-
1
-
-
0031710509
-
Chemical genetics resulting from a passion for synthetic organic chemistry
-
Schreiber, S.L. (1998). Chemical genetics resulting from a passion for synthetic organic chemistry. Bioorg. Med. Chem., 6, 1127-1152.
-
(1998)
Bioorg. Med. Chem.
, vol.6
, pp. 1127-1152
-
-
Schreiber, S.L.1
-
2
-
-
0037416141
-
The small-molecule approach to biology
-
Schreiber, S.L. (2003). The small-molecule approach to biology. Chem. Eng. News, 81, 51-61.
-
(2003)
Chem. Eng. News
, vol.81
, pp. 51-61
-
-
Schreiber, S.L.1
-
3
-
-
21144440283
-
Chemical genetics to chemical genomics: small molecules offer big insights
-
Spring, D.R. (2005). Chemical genetics to chemical genomics: small molecules offer big insights. Chem. Soc. Rev., 34, 472-482.
-
(2005)
Chem. Soc. Rev.
, vol.34
, pp. 472-482
-
-
Spring, D.R.1
-
4
-
-
33745726644
-
Chemical genetics
-
Walsh, D.P., Chang, Y.-T. (2006). Chemical genetics. Chem. Rev., 106, 2476-2530.
-
(2006)
Chem. Rev.
, vol.106
, pp. 2476-2530
-
-
Walsh, D.P.1
Chang, Y.-T.2
-
6
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stockwell, B.R. (2004). Exploring biology with small organic molecules. Nature, 432, 846-854.
-
(2004)
Nature
, vol.432
, pp. 846-854
-
-
Stockwell, B.R.1
-
7
-
-
0036603953
-
From combinatorial chemistry to chemical microarray
-
Lam, K.S., Renil, M. (2002). From combinatorial chemistry to chemical microarray. Curr. Opin. Chem. Biol., 6, 353-358.
-
(2002)
Curr. Opin. Chem. Biol.
, vol.6
, pp. 353-358
-
-
Lam, K.S.1
Renil, M.2
-
8
-
-
4444307607
-
Recent advances in small moelcule microarrays: applications and technology
-
Walsh, D.P., Chang, Y.T. (2004). Recent advances in small moelcule microarrays: applications and technology. Comb. Chem. High Throughput Screen., 7, 557-564.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, pp. 557-564
-
-
Walsh, D.P.1
Chang, Y.T.2
-
9
-
-
15744378859
-
Ligand discovery using small molecule microarrays
-
He, X.G., Gerona-Navarro, G., Jaffrey, S.R. (2005). Ligand discovery using small molecule microarrays. J. Pharmacol. Exp. Ther., 313, 1-7.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.313
, pp. 1-7
-
-
He, X.G.1
Gerona-Navarro, G.2
Jaffrey, S.R.3
-
10
-
-
13444302617
-
Small molecule microarrays: recent advances and applications
-
Uttamchandani, M., Walsh, D.P., Yao, S.Q., Chang, Y.T. (2005). Small molecule microarrays: recent advances and applications. Curr. Opini. Chem. Biol., 9, 4-13.
-
(2005)
Curr. Opini. Chem. Biol.
, vol.9
, pp. 4-13
-
-
Uttamchandani, M.1
Walsh, D.P.2
Yao, S.Q.3
Chang, Y.T.4
-
11
-
-
33745220936
-
Chemical microarray: a new tool for drug screening and discovery
-
Ma, H., Horiuchi, K.Y. (2006). Chemical microarray: a new tool for drug screening and discovery. Drug Discov. Today, 11, 661-668.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 661-668
-
-
Ma, H.1
Horiuchi, K.Y.2
-
12
-
-
33645527760
-
Protein and small molecule microarrays: powerful tools for high-throughput proteomics
-
Uttamchandani, M., Wang, J., Yao, S.Q. (2006). Protein and small molecule microarrays: powerful tools for high-throughput proteomics. Mol. Biosyst., 2, 58-68.
-
(2006)
Mol. Biosyst.
, vol.2
, pp. 58-68
-
-
Uttamchandani, M.1
Wang, J.2
Yao, S.Q.3
-
13
-
-
33751515126
-
Small molecule microarrays: applications using specially tagged chemical libraries
-
Wang, J., Uttamchandani, M., Sun, H.Y., Yao, S.Q. (2006). Small molecule microarrays: applications using specially tagged chemical libraries. Qsar Comb. Sci., 25, 1009-1019.
-
(2006)
Qsar Comb. Sci.
, vol.25
, pp. 1009-1019
-
-
Wang, J.1
Uttamchandani, M.2
Sun, H.Y.3
Yao, S.Q.4
-
14
-
-
0033199751
-
Printing small molecules as microarrays and detecting protein-ligand interactions en masse
-
MacBeath, G., Koehler, A.N., Schreiber, S.L. (1999). Printing small molecules as microarrays and detecting protein-ligand interactions en masse. J. Am. Chem. Soc., 121, 7967-7968.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 7967-7968
-
-
MacBeath, G.1
Koehler, A.N.2
Schreiber, S.L.3
-
15
-
-
4644273636
-
Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes
-
Wong, J.C., Sternson, S.M., Louca, J.B., Hong, R., Schreiber, S.L. (2004). Modular synthesis and preliminary biological evaluation of stereochemically diverse 1,3-dioxanes. Chem. Biol., 11, 1279-1291.
