Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors

Cancer Research

Volumn 65, Issue 22, 2005, Pages 10170-10173

  Alazzouzi, Hafid ^a   Davalos, Veronica ^a   Kokko, Antti ^b   Domingo, Enric ^a   Woerner, Stefan M ^c   Wilson, Andrew J ^d   Konrad, Lars ^c   Laiho, Päivi ^b   Espín, Eloi ^a   Armengol, Manel ^a   Imai, Kohzoh ^e   Yamamoto, Hiroyuki ^e   Mariadason, John M ^d   Gebert, Johannes F ^c   Aaltonen, Lauri A ^b   Schwartz Jr , Simo ^a   Arango, Diego ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITY OF HELSINKI   (Finland)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d ALBERT EINSTEIN CANCER CENTER   (United States)

^e SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; EPHRIN RECEPTOR B2; PROTEIN TYROSINE KINASE;

ARTICLE; COLORECTAL TUMOR; CONTROLLED STUDY; DNA METHYLATION; ENZYME INACTIVATION; EXON; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION;

ADENOMA; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; ENZYME ACTIVATION; EXONS; FRAMESHIFT MUTATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HUMANS; MICROSATELLITE REPEATS; PROMOTER REGIONS (GENETICS); RECEPTOR, EPHB2; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 28544450494     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2580     Document Type: Article

References (19)

1. Powell SM, Zilz N, Beazer-Barclay Y, et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992;359:235-7.
2. Mitchell KO, Ricci MS, Miyashita T, et al. Bax is a transcriptional target and mediator of c-myc-induced apoptosis. Cancer Res 2000;60:6318-25.
3. Batlle E, Henderson JT, Beghtel H, et al. β-Catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002;111:251-63.
4. van de Wetering M, Sancho E, Verweij C, et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50.
5. Batlle E, Bacani J, Begthel H, et al. EphB receptor activity suppresses colorectal cancer progression. Nature 2005;435:1126-30.
6. Duval A, Hamelin R. Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res 2002;62:2447-54.
7. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
8. Mariadason JM, Arango D, Shi Q, et al. Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer Res 2003;63:8791-812.
9. Woerner SM, Kloor M, Mueller A, et al. Microsatellite instability of selective target genes in HNPCC-associated colon adenomas. Oncogene 2005;24:2525-35.
10. Salovaara R, Loukola A, Kristo P, et al. Population-based molecular detection of hereditary nonpolyposis colorectal cancer. J Clin Oncol 2000;18:2193-200.
11. Aaltonen LA, Salovaara R, Kristo P, et al. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 1998;338:1481-7.
12. Boland CR, Thibodeau SN, Hamilton SR, et al. A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res 1998;58:5248-57.
13. Alazzouzi H, Alhopuro P, Salovaara R, et al. SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res 2005;11:2606-11.
14. Oliveira C, Pinto M, Duval A, et al. BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 2003;22:9192-6.
15. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 1996;93:9821-6.
16. Blom N, Gammeltoft S, Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 1999;294:1351-62.
17. Gerdes H, Chen Q, Elahi AH, et al. Recurrent deletions involving chromosomes 1, 5, 17, and 18 in colorectal carcinoma: possible role in biological and clinical behavior of tumors. Anticancer Res 1995;15:13-24.
18. Praml C, Finke LH, Herfarth C, Schlag P, Schwab M, Amler L. Deletion mapping defines different regions in 1p34.2-pter that may harbor genetic information related to human colorectal cancer. Oncogene 1995;11:1357-62.
19. Oba SM, Wang YJ, Song JP, et al. Genomic structure and loss of heterozygosity of EPHB2 in colorectal cancer. Cancer Lett 2001;164:97-104.