Continuous Particle Separation Through Deterministic Lateral Displacement

Science

Volumn 304, Issue 5673, 2004, Pages 987-990

  Huang, Lotien Richard ^a   Cox, Edward C ^b   Austin, Robert H ^b   Sturm, James C ^a  

^a Princeton University   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BIFURCATION (MATHEMATICS); CHROMOSOMES; LAMINAR FLOW; OPTICAL RESOLVING POWER;

MICROSPHERES; MIGRATION PATHS; PARTICLE SEPARATION;

FLUID MECHANICS;

MICROSPHERE; NANOPARTICLE;

FLUID DYNAMICS;

ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; DEVICE; FLOW KINETICS; GEL PERMEATION CHROMATOGRAPHY; HYDRODYNAMICS; LAMINAR FLOW; PARAMETER; PARTICLE SIZE; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SUPRAMOLECULAR CHEMISTRY; TECHNIQUE; TRANSPORT KINETICS; VELOCITY; VIRUS PARTICLE; DIFFUSION; ELECTRICITY; ELECTRONICS; FIELD FLOW FRACTIONATION; FLUORESCENCE MICROSCOPY; FRACTIONATION; INSTRUMENTATION; METHODOLOGY; MICROFLUIDICS; PHYSICAL CHEMISTRY;

BACTERIA (MICROORGANISMS);

CHEMICAL FRACTIONATION; CHEMISTRY, PHYSICAL; CHROMOSOMES, ARTIFICIAL, BACTERIAL; DIFFUSION; ELECTRICITY; FRACTIONATION, FIELD FLOW; MICROFLUIDICS; MICROSCOPY, FLUORESCENCE; MICROSPHERES; MINIATURIZATION; PARTICLE SIZE; RHEOLOGY;

EID: 2342619619     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1094567     Document Type: Article

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31. Supported by grants from the Defense Advanced Research Projects Agency (MDA972-00-1-0031), NIH (HG01506), NSF Nanobiololy Technology Center (BSCECS9876771), and the State of New Jersey (NJCST 99-100-082-2042-007). We thank K. Osoegawa and P. de Jong for supplying the bacterial artificial chromosome libraries; J. O. Tegenfeldt, P. Silberzan, S. Park, T. Duke, S. Weiss, D. Botstein, and P. M. Chaikin: and members of our laboratories for discussion. We acknowledge support from the Cornell University National Fabrication Center, where the deep silicon etching process of the device reported here was performed.