-
(2004)
Chem. Biol.
, vol.11
, pp. 1279-1291
-
-
Wong, J.C.1
Sternson, S.M.2
Louca, J.B.3
Hong, R.4
Schreiber, S.L.5
-
16
-
-
0035900973
-
Reaction microarrays: a method for rapidly determining the enantiometroc excess of thousands of samples
-
Korbel, G.A., Lalic, G., Shair, M.D. (2001). Reaction microarrays: a method for rapidly determining the enantiometroc excess of thousands of samples. J. Am. Chem. Soc., 123, 361-362.
-
(2001)
J. Am. Chem. Soc.
, vol.123
, pp. 361-362
-
-
Korbel, G.A.1
Lalic, G.2
Shair, M.D.3
-
17
-
-
4944255180
-
Reaction discovery enabled by DNA-templated synthesis and in vitro selection
-
Kanan, M.W., Rozenman, M.M., Sakurai, K., Snyder, T.M., Liu, D.R. (2004). Reaction discovery enabled by DNA-templated synthesis and in vitro selection. Nature, 431, 545-549.
-
(2004)
Nature
, vol.431
, pp. 545-549
-
-
Kanan, M.W.1
Rozenman, M.M.2
Sakurai, K.3
Snyder, T.M.4
Liu, D.R.5
-
18
-
-
0032879750
-
Synthesis and million evaluation of a library of polycyclic small molecules for use in chemical genetic assays
-
Tan, D.S., Foley, M.A., Stockwell, B.R., Shair, M.D., Schreiber, S.L. (1999). Synthesis and million evaluation of a library of polycyclic small molecules for use in chemical genetic assays. J. Am. Chem. Soc., 121, 9073-9087.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 9073-9087
-
-
Tan, D.S.1
Foley, M.A.2
Stockwell, B.R.3
Shair, M.D.4
Schreiber, S.L.5
-
19
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber, S.L. (2000). Target-oriented and diversity-oriented organic synthesis in drug discovery. Science, 287, 1964-1969.
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
20
-
-
0142147275
-
Generating diverse skeletons of small molecules combinatorially
-
Burke, M.D., Berger, E.M., Schreiber, S.L. (2003). Generating diverse skeletons of small molecules combinatorially. Science, 302, 613-618.
-
(2003)
Science
, vol.302
, pp. 613-618
-
-
Burke, M.D.1
Berger, E.M.2
Schreiber, S.L.3
-
21
-
-
0026419319
-
Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
-
Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T., Cuervo, J.H. (1991). Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature, 354, 84-86.
-
(1991)
Nature
, vol.354
, pp. 84-86
-
-
Houghten, R.A.1
Pinilla, C.2
Blondelle, S.E.3
Appel, J.R.4
Dooley, C.T.5
Cuervo, J.H.6
-
22
-
-
0026419328
-
A new type of synthetic peptide library for identifying ligand-binding activity
-
Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M., Knapp, R.J. (1991). A new type of synthetic peptide library for identifying ligand-binding activity. Nature, 354, 82-84.
-
(1991)
Nature
, vol.354
, pp. 82-84
-
-
Lam, K.S.1
Salmon, S.E.2
Hersh, E.M.3
Hruby, V.J.4
Kazmierski, W.M.5
Knapp, R.J.6
-
23
-
-
0027362628
-
Complex synthetic chemical libraries indexed with molecular tags
-
Ohlmeyer, M.H. J., Swanson, R.N., Dillard, L.W., et al. (1993). Complex synthetic chemical libraries indexed with molecular tags. Proc. Nat. Acad. Sci. USA, 90, 10922-10926.
-
(1993)
Proc. Nat. Acad. Sci. USA
, vol.90
, pp. 10922-10926
-
-
Ohlmeyer, M.H.J.1
Swanson, R.N.2
Dillard, L.W.3
-
24
-
-
33751157590
-
A general method for molecular tagging of encoded combinatorial chemistry libraries
-
Nestler, H.P., Bartlett, P.A., Still, W.C. (1994). A general method for molecular tagging of encoded combinatorial chemistry libraries. J. Org. Chem., 59, 4723-4724.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 4723-4724
-
-
Nestler, H.P.1
Bartlett, P.A.2
Still, W.C.3
-
25
-
-
0037009016
-
Fabrlication of carbohydrate chips for studying protein-carbohydrate interactions
-
Park, S., Shin, I. (2002). Fabrlication of carbohydrate chips for studying protein-carbohydrate interactions. Angew. Chem. Int. Ed., 41, 3180-3182.
-
(2002)
Angew. Chem. Int. Ed.
