Review article: Theory, fabrication and applications of microfluidic and nanofluidic biosensors

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

Volumn 370, Issue 1967, 2012, Pages 2269-2303

  Prakash, Shaurya ^a   Pinti, Marie ^a   Bhushan, Bharat ^a  

^a Ohio State University   (United States)

Author keywords

Biosensors; Cancer; Devices; Fluid slip; Microfluidics; Nanofluidics

Indexed keywords

ELECTRIC PROPERTIES; MECHANICAL PROPERTIES; MICROFLUIDICS; NANOFLUIDICS; SIGNAL TRANSDUCTION;

BIOLOGICAL SPECIES; CANCER; DEVICES; FLUID SLIP; SAMPLE EXTRACTION; SENSING ELEMENTS; SINGLE PLATFORM; SPECIAL CLASS;

BIOSENSORS;

GENETIC PROCEDURES; HUMAN; MICROFLUIDICS; REVIEW; SURFACE PLASMON RESONANCE; THEORETICAL MODEL;

BIOSENSING TECHNIQUES; HUMANS; MICROFLUIDICS; MODELS, THEORETICAL; SURFACE PLASMON RESONANCE;

EID: 84860647372     PISSN: 1364503X     EISSN: None     Source Type: Journal    
DOI: 10.1098/rsta.2011.0498     Document Type: Review

References (173)

