Binding Affinities of Host-Guest, Protein-Ligand, and Protein-Transition-State Complexes

Angewandte Chemie - International Edition

Volumn 42, Issue 40, 2003, Pages 4872-4897

  Houk, K N ^a   Leach, Andrew G ^a   Kim, Susanna P ^a   Zhang, Xiyun ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Binding affinities; Enthalpy entropy compensation; Enzyme catalysis; Host guest systems; Solvent accessible surface area

Indexed keywords

ASSOCIATION REACTIONS; CATALYSIS; COMPLEXATION; WATER;

SYNTHETIC HOSTS;

PROTEINS;

2 CHLOROPHENOL; 3 CHLOROPHENOL; 3 NITROPHENOL; 4 CHLOROPHENOL; 4 NITROPHENOL; ACETIC ACID; ACETONITRILE; ALBUMIN; ALCOHOL; ALPHA CYCLODEXTRIN; ANTIBODY; ANTIGEN; BENZENE; BENZOIC ACID; BETA CYCLODEXTRIN; BUTANOL; CATALYTIC ANTIBODY; CYCLODEXTRIN; CYCLOHEXANOL; GAMMA CYCLODEXTRIN; HEXANOIC ACID; HEXANOL; LIGAND; ORGANIC COMPOUND; PARA CRESOL; PENTANOL; PHENOL; PROPANOL; PYRIDINE; SOLVENT;

ANTIGEN ANTIBODY COMPLEX; BINDING AFFINITY; COMPLEX FORMATION; ENTHALPY; ENTROPY; ENZYME INHIBITOR COMPLEX; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR RECOGNITION; PROTEIN BINDING; REVIEW; THERMODYNAMICS;

ANIMALS; BINDING SITES; LIGANDS; PROTEIN BINDING; PROTEINS; SUBSTRATE SPECIFICITY;

EID: 0242386506     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200200565     Document Type: Review

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