, vol.41
, pp. 3180-3182
-
-
Park, S.1
Shin, I.2
-
26
-
-
1842830161
-
Carbohydrate chips for studying high-throughput carbohydrate-protein interactions
-
Park, S., Lee, M.-R., Pyo, S.-J., Shin, I. (2004). Carbohydrate chips for studying high-throughput carbohydrate-protein interactions. J. Am. Chem. Soc., 126, 4812-4819.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 4812-4819
-
-
Park, S.1
Lee, M.-R.2
Pyo, S.-J.3
Shin, I.4
-
27
-
-
3042646556
-
Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology: glycan-dependent gp120/protein interactions
-
Adams, E.W., Ratner, D.M., Bokesch, H.R., McMahon, J.B., O'Keefe, B.R., Seeberger, P.H. (2004). Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology: glycan-dependent gp120/protein interactions. Chem. Biol., 11, 875-881.
-
(2004)
Chem. Biol.
, vol.11
, pp. 875-881
-
-
Adams, E.W.1
Ratner, D.M.2
Bokesch, H.R.3
McMahon, J.B.4
O'Keefe, B.R.5
Seeberger, P.H.6
-
28
-
-
0034624574
-
Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis
-
Lee, D., Sello, J.K., Schreiber, S.L. (2000). Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis. Org. Lett., 2, 709-712.
-
(2000)
Org. Lett.
, vol.2
, pp. 709-712
-
-
Lee, D.1
Sello, J.K.2
Schreiber, S.L.3
-
29
-
-
0034674919
-
Small-molecule microarrays: covalent attachment and screening of alcohol-containing small molecules on glass slides
-
Hergenrother, P.J., Depew, K.M., Schreiber, S.L. (2000). Small-molecule microarrays: covalent attachment and screening of alcohol-containing small molecules on glass slides. J. Am. Chem. Soc., 122, 7849-7850.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 7849-7850
-
-
Hergenrother, P.J.1
Depew, K.M.2
Schreiber, S.L.3
-
30
-
-
0038682103
-
Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands
-
Barnes-Seeman, D., Park, S.B., Koehler, A.N., Schreiber, S.L. (2003). Expanding the functional group compatibility of small-molecule microarrays: discovery of novel calmodulin ligands. Angew. Chem. Int. Ed., 42, 2376-2379.
-
(2003)
Angew. Chem. Int. Ed.
, vol.42
, pp. 2376-2379
-
-
Barnes-Seeman, D.1
Park, S.B.2
Koehler, A.N.3
Schreiber, S.L.4
-
31
-
-
0037595546
-
Comprehensive identification of human bZIP interactions with coiled-coil arrays
-
Newman, J.R. S., Keating, A.E. (2003). Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science, 300, 2097-2101.
-
(2003)
Science
, vol.300
, pp. 2097-2101
-
-
Newman, J.R.S.1
Keating, A.E.2
-
32
-
-
0037132625
-
Peptide microarrays for the determinaiton of protease substrate specificity
-
Salisbury, C.M., Maly, D.J., Ellman, J.A. (2002). Peptide microarrays for the determinaiton of protease substrate specificity. J. Am. Chem. Soc., 124, 14868-14870.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 14868-14870
-
-
Salisbury, C.M.1
Maly, D.J.2
Ellman, J.A.3
-
33
-
-
0035017737
-
Peptide and small molecule microarray for high throughput cell adhesion and functional assays
-
Falsey, J.R., Renil, M., Park, S., Li, S., Lam, K.S. (2001). Peptide and small molecule microarray for high throughput cell adhesion and functional assays. Bioconjug. Chem., 12, 346-353.
-
(2001)
Bioconjug. Chem.
, vol.12
, pp. 346-353
-
-
Falsey, J.R.1
Renil, M.2
Park, S.3
Li, S.4
Lam, K.S.5
-
34
-
-
0037345651
-
a-Oxo semicarbazone peptide or oligodeoxynucleotide microarrays
-
Olivier, C., Hot, D., Huot, L., et al. (2003). a-Oxo semicarbazone peptide or oligodeoxynucleotide microarrays. Bioconjug. Chem., 14, 430-439.
-
(2003)
Bioconjug. Chem.
, vol.14
, pp. 430-439
-
-
Olivier, C.1
Hot, D.2
Huot, L.3
-
35
-
-
1642314571
-
Peptide-protein microarrays for the simultaneous detection of pathogen infenctions
-
Duburcq, X., Olivier, C., Malingue, F., et al. (2004). Peptide-protein microarrays for the simultaneous detection of pathogen infenctions. Bioconjug. Chem., 15, 307-316.
-
(2004)
Bioconjug. Chem.
, vol.15
, pp. 307-316
-
-
Duburcq, X.1
Olivier, C.2
Malingue, F.3
-
36
-
-
9344225707
-
Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human IgG
-
Uttamchandani, M., Walsh, D.P., Khersonsky, S.M., Huang, X., Yao, S.Q., Chang, Y.-T. (2004). Microarrays of tagged combinatorial triazine libraries in the discovery of small-molecule ligands of human Ig G.J. Comb. Chem., 6, 862-868.
-
(2004)
J. Comb. Chem.
, vol.6
, pp. 862-868
-
-
Uttamchandani, M.1
Walsh, D.P.2
Khersonsky, S.M.3
Huang, X.4
Yao, S.Q.5
Chang, Y.-T.6
-
37
-
-
3142684595
-
Aminoglycoside microarrays to study antibiotic resistance
-
Disney, M.D., Magnet, S., Blanchard, J.S., Seeberger, P.H. (2004). Aminoglycoside microarrays to study antibiotic resistance. Angew. Chem. Int. Ed., 43, 1591-1594.