1. Radadia, A. D., Morgan, R. D., Masel, R. I. & Shannon, M. A. 2009 Partially buried microcolumns for micro-gas analyzers. Anal. Chem. 81, 3471-3477. (doi:10.1021/ac8027382)
2. Nemes, P., Knolhoff, A. M., Rubakhin, S. S. & Sweedler, J. V. 2011 Metabolic differentiation of neuronal phenotypes by single-cell capillary electrophoresis-electrospray ionization-mass spectrometry. Anal. Chem. 83, 6810-6817. (doi:10.1021/ac2015855)
3. Buffi, N., Merulla, D., Beutier, J., Barbaud, F., Beggah, S., von Lintel, H., Renauda, P. & van der Meer, J. R. 2011 Development of a microfluidics biosensor for agarose-bead immobilized Escherichia coli bioreporter cells for arsenite detection in aqueous samples. Lab Chip 11, 2369-2377. (doi:10.1039/c1lc20274j)
4. Lee, J. H. & Han, J. 2010 Concentration-enhanced rapid detection of human chorionic gonadotropin as a tumor marker using nanofluidic preconcentrator. Microfluid. Nanofluid. 9, 973-979. (doi:10.1007/s10404-010- 0598-z)
5. Zubair, A., Burbelo, P. D., Vincent, L. G., Iadarola, M. J., Smith, P. D. & Morgan, N. Y. 2011 Microfluidic LIPS serum antibody detection: demonstration of a rapid test for HSV-2 infection. Biomed. Microdevices 13, 1053-1062. (doi:10.1007/s10544-011-9575-x)
6. Gervais, L., Hitzbleck, M. & Delamarche, E. 2011 Capillary-driven multiparametric microfluidic chips for one-step immunoassays. Biosens. Bioelectron. 27, 64-70. (doi:10.1016/j.bios.2011.06.016)
7. Hu, J., Sun, X., Agarwal, A. & Kimerling, L. C. 2009 Design guidelines for optical resonator biochemical sensors. J. Opt. Soc. Am. B 26, 1032-1041. (doi:10.1364/JOSAB.26.001032)
8. Fukuyama, M. et al. 2010 Selective detection of antigen-antibody reaction using Si ring optical resonators. Jpn J. Appl. Phys. 49, 04DL09. (doi:10.1143/JJAP.49.04DL09)
9. White, I. M., Zhu, H., Suter, J. D., Fan, X. & Zourob, M. 2009 Label-free detection with the liquid core optical ring resonator sensing platform. Methods Mol. Biol. 503, 139-165. (doi:10.1007/978-1-60327-567-5-7)
10. Fang, S., Lee, H. J., Wark, A. W. & Corn, R. M. 2006 Attomole microarray detection of microRNAs by nanoparticle-amplified SPR imaging measurements of surface polyadenylation reactions. J. Am. Chem. Soc. 128, 14044-14 046. (doi:10.1021/ja065223p) (Pubitemid 44657494)
11. Choi, S. & Chae, J. 2009 Surface plasmon resonance biosensor based on Vroman effect: towards cancer biomarker detection. In Proc. IEEE 15th Int. Mixed-Signals, Sensors, and Systems Test Workshop, Scottsdale, AZ, 10-12 June 2009. (doi:10.1109/IMS3TW.2009.5158683)
12. Metzger, J., von Landenberg, P., Kehrel, M., Buhl, A., Lackner, K. J. & Luppa, P. B. 2007 Biosensor analysis of 2-Glycoprotein I-reactive autoantibodies: evidence for isotype-specific binding and differentiation of pathogenic from infection-induced antibodies. Clin. Chem. 53, 1137-1143. (doi:10.1373/clinchem.2006.079632) (Pubitemid 46867532)
13. Chou, T.-H., Chuang, C.-Y. & Wu, C.-M. 2010 Quantification of Interleukin-6 in cell culture medium using surface plasmon resonance biosensors. Cytokine 51, 107-111. (doi:10.1016/j.cyto.2010.04.004)
14. Piliarik, M., Bockova, M. & Homola, J. 2010 Surface plasmon resonance biosensor for parallelized detection of protein biomarkers in diluted blood plasma. Biosens. Bioelectron. 26, 1656-1661. (doi:10.1016/j.bios.2010.08.063)
15. Malic, L., Veres, T. & Tabrizian, M. 2011 Nanostructured digital microfluidics for enhanced surface plasmon resonance imaging. Biosens. Bioelectron. 26, 2053-2059. (doi:10.1016/j.bios.2010.09.001)
16. Springer, T., Piliarik, M. & Homola, J. 2010 Real-time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor. Anal. Bioanal. Chem. 398, 1955-1961. (doi:10.1007/s00216-010-4159-9)
17. Pei, R., Cheng, Z., Wang, E. & Yang, X. 2001 Amplification of antigen-antibody interactions based on biotin labeled protein-streptavidin network complex using impedance spectroscopy. Biosens. Bioelectron. 16, 355-361. (doi:10.1016/S0956-5663(01)00150-6) (Pubitemid 32728157)
18. Vitarelli, M. J., Prakash, S. & Talaga, D. S. 2011 Determining nanocapillary geometry from electrochemical impedance spectroscopy using a variable topology network circuit model. Anal. Chem. 83, 533-541. (doi:10.1021/ac102236k)
19. Rodriguez, M. C., Kawde, A. N. & Wang, J. 2005 Aptamer biosensor for label-free impedance spectroscopy detection of proteins based on recognition-induced switching of the surface charge. Chem. Commun. 4267-4269. (doi:10.1039/b506571b) (Pubitemid 41345331)
20. Kwayke, S., Goral, V. N. & Baeumner, A. J. 2006 Electrochemical microfluidic biosensor for nucleic acid detection with integrated minipotentiostat. Biosens. Bioelectron. 21, 2217-2223. (doi:10.1016/j.bios.2005. 11.017)
21. Martinez, N. A., Schneider, R. J., Messina, G. A. & Raba, J. 2010 Modified paramagnetic beads in a microfluidic system for the determination of ethinylestradiol (EE2) in river water samples. Biosens. Bioelectron. 25, 1376-1381. (doi:10.1016/j.bios.2009.10.031)
22. Sotiropoulou, S. & Caniotakis, N. A. 2005 Lowering the detection limit of the acetylcholinesterase biosensor using a nanoporous carbon matrix. Anal. Chim. Acta 530, 199-204. (doi:10.1016/j.aca.2004.09.007) (Pubitemid 40215743)
