaxis Eur. J. Immunol. 32 2002 3745 3755
25. N. Sharfe, A. Freywald, A. Toro, and C.M. Roifman Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cells J. Immunol. 170 2003 6024 6032
26. J.G. Shelton, L.S. Steelman, J.T. Lee, S.L. Knapp, W.L. Blalock, P.W. Moye, R.A. Franklin, S.C. Pohnert, A.M. Mirza, M. McMahon, and J.A. McCubrey Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells Oncogene 22 2003 2478 2492
27. T. Sorlie, C.M. Perou, R. Tibshirani, T. Aas, S. Geisler, H. Johnsen, T. Hastie, M.B. Eisen, M. van de Rijn, and S.S. Jeffrey Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications Proc. Natl. Acad. Sci. USA 98 2001 10869 10874
28. J. Tong, S. Elowe, P. Nash, and T. Pawson Manipulation of EphB2 regulatory motifs and SH2 binding sites switches MAPK signaling and biological activity J. Biol. Chem. 278 2003 6111 6119
29. V. VanBuren, Y. Piao, D.B. Dudekula, Y. Qian, M.G. Carter, P.R. Martin, C.A. Stagg, U.C. Bassey, K. Aiba, and T. Hamatani Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set Genome Res. 12 2002 1999 2003
30. J. Walker-Daniels, K. Coffman, M. Azimi, J.S. Rhim, D.G. Bostwick, P. Snyder, B.J. Kerns, D.J. Waters, and M.S. Kinch Overexpression of the EphA2 tyrosine kinase in prostate cancer Prostate 41 1999 275 280
31. J. Walker-Daniels, D.J. Riese 2nd, and M.S. Kinch c-Cbl-dependent EphA2 protein degradation is induced by ligand binding Mol. Cancer Res. 1 2002 79 87
32. S.M. Wilhelm, C. Carter, L. Tang, D. Wilkie, A. McNabola, H. Rong, C. Chen, X. Zhang, P. Vincent, and M. McHugh BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis Cancer Res. 64 2004 7099 7109
33. D.G. Wilkinson Eph receptors and ephrins: regulators of guidance and assembly Int. Rev. Cytol. 196 2000 177 244
34. D.P. Zelinski, N.D. Zantek, J.C. Stewart, A.R. Irizarry, and M.S. Kinch EphA2 overexpression causes tumorigenesis of mammary epithelial cells Cancer Res. 61 2001 2301 2306