-
(2004)
Angew. Chem. Int. Ed.
, vol.43
, pp. 1591-1594
-
-
Disney, M.D.1
Magnet, S.2
Blanchard, J.S.3
Seeberger, P.H.4
-
38
-
-
0028907140
-
Hydrocoating: a new method for coupling biomolecules to solid phases
-
Gregorius, K., Mouritsen, S., Elsner, H.I. (1995). Hydrocoating: a new method for coupling biomolecules to solid phases. J. Immunol. Methods, 181, 65-73.
-
(1995)
J. Immunol. Methods
, vol.181
, pp. 65-73
-
-
Gregorius, K.1
Mouritsen, S.2
Elsner, H.I.3
-
39
-
-
0035577868
-
In situ deprotection: a method for covalent immobilization of peptides with well-defined orientation for use in solid phase immunoassays such as enzyme-linked immunosorbent assay
-
Gregorius, K., Theisen, M. (2001). In situ deprotection: a method for covalent immobilization of peptides with well-defined orientation for use in solid phase immunoassays such as enzyme-linked immunosorbent assay. Anal. Biochem., 299, 84-91.
-
(2001)
Anal. Biochem.
, vol.299
, pp. 84-91
-
-
Gregorius, K.1
Theisen, M.2
-
40
-
-
0027944205
-
Synthesis of proteins by native chemical ligation
-
Dawson, P.E., Muir, T.W., Clark-Lewis, I., Kent, S.B. H. (1994). Synthesis of proteins by native chemical ligation. Science, 266, 776-779.
-
(1994)
Science
, vol.266
, pp. 776-779
-
-
Dawson, P.E.1
Muir, T.W.2
Clark-Lewis, I.3
Kent, S.B.H.4
-
41
-
-
0037135998
-
Developing site-specific immobilization strategies of peptides in a microarray
-
Lesaicherre, M.L., Uttamchandani, M., Chen, G.Y. J., Yao, S.Q. (2002). Developing site-specific immobilization strategies of peptides in a microarray. Bioorg. Med. Chem. Lett., 12, 2079-2083.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 2079-2083
-
-
Lesaicherre, M.L.1
Uttamchandani, M.2
Chen, G.Y.J.3
Yao, S.Q.4
-
42
-
-
18844410861
-
Fabrication of chemical microarrays by efficient immobilization of hydrazide-linked substances on epoxide-coated glass surfaces
-
Lee, M.-R., Shin, I. (2005). Fabrication of chemical microarrays by efficient immobilization of hydrazide-linked substances on epoxide-coated glass surfaces. Angew. Chem. Int. Ed., 44, 2881-2884.
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 2881-2884
-
-
Lee, M.-R.1
Shin, I.2
-
43
-
-
0037021535
-
Synthesis of sugar arrays in microtiter plate
-
Fazio, F., Bryan, M.C., Blixt, O., Paulson, J.C., Wong, C.-H. (2002). Synthesis of sugar arrays in microtiter plate. J. Am. Chem. Soc., 124, 14397-14402.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 14397-14402
-
-
Fazio, F.1
Bryan, M.C.2
Blixt, O.3
Paulson, J.C.4
Wong, C.-H.5
-
44
-
-
0348050489
-
Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays
-
Köhn, M., Wacker, R., Peters, C., et al. (2003). Staudinger ligation: a new immobilization strategy for the preparation of small-molecule arrays. Angew. Chem. Int. Ed., 42, 5830-5834.
-
(2003)
Angew. Chem. Int. Ed.
, vol.42
, pp. 5830-5834
-
-
Köhn, M.1
Wacker, R.2
Peters, C.3
-
45
-
-
3242672218
-
Covalent display of oligosaccharide arrays in microtiter plates
-
Bryan, M.C., Fazio, F., Lee, H.-K., et al. (2004). Covalent display of oligosaccharide arrays in microtiter plates. J. Am. Chem. Soc., 126, 8640-8641.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 8640-8641
-
-
Bryan, M.C.1
Fazio, F.2
Lee, H.-K.3
-
46
-
-
2442580955
-
High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays
-
Bryan, M.C., Lee, L.V., Wong, C.-H. (2004). High-throughput identification of fucosyltransferase inhibitors using carbohydrate microarrays. Bioorg. Med. Chem. Lett., 14, 3185-3188.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3185-3188
-
-
Bryan, M.C.1
Lee, L.V.2
Wong, C.-H.3
-
47
-
-
26444450696
-
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12
-
Calarese, D.A., Lee, H.-K., Huang, C.-Y., et al. (2005). Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proc. Natl. Acad. Sci. USA, 102, 13372-13377.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13372-13377
-
-
Calarese, D.A.1
Lee, H.-K.2
Huang, C.-Y.3
-
48
-
-
0037082167
-
DNA microarrays with PANAM dendritic linker systems
-
Benters, R., Niemeyer, C.M., Drutschmann, D., Blohm, D., Wöhrle, D. (2002). DNA microarrays with PANAM dendritic linker systems. Nucleic Acids Res., 30, e10.