23. Chen, L., McBranch, D. W., Wang, H.-L., Helgeson, R., Wudl, F. & Whitten, D. G. 1999 Highly sensitive biological and chemical sensors based on reversible fluorescence quenching in a conjugated polymer. Proc. Natl Acad. Sci. USA 96, 12287-12 292. (doi:10.1073/pnas.96.22.12287) (Pubitemid 29513494)
24. Zhang, G.-J., Chua, J. H., Chee, R.-E., Agarwal, A. & Wong, S. M. 2009 Label-free direct detection of MiRNAs with silicon nanowire biosensors. Biosens. Bioelectron. 24, 2504-2508. (doi:10.1016/j.bios.2008.12.035)
25. Javanmard, M. & Davis, R. W. 2011 A microfluidic platform for electrical detection of DNA hybridization. Sens. Actuators B 154, 22-27. (doi:10.1016/j.snb.2010.03.067)
26. Maeng, J. H., Lee, B. C., Ko, Y. J., Cho, W., Ahn, Y., Cho, N. G., Lee, S. H. & Hwang, S. Y. 2008 A novel microfluidic biosensor based on an electrical detection system for alpha-fetoprotein. Biosens. Bioelectron. 23, 1319-1325. (doi:10.1016/j.bios.2007.11.019)
27. 3 microelectrodes. Sens. Actuators B 98, 269-274. (doi:10.1016/j.snb.2003.10.036)
28. Fan, Y., Chen, X., Trigg, A. D., Tung, C.-h., Kong, J. & Gao, Z. 2007 Detection of MicroRNAs using target-guided formation of conducting polymer nanowires in nanogaps. J. Am. Chem. Soc. 129, 5437-5443. (doi:10.1021/ja067477g) (Pubitemid 46697631)
29. Iqbal, S. M., Balasundaram, G., Ghosh, S., Bergstrom, D. E. & Bashir, R. 2005 Direct current electrical characterization of DS-DNA in nanogap junctions. Appl. Phys. Lett. 86, 153901. (doi:10.1063/1.1900315) (Pubitemid 40861470)
30. Macanovic, A., Marquette, C., Polychronakos, C. & Lawrence, M. F. 2004 Impedance-based detection of DNA sequences using a silicon transducer with PNA as the probe layer. Nucleic Acids Res. 32, e20. (doi:10.1093/nar/gnh003)
31. Durand, N. F. Y. & Renaud, P. 2009 Label-free determination of protein-surface interaction kinetics by ionic conductance inside a nanochannel. Lab Chip 9, 319-324. (doi:10.1039/b811006a)
32. Chen, R., Bangsaruntip, S., Drouvalakis, K. A., Kam, N. W. S., Shim, M., Li, Y., Kim, W., Utz, P. J. & Dai, H. 2003 Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proc. Natl Acad. Sci. USA 100, 4984-4989. (doi:10.1073/pnas.0837064100) (Pubitemid 36542645)
33. Cui, Y., Wei, Q., Park, H. & Lieber, C. M. 2001 Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species. Science 293, 1289-1292. (doi:10.1126/science.1062711) (Pubitemid 32777412)
34. Hahm, J. & Lieber, C. M. 2004 Direct ultrasensitive electrical detection of DNA and DNA sequence variations using nanowire nanosensors. Nano Lett. 4, 51-54. (doi:10.1021/nl034853b) (Pubitemid 38167862)
35. Alvarez, M., Calle, A., Tamayo, J., Lechuga, L., Abad, A. & Montoya, A. 2003 Development of nanomechanical biosensors for detection of the pesticide DDT. Biosens. Bioelectron. 18, 649-653. (doi:10.1016/S0956-5663(03)00035-6) (Pubitemid 36428654)
36. Waggoner, P. S., Tan, C. P. & Craighead, H. G. 2010 Microfluidic integration of nanomechanical resonators for protein analysis in serum. Sens. Actuators B 150, 550-555. (doi:10.1016/j.snb.2010.08.041)
37. Hwang, K. S., Lee, S.-M., Kim, S. K., Lee, J. H. & Kim, T. S. 2009 Micro-and nanocantilever devices and systems for biomolecule detection. Annu. Rev. Anal. Chem. 2, 77-98. (doi:10.1146/annurev-anchem-060908-155232)
38. Lee, S. & Bhushan, B. 2010 Biological molecules in therapeutic nanodevices. In Spinger handbook of nanotechnology (ed. B. Bhushan), pp. 453-484. Berlin, Germany: Springer.
39. Olthius, W., Bergveld, P. & Kruise, J. 1997 The exploitation of ISFETs to determine acid-base behaviour of proteins. Electrochim. Acta 43, 3483-3488. (doi:10.1016/S0013-4686(98)00095-4) (Pubitemid 128412583)
40. Schoning, M. J. & Poghossian, A. 2002 Recent advances in biologically sensitive field-effect transistors (BioFETS). Analyst 127, 1137-1151. (doi:10.1039/b204444g)
41. Bhushan, B. 2010 MEMS/NEMS and BioMEMS/BioNEMS: materials, devices, and biomimetics. In Springer handbook of nanotechnology (ed. B. Bhushan), pp. 1663-1740. Berlin, Germany: Springer.
42. Bhushan, B., Tokachichu, D., Keener, M. T. & Lee, S. C. 2006 Nanoscale adhesion, friction, and wear studies of biomolecules on silicon-based surfaces. Acta Biomater. 2, 39-49. (doi:10.1016/j.actbio.2005.08.010) (Pubitemid 43348743)
43. Bhushan, B., Tokachichu, D. R., Keener, M. T. & Lee, S. C. 2005 Morphology and adhesion of biomolecules on silicon based surfaces. Acta Biomater. 1, 327-341. (doi:10.1016/j.actbio.2005.01.002) (Pubitemid 43348792)
44. Wang, J. 1999 Towards genoelectronics: electrochemical biosensing of DNA hybridization. Chem. Eur. J. 5, 1681-1685. (doi:10.1002/(SICI)1521- 3765(19990604)5:6<1681:AID-CHEM 1681>3.0.CO;2-U) (Pubitemid 129611584)
45. Mannoor, M. S., Zhang, S., Link, A. J. & McAlpine, M. C. 2010 Electrical detection of pathogenic bacteria via immobilized antimicrobial peptides. Proc. Natl Acad. Sci. USA 107, 19 207-19 212. (doi:10.1073/pnas. 1008768107)
46. Tsai, H.-K. A., Moschou, E. A., Kulinsky, L., Daunert, S. & Madou, M. J. 2009 Integrating biosensors and drug delivery: a step closer toward scalable responsive drug delivery systems. Adv. Mater. 21, 656-660. (doi:10.1002/adma. 200801770)
47. Watts, A. S., Urbas, A. A., Moschou, E., Gavalas, V. G., Zoval, J. V., Madou, J. & Bachas, L. G. 2007 Centrifugal microfluidics with integrated sensing microdome optodes for multiion detection. Anal. Chem. 79, 8046-8054. (doi:10.1021/ac0709100) (Pubitemid 350060000)
48. Nelson, W. C., Peng, I., Lee, G.-A., Loo, J. A., Garrell, R. L. & Kim, C.-J. 2010 Incubated protein reduction and digestion on an electrowetting-on-dielectric digital microfluidic chip for MALDI-MS. Anal. Chem. 82, 9932-9937. (doi:10.1021/ac101833b)
49. Shah, G. J., Veale, J. L., Korin, Y., Reed, E. F., Gritsch, H. A. & Kim, C.-J. 2010 Specific binding and magnetic concentration of CD8+ T-lymphocytes on electrowetting-on-dielectric platform. Biomicrofluidics 4, 044106. (doi:10.1063/1.3509457)
50. Lang, H. P., Hegner, M. & Gerber, C. 2005 Cantilever array sensors. Mater. Today 4, 30-36. (doi:10.1016/S1369-7021(05)00792-3) (Pubitemid 40352463)
51. Olthius, W., Bergveld, P. & Kruise, J. 1997 The exploitation of ISFETs to determine acid-base behaviour of proteins. Electrochim. Acta 43, 3483-3488. (doi:10.1016/S0013-4686(98)00095-4) (Pubitemid 128412583)
52. Metzger, J., von Landenberg, P., Kehrel, M., Buhl, A., Lackner, K. J. & Luppa, P. B. 2007 Biosensor analysis of 2-glycoprotein I-reactive autoantibodies: evidence for isotype-specific binding and differentiation of pathogenic from infection-induced antibodies. Clin. Chem. 53, 1137-1143. (doi:10.1373/clinchem.2006.079632) (Pubitemid 46867532)
53. Prakash, S. & Karacor, M. B. 2010 Surface mediated flows in glass nanofluidic channels. In Proc. 13th Solid-State Sensors, Actuators and Microsystems Workshop. Hilton Head Island, SC: Transducer Research Foundation.
54. Cho, S. K., Moon, H. & Kim, C.-J. 2003 Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic-based circuits. J. Microelectromech. Syst. 12, 70-80. (doi:10.1109/JMEMS.2002.807467)
55. Wheeler, A. R., Moon, H., Bird, C. A., Loo, R. R. O., Kim, C.-J., Loo, J. A. & Garrell, R. L. 2005 Digital microfluidics with in-line sample purification for proteomics analysis with MALDI-MS. Anal. Chem. 77, 534-540. (doi:10.1021/ac048754+) (Pubitemid 40116833)
56. Prakash, S., Karacor, M. B. & Banerjee, S. 2009 Surface modification in microsystems and nanosystems. Surf. Sci. Rep. 64, 233-254. (doi:10.1016/j.surfrep.2009.05.001)
57. Yanik, A. A., Huang, M., Artar, A., Chang, T.-Y. & Altug, H. 2010 Integrated nanoplasmonic-nanofluidic biosensors with targeted delivery of analytes. Appl. Phys. Lett. 96, 021101. (doi:10.1063/1.3290633)
58. Bhushan, B., Kasai, T., Kulik, G., Barbieri, L. & Hoffman, P. 2005 AFM study of perfluorosilane and alkylsilane self-assembled monolayers for anti-stiction in MEMS/NEMS. Ultramicroscopy 105, 176-188. (doi:10.1016/j. ultramic.2005.06.034) (Pubitemid 41539705)
59. Raiteri, R., Grattarola, M., Butt, M. & Skladal, P. 2001 Micromechanical cantilever-based biosensor. Sens. Actuators B 79, 115-126. (doi:10.1016/S0925-4005(01)00856-5) (Pubitemid 32866876)
60. Easley, C. J. et al. 2006 A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability. Proc. Natl Acad. Sci. USA 103, 19272-19 277. (doi:10.1073/pnas. 0604663103) (Pubitemid 46026023)
61. Chen, I. J. & White, I. M. 2011 High-sensitivity electrochemical enzyme linked assay on a microfluidic interdigitated microelectrode. Biosens. Bioelectron. 26, 4375-4381. (doi:10.1016/j.bios.2011.04.044)
62. Srinivasan, V., Pamula, V., Pollack, M. & Fair, R. 2003 A digital microfluidic biosensor for multianalyte detection. In Proc. IEEE 16th Annu. Int. Conf. Micro Electro Mechanical Systems, 19-23 January 2003, pp. 327-330. (doi:10.1109/MEMSYS.2003.1189752)
63. Newman, J. & Turner, A. 2005 Home blood glucose biosensors: a commercial perspective. Biosens. Bioelectron. 20, 2435-2453. (doi:10.1016/j.bios.2004.11.012) (Pubitemid 40602183)
64. Auroux, P.-A., Iossifidis, D., Reyes, D. R. & Manz, A. 2002 Micro total analysis systems. 2. Analytical standard operations and applications. Anal. Chem. 74, 2637-2652. (doi:10.1021/ac020239t) (Pubitemid 34651166)
65. Noroozi, Z., Kido, H., Peytavi, R., Nakajima-Sasaki, R., Jasinkas, A., Micic, M., Felgner, P. L. & Madou, M. J. 2011 A multiplexed immunoassay system based upon reciprocating centrifugal microfluidics. Rev. Sci. Instrum. 82, 064303. (doi:10.1063/1.3597578)
66. Rogers, K. 2000 Principles of affinity-based biosensors. Mol. Biotechnol. 14, 109-129. (doi:10. 1385/MB:14:2:109) (Pubitemid 30414304)
67. Prakash, S., Piruska, A., Gatimu, E. N., Bohn, P. W., Sweedler, J. V. & Shannon, M. A. 2008 Nanofluidics: systems and applications. IEEE Sens. J. 8, 441-450. (doi:10.1109/JSEN.2008.918758)
68. Conlisk, A. T. 2012 Essentials of micro and nanofluidics with applications to the biological and chemical sciences. Cambridge, UK: Cambridge University Press.
69. Zaytseva, N. V., Montagna, R. A. & Baeumner, A. J. 2005 Microfluidic biosensor for the serotype-specific detection of Dengue virus. Anal. Chem. 77, 7520-7527. (doi:10.1021/ac0509206) (Pubitemid 41746217)
70. Huang, L. R., Cox, E. C., Austin, R. H. & Sturm, J. C. 2004 Continuous particle separation through deterministic lateral displacement. Science 304, 987-990. (doi:10.1126/science.1094567) (Pubitemid 38638091)