-
(2002)
Nucleic Acids Res.
, vol.30
-
-
Benters, R.1
Niemeyer, C.M.2
Drutschmann, D.3
Blohm, D.4
Wöhrle, D.5
-
49
-
-
0141843623
-
Site-specific protein immobilization by Staudinger ligation
-
Soellner, M.B., Dickson, K.A., Nilsson, B.L., Raines, R.T. (2003). Site-specific protein immobilization by Staudinger ligation. J. Am. Chem. Soc., 125, 11790-11791.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 11790-11791
-
-
Soellner, M.B.1
Dickson, K.A.2
Nilsson, B.L.3
Raines, R.T.4
-
50
-
-
0036199649
-
Peptide chips for the quantitative evaluation of protein kinase activity
-
Houseman, B.T., Huh, J.H., Kron, S.J., Mrksich, M. (2002). Peptide chips for the quantitative evaluation of protein kinase activity. Nat. Biotechnol., 20, 270-274.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 270-274
-
-
Houseman, B.T.1
Huh, J.H.2
Kron, S.J.3
Mrksich, M.4
-
51
-
-
0036232915
-
Carbohydrate arrays for the evaluation of protein binding and enzymatic modification
-
Houseman, B.T., Mrksich, M. (2002). Carbohydrate arrays for the evaluation of protein binding and enzymatic modification. Chem. Biol., 9, 443-454.
-
(2002)
Chem. Biol.
, vol.9
, pp. 443-454
-
-
Houseman, B.T.1
Mrksich, M.2
-
52
-
-
4344714851
-
A photochemical method for patterning the immobilization of ligands and cells to self-assembled monolayers
-
Dillmore, W.S., Yousaf, M.N., Mrksich, M. (2004). A photochemical method for patterning the immobilization of ligands and cells to self-assembled monolayers. Langmuir, 20, 7223-7231.
-
(2004)
Langmuir
, vol.20
, pp. 7223-7231
-
-
Dillmore, W.S.1
Yousaf, M.N.2
Mrksich, M.3
-
53
-
-
24944450694
-
Protein-reactive natural products
-
Drahl, C., Cravatt, B.F., Sorensen, E.J. (2005). Protein-reactive natural products. Angew. Chem. Int. Ed., 44, 5788-5809.
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 5788-5809
-
-
Drahl, C.1
Cravatt, B.F.2
Sorensen, E.J.3
-
54
-
-
0029842109
-
Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
-
Choi, J., Chen, J., Schreiber, S.L., Clardy, J. (1996). Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science, 273, 239-242.
-
(1996)
Science
, vol.273
, pp. 239-242
-
-
Choi, J.1
Chen, J.2
Schreiber, S.L.3
Clardy, J.4
-
55
-
-
0037108767
-
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
-
Jin, L., Harrison, S.C. (2002). Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. Proc. Nat. Acad. Sci. USA, 99, 13522-13526.
-
(2002)
Proc. Nat. Acad. Sci. USA
, vol.99
, pp. 13522-13526
-
-
Jin, L.1
Harrison, S.C.2
-
56
-
-
0344667656
-
Immobilization of natural products on glass slides by using photoaffinity reaction and the detection of protein-small-molecule interactions
-
Kanoh, N., Kumashiro, S., Simizu, S., et al. (2003). Immobilization of natural products on glass slides by using photoaffinity reaction and the detection of protein-small-molecule interactions. Angew. Chem. Int. Ed., 42, 5584-5587.
-
(2003)
Angew. Chem. Int. Ed.
, vol.42
, pp. 5584-5587
-
-
Kanoh, N.1
Kumashiro, S.2
Simizu, S.3
-
57
-
-
20644461495
-
Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics
-
Kanoh, N., Honda, K., Simizu, S., Muroi, M., Osada, H. (2005). Photo-cross-linked small-molecule affinity matrix for facilitating forward and reverse chemical genetics. Angew. Chem. Int. Ed., 44, 3559-3562.
-
(2005)
Angew. Chem. Int. Ed.
, vol.44
, pp. 3559-3562
-
-
Kanoh, N.1
Honda, K.2
Simizu, S.3
Muroi, M.4
Osada, H.5
-
58
-
-
33845963410
-
Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions
-
Kanoh, N., Asami, A., Kawatani, M., et al. (2006). Photo-cross-linked small-molecule microarrays as chemical genomic tools for dissecting protein-ligand interactions. Chem. Asian J., 1, 789-797.
-
(2006)
Chem. Asian J.
, vol.1
, pp. 789-797
-
-
Kanoh, N.1
Asami, A.2
Kawatani, M.3
-
59
-
-
33645653692
-
SPR imaging of photo-cross-linked small-molecule arrays on gold
-
Kanoh, N., Kyo, M., Inamori, K., et al. (2006). SPR imaging of photo-cross-linked small-molecule arrays on gold. Anal. Chem., 78, 2226-2230.
-
(2006)
Anal. Chem.