71. Belgrader, P., Bennett, W., Hadley, D., Richards, J., Stratton, P., Mariella, R. & Milanovich, F. 1999 Infectious disease: PCR detection of bacteria in seven minutes. Science 284, 449-450. (doi:10.1126/science.284.5413. 449) (Pubitemid 29289608)
72. Blazej, R. G., Kumaresan, P. & Mathies, R. A. 2006 Microfabricated bioprocessor for integrated nanoliter-scale Sanger DNA sequencing. Proc. Natl Acad. Sci. USA 103, 7240-7245. (doi:10.1073/pnas.0602476103) (Pubitemid 43727817)
73. Bliss, C. L., McMullin, J. N. & Backhouse, C. J. 2007 Rapid fabrication of a microfluidic device with integrated optical waveguides for DNA fragment analysis. Lab Chip 7, 1280-1287. (doi:10.1039/b708485d) (Pubitemid 47482982)
74. Tegenfeldt, J. O., Prinz, C., Cao, H., Huang, R. L., Austin, R. H., Chou, S. Y., Cox, E. C. & Sturm, J. C. 2004 Micro-and nanofluidics for DNA analysis. Anal. Bioanal. Chem. 318, 1678-1692. (doi:10.1007/s00216-004-2526-0) (Pubitemid 40877643)
75. Srinivas, P. R., Verma, M., Zhao, Y. & Srivastava, S. 2002 Proteomics for cancer biomarker discovery. Clin. Chem. 48, 1160-1169. (Pubitemid 34809820)
76. Jain, K. K. 2004 Applications of biochips: from diagnostics to personalized medicine. Curr. Opin. Drug Discov. Dev. 7, 5507-5512.
77. Yager, P., Edwards, T., Fu, E., Helton, K., Nelson, K., Tam, M. R. & Weigl, B. H. 2006 Microfluidic diagnostic technologies for global public health. Nature 442, 412-418. (doi:10.1038/nature05064) (Pubitemid 44264785)
78. Gardeniers, H. & Van Den Berg, A. 2004 Micro-and nanofluidic devices for environmental and biomedical applications. Int. J. Environ. Anal. Chem. 84, 809-819. (doi:10.1080/03067310310001626678) (Pubitemid 39484139)
79. Jain, K. K. 2005 Nanotechnology in clinical laboratory diagnostics. Clin. Chim. Acta 358, 37-54. (doi:10.1016/j.cccn.2005.03.014) (Pubitemid 40966630)
80. Jain, K. K. 2005 The role of nanobiotechnology in drug discovery. Drug Discov. Today 10, 1435-1442. (doi:10.1016/S1359-6446(05)03573-7) (Pubitemid 41483872)
81. Squires, T. M., Messinger, R. J. & Manalis, S. R. 2008 Making it stick: convection, reaction and diffusion in surface-based biosensors. Nat. Biotechnol. 26, 417-426. (doi:10.1038/nbt1388) (Pubitemid 351501812)
82. Piruska, A., Gong, M., Sweedler, J. V. & Bohn, P. W. 2010 Nanofluidics in chemical analysis. Chem. Soc. Rev. 39, 1060-1072. (doi:10.1039/b900409m)
83. Wu, Y., Misra, S., Karacor, M. B., Prakash, S. & Shannon, M. A. 2010 Dynamic response of AFM cantilevers to dissimilar functionalized silica surfaces in aqueous electrolyte solutions. Langmuir 26, 16963-16 972. (doi:10.1021/la103005c)
84. Israelachvili, J. N. 1992 Intermolecular and surface forces, 2nd edn. San Diego, CA: Academic Press.
85. Kemery, P. J., Steehler, J. K. & Bohn, P. W. 1998 Electric field mediated transport in nanometer diameter channels. Langmuir 14, 2884-2889. (doi:10.1021/la980147s) (Pubitemid 128581267)
86. Burgeen, D. & Nakache, F. R. 1964 Electrokinetic flow in ultrafine capillary slits. J. Phys. Chem. 68, 1084-1091. (doi:10.1021/j100787a019)
87. Li, D. 2004 Electrokinetics in microfluidics. New York, NY: Academic Press.
88. Rice, C. L. & Whitehead, R. 1965 Electrokinetic flow in a narrow cylindrical capillary. J. Phys. Chem. 69, 4017-4024. (doi:10.1021/j100895a062)
89. Abgrall, P. & Nguyen, N. T. 2008 Nanofluidic devices and their applicactions. Anal. Chem. 80, 2326-2341. (doi:10.1021/ac702296u) (Pubitemid 351499814)
90. Kuo, T.-C., Sloan, L. A., Sweedler, J. V. & Bohn, P. W. 2001 Manipulating molecular transport through nanoporous membranes by control of electrokinetic flow: effect of surface charge density and debye length. Langmuir 17, 6298-6303. (doi:10.1021/la010429j) (Pubitemid 35330708)
91. Donnan, F. G. 1995 Theory of membrane equilibria and membrane potentials in the prescence of non-dialysing electrolytes: a contribution to physical-chemical physiology. J. Membr. Sci. 100, 45-55. (doi:10.1016/0376- 7388(94)00297-C)
92. Zhang, Y., Hu, Y., Wilson, G. S., Moatti-Sirat, D., Poitout, V. & Reach, G. 1994 Elimination of the acetaminophen interference in an implantable glucose sensor. Anal. Chem. 66, 1183-1188. (doi:10.1021/ac00079a038)
93. Matsumoto, T., Furusawa, M., Fujiwara, H., Matsumoto, Y. & Ito, N. 1998 A micro-planar amperometric glucose sensor unsusceptible to interference species. Sens. Actuators B 49, 68-72. (doi:10.1016/S0925-4005(98)00145-2) (Pubitemid 128458047)
94. Stern, E., Wagner, R., Sigworth, F. J., Breaker, R., Fahmy, T. M. & Reed, M. A. 2007 Importance of the Debye screening length on nanowire field effect transistor sensors. Nano Lett. 7, 3405-3409. (doi:10.1021/nl071792z) (Pubitemid 350216036)
95. Kim, D. R., Lee, C. H. & Zheng, X. 2009 Probing flow velocity with silicon nanowire sensors. Nano Lett. 9, 1984-1988. (doi:10.1021/nl900238a)
96. Tamaki, E., Hibara, A., Kima, H.-B., Tokeshi, M. & Kitamori, T. 2006 Pressure-driven flow control system for nanofluidic chemical process. J. Chromatogr. A 1137, 256-262. (doi:10.1016/j.chroma.2006.10.097) (Pubitemid 44834522)
97. Erikson, D. & Li, D. 2003 Analysis of alternating electroosmotic flows in a rectangular microchannel. Langmuir 19, 5421-5430. (doi:10.1021/la027035s)
98. Mala, G. M., Yang, C. & Li, D. 1998 Electrical double layer potential distribution in a rectangular microchannel. Colloid Surf. A 135, 109-116. (doi:10.1016/S0927-7757(97)00215-X) (Pubitemid 28197941)
99. Qu, W. & Li, D. 2000 A model for overlapped EDL fields. J. Colloid Interf. Sci. 224, 397-407. (doi:10.1006/jcis.1999.6708) (Pubitemid 30215146)
100. Erikson, D. & Li, D. 2003 Three-dimensional structure of electroosmotic flow over hetereogeneous surfaces. J. Phys. Chem. B 107, 12 212-12 220. (doi:10.1021/jp027724c)
101. Golden, J. P., Floyd-Smith, T. M., Mott, D. R. & Ligler, F. S. 2007 Target delivery in a microfluidic immunosensor. Biosens. Bioelectron. 22, 2763-2767. (doi:10.1016/j.bios.2006.12.017) (Pubitemid 46484274)
102. Vijayendran, R. A., Motsegood, K. M., Beebe, D. J. & Leckband, D. E. 2003 Evaluation of a three-dimensional micromixer in a surface-based biosensor. Langmuir 19, 1824-1828. (doi:10.1021/la0262250)
103. Bhushan, B. 2010 Nanotribology, nanomechanics, and materials characterization. In Springer handbook of nanotechnology (ed. B. Bhushan), p. 789-856. Berlin, Germany: Springer.
104. Henniker, J. 1962 Triboelectricity in polymers. Nature 196, 474. (doi:10.1038/196474a0)
105. Sakaguchi, M. & Kashiwabara, H. 1992 A generation mechanism of triboelectricity due to the reaction of mechaniradicals with mechanoions which are produced by mechanical fracture of solid polymer. Colloid Polym. Sci. 270, 621-626. (doi:10.1007/BF00654038)
106. Freeman, G. R. & March, N. H. 1999 Triboelectricity and some associated phenomena. Mater. Sci. Technol. 15, 1454-1458. (Pubitemid 129715782)
107. Vinogradova, O. I. & Belyaev, A. V. 2010 Wetting, roughness and hydrodynamic slip. In Nanoscale liquid interfaces, ch. 1. Singapore: Pan Stanford Publishing Pte Ltd.
108. Wang, Y. & Bhushan, B. 2010 Liquid microdroplet sliding on hydrophobic surfaces in the presence of electric field. Langmuir 26, 4013-4017. (doi:10.1021/la903460a)
109. Wang, Y. & Bhushan, B. 2010 Boundary slip and nanobubble study in micro/nanofluidics with atomic force microscope. Soft Matter 6, 29-66. (doi:10.1039/b917017k)
110. Wang, Y., Bhushan, B. & Maali, A. 2009 Atomic force microscopy measurement of boundary slip on hydrophilic, hydrophobic, and superhydrophobic surfaces. J. Vac. Sci. Technol. 27, 754-760. (doi:10.1116/1.3086637)
111. Mazumder, M. & Bhushan, B. 2011 Propensity and geometrical distribution of surface nanobubbles: effect of electrolyte, roughness, pH, and substrate bias. Soft Matter 7, 9184-9196. (doi:10.1039/C1SM05560G)
112. Bhushan, B. & Pan, Y. 2011 Role of electric field on surface wetting of polystyrene surface. Langmuir 27, 9425-9429. (doi:10.1021/la201636g)
113. Siegrist, J., Gorkin, R., Bastien, M., Stewart, G., Peytavi, R., Kido, H., Bergeron, M. & Madou, M. J. 2010 Validation of a centrifugal microfluidic sample lysis and homogenization platform for nucleic acid extraction with clinical samples. Lab Chip 10, 363-371. (doi:10.1039/b913219h)
114. Hong, C. C., Chang, P. H., Lin, C. C. & Hong, C. L. 2010 A disposable microfluidic biochip with on-chip molecularly imprinted biosensors for optical detection of anesthetic propofol. Biosens. Bioelectron. 25, 2058-2064. (doi:10.1016/j.bios.2010.01.037)
115. Chikkaveeraiah, B. V., Liu, H., Mani, V. & Papadimitrakopoulos, F. 2009 A microfluidic electrochemical device for high sensitivity biosensing: detection of nanomolar hydrogen peroxide. Electrochem. Commun. 11, 819-822. (doi:10.1016/j.elecom.2009.02.002)
116. Madou, M. 1997 Fundamentals of microfabrication. Boca Raton, FL: CRC Press LLC.
117. Yeom, J. & Shannon, M. A. 2010 Detachment lithography of photosensitive polymers: a route to fabricating three-dimensional structures. Adv. Funct. Mater. 20, 289-295. (doi:10.1002/adfm.200900686)
118. Pinti, M. & Prakash, S. 2011 A two-step wet etch process for the facile fabrication of hybrid micro-nanofluidic devices. In Proc. 2011 ASME Int. Mechanical Engineering Congress and Exposition, Denver, CO, 11-17 November 2011, IMECE2011-64508.
119. Zhu, H., Holl, M., Ray, T., Bhushan, S. & Meldrum, D. R. 2009 Characterization of deep wet etching of fused silica glass for single cell and optical sensor deposition. J. Micromech. Microeng. 19, 065013. (doi:10.1088/0960-1317/19/6/065013)
120. Ventra, M. D., Evoy, S. & Heflin, J. R. (eds) 2004 Introduction to nanoscale science and technology, p. 632. Boston, MA: Kluwer Academic Publishers.
121. Mao, P. & Han, J. 2005 Fabrication and characterization of 20 nm planar nanofluidic channels by glass-glass and glass-silicon bonding. Lab Chip 5, 837-844. (doi:10.1039/b502809d) (Pubitemid 41117310)
122. Goral, V. N., Zaytseva, N. V. & Baeumner, A. J. 2006 Electrochemical microfluidic biosensor for the detection of nucleic acid sequences. Lab Chip 6, 414-421. (doi:10.1039/b513239h) (Pubitemid 43327567)
123. Flachsbart, B. R., Wong, K., Iannacone, J. M., Abante, E. N., Vlach, R. L., Rauchfuss, P. A., Bohn, P. W., Sweedler, J. V. & Shannon, M. A. 2006 Design and fabrication of a multilayered polymer microfluidic chip with nanofluidic interconnects via adhesive contact printing. Lab Chip 6, 667-674. (doi:10.1039/b514300d)
124. Svoboda, K. & Block, S. M. 1994 Biological applications of optical forces. Annu. Rev. Biophys. Biomol. Struct. 23, 247-285. (doi:10.1146/annurev. bb.23.060194.001335) (Pubitemid 24217369)