, vol.78
, pp. 2226-2230
-
-
Kanoh, N.1
Kyo, M.2
Inamori, K.3
-
60
-
-
13444288243
-
Glycoprofiling with micro-arrays of glycoconjugates and lectins
-
Angeloni, S., Ridet, J.L., Kusy, N., et al. (2005). Glycoprofiling with micro-arrays of glycoconjugates and lectins. Glycobiology, 15, 31-41.
-
(2005)
Glycobiology
, vol.15
, pp. 31-41
-
-
Angeloni, S.1
Ridet, J.L.2
Kusy, N.3
-
61
-
-
33646587681
-
A robust small-molecule microarray platform for screening cell lysates
-
Bradner, J.E., McPherson, O.M., Mazitschek, R., et al. (2006). A robust small-molecule microarray platform for screening cell lysates. Chem. Biol., 13, 493-504.
-
(2006)
Chem. Biol.
, vol.13
, pp. 493-504
-
-
Bradner, J.E.1
McPherson, O.M.2
Mazitschek, R.3
-
62
-
-
0037136030
-
Antibody-based fluorescence detection of kinase activity on a peptide array
-
Lesaicherre, M.L., Uttamchandani, M., Chen, G.Y. J., Yao, S.Q. (2002). Antibody-based fluorescence detection of kinase activity on a peptide array. Bioorg. Med. Chem. Lett., 12, 2085-2088.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 2085-2088
-
-
Lesaicherre, M.L.1
Uttamchandani, M.2
Chen, G.Y.J.3
Yao, S.Q.4
-
63
-
-
0035801347
-
From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling
-
Winssinger, N., Harris, J.L., Backes, B.J., Schultz, P.G. (2001). From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling. Angew. Chem. Int. Ed., 40, 3152-3154.
-
(2001)
Angew. Chem. Int. Ed.
, vol.40
, pp. 3152-3154
-
-
Winssinger, N.1
Harris, J.L.2
Backes, B.J.3
Schultz, P.G.4
-
64
-
-
27944500629
-
PNA encoding (PNA = peptide nucleic acid): from solution-based libraries to organized microarrays
-
Harris, J.L., Winssinger, N. (2005). PNA encoding (PNA = peptide nucleic acid): from solution-based libraries to organized microarrays. Chem. Eur. J., 11, 6792-6801.
-
(2005)
Chem. Eur. J.
, vol.11
, pp. 6792-6801
-
-
Harris, J.L.1
Winssinger, N.2
-
65
-
-
2342505768
-
Encoded self-assembling chemical libraries
-
Melkko, S., Scheuermann, J., Dumelin, C.E., Neri, D. (2004). Encoded self-assembling chemical libraries. Nat. Biotechnol., 22, 568-574.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 568-574
-
-
Melkko, S.1
Scheuermann, J.2
Dumelin, C.E.3
Neri, D.4
-
66
-
-
33750311712
-
DNA-encoded chemical libraries
-
Scheuermann, J., Dumelin, C.E., Melkko, S., Neri, D. (2006). DNA-encoded chemical libraries. J. Biotechnol., 126, 568-581.
-
(2006)
J. Biotechnol.
, vol.126
, pp. 568-581
-
-
Scheuermann, J.1
Dumelin, C.E.2
Melkko, S.3
Neri, D.4
-
67
-
-
25444480799
-
Fluorous-based carbohydrate microarrays
-
Ko, K.-S., Jaipuri, F.A., Pohl, N.A. (2005). Fluorous-based carbohydrate microarrays. J. Am. Chem. Soc., 127, 13162-13163.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 13162-13163
-
-
Ko, K.-S.1
Jaipuri, F.A.2
Pohl, N.A.3
-
68
-
-
0037835827
-
Fluorous technologies for solution-phase high-throughput organic synthesis
-
Zhang, W. (2003). Fluorous technologies for solution-phase high-throughput organic synthesis. Tetrahedron, 59, 4475-4489.
-
(2003)
Tetrahedron
, vol.59
, pp. 4475-4489
-
-
Zhang, W.1
-
69
-
-
35649004408
-
Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors
-
Vegas, A.J., Bradner, J.E., Tang, W., et al. (2007). Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors. Angew. Chem. Int. Ed., 46, 7960-7964.
-
(2007)
Angew. Chem. Int. Ed.
, vol.46
, pp. 7960-7964
-
-
Vegas, A.J.1
Bradner, J.E.2
Tang, W.3
-
70
-
-
38849138708
-
Fluorous tagged small molecule microarrays
-
Nicholson, R.L., Ladlow, M.L., Spring, D.R. (2007). Fluorous tagged small molecule microarrays. Chem. Commun., 3906-3908.
-
(2007)
Chem. Commun.