125. Ashkin, A. & Dziedzic, J. M. 1989 Internal cell manipulation using infrared laser traps. Proc. Natl Acad. Sci. USA 86, 7914-7918. (doi:10.1073/pnas.86.20.7914)
126. Stavis, C. et al. 2011 Functionalization of thin-film diamond for highly stable and selective biological interfaces. Proc. Natl Acad. Sci. USA 108, 983-988. (doi:10.1073/pnas.1006660107)
127. Qiang, L., Vaddiraju, A., Rusling, J. F. & Papadimitrakopoulos, F. 2010 Highly sensitive and reusable Pt-black microfluidic electrodes for long-term electrochemical sensing. Biosens. Bioelectron. 26, 682-688. (doi:10.1016/j.bios.2010.06.064)
128. Wang, L. P., Shao, P. G., von Kan, J. A., Ansari, K., Bettiol, A. A., Pan, X. T., Wohland, T. & Watt, F. 2007 Fabrication of nanofluidic devices utilizing proton beam writing and thermal bonding techniques. Nucl. Instrum. Meth. B 260, 450-454. (doi:10.1016/j.nimb.2007.02.062) (Pubitemid 46874697)
129. Moritz, J., Dieny, B. Nozieres, J. P., Landis, S., Lebib, A. & Chen, Y. 2002 Domain structure in magnetic dots prepared by nanoimprint and e-beam lithography. J. Appl. Phys. 91, 7314-7316. (doi:10.1063/1.1452260) (Pubitemid 34636808)
130. Abgrall, P., Lowb, L.-N. & Nguyen, N.-T. 2007 Fabrication of planar nanofluidic channels in a thermoplastic by hot-embossing and thermal bonding. Lab Chip 7, 520-522. (doi:10.1039/b616134k) (Pubitemid 46496549)
131. Park, S.-m., Huh, Y. S., Craighead, H. G. & Erickson, D. 2009 A method for nanofluidic device prototyping using elastomeric collapse. Proc. Natl Acad. Sci. USA 106, 15549-15 554. (doi:10.1073/pnas.0904004106)
132. Zhang, Z. L. & MacDonald, N. C. 1992 An RIE process for submicron, silicon electromechanical structures. J. Micromech. Microeng. 2, 31. (doi:10.1088/0960-1317/2/1/007)
133. Abbasi, F., Mirzadeh, H. & Katbab, A. A. 2001 Modification of polysiloxane polymers for biomedical applications: a review. Polym. Int. 50, 1279-1287. (doi:10.1002/pi.783) (Pubitemid 34039540)
134. De Campos, A. M., Sanchez, A., Gref, R., Calvo, P. & Alonso, M. J. 2003 The effect of a PEG versus a chitosan coating on the interaction of drug colloidal carriers with the ocular mucosa. Eur. J. Pharm. Sci. 20, 73-81. (doi:10.1016/S0928-0987(03)00178-7) (Pubitemid 37103234)
135. Deng, L., Wang, Y., Shang, L., Wen, D., Wang, F. & Dong, S. 2008 A sensitive NADH and glucose biosensor tuned by visible light based on thionine bridged carbon nanotubes and gold nanoparticles multilayer. Biosens. Bioelectron. 24, 951-957. (doi:10.1016/j.bios.2008.07.066)
136. Krenkova, J. & Foret, F. 2004 Immobilized microfluidic enzymatic reactors. Electrophoresis 25, 3550-3563. (doi:10.1002/elps.200406096) (Pubitemid 40012112)
137. Pijanowska, D. G., Remiszewska, E., Lysko, J. M., Jazwinski, J. & Torbicz, W. 2003 Immobilization of bioreceptors for microreactors. Sens. Actuators B 91, 152-157. (doi:10. 1016/S0925-4005(03)00081-9)
138. Rosi, N. R. & Mirkin, C. A. 2005 Nanostructures in biodiagnostics. Chem. Rev. 105, 1547-1562. (doi:10.1021/cr030067f) (Pubitemid 40596871)
139. Ayhan, H., Cicek, H. & Tuncel, S. A. 2003 Investigation of surface properties of biodegradable albumin microspheres via phagocytosis phenomena. J. Bioact. Compat. Polym. 18, 273-282. (doi:10.1177/088391103036043) (Pubitemid 37238086)
140. Falconnet, D., Csucs, G., Grandin, H. M. & Textor, M. 2006 Surface engineering approaches to micropattern surfaces for cell-based assays. Biomaterials 27, 3044-3063. (doi:10.1016/j.biomaterials.2005.12.024) (Pubitemid 43247579)
141. Franks, W., Tosatti, S., Heer, F., Seif, P., Textor, M. & Hierlemann, A. 2007 Patterned cell adhesion by self-assembled structures for use with a CMOS cell-based biosensor. Biosens. Bioelectron. 22, 1426-1433. (doi:10.1016/j.bios.2006.06.031) (Pubitemid 46164773)
142. Gray, J. J. 2004 The interaction of proteins with solid surfaces. Curr. Opin. Struc. Biol. 14, 110-115. (doi:10.1016/j.sbi.2003.12.001) (Pubitemid 38249599)
143. Sauberlich, S., Klee, D., Richter, E. J., Hocker, H. & Spiekermann, H. 1999 Cell culture tests for assessing the tolerance of soft tissue to variously modified titanium surfaces. Clin. Oral Implan. Res. 10, 379-393. (doi:10.1034/j.1600-0501.1999.100505.x)
144. Yang, W. S. et al. 2002 DNA-modified nanocrystalline diamond thin-films as stable, biologically active substrates. Nat. Mater. 1, 253-257. (doi:10.1038/nmat779)
145. Cirino, N. M., Musser, K. A. & Egan, C. 2004 Multiplex diagnostic platforms for detection of biothreat agents. Expert Rev. Mol. Diagn. 4, 841-857. (doi:10.1586/14737159.4.6.841) (Pubitemid 39487588)
146. Danielsson, B. 1990 Calorimetric biosensors. J. Biotechnol. 15, 187-200. (doi:10.1016/0168-1656(90)90026-8) (Pubitemid 20226959)
147. Palchetti, I. & Mascini, M. 2008 Nucleic acid biosensors for environmental pollution monitoring. Analyst 133, 846-854. (doi:10.1039/b802920m)
148. Wu, L. Q., Ghodssi, R., Elabd, Y. A. & Payne, G. F. 2005 Biomimetic pattern transfer. Adv. Funct. Mater. 15, 189-195. (doi:10.1002/adfm.200400279) (Pubitemid 40384668)
149. Bhushan, B. 2009 Biomimetics: lessons from nature-an overview. Phil. Trans. R. Soc. A 367, 1445-1486. (doi:10.1098/rsta.2009.0011)
150. Bogunia-Kubik, K. & Sugisaka, M. 2002 From molecular biology to nanotechnology and nanomedicine. BioSystems 65, 123-138. (doi:10.1016/S0303- 2647(02)00010-2) (Pubitemid 34586773)
151. Ciardelli, G., Rechichi, A., Sartori, S., D'Acunto, M., Caporale, A., Peggion, E., Vozzi, G. & Giusti, P. 2006 Bioactive polyurethanes in clinical applications. Polym. Adv. Technol. 17, 786-789. (doi:10.1002/pat.781) (Pubitemid 44883662)
152. Freitas, R. A. 2005 What is nanomedicine? Nanomed. Nanotechnol. Biol. Med. 1, 2-9. (doi:10. 1016/j.nano.2004.11.003)
153. Grayson, A. C. R., Shawgo, R. S., Johnson, A. M., Flynn, N. T., Li, Y. W., Cima, M. J. & Langer, R. 2004 A BioMEMS review: MEMS technology for physiologically integrated devices. Proc. IEEE 92, 6-21. (doi:10.1109/JPROC. 2003.820534) (Pubitemid 40890769)
154. Herrmann, M., Roy, E., Veres, T. & Tabrizian, M. 2007 Microfluidic ELISA on non-passivated PDMS chip using magnetic bead transfer inside dual networks of channels. Lab Chip 7, 1546-1552. (doi:10.1039/b707883h) (Pubitemid 350013192)
155. Langer, R. & Peppas, N. A. 2004 Advances in biomaterials, drug delivery, and bionanotechnology. AIChE J. 49, 2990-3006. (doi:10.1002/aic. 690491202)
156. Jackman, R. J., Wilbus, J. L. & Whitesides, G. M. 1995 Fabrication of submicrometer features on curved substrates by microcontact printing. Science
157. van Delft, K. M., Eijkel, J. C. T., Mijatovic, D., Druzhinina, T. S., Rathgen, H., Tas, N. R., van den Berg, A. & Mugele, F. 2007 Micromachined Fabry-Pérot interferometer with embedded nanochannels for nanoscale fluid dynamics. Nano Lett. 7, 345-350. (doi:10.1021/nl062447x) (Pubitemid 46383595)
158. Prakash, S., Yeom, J., Jin, N., Adesida, I. & Shannon, M. A. 2007 Characterization of ionic transport at the nanoscale. Proc. Inst. Mech. Eng. Part N J. Nanoeng. Nanosyst. 220, 45-52. (doi:10.1243/17403499JNN91)
159. Singh, M., Verma, N., Garg, A. K. & Redhu, N. 2008 Urea biosensors. Sens. Actuators B 134, 345-351. (doi:10.1016/j.snb.2008.04.025)
160. Chou, I. H., Benford, M., Beier, H. T. & Cote, G. L. 2008 Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy. Nano Lett. 8, 1729-1735. (doi:10.1021/nl0808132)
161. Messina, G. A., Panini, N. V., Martinez, N. A. & Raba, J. 2008 Microfluidic immunosensor design for the quantification of interleukin-6 in human serum samples. Anal. Biochem. 380, 262-267. (doi:10.1016/j.ab.2008.05.055)
162. Zhang, X.-B., Kong, R.-M. & Lu, Y. 2011 Metal ion sensors based on DNAzymes and related DNA molecules. Annu. Rev. Anal. Chem. 4, 105-128. (doi:10.1146/annurev.anchem. 111808.073617)
163. 2+ in aqueous solution based on structure-switching DNA. Chem. Commun. 6005-6007. (doi:10.1039/b812755g)
164. Lan, T., Furuya, K. & Lu, Y. 2010 A highly selective lead sensor based on a classic lead DNAzyme. Chem. Commun. 46, 3896-3898. (doi:10.1039/b926910j)
165. Shingara, J., Keiger, K., Shelton, J., Laosinchai-Wolf, W., Powers, P., Conrad, R., Brown, D. & Labourier, E. 2005 An optimized isolation and labeling platform for accurate microRNA expression profiling. RNA 11, 1461-1470. (doi:10.1261/rna.2610405) (Pubitemid 41215448)
166. Bunimovich, Y. L., Shin, Y. S., Yeo, W. S., Amori, M., Kwong, G. & Heath, J. R. 2006 Quantitaive real-time measurements of DNA hybridization with alkylated nonoxidized silicon nanowires in electrolyte solution. J. Am. Chem. Soc. 128, 16 323-16 331. (doi:10.1021/ja065923u) (Pubitemid 44936627)
167. Chen, X., Matsumoto, N., Hu, Y. & Wilson, G. S. 2002 Electrochemically mediated electrodeposition/electropolymerization to yield a glucose microbiosensor with improved characteristics. Anal. Chem. 74, 368-372. (doi:10.1021/ac015628m) (Pubitemid 34072702)
168. Yang, Y. L., Tseng, T. F. & Lou, S. L. 2007 Using MPTMS as permselective membranes of biosensors. In Proc. 29th Annu. Int. Conf. of the IEEE Engineering in Medicine and Biology Society, 22-26 August 2007, pp. 6624-6627. (doi:10.1109/IEMBS.2007.4353878)
169. Soldatkin, A. P., El'skaya, A. V., Shul'ga, A. A., Jdanova, A. S., Dzyadevich, S. V., Jaffrezic-Renault, N., Martelet, C. & Clechet, P. 1994 Glucose sensitive conductometric biosensor with additional Nafion membrane: reduction of influence of buffer capacity on the sensor response and extension of dynamic range. Anal. Chim. Acta 288, 197-203. (doi:10.1016/0003-2670(93) E0627-J) (Pubitemid 24101052)
170. Choi, S. & Chae, J. 2010 Methods of reducing non-specific adsorption in microfluidic biosensors. J. Micromech. Microeng. 20, 075015. (doi:10.1088/0960-1317/20/7/075015)
171. Vroman, L. & Adams, A. L. 1969 Findings with the recording ellipsometer suggesting rapid exchange of specific plasma proteins at liquid solid interfaces. Surf. Sci. 16, 438-446. (doi:10. 1016/0039-6028(69)90037-5)
172. Jung, S.-Y., Lim, S.-M., Albertorio, F., Kim, G., Gurau, M. C., Yang, R. D., Holden, M. A. & Cremer, P. S. 2003 The Vroman effect: a molecular level description of fibrinogen displacement. J. Am. Chem. Soc. 125, 12 782-12 786. (doi:10.1021/ja037263o) (Pubitemid 37280446)
173. Choi, S. & Chae, J. 2009 A regenerative biosensing surface in microfluidics using electrochemical desorption of short-chain self-assembled monolayer. Microfluid. Nanofluid. 7, 819-827. (doi:10.1007/s10404-009-0440-7)