, pp. 3906-3908
-
-
Nicholson, R.L.1
Ladlow, M.L.2
Spring, D.R.3
-
71
-
-
0141732260
-
Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening
-
Khersonsky, S.M., Jung, D.-W., Kang, T.-W., et al. (2003). Facilitated forward chemical genetics using a tagged triazine library and zebrafish embryo screening. J. Am. Chem. Soc., 125, 11804-11805.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 11804-11805
-
-
Khersonsky, S.M.1
Jung, D.-W.2
Kang, T.-W.3
-
72
-
-
0036193564
-
Carbohydrate microarrays for the recognition of cross reactive molecular markers of microbes and host cells
-
Wang, D., Liu, S., Trummer, B.J., Deng, C., Wang, A. (2002). Carbohydrate microarrays for the recognition of cross reactive molecular markers of microbes and host cells. Nat. Biotechnol., 20, 275-281.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 275-281
-
-
Wang, D.1
Liu, S.2
Trummer, B.J.3
Deng, C.4
Wang, A.5
-
73
-
-
0035990941
-
Saccharide display on microtiter plates
-
Bryan, M.C., Plettenburg, O., Sears, P., Rabuka, D., Wacowich-Sgarbi, S., Wong, C.-H. (2002). Saccharide display on microtiter plates. Chem. Biol., 9, 713-720.
-
(2002)
Chem. Biol.
, vol.9
, pp. 713-720
-
-
Bryan, M.C.1
Plettenburg, O.2
Sears, P.3
Rabuka, D.4
Wacowich-Sgarbi, S.5
Wong, C.-H.6
-
74
-
-
0041806643
-
Printing chemical libraries on microarrays for fluid phase nanoliter reactions
-
Gosalia, D.N., Diamond, S.L. (2003). Printing chemical libraries on microarrays for fluid phase nanoliter reactions. Proc. Nat. Acad. Sci. USA, 100, 8721-8726.
-
(2003)
Proc. Nat. Acad. Sci. USA
, vol.100
, pp. 8721-8726
-
-
Gosalia, D.N.1
Diamond, S.L.2
-
75
-
-
20544440319
-
Nanoliter homogeneous ultra-high throughput screening microarray for lead discoveries and IC50 profiling
-
Ma, H., Horiuchi, K.Y., Wang, Y., Kucharewicz, S.A., Diamond, S.L. (2005). Nanoliter homogeneous ultra-high throughput screening microarray for lead discoveries and IC50 profiling. Assay Drug Dev. Technol., 3, 177-187.
-
(2005)
Assay Drug Dev. Technol.
, vol.3
, pp. 177-187
-
-
Ma, H.1
Horiuchi, K.Y.2
Wang, Y.3
Kucharewicz, S.A.4
Diamond, S.L.5
-
76
-
-
9244230048
-
Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screen
-
Bailey, S.N., Sabatini, D.M., Stockwell, B.R. (2004). Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screen. Proc. Nat. Acad. Sci. USA, 101, 16144-16149.
-
(2004)
Proc. Nat. Acad. Sci. USA
, vol.101
, pp. 16144-16149
-
-
Bailey, S.N.1
Sabatini, D.M.2
Stockwell, B.R.3
-
77
-
-
0000951677
-
Use of peptide synthesis to probe vital antigens for epitopes to a resolution of a single amino acid
-
Geysen, H.M., Meloen, R.H., Barteling, S.J. (1984). Use of peptide synthesis to probe vital antigens for epitopes to a resolution of a single amino acid. Proc. Nat. Acad. Sci. USA, 81, 3998-4002.
-
(1984)
Proc. Nat. Acad. Sci. USA
, vol.81
, pp. 3998-4002
-
-
Geysen, H.M.1
Meloen, R.H.2
Barteling, S.J.3
-
78
-
-
0026656122
-
SPOT-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
-
Frank, R. (1992). SPOT-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron, 48, 9217-9232.
-
(1992)
Tetrahedron
, vol.48
, pp. 9217-9232
-
-
Frank, R.1
-
79
-
-
33744540320
-
Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis
-
Blackwell, H.E. (2006). Hitting the SPOT: small-molecule macroarrays advance combinatorial synthesis. Curr. Opin. Chem. Biol., 10, 203-212.
-
(2006)
Curr. Opin. Chem. Biol.
, vol.10
, pp. 203-212
-
-
Blackwell, H.E.1
-
80
-
-
0026108692
-
Light-directed, spatially addressable parallel chemical synthesis
-
Fodor, S.P. A., Read, J.L., Pirrung, M.C., Stryer, L., Lu, A.T., Solas, D. (1991). Light-directed, spatially addressable parallel chemical synthesis. Science, 251, 767-773.
-
(1991)
Science
, vol.251
, pp. 767-773
-
-
Fodor, S.P.A.1
Read, J.L.2
Pirrung, M.C.3
Stryer, L.4
Lu, A.T.5
Solas, D.6
-
81
-
-
84984933234
-
High density synthetic oligonucleotide arrays
-
Lipshutz, R.J., Fodor, S.P. A., Gingeras, T.R., Lockhart, D.J. (1999). High density synthetic oligonucleotide arrays. Nat. Genet., 21, 20-24.
-
(1999)
Nat. Genet.
, vol.21
, pp. 20-24
-
-
Lipshutz, R.J.1
Fodor, S.P.A.2
Gingeras, T.R.3
Lockhart, D.J.4
-
82
-
-
1842502934
-
Photolithigraphic synthesis of peptoids
-
Li, S., Bowerman, D., Marthandan, N., et al. (2004). Photolithigraphic synthesis of peptoids. J. Am. Chem. Soc., 126, 4088-4089.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 4088-4089
-
-
Li, S.1
Bowerman, D.2
Marthandan, N.3
-
83
-
-
0034622925
-
Printing proteins as microarrays for high-throughput function determination
-
MacBeath, G., Schreiber, S.L. (2000). Printing proteins as microarrays for high-throughput function determination. Science, 289, 1760-1763.
-
(2000)
Science
, vol.289
, pp. 1760-1763
-
-
MacBeath, G.1
Schreiber, S.L.2
-
84
-
-
0024852342
-
Catalyzed reporter deposition, a novel method of signal amplification
-
Bobrow, M.N., Harris, T.D., Shaughnessy, K.J., Litt, G.J. (1989). Catalyzed reporter deposition, a novel method of signal amplification. J. Immnol. Methods, 125, 279-285.
-
(1989)
J. Immnol. Methods
, vol.125
, pp. 279-285
-
-
Bobrow, M.N.1
Harris, T.D.2
Shaughnessy, K.J.3
Litt, G.J.4
-
85
-
-
0242386506
-
Binding affinities of host-guest, protein-ligand, and protein-transition-state complex
-
Houk, K.N., Leach, A.G., Kim, S.P., Zhang, X. (2003). Binding affinities of host-guest, protein-ligand, and protein-transition-state complex. Angew. Chem. Int. Ed., 42, 4872-4897.
-
(2003)
Angew. Chem. Int. Ed.
, vol.42
, pp. 4872-4897
-
-
Houk, K.N.1
Leach, A.G.2
Kim, S.P.3
Zhang, X.4
-
86
-
-
0035478125
-
Surface plasmon resonance: towards an understanding of the mechanisms of biological molecular recognition
-
McDonnell, J.M. (2001). Surface plasmon resonance: towards an understanding of the mechanisms of biological molecular recognition. Curr. Opin. Chem. Biol., 5, 572-577.
-
(2001)
Curr. Opin. Chem. Biol.
, vol.5
, pp. 572-577
-
-
McDonnell, J.M.1
-
87
-
-
0141976694
-
Chemical microarrays, fragment diversity, label-free imaging by plasmon resonance: a chemical genomics approach
-
Vetter, D. (2002). Chemical microarrays, fragment diversity, label-free imaging by plasmon resonance: a chemical genomics approach. J. Cell. Biochem., Suppl., 39, 79-84.
-
(2002)
J. Cell. Biochem., Suppl.
, vol.39
, pp. 79-84
-
-
Vetter, D.1
-
88
-
-
4444328431
-
-
In Protein-Ligand Interactions: From Molecular Recognition to Drug Design, G. Schneider, ed. Wiley-VCH, Weinheim, germany
-
Metz, G., Ottlesen, H., Vetter, D. (2003). In Protein-Ligand Interactions: From Molecular Recognition to Drug Design, G. Schneider, ed. Wiley-VCH, Weinheim, germany, pp. 213-236.
-
(2003)
, pp. 213-236
-
-
Metz, G.1
Ottlesen, H.2
Vetter, D.3
-
89
-
-
33646830791
-
Small molecule microarrays: development of novel linkers and an efficient detection method for bound proteins
-
Kurosu, M., Mowers, W.A. (2006). Small molecule microarrays: development of novel linkers and an efficient detection method for bound proteins. Bioorg. Med. Chem. Lett., 16, 3392-3395.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 3392-3395
-
-
Kurosu, M.1
Mowers, W.A.2
-
90
-
-
0037061492
-
Dissecting glucose signaling with diversity-oriented synthesis and small-molecule microarrays
-
Kuruvilla, F.G., Shamji, A.F., Sternson, S.M., Hergenrother, P.J., Schreiber, S.L. (2002). Dissecting glucose signaling with diversity-oriented synthesis and small-molecule microarrays. Nature, 416, 653-657.
-
(2002)
Nature
, vol.416
, pp. 653-657
-
-
Kuruvilla, F.G.1
Shamji, A.F.2
Sternson, S.M.3
Hergenrother, P.J.4
Schreiber, S.L.5
-
91
-
-
0038713943
-
Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis
-
Koehler, A.N., Shamji, A.F., Schreiber, S.L. (2003). Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis. J. Am. Chem. Soc., 125, 8420-8421.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 8420-8421
-
-
Koehler, A.N.1
Shamji, A.F.2
Schreiber, S.L.3
-
92
-
-
0037122032
-
Using mass spectrometry to characterize self-assembled monolayers presenting peptides, proteins, and carbohydrates
-
Su, J., Mrksich, M. (2002). Using mass spectrometry to characterize self-assembled monolayers presenting peptides, proteins, and carbohydrates. Angew. Chem. Int. Ed., 41, 4715-4718.
-
(2002)
Angew. Chem. Int. Ed.
, vol.41
, pp. 4715-4718
-
-
Su, J.1
Mrksich, M.2
-
93
-
-
2542627454
-
Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor
-
Min, D.-H., Tang, W.-J., Mrksich, M. (2004). Chemical screening by mass spectrometry to identify inhibitors of anthrax lethal factor. Nat. Biotechnol., 22, 717-723.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 717-723
-
-
Min, D.-H.1
Tang, W.-J.2
Mrksich, M